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Oxidative Stress:Role in Acetamiprid-Induced Impairment of the Male Mice Reproductive System

Agricultural Sciences in China 2011年第5期10卷 786-796页

作者： zhang Jiao-jiao WANG Yi xianG Hai-yang LI Meng-xue LI Wen-hao MA Kai-ge WANG xian-zhong zhang Jia-hua College of Animal Science and Technology Southwest University Chongqing 400716 P.R.China

Acetamiprid has a wide range of influence on physiological functions in *** objective of this study was to examine the effect of acetamiprid on the reproductive function of male mice,and to study the role of oxidative stress in acetamiprid-induced damage to the *** adult Kunmin male mice （25-30 g） were divided into five groups （n=10 per group）,i.e.,control,blank,acetamiprid alone,acetamiprid and vitamin E,and vitamin E *** groups were treated for 35 *** results showed that acetamiprid significantly decreased the body weight and the weight of testosterone-responsive organs,such as the testis,epididymis,seminal vesicle,and ***,acetamiprid also significantly reduced the serum testosterone concentration,and decreased sperm count,viability,motility,and the intactness of the acrosome （P〈0.05 for each parameter）.The mice treated with acetamiprid had damaged seminiferous tubules and Leydig cells based on the histological structure of testes;there was degeneration of the mitochondria and endoplasmic reticulum of Leydig *** deleterious effects of acetamiprid may be mediated by increasing oxidative stress,as acetamiprid increased malondialdehyde and nitric oxide in the testes,reduced the activity of catalase,glutathione peroxidase,superoxide dismutase,and activated *** concentration of acetamiprid in the testes was lower than that in liver,so did the concentrations of liver function tests,including aspartate transaminase （AST）,alanine transaminase （ALT） and alkaline phosphatase （ALP）,which suggest that male reproductive function may be affected through the indirect action of its *** E significantly ameliorated the effects of *** conclude that acetamiprid damages male reproductive function through inducing oxidative stress in the testes.

关键词： acetamiprid oxidative stress reproductive function testis

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The relationship between single nucleotide polymorphisms in estrogenmetabolizing genes CYP1A1,CYP17,COMT and estrogen receptor alpha and the risk of endometrial adenocarcinoma among the Chinese women

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现代妇产科进展 2007年第1期16卷 76-80页

作者： Yang Xingsheng Liu Jie zhong Yanhui zhang xian Wang Yan Department of Gynecology and Obstetrics Qilu Hospital of Shandong University Jinan 250012

Objective:To explore whether polymorphisms of the genes responsible for catechol estrogen(CE)formation via estrogen biosynthesis(CYP17)and hydroxylation (CYP1A1)and CE inactivation(COMT)and ERa are associated with an elevated risk for en- dometrial adenocarcinoma in Chinese ***:A multigenic case-control study was conducted,eighty-seven endometrial adenocarcinoma patients and ninety controls were recrui- ***-RFLP assays were used to determine the genotypes of estrogen-metabolizing genes and ERa ***:The endometrial adenocarcinoma risk associated with individual susceptibili- ty genotypes varied among the six polymorphic sites and was the highest for CYP17,followed by CYP1 A1 Ile-Val,CYP1A1 MspI,COMT,ERa XhaI and ERa *** logistic regres- sion showed the CYP1A1 MspI genotype was the most significant determinant for endometrial adenocarcinoma development and was associated with a 3.61 fold increase in risk(95% confi- dence interval,1.73～7.55).Furthermore,a trend of increasing risk for developing endometrial adenocarcinoma was found in women harboring higher numbers of high-risk ***- sion:The CYP1A1,CYP17 and ERa XbaI genotypes are related to the susceptibility of endome- trial adenocarcinoma,they may be useful markers for predicting endometrial adenocarcinoma *** allele encoding for low acticity COMT,ERa PvuII may not be a genetic risk factor for endometrial adenocarcinoma.

关键词：子宫内膜肿瘤基因治疗方法护理措施

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Promising xenograft animal model recapitulating the features of human pancreatic cancer

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World Journal of Gastroenterology 2020年第32期26卷 4802-4816页

作者： Jin-Xin Miao Jian-Yao Wang Hao-Ze Li Hao-Ran Guo Louisa S Chard Dunmall zhong-xian zhang Zhen-Guo Cheng Dong-Ling Gao Jian-Zeng Dong zhong-De Wang Yao-He Wang Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapyAcademy of Medical SciencesZhengzhou UniversityZhengzhou 450000Henan ProvinceChina Academy of Chinese Medical Sciences Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Centre for Biomarkers and Biotherapeutics Barts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUnited Kingdom Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Animal Dairy and Veterinary SciencesUtah State UniversityLogan UT 84341United States

BACKGROUND Multiple sites of metastasis and desmoplastic reactions in the stroma are key features of human pancreatic cancer(PC).There are currently no simple and reliable animal models that can mimic these features for accurate disease *** To create a new xenograft animal model that can faithfully recapitulate the features of human *** Interleukin 2 receptor subunit gamma(IL2RG)gene knockout Syrian hamster was created and characterized.A panel of human PC cell lines were transplanted into IL2RG knockout Syrian hamsters and severe immune-deficient mice subcutaneously or *** growth,local invasion,remote organ metastasis,histopathology,and molecular alterations of tumor cells and stroma were compared over *** The Syrian hamster with IL2RG gene knockout(named ZZU001)demonstrated an immune-deficient phenotype and ***001 hamsters faithfully recapitulated most features of human PC,in particular,they developed metastasis at multiple *** tissues derived from ZZU001 hamsters displayed desmoplastic reactions in the stroma and epithelial to mesenchymal transition phenotypes,whereas PC tissues derived from immune-deficient mice did not present such *** ZZU001 hamsters engrafted with human PC cells are a superior animal model compared to immune-deficient ***001 hamsters can be a valuable animal model for better understanding the molecular mechanism of tumorigenesis and metastasis and the evaluation of new drugs targeting human PC.

关键词： Pancreatic cancer Xenotrans plantation Syrian hamster IL-2 receptor gamma chain gene Metastasis Animal model

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Effect of apigenin on the reproductive system in male mice

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Health 2010年第5期2卷 435-440页

作者： Hui Li Hong-Bo Li Ming zhang Fang Yan zhong-xian zhang Zhi-Lan Li 不详

This study aimed to characterize the effect of apigenin on the reproductive system in male mice. Adult male mice were treated with intraperitoneal injection of apigenin at the dose levels of 5, 10, 15, 20 and 25 mg/***, 0.05% DMSO and 0.9% normal saline daily for seven days. Then, testis and epididymis sperms in sperm motility, sperm morphology, the percentages of ploidy cells and seminiferous epithelium cells at the cell-circle phase, and the ratio of ploidy cells were evaluated. The results showed that sperm density significantly reduced in the 25 mg/kg group compared with the solvent control group. The abnormal sperms were mainly amorphous;non-hook sperms took the second largest group;and banana, double-tail and folded-tail sperms were rare. Abnormal sperms were mainly in the head sperm. Moreover, after intraperitoneal injection of 5 mg/kg apigenin, the percentage of 1C population increased, and the percentage of 4C declined, leading to a significant increase of the 1C:4C ratio, compared with the solvent and negative control groups. The percentage of seminiferous epithelium cells at the cell-circle phase of G0/G1 exhibited a significant increase in the 25 mg/kg group compared with the control groups. Taken together, that apigenin has adverse effects on the reproductive system in adult male mice is demonstrated.

关键词： Apigenin Male Mice Intraperitoneal Injection Sperm Motility Sperm Morphology Flow Cytometry

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Fate of Fertilizer Nitrogen Applied to Crops Grown on Fluvo-Aquic Soil in Huang-Huai-Hai Plain

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Pedosphere 1991年第2期1卷 145-155页

作者： WANGxian－zhong zhangSHAO－LIN 等 InstituteofSoilScience AcademiaSinicaP.O.Box821Nanjing（China） InstituteofSoilScience AcademiaSinica

The fate of urea-and ammonium bicarbonate (ABC)-nitrogen (N) applied by prevailing traditional techniques to winter wheat (Triticum aestivum L.) or maize (Zea mays L.) grown in the fields of Fluvo-aquic soil was investigated using 15N tracer-micro-plot technique. Results show that:(1) at maturity of wheat, N recovery in plants and N losses of urea and ABC applied at seeding in autumn were 31-39%, and 34-46%, respectively, while the corresponding figures for side-banding at 10 cm depth in early spring were 51-57%, and 5-12%; surface-broadcast of urea followed by irrigation at early spring was as efficient as the side-banding in improving N recovery in plants and reducing N loss, however, such technique was found less satisfactory with ABC. (2) At the maturity of maize, N recovery in the plants and N loss of urea and ABC sidebanded at seedling stage or prior to tasseling ranged from 23% to 57%, and 9% to 26%, respectively. (3) Either in Wheat or in maize experiment, the majority of residual fertilizer N in soil profile (0-60 cm) was in the form of biologically immobilized organic N, however, the contribution of ammonium fixation by clay minerals increased markedly with depth in soil profile. (4) Though the proportion of residual fertilizer N was generally highest in the top 20 cm soil layer, considerable reaidual N (mostly 6-11 % of the N applied) was found in 60-100 cm soil layers.

关键词： ammonium bicarbonate fate of fertilizer N urea maize wheat

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Genetic Analysis of Cotton Fiber Traits by Molecular Markers

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棉花学报 2008年第S1期20卷 127-页

作者： LIN zhong-Xu,zhang xian-long(Huazhong Agricultural University,Wuhan,430070,China) Huazhong Agricultural University Wuhan430070China

*** of EST-SSRs derived from ***:One hundred and nineteen EST-SSRs were developed based on 98 unique ESTs from a cDNA library constructed in our laboratory using developing fibers from *** *** the SSRs,trinucleotide A... 详细信息

关键词： QTLs SSRs Genetic Analysis of Cotton Fiber Traits by Molecular Markers

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浅谈新时期民族博物馆建设

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宁德师专学报（哲学社会科学版） 2009年第3期 20-22页

作者：钟章贤闽东畲族文物馆福建宁德352100

我国是个统一的多民族国家,各族人民在历史长河中创造了光辉灿烂的文化,民族博物馆作为民族资源的收藏、研究、展示和教育中心,具有重要的作用,新时期的民族博物馆由于诸多原因,面临着严峻考验,民族博物馆建设要精心考虑其选址、布局展... 详细信息

我国是个统一的多民族国家,各族人民在历史长河中创造了光辉灿烂的文化,民族博物馆作为民族资源的收藏、研究、展示和教育中心,具有重要的作用,新时期的民族博物馆由于诸多原因,面临着严峻考验,民族博物馆建设要精心考虑其选址、布局展陈等几个因素。

关键词：民族博物馆选址布局展示

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A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo zhang Yinfan Liu xian Jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

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基层党建引领乡村治理权力重塑的理论与实践

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沈阳农业大学学报（社会科学版） 2018年第5期20卷 519-523页

作者：张小莉钟宪章中共辽宁省委党校校刊编辑部辽宁沈阳110004 中共辽宁省委党校党建教研部辽宁沈阳110004

新时代基层党建引领乡村治理的内在逻辑是基层治理现代化的重要理论与实践问题。本质上,党建引领乡村治理的内在逻辑是农村基层党组织的权力重塑过程。农村基层党组织的权力重塑是指基层党组织维持和扩展党组织权力的行动过程。重塑权... 详细信息

新时代基层党建引领乡村治理的内在逻辑是基层治理现代化的重要理论与实践问题。本质上,党建引领乡村治理的内在逻辑是农村基层党组织的权力重塑过程。农村基层党组织的权力重塑是指基层党组织维持和扩展党组织权力的行动过程。重塑权力与资源依赖关系是农村基层党组织权力实现的动机,适应环境与改变环境是基层党组织权力实现的行动策略。当前,党建引领乡村治理的权力实现过程,主要包括权力载体的再造、治理性权力与领导性权力的实现。在现实实践中,不同地域的基层党组织在权力重塑的能力上表现出差异性,使基层党组织引领乡村治理的状态各不相同。新时代中国乡村振兴需要从基层党组织的动力、社会功能和组织建设等方面,提升党建引领乡村治理的权力实现能力。

关键词：党建引领乡村治理权力实现治理性权力领导性权力乡村振兴战略

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一氧化碳的双共振多光子电离研究

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物理化学学报 1985年第1期1卷 66-75页

作者：沙国河钟宪赵申张存浩中国科学院大连化学物理研究所

用两束脉冲染料激光进行了CO的光学双共振四光子电离,获得了转动分辩的CO A1Π←X1Σ+和B1Σ+←A1Π跃迁的光谱。观察到了在此2+1光子相继吸收中特有的选择定则。动力学研究表明CO基态到A1Π态的双光子吸收是速率决定步骤,其吸收截面约... 详细信息

用两束脉冲染料激光进行了CO的光学双共振四光子电离,获得了转动分辩的CO A1Π←X1Σ+和B1Σ+←A1Π跃迁的光谱。观察到了在此2+1光子相继吸收中特有的选择定则。动力学研究表明CO基态到A1Π态的双光子吸收是速率决定步骤,其吸收截面约为1×10-49cm4s。还测定了A1Π态的单态转动传能截面。对于宇称指数e守恒、△J×±1的过程的截面约为52;随△J值增大而减小。对相同的△J,e正负变号的过程的截面总是小于e不变过程的截面。

关键词：跃迁选择定则光子双共振玻色子吸收截面共振多光子电离工业气体一氧化碳

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