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Exosome Is an Important Novel Way of Acupuncture Information Transmission

World Journal of Traditional Chinese Medicine 2020年第4期6卷 377-383页

作者： Ning-Cen Li Ming-Yue Li zhong-xi lu Mu-Yang Li Xue-Mao Zhuo Yong Chen Ting-Ting Wang Li-Ying xing Mei-Juan Wang Kai Shan Ze-Lin Chen Calista Hui-Min Lim Bo Chen Yi Guo Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Novahealth TCM Clinic Pte Ltd. Singapore

As a physical stimulation of the body surface,the process of transmitting acupuncture information from acupoints to target organs through meridians and collaterals is complex,and network regulation is the most basic mode of *** are membrane vesicles formed by various types of cells and secreted to the extracellular matrix through a series of *** speculate that exosomes and their carriers,as important carriers of communication among neurons,endocrine cells,and immune cells,may play an important role in the process of acupuncture information *** in the acupoint area is an important interactive form of transformation from physical information to chemical *** exosome is an important means of delivery for acupuncture to play an important role in the network *** structure and information molecules of exosomes are the important material bases for acupuncture *** experimental research,it was found that acupuncture can regulate the release of exosome and may have a certain relationship with acupuncture ***,exosome may play an important role in the process of acupuncture information transmission,which is an important new way of acupuncture information transmission.

关键词： Acupuncture exosome information transmission network regulation

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： xiaoling zhong Wenjiao Tai Meng-lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-xin Yang Bao-xia Dong Tong-Bu lu Di-Chang zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Neuroendocrine-Immune Regulating Mechanisms for the Anti-Inflammatory and Analgesic Actions of Acupuncture

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 384-392页

作者： Zhi-Fang Xu Shou-Hai Hong Shen-Jun Wang Xue Zhao Yang-Yang Liu Sha-Sha Ding Yuan Xu Kuo Zhang Nan-Nan Yu zhong-xi lu Fu-Ming Yang Yi-Nan Gong Qin-Qin He Kun Yu Yi-Ping Zhang Bao-Min Dou Lin Yao Ya-Wen Yan Tao Yang Yan-Fang Zhang Bao-Hu Liu Yong-Ming Guo Hsuah-Nee-Connie Wong Yi Guo Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina

Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international *** studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced *** on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target *** have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic *** on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune *** indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/*** addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 ***,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.

关键词： Acupuncture anti-inflammation analgesia neuro-endocrine-immune network CXCL1

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng xi luo Yuntao Zhang Yuqin Dong Jin zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan zhong Yashuang Xu Junhui Ren Yi Liang xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Densification of the packing structure under vibrations

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International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 499-503页

作者： xi-zhong An School of Materials and Metallurgy Northeastern University

Two packing structures with the maximum packing densities of 0.64 and 0.74 for the amorphous state and crystalline state, respectively, were numerically reproduced in the packing densification of equal spheres subjected to one- dimensional and three-dimensional vibrations using the discrete element method （DEM）, and the results were physically validated. These two packing structures were analyzed in terms of coordination number （CN）, radial distribution function （RDF）, angular distribution function （ADF）, and pore size distribution （Voronoi/Delaunay tessellation）. It is shown that CN distributions have the peak values of 7 and 12 for the amorphous state and crystalline state, respectively. RDF and ADF distributions show isolated peaks and orientation preferences for the crystalline state, indicating the long range and angle correlation among particles commonly observed in the crystalline state. Voronoi/Delaunay tessellation also shows smaller and narrower pore size distribution for the crystalline state.

关键词： particle packing densification vibrations discrete element method

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao xiA Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI Chen xiAO Renyou XU Wenwen WANG xiantao SHANG Shiyang lu Dapeng ZHU Hong-xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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Better Choice:Linear Long Chains Rather than Branched Ones to Improve Mechanical Performance of Polyethylene through Generating Shish-Kebabs

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Chinese Journal of Polymer Science 2020年第7期38卷 715-729,I0006页

作者： lu-Feng Deng xi-xi Zhang Dong Zhou Jian-Hua Tang Jun Lei Jun-Fang Li zhong-Ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China College of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

We utilized two structurally different long chains(linear and branched ultra-high molecular weight polyethylene)to reveal the dependence of flow-induced crystallization on long chain architecture,and prepared two bi-disperse systems of 98 wt%short chain and 2 wt%long chain.A flow field was applied to the bi-disperse polyethylene melt by a modified injection-molding machine,known as oscillation shear injection molding(OSIM).For the first time,the structural influence of long chains on flow-induced shish-kebab formation was systematically *** the intermediate layer of OSIM samples,the branched long chains were better than the linear long chains at inducing shish-kebab formation,agreeing with the reported literatures,because the branches can maintain their oriented conformations *** unexpectedly,the reverse is the case for the core layer of OSIM samples,where the shear flow was much weaker than the intermediate *** understand the unexpected phenomenon,the lifetime of shishes induced by different long chains was *** demonstrated that the linear-induced shishes possessed higher thermal stability than the branched-induced ones so that the linear-induced shishes could survive in the core layer of OSIM ***,unlike other methods for flow-induced crystallization,OSIM could create samples for measuring mechanical properties,and thus offer the chance to reveal the relationship between structure and *** mechanical results demonstrated that both long chains remarkably enhanced the mechanical properties because of the significant promoting effect of long chains and intense flow fields on shish-kebab ***,the linear long chains induced more stable and flawless shishes with higher tensile strength and modulus(80.4 and 1613.5 Mpa,respectively)than the branched ones(74.4 and 1489.3 Mpa).Our research not only helps elucidate the mechanism of shish-kebab formation but also provides a better choice to reinforce

关键词： Polyethylene Crystallization Shear-induced Long chain Short chain

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Carbon nanotubes/graphitic carbon nitride nanocomposites for all-solid-state supercapacitors

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Science China(Technological Sciences) 2020年第9期63卷 1714-1720页

作者： lu Chao CHEN xi Deparment of Earth and Environmental Engineering Columbia UniversityNew York 10027USA School of Chemical Engineering.Northwest University Xi'an 710069China

All-solid-state supercapacitors with high power density and working stability are high-efficiency energy storage devices for smart electronic equipment. Developing electrode materials with fast ions and electrons transport is critical to improving the energy storage capability. Here, we report carbon nanotubes/graphitic carbon nitride nanocomposites with large specific surface area, porous structure and high electrical conductivity toward high-performance supercapacitors. The large surface area with porosity provides reservoir for ion accommodation during charge-discharge processes, and the high conductivity facilitates electrons and ions transport. Furthermore, nitrogen sites in electrodes contribute significant pseudocapacitance for supercapacitors. The nanocomposites based device gives a high specific capacity of 148 F g^(–1) at current density of 1 A g^(–1) with good rate capability from 1 to 10 A g^(–1). Additionally, the device displays excellent working stability with capacitance retention of 93%even after 10000 cycles at 1 A g^(–1) under 0.8 V in air. This study sheds light on design of nanocomposites with highly efficient charge transfer and will accelerate development of next-generation solid state energy devices.

关键词： carbon nanotubes graphitic carbon nitride nanocomposite nitrogen doping high capacity supercapacitors

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