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Construction and analysis of tree models for chromosomal classification of diffuse large B-cell lymphomas

World Journal of Gastroenterology 2007年第11期13卷 1737-1742页

作者： Hui-Yong Jiang zhong-xi huang Xue-Feng Zhang Richard Desper Tong Zhao Department of General Surgery General Hospital of Shenyang Military Region Shenyang 110016 Liaoning Province China Department of Pathology Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China Department of Biology University College London Darwin Building Gower Street London WC1E 6BT United Kingdom

AIM: To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-step and multi-pathway processes of DLBCL tumorigenesis. METHODS: Maximum-weight branching and distancebased models were constructed based on the comparative genomic hybridization (CGH) data of 123 DLBCL samples using the established methods and software of Desper et al . A maximum likelihood tree model was also used to analyze the data. By comparing with the results reported in literature, values of tree models in the classification of DLBCL were elucidated. RESULTS: Both the branching and the distance-based trees classified DLBCL into three groups. We combined the classification methods of the two models and classified DLBCL into three categories according to their characteristics. The first group was marked by +Xq, +Xp, -17p and +13q; the second group by +3q, +18q and +18p; and the third group was marked by -6q and +6p. This chromosomal classification was consistent with cDNA classification. It indicated that -6q and +3q were two main events in the tumorigenesis of lymphoma. CONCLUSION: Tree models of lymphoma established from CGH data can be used in the classification of DLBCL. These models can suggest multi-gene, multistep and multi-pathway processes of tumorigenesis. Two pathways, -6q preceding +6q and +3q preceding+18q, may be important in understanding tumorigenesis of DLBCL. The pathway, -6q preceding +6q, may have a close relationship with the tumorigenesis of non-GCB DLBCL.

关键词： Lymphoma Subclassification Comparative gene hybridization Tree model Tumorigenesis

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Prospective,single-center cohort studyanalyzing the efficacy of complete laparoscopic resection on recurrent hepatocellular carcinoma

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Chinese Journal of Cancer 2016年第5期35卷 229-235页

作者： Jie Zhang zhong-Guo Zhou zhong-xi huang Ke-Li Yang Jian-Cong Chen Jin-Bin Chen Li Xu Min-Shan Chen Yao-Jun Zhang Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine

Background:Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma(HCC).However,few studies have examined the treatment of recurrent HCC in patients who received a prior *** present prospective study compared the clinical efficacy of laparoscopic surgery with conventional open surgery in HCC patients with postoperative tumor ***:We conducted a prospective study of 64 patients,all of whom had undergone open surgery once before,who were diagnosed with recurrent HCC between June 2014 and November *** laparoscopic group(n = 31)underwent laparoscopic hepatectomy,and the control group(n = 33) underwent conventional open *** time,intraoperative blood loss,surgical margins,postoperative pain scores,postoperative time until the patient could walk,anal exsufflation time,length of hospital stay,and inpatient costs were compared between the two *** patients were followed up for 1 year after surgery,and relapse-free survival was compared between the two ***:All surgeries were successfully *** conversion to open surgery occurred in the laparoscopic group,and no serious postoperative complications occurred in either *** significant difference in inpatient costs was found between the laparoscopic group and the control group(P = 0.079),but significant differences between the two groups were observed for operation time(116.7 ± 37.5 vs.148.2 ± 46.7 min,P = 0.031),intraoperative blood loss(117.5 ± 35.5 vs.265.9 ± 70.3 mL,P = 0.012),postoperative time until the patient could walk(1.6 ± 0.6vs.2.2 ± 0.8 days,P < 0.05),anal exsufflation time(2.1 ± 0.3 vs.2.8 ± 0.7 days,P = 0.041),visual analogue scale pain score(P < 0.05),postoperative hepatic function(P < 0.05),and length of hospital stay(4.5 ± 1.3 vs.6.0 ± 1.2 days,P = 0.014).During the 1-year postoperative follow-up period,6 patients in each group had recurrent HCC on the side of the initial operation,but no significant difference

关键词：英语教学教学理念英语阅读

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铝电解烟气净化系统的优化设计

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中国有色冶金 2008年第1期37卷 42-44页

作者：席仲黄中国铝业青海分公司青海大通810108

针对铝电解干法净化系统中的缺陷进行优化设计,采用逆向二段干法吸附净化技术,以较低的反应段气固比,实现极高的氟净化效率。

关键词：铝电解干法净化逆向二段干法净化含氟烟气净化效率

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基于非结构网格的螺旋桨周围流场大涡模拟

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水动力学研究与进展（A辑） 2008年第4期23卷 419-425页

作者：韦喜忠黄振宇洪方文中国船舶科学研究中心江苏无锡214082

采用基于非结构网格的有限体积法对螺旋桨的水动力性能和周围黏性流场进行了大涡模拟,在加权最小二乘法重构流动物理量梯度的基础上,分别以三阶精度的UMUSCL(Unstructured Monotonic Upstream-centered Schemes for Conversation Law)... 详细信息

采用基于非结构网格的有限体积法对螺旋桨的水动力性能和周围黏性流场进行了大涡模拟,在加权最小二乘法重构流动物理量梯度的基础上,分别以三阶精度的UMUSCL(Unstructured Monotonic Upstream-centered Schemes for Conversation Law)插值方法和方向导数法离散控制方程的对流项和亚格子应力项,计算得到的螺旋桨的定常水动力性能、叶片表面压力和尾流场速度与试验吻合很好。

关键词：大涡模拟有限体积法非结构网格螺旋桨

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浅析电解铝生产中烟气处理及其余热利用

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有色冶金节能 2011年第6期26卷 44-45页

作者：席仲黄中国铝业青海分公司青海大通810108

介绍了铝电解生产中的污染源,讨论了烟气净化的途径和烟气能源利用方案。

关键词：铝电解烟气处理再利用

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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili Wang Jiancheng huang Yanan Du Wei huang Yufeng Xue xiaokun Xu Guannan zhong Yuanyuan Shi Bin Hong xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing huang Yonghua Zhao Lei xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu xi Xu Tianyi huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng xi Luo Yuntao Zhang Yuqin Dong Jin zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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球等鞭金藻8701的耐低温机理

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水产学报 2001年第1期25卷 20-25页

作者：宫相忠唐学玺黄健张学成杨震张凯松青岛海洋大学海洋生命学院!山东青岛266003

对耐低温品系球等鞭金藻 870 1在低温下与活性氧清除和伤害有关的几个生理生化指标进行了研究 ,探讨了其耐低温机理 ,并与该藻种的低温敏感品系球等鞭金藻 30 11进行了比较。结果表明 ,⑴球等鞭金藻 870 1在低温下 ( 8℃ )培养一周 ,其... 详细信息

对耐低温品系球等鞭金藻 870 1在低温下与活性氧清除和伤害有关的几个生理生化指标进行了研究 ,探讨了其耐低温机理 ,并与该藻种的低温敏感品系球等鞭金藻 30 11进行了比较。结果表明 ,⑴球等鞭金藻 870 1在低温下 ( 8℃ )培养一周 ,其超氧化物歧化酶 (SOD)活性略有下降 ,但仍保持极高的酶活性 ,因此能够及时清除低温胁迫产生的过量活性氧 ,使其细胞内保持较低的膜脂过氧化水平和较低的电解质外渗率 ;⑵球等鞭金藻30 11在低温下胁迫一周 ,其细胞内的膜脂过氧化水平和电解质外渗率大大高于球等鞭金藻 870 1,这与其SOD活性较低 ,并且在低温下其活性大幅度下降有关 ;⑶与SOD相比 ,两种不同品系球等鞭金藻的过氧化物酶(POD)对减轻其低温伤害、提高其耐低温能力 ,不起主要作用

关键词：球等鞭金藻8701 耐低温机理超氧化物歧化酶过氧化物酶膜脂过氧化作用电解质外渗率

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