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Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice

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Neuroscience Bulletin 2021年第8期37卷 1119-1134页

作者： Zhijun Diao Yuanyuan Di Meilin wu Chenyang Zhai Mengsi Kang Yongfeng Li Yingxun Liu Chunling wei Qiaohua Zheng Jing Han Zhiqiang Liu Yingfang Tian wei Ren Key Laboratory of Modern Teaching Technology Ministry of EducationShaanxi Normal UniversityXi’an710062China College of Life Sciences Shaanxi Normal UniversityXi’an710119China

Plasticity in the glutamatergic synapses on striatal medium spiny neurons(MSNs)is not only essential for behavioral adaptation but also extremely vulnerable to drugs of *** on these synapses by even a single exposure to an addictive drug may interfere with the plasticity required by behavioral learning and thus produce *** the present work,we found that the negative reinforcement learning,escaping mild foot-shocks by correct nose-poking,was impaired by a single in vivo exposure to 20 mg/kg cocaine 24 h before the learning in *** a single exposure to cocaine or reinforcement learning potentiates the glutamatergic synapses on MSNs expressing the striatal dopamine 1(D1)receptor(D1-MSNs).However,24 h after the cocaine exposure,the potentiation required for reinforcement learning was *** manipulation of the activity of striatal D1-MSNs in D1-cre mice demonstrated that activation of these MSNs impaired reinforcement learning in normal D1-cre mice,but inhibition of these neurons reversed the reinforcement learning impairment induced by *** results suggest that cocaine potentiates the activity of direct pathway neurons in the dorsomedial striatum and this potentiation might disrupt the potentiation produced during and required for reinforcement learning.

关键词： Cocaine Reinforcement learning Striatum Medium spiny neurons Long-term potentiation

Retrograde trafficking of VMAT2 and its role in protein stability in non-neuronal cells

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The Journal of Biomedical Research 2016年第6期30卷 502-509页

作者： Qiuzi wu Hongfei Xu wei Wang Fei Chang Yu Jiang Yongjian Liu Department of Physiology School of Basic Medical ScienceNanjing Medical University Department of Pharmacology & Chemical Biology University of Pittsburgh School of Medicine

Increasing evidence suggests that the impaired neuroprotection of vesicular monoamine transporter 2（VMAT2）contributes to the pathogenesis of Parkinson＇s *** has been linked to aberrant subcellular retrograde trafficking as strongly indicated by recent genomic studies on familial Parkinson＇s ***,whether VMAT2 function is regulated by retrograde trafficking is *** using biochemistry and cell biology approaches,we have shown that VMAT2 was stringently localized to the trans-Golgi network and underwent retrograde trafficking in non-neuronal *** transporter also interacted with the key component of retromer,Vps35,biochemically and *** specific siRNA,we further showed that Vps35 depletion altered subcellular localization of ***,siRNA-mediated Vps35 knockdown also decreased the stability of VMAT2 as demonstrated by the reduced ***,our work suggested that altered vesicular trafficking of VMAT2 may play a vital role in neuroprotection of the transporter as well as in the pathogenesis of Parkinson＇s disease.

关键词： Parkinson's disease VMAT2 Vps35 retrograde trafficking

Subdural effusion associated with COVID-19 encephalopathy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1799-1803页

作者： Zhi-Yuan Xue zhong-Lin Xiao Ming Cheng Tao Xiang Xiao-Li wu Qiao-Ling Ai Yang-Ling wu Tao Yang Department of Rehabilitation Medicine Chengdu Jinniu District People’s HospitalChengdu 610000Sichuan ProvinceChina Department of Rehabilitation Medicine The General Hospital of the Western Theater Command of the People’s Liberation Army of ChinaChengdu 610000Sichuan ProvinceChina

BACKGROUND The precise mechanism by which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)impacts the central nervous system remains unclear,with manifestations spanning from mild symptoms(e.g.,olfactory and gustatory deficits,hallucinations,and headache)to severe complications(e.g.,stroke,seizures,encephalitis,and neurally demyelinating lesions).The occurrence of single-pass subdural effusion,as described below,is extremely *** SUMMARY A 56-year-old male patient presented with left-sided limb weakness and slurred speech as predominant clinical *** comprehensive imaging and diagnostic assessments,he was diagnosed with cerebral infarction complicated by hemorrhagic transformation affecting the right frontal,temporal,and parietal *** addition,an intracranial infection with SARS-CoV-2 was identified during the rehabilitation process;consequently,an idiopathic subdural effusion ***,the subdural effusion underwent absorption within 6 d,with no recurrence observed during the 3-month *** Subdural effusion is a potentially rare intracranial complication associated with SARS-CoV-2 infection.

关键词： Cerebral infarction Hemorrhagic transformation Subdural effusion COVID-19 encephalopathy Novel coronavirus infection Brain fog Case report

Current status and challenge in clinical work of autism spectrum disorders in China

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World Journal of Pediatrics 2018年第3期14卷 209-211页

作者： Zhi-wei Zhu Yan Jin Ling-Ling wu Xiao-Lin Liu Department of Developmental and Behavioral Pediatrics Children's HospitalZhejiang University School of MedicineNo.3333 Binsheng RoadHangzhou 310052China

Autism spectrum disorders (ASDs) are a group of neurodevelopmentaldisorders featured by social communicationand interaction deficits, and with limited interests andrepetitive behaviors. In China, ASDs was first reported byTao from Nanjing Brain Hospital in the early 1980s [ 1 , 2 ].Since then, more children with autism have been *** the past more than 30 years have witnessed steadygrowth in ASD research and clinical diagnosis and interventionin China, there are still many challenges to *** this article, we will present the current status of prevalence,screening and diagnosis of ASD in China and proposefurther eff orts for practitioners and policy-makers to secureoptimal outcomes for children with ASD.

关键词： Current status challenge

A whole-genome association approach for large-scale interspecies traits

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Science China(Life Sciences) 2021年第8期64卷 1372-1374页

作者： Huizhong Fan Lei Chen Yibo Hu Guohui Shi Yi Dai Fuwen wei Qi wu Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China JUniversity of Chinese Academy of Sciences Beijing I0010IChina ANorthwestern Polytechnical University Xi'an 710129China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Dear Editor,The genetic mechanism of large-scale interspecies traits,including evolutionary novelties and the characteristics of high taxa,is a central issue in evolutionary *** present,genome-wide association studies(GWAS)are known as one of the most powerful and affordable tools for understanding the association between heritable variations and phenotypic changes in populations of single ***,it would be interesting to determine whether GWAS can be applied to study large-scale interspecies traits.

关键词： scale evolutionary interspecies

How Well does BCC_CSM1.1 Reproduce the 20th Century Climate Change over China?

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Atmospheric and Oceanic Science Letters 2013年第1期6卷 21-26页

作者： XIN Xiao-Ge wu Tong-Wen LI Jiang-Long WANG Zai-Zhi LI wei-Ping wu Fang-Hua Beijing Climate Center China Meteorological Administration

The historical simulation of phase five of the Coupled Model Intercomparison Project （CMIP5） ex- periments performed by the Beijing Climate Center cli- mate system model （BCC_CSM1.1） is evaluated regard- ing the time evolutions of the global and China mean sur- face air temperature （SAT） and surface climate change over China in recent decades. BCC CSM1.1 has better capability at reproducing the time evolutions of the global and China mean SAT than BCC_CSM1.0. By the year 2005, the BCC_CSM1.1 model simulates a warming am- plitude of approximately I℃ in China over the 1961- 1990 mean, which is consistent with observation. The distributions of the warming trend over China in the four seasons during 1958-2004 are basically reproduced by BCC CSM1.1, with the warmest occurring in winter. Al- though the cooling signal of Southwest China in spring is partly reproduced by BCC_CSM1.1, the cooling trend over central eastern China in summer is omitted by the model. For the precipitation change, BCC_CSM1.1 has good performance in spring, with drought in Southeast China. After removing the linear trend, the interannual correlation map between the model and the observation shows that the model has better capability at reproducing the summer SAT over China and spring precipitation over Southeast China.

关键词： BCC_CSM climate system model simula- tion climate change

Quantum parametric amplification of phonon-mediated magnon-spin interaction

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Science China(Physics,Mechanics & Astronomy) 2023年第11期66卷 92-105页

作者： Yan Wang Hui-Lai Zhang Jin-Lei wu Jie Song Kun Yang wei Qin Hui Jing Le-Man Kuang School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou450001China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou450001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China School of Physics Harbin Institute of TechnologyHarbin150001China Theoretical Quantum Physics Laboratory RIKEN Cluster for Pioneering ResearchWako-shiSaitama351-0198Japan Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha410081China

The recently developed hybrid magnonics provides new opportunities for advances in both the study of magnetism and the development of quantum information ***,engineering coherent quantum state transfer between magnons and specific information carriers,in particular,mechanical oscillators and solid-state spins,remains challenging due to the intrinsically weak interactions and the frequency mismatch between different ***,we show how to strongly couple the magnon modes in a nanomagnet to the quantized mechanical motion(phonons)of a micromechanical cantilever in a hybrid tripartite *** coherent and enhanced magnon-phonon coupling is engineered by introducing the quantum parametric amplification of the mechanical *** experimentally feasible parameters,we show that the mechanical parametric drive can be adjusted to drive the system into the strong-coupling regime and even the ultrastrong-coupling ***,we show the coherent state transfer between the nanomagnet and a nitrogen-vacancy center in the dispersive-coupling regime,with the magnon-spin interaction mediated by the virtually-excited squeezed *** amplified mechanical noise can hardly interrupt the coherent dynamics of the system even for low mechanical quality factors,which removes the requirement of applying additional engineered-reservoir *** work opens up prospects for developing novel quantum transducers,quantum memories and high-precision measurements.

关键词： mechanical parametric amplification strong-coupling regime hybrid quantum system

基于粒子群优化算法的农业机器人控制策略研究

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农机化研究 2025年第1期47卷 205-209页

作者：王娜吴延凯许娜河南工业职业技术学院河南南阳473000

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较... 详细信息

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较快,能够满足设计要求,证明系统具有一定的可行性。

关键词：农业机器人粒子群优化约束模型避障路径规划

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Associations Between Epidermal Growth Factor Receptor Gene Mutation and Serum Tumor Markers in Advanced Lung Adenocarcinomas: A Retrospective Study

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Chinese Medical Sciences Journal 2014年第3期29卷 156-161页

作者： Ying-qiu Pan wei-wu Shi Dan-ping Xu Hui-hui Xu Mei-ying Zhou wei-hua Yan Medical Research Center Taizhou Hospital of Zhejiang ProvinceWenzhou Medical College

Objective To investigate the associations between epidermal growth factor receptor （EGFR） gene mutations and serum tumor markers in advanced lung adenocarcinomas. Methods We investigated the association between EGFR gene mutations and clinical features, including serum tumor marker levels, in 97 advanced lung adenocarcinomas patients who did not undergo the treatment of EGlaR tyrosine kinase inhibitors. EGFR gene mutation was detected by real-time PCR at exons 18, 19, 20, and 21. Serum tumor marker concentrations were analyzed by chemiluminescence assay kit at the same time. Results EGFR gene mutations were detected in 42 （43%） advanced lung adenocarcinoma patients. Gender （P=0.003）, smoking status （P=0.001）, and abnormal serum status of carcinoembryonic antigen （CEA, P=0.028） were significantly associated with EGFR gene mutation incidence. Multivariate analysis showed the abnormal CEA level in serum was independently associated with the incidence of EGFR gene mutation （P=0.046） with an odds ratio of 2.613 （95% Ch 1.018-6.710）. However, receiver operating characteristic （ROC） curve analysis revealed CEA was not an ideal predictive marker for EGFR gene mutation status in advanced lung adenocarcinoma （the area under the ROC curve was 0.608, P=0.069）. Conclusions EGFR gene mutation status is significantly associated with serum CEA status in advanced lung adenocarcinmoas. However, serum CEA is not an ideal predictor for EGFR mutation.

关键词： advanced lung adenocarcinomas epidermal growth factor receptor gene mutation epidermal growth factor receptor tyrosine kinase inhibitor carcinoembryonic antigen