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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun shuai Wang Yanbo liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan zhong Karissa Kusuma Yi liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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含凹陷管道的完整性评价

西南石油大学学报（自然科学版） 2011年第4期33卷 157-164,200-201页

作者：焦中良帅健中国石油大学(北京)机械与储运工程学院北京昌平102249

针对凹陷引起的管道应力集中问题,基于深度的评价准则已不能满足工程应用,提出包含内检测、噪声处理、几何插值和应变求解的基于应变的评价流程。单纯凹陷对管道的剩余强度影响不大,但与焊缝、裂纹及划伤等其他种类缺陷联合作用时,则可... 详细信息

针对凹陷引起的管道应力集中问题,基于深度的评价准则已不能满足工程应用,提出包含内检测、噪声处理、几何插值和应变求解的基于应变的评价流程。单纯凹陷对管道的剩余强度影响不大,但与焊缝、裂纹及划伤等其他种类缺陷联合作用时,则可能加快管道的断裂失效,可以采用弹塑性断裂理论对含裂纹和划伤凹陷进行剩余强度计算,当凹陷位于焊缝时,建议直接修复或替换。在内压波动影响下,无约束凹陷的疲劳问题较为严重,提出采用雨流计数法对管道的压力历程进行循环计数,根据疲劳累积损伤理论确定管道的疲劳寿命或检修周期。通过对目前国外主要标准的分析和比较,结合凹陷的自身特性,提出了更加合理的管道凹陷完整性评价体系。

关键词：管道凹陷应变计算剩余强度疲劳寿命完整性评价

Posttraumatic stress symptoms among Chinese university students during the COVID-19 pandemic:Prevalence,correlates,and mental health help-seeking

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World Journal of Psychiatry 2025年第1期15卷 145-152页

作者： Rui-Yao Wu Lin-Feng Ge Bao-liang zhong Department of Psychiatry The Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430012Hubei ProvinceChina Department of Psychiatry Wuhan Mental Health CenterWuhan 430012Hubei ProvinceChina

BACKGROUND Revisiting the epidemiology of posttraumatic stress symptoms(PTSSs)among university students during the coronavirus disease 2019(COVID-19)pandemic as well as understanding the mental health help-seeking behavior of individuals with PTSSs has critical implications for public mental health strategies in future medical *** To investigate the prevalence and correlates of PTSSs among university students during the first wave of the COVID-19 pandemic in China and to examine mental health help-seeking behaviors among these *** A total of 2507 Chinese university students were recruited via snowball *** students completed the Seven-item Screening Scale for Post-traumatic Stress Disorder during the first wave of the COVID-19 pandemic in ***-graphic characteristics,pandemic-related characteristics,and mental health help-seeking behaviors of students with PTSSs were also *** The prevalence of PTSSs among the participants was 28.0%.Seven significant correlates of PTSSs were identified(odds ratio=1.23-3.65,P≤0.024):Female sex,being 19 years old or older,living with others or alone,a low level of family economic status,fair or poor interpersonal relationships,severe or very severe local pandemic,and having family members diagnosed with ***,only 3.28%of the students with PTSSs reported seeking help from mental health *** the 23 students who sought help from mental health specialists,13 opted for online or telephone-based psychological *** Our data suggest that there was a high risk of PTSSs among university students and a high level of unmet mental health needs during the COVID-19 *** delivery of mental health services online or via telephone is a promising approach to address these unmet needs.

关键词： Posttraumatic stress symptoms University students COVID-19 Mental health help-seeking China

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香菇子实体中单核苷类成分研究

食品与生物技术学报 2017年第3期36卷 283-286页

作者：唐庆九王淑蕾王晨光刘艳芳张忠周帅梁敬钰上海市农业科学院食用菌研究所上海201403 中国药科大学中药学院江苏南京210009

以离子交换柱层析为主要手段从香菇子实体的水提物中分离得到6个单核苷类化合物,经EI-MS、~1H-NMR和^(13)C-NMR鉴定分析,这6个化合物分别是:尿苷、尿嘧啶、鸟苷、香菇嘌呤、腺苷和腺嘌呤,其中腺嘌呤为首次从香菇中分离得到,香菇嘌呤的... 详细信息

以离子交换柱层析为主要手段从香菇子实体的水提物中分离得到6个单核苷类化合物,经EI-MS、~1H-NMR和^(13)C-NMR鉴定分析,这6个化合物分别是:尿苷、尿嘧啶、鸟苷、香菇嘌呤、腺苷和腺嘌呤,其中腺嘌呤为首次从香菇中分离得到,香菇嘌呤的核磁数据首次得到全面归属。

关键词：香菇单核苷类化合物离子交换柱层析腺嘌呤香菇嘌呤

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Sedimentary features and sequence stratigraphy of the successions around the Carboniferous-Permian boundary in the Ordos Basin:links to glacial and volcanic impacts

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Journal of Palaeogeography 2023年第3期12卷 358-383页

作者： zhong-shuai Hou Shi-Yue Chen Zhao liang Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China Interdisciplinary Science Research Institute Hebei GEO UniversityShijiazhuang 050031China School of Geosciences China University of PetroleumQingdao 266580China

The sedimentary successions around the Carboniferous-Permian boundary(CPB)in the Ordos Basin were investigated using extensive outcrop,borehole,well logging,thin section,and geochemistry data to study sedimentary and sequence stratigraphic responses to glaciation and volcanism in paleotropical transitional *** the studied interval,five distinct lithofacies have been identified,including bauxite,coal,and carbonaceous shale(No.8+9 coal seams),sandstone(Qiaotou),limestone(Baode),and mudstone,which can be classified into three lithofacies *** most complete lithofacies associ-ation is composed of bauxite,coal,carbonaceous shale,sandstone,limestone/mudstone or their combinations from the bottom to the top,while coal and carbonaceous shale,as well as sandstone,are absent locally,resulting in the formation of the other two types of lithofacies *** occurrence of bauxite in-dicates shelf exposure and weathering,the occurrence of coal and carbonaceous shale indicates swampiness of the shelf,and the occurrence of sandstone reveals river rejuvenation;all of these are thought to be sedimentary responses to the transcontinental glacier expansion in Gondwana around the *** presence of limestone and mudstone indicates carbonate platform and lagoon deposition,respectively,in the context of the earliest Asselian transgression caused by volcanism-induced glacier *** lithofacies associations record the regressive-transgressive cycles that occurred because of glaciation and volcanism near the *** top surface of bauxite can be used as a sequence boundary,while the lowstand systems tract consists of the No.8+9 coal seams and the Qiaotou sandstone,and the transgressive systems tract consists of the overlying Baode limestone and laterally equivalent *** lowstand systems tract,which contains source rock and hydrocarbon reservoirs,and the overlying transgressive systems tract,which serves as cap rock,form an excellent source-reservoi

关键词： Glaciation Volcanism Incised valley Sequence stratigraphy Ordos basin

Evolution of In783 alloy in microstructure and properties enduring different service times

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Rare Metals 2024年第1期43卷 334-341页

作者： zhong-shuai Han Jin-Feng Du Jun liang Zheng Zhang School of Material Science and Engineering Beihang UniversityBeijing 100191China Shenhua Guohua(Beijing)Electric Power Research Institute Co. Ltd.Beijing 100025China

Impact, tensile, and fatigue tests were performed in In783 alloy serving 4000, 23,000 and 48,000 h. The microstructure was then analysed by optical microscopy(OM), scanning electron microscopy(SEM), and transmission electron microscopy(TEM) to probe the relationship between microstructure and properties. The results show that a new Ni_(5)Al_(3) phase is found, which grows gradually in β phase with serving time increasing,destroying the martensitic structure of the β phase, and degenerating the toughness of the β phase(approximately13.88% reduction). Therefore, the degradation of the βphase results in a sharp dropping of the resistance to stress accelerated grain boundary oxygen(SAGBO) during serving;thus, the intergranular fracture morphology degree increases with duration of service(almost 40% increase from the fractured surface). In addition, the strength of alloy will be gradually enhanced when the γ'phase becomes relatively bulky with serving time increasing due to considerable distortion of the dislocations as a result of the spacing of individual particles, in which any movement of the dislocation will have to overcome a larger number of obstacles per unit length.

关键词： In783 Microstructure Properties βphase Ni_(5)Al_(3)phase

A perspective on graphene for supercapacitors: Current status and future challenges

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Journal of Energy Chemistry 2021年第2期30卷 354-357,I0012页

作者： Feng Su zhong-shuai Wu Dalian National Laboratory for Clean Energy.Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Supercapacitors,also known as ultracapacitors or electrochemical capacitors,possess intriguing merits of high power density(10-100 times higher than that of batteries),long life expectancy(millions of cycles),wide ope... 详细信息

关键词： Graphene Supercapacitors Energy storage Electric double layer capacitors Pseudocapacitors Hybrid supercapacitors