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Expressions of TGF-β2, bFGF and ICAM-1 in lens epithelial cells of complicated cataract with silicone oil tamponade

International Journal of Ophthalmology(English edition) 2017年第7期10卷 1034-1039页

作者： Bei Liu Jing Gao Bo-Chang Lyu Shan-Shuang Du Cheng Pei zhong-qiao zhu Bo Ma Shaanxi Ophthalmic Medical Center Xi'an No.4 Hospitalthe Affiliated Guangren HospitalSchool of MedicineXi'an Jiaotong University Department of Ophthalmology the First Affiliated HospitalSchool of MedicineXi'an Jiaotong University

AIM： To investigate the expression differences of transforming growth factor-β2（TGF-β2）, basic fibroblast growth factor（b FGF） and intercellular cell-adhesion molecule-1（ICAM-1） in lens epithelial cells（LECs） of complicated cataract with silicone oil tamponade and agerelated cataract. METHODS： Totally 150 eyes of 150 patients（aged 35 to 77y） were investigated, including 75 patients with complicated cataract after silicone oil tamponade and 75 patients with age-related cataract. The central piece of anterior capsules was collected during cataract surgery. TGF-β2, b FGF and ICAM-1 were detected in the 60 specimens of the two groups by immunohistochemistry. The expression levels of the three kinds of messenger ribonucleic acid（m RNA） were determined by real-time quantitative reverse transcriptionpolymerase chain reaction in the 90 specimens of the two ***： TGF-β2 was detected in the cytomembrane and cytoplasm of the LECs and b FGF was detected in the nucleus. ICAM-1 was positive in the cytomembrane of the LECs and the distribution of positive cells was uneven. The m RNA genes expression of the TGF-β2, b FGF and ICAM-1 was significant differences between the two groups and markedly increased in complicated cataract group（P〈0.05）.CONCLUSION： The up-regulated TGF-β2, b FGF and ICAM-1 maybe associate with the occurrence and development of complicated cataract with silicone oil tamponade.

关键词： transforming growth factor-β2 basic fibroblast growth factor intercellular cell-adhesion molecule-1 lens epithelial cell complicated cataract age-related cataract silicone oil

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Multi-dimensional Bi@C electrocatalyst for Cr3+/Cr2+ redox reaction boosting high-performance iron-chromium flow batteries

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Science China Chemistry 2025年

作者： Min Wu Mingjun Nan Shumin Liu Caihe zhong Lin qiao Huamin Zhang Xiangkun Ma Department of Materials Science and Engineering Dalian Maritime University Division of Energy Storage Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences

With the increasing demand for energy storage technology, iron-chromium flow batteries（ICFBs） have been widely concerned because of their price advantage. However, the low electrochemical activity of Cr3+/Cr2+redox couples and the side hydrogen evolution reaction limit the industrial application of ICFBs. A multi-dimensional Bi/carbon composite electrocatalyst（Bi@C）for ICFB is designed and prepared to improve the electrochemical activity of Cr3+/Cr2+redox couples. Benefiting by using the Bimetal organic framework（Bi-MOF） with solid matrix as precursors, Bi nanospheres are highly dispersed on the Bi@C electrocatalyst that effectively enhances the electrochemical activity. The special morphology of Bi@C electrocatalyst helps the transfer of electrons and ions, significantly reducing the polarization of battery. Herein, the 3D porous carbon frames accelerate mass transfer, and the 2D carbon nanobelts and carbon layer coating on 0D Bi nanospheres improve the conductivity of Bi nanospheres. Therefore, the ICFB with multi-dimensional Bi@C electrocatalyst exhibits coulombic efficiency of 98.10% and energy efficiency of 79.14% at 140 mA cm-2, which is higher than ICFBs with commercial graphite carbon electrocatalyst and with heat treatment carbon felt. This work provides a simple and economical method to fabricate a high-performance multidimensional Bi@C electrocatalyst for Cr3+/Cr2+redox couples, boosting the development of ICFBs.

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Dual‑Donor‑Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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Nano-Micro Letters 2025年第3期17卷 376-388页

作者： Anhai Liang Yuqing Sun Sein Chung Jiyeong Shin Kangbo Sun Chaofeng zhu Jingjing Zhao Zhenmin Zhao Yufei zhong Guangye Zhang Kilwon Cho Zhipeng Kan Center On Nanoenergy Research Institute of Science and Technology for Carbon Peak&NeutralitySchool of Physical Science&TechnologyGuangxi UniversityNanning 530004People’s Republic of China Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673South Korea College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118People’s Republic of China Zhejiang Engineering Research Center for Fabrication and Application of Advanced Photovoltaic Materials School of Materials Science and EngineeringNingboTech UniversityNingbo 315100People’s Republic of China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004People’s Republic of China

Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains ***, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching *** a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance *** findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

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巩膜环扎加压术后屈光度的改变

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国际眼科杂志 2011年第12期11卷 2183-2184页

作者：王勇任梅王丽丽朱仲侨中国陕西省西安市第四医院眼科 710004 中国陕西省西安市中心医院眼科 710003

目的:探讨视网膜脱离巩膜环扎加压术后眼部屈光状态的改变。方法:用眼科A超、检影验光等对23例23眼原发性视网膜脱离患者手术前1d及术后1,4,12wk时的眼轴长度、眼屈光度等进行测量并将结果进行比较。结果:眼轴长度、晶状体厚度增加在术... 详细信息

目的:探讨视网膜脱离巩膜环扎加压术后眼部屈光状态的改变。方法:用眼科A超、检影验光等对23例23眼原发性视网膜脱离患者手术前1d及术后1,4,12wk时的眼轴长度、眼屈光度等进行测量并将结果进行比较。结果:眼轴长度、晶状体厚度增加在术后1,4,12wk时均较术前增长(P<0.01)。眼屈光度增加、前房深度变浅,及角膜曲率增加在术后1,4,12wk时均较术前增加,且向负值偏移(P<0.05)。结论:巩膜环扎加压术后眼轴长度和屈光状态的变化与眼内嵴有关,术后眼轴增长是眼屈光度负值增加的主要因素。

关键词：巩膜环扎加压术眼轴屈光

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基于危险态势识别的智能车驾驶模式选择

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华南理工大学学报（自然科学版） 2016年第8期44卷 139-146,154页

作者：严利鑫黄珍吴超仲秦伶巧朱敦尧冉斌武汉理工大学智能交通系统研究中心湖北武汉430063 武汉理工大学国家水运安全工程技术研究中心湖北武汉430063 威斯康星大学麦迪逊分校土木与环境工程学院威斯康星麦迪逊53706 武汉理工大学自动化学院湖北武汉430070

人机共驾是智能车发展中必须经历的一个重要阶段,而人机切换时机选择是人机共驾需要解决的一个关键问题。为此,文中以实车实验采集的数据为依据,根据驾驶人经验及经K-均值聚类得出的危险态势等级对驾驶模式选择方式(安全驾驶、进行警示... 详细信息

人机共驾是智能车发展中必须经历的一个重要阶段,而人机切换时机选择是人机共驾需要解决的一个关键问题。为此,文中以实车实验采集的数据为依据,根据驾驶人经验及经K-均值聚类得出的危险态势等级对驾驶模式选择方式(安全驾驶、进行警示和自动切换)进行了标定。通过引入车速均值、加速度标准差、车头时距、前轮转角标准差、车道偏离量以及驾驶人经验等6项指标作为特征向量,提出了基于径向基核函数序列最小优化算法(SMO)的智能车驾驶模式选择模型。并以决策树、径向基神经网络、支持向量机(SVM)作为对照。研究结果表明,文中提出的基于SMO方法的驾驶模式识别模型的准确率达到91.7%,相较于其他3种识别方法具有较大的优越性.

关键词：智能车驾驶模式 K-均值聚类序列最小优化算法交通安全

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玻璃体切割联合小直径球内异物取出术临床疗效

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国际眼科杂志 2011年第9期11卷 1619-1621页

作者：刘蓓王丽丽朱忠桥杜善双中国陕西省西安市第四医院眼科 710004 中国陕西省西安市中心医院眼科 710003

目的:探讨玻璃体切割联合球内异物取出术治疗眼球内异物伤(异物直径≤3mm)的临床疗效。方法:选择2006-01/2010-01来我院治疗的眼内异物伤患者25例25眼,采用玻璃体切割联合球内异物取出术,13例13眼术中部分或全部保留晶状体前囊膜。随访6... 详细信息

目的:探讨玻璃体切割联合球内异物取出术治疗眼球内异物伤(异物直径≤3mm)的临床疗效。方法:选择2006-01/2010-01来我院治疗的眼内异物伤患者25例25眼,采用玻璃体切割联合球内异物取出术,13例13眼术中部分或全部保留晶状体前囊膜。随访6mo,18例18眼二期植入人工晶状体或缝合固定,随访处理并发症。分析手术适应证,手术并发症,术后疗效。结果:患者25例25眼均一期成功取出球内异物。睫状体脱离1例药物治疗痊愈。视网膜脱离患者行玻璃体切割注硅油术后视网膜复位。随访6mo时视力提高者23眼,无变化2眼。结论:玻璃体切割联合球内异物取出术治疗眼球内异物伤(异物直径≤3mm)是有效的临床治疗方法。

关键词：小直径眼球内异物伤玻璃体切割

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Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry and π-bridge effect design philosophy

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Science China Chemistry 2025年

作者： Qiong Liu Qiyun Deng Changxu zhu Kongqi Chen Lidan Chen Zhaohui Sun Ben zhong Tang Zhiming Wang AIE Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province South China University of Technology Department of Laboratory Medicine General Hospital of Southern Theater Command School of Life Sciences The Chinese University of Hong Kong Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong HKUST-Shenzhen Research Institute

The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging *** this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge *** a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these ***,the probe TPhIQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission (AIE) effect,and the ability to distinguish tumor cells from normal ***,it efficiently generated reactive oxygen species (ROS) and specifically labeled lipid droplets,enabling the precise staining and killing of cancer *** study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy (PDT) by harnessing the unique properties of AIE materials.

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合并脉络膜脱离的孔源性视网膜脱离临床特点及手术疗效分析

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国际眼科杂志 2009年第9期9卷 1771-1772页

作者：赵曦泉王建洲朱忠桥杨新光中国陕西省西安市第四医院眼科 710004

目的:分析合并脉络膜脱离的裂孔性视网膜脱离的临床特点及手术治疗效果。方法:合并脉络膜脱离的裂孔性视网膜脱离患者64例64眼,26例行巩膜扣带术,38例行玻璃体视网膜手术,术中均不行巩膜外冷凝,观察眼部表现及手术复位率等情况,分析合... 详细信息

目的:分析合并脉络膜脱离的裂孔性视网膜脱离的临床特点及手术治疗效果。方法:合并脉络膜脱离的裂孔性视网膜脱离患者64例64眼,26例行巩膜扣带术,38例行玻璃体视网膜手术,术中均不行巩膜外冷凝,观察眼部表现及手术复位率等情况,分析合并脉络膜脱离的裂孔性视网膜脱离临床特点。结果:本组病例>-6.00D高度近视占总病例数的41%。64例合并脉络膜脱离的孔源性视网膜脱离均有葡萄膜炎反应,眼压2.00～8.00mmHg;26例行巩膜扣带术,19例视网膜复位,复位率73%,行玻璃体视网膜手术38例,32例视网膜复位,一次手术复位率84%。结论:合并脉络膜脱离的孔源性视网膜脱离高度近视眼、人工晶状体眼及无晶状体眼多发,视网膜光凝替代术中巩膜外冷凝可能提高视网膜复位率及减少术后复发率。

关键词：视网膜脱离脉络膜脱离

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan zhu Liang-Jin Xu Yu-Wu zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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非增殖期糖尿病性视网膜病变临床治疗分析

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国际眼科杂志 2010年第10期10卷 1984-1985页

作者：杜善双段琼朱忠桥刘蓓中国陕西省西安市第四医院眼科 710004 西安高新医院眼科中国陕西省西安市710077

目的:探讨视网膜局部光凝术联合药物治疗非增殖性糖尿病性视网膜病变(non-proliferative diabetic retinopathy,NPDR)的效果。方法:利用532半导体绿激光机对III期糖尿病视网膜病变(diabeticretinopathy,DR)患者进行局部光凝,应用药物控... 详细信息

目的:探讨视网膜局部光凝术联合药物治疗非增殖性糖尿病性视网膜病变(non-proliferative diabetic retinopathy,NPDR)的效果。方法:利用532半导体绿激光机对III期糖尿病视网膜病变(diabeticretinopathy,DR)患者进行局部光凝,应用药物控制患者血糖、血压、血脂和血流变。结果:治疗后185眼中视力提高及稳定者168眼,有效率90.8%,视力下降及出现并发症者17眼(9.2%),治疗前后有显著的临床意义。结论:局部视网膜光凝术联合药物治疗NPDR安全有效。

关键词：糖尿病性视网膜病变局部激光光凝术药物治疗血糖血压血脂血流变

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