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SKINNY的差分故障攻击与ForkAE的密钥恢复攻击

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密码学报（中英文） 2024年第3期11卷 692-705页

作者：谢敏江家煜陈杰西安电子科技大学空天地一体化综合业务网全国重点实验室西安710071 河南省网络密码技术重点实验室郑州450001

作为LWC竞赛的候选算法之一,ForkAE是基于叉形密码结构的一系列轻量级认证加密算法,其中使用的加密原语为轻量级可调分组密码族SKINNY.本文首先给出了一种对SKINNY族内各算法进行差分故障攻击的方法.对于SKINNY-64-64和SKINNY-64-128,... 详细信息

作为LWC竞赛的候选算法之一,ForkAE是基于叉形密码结构的一系列轻量级认证加密算法,其中使用的加密原语为轻量级可调分组密码族SKINNY.本文首先给出了一种对SKINNY族内各算法进行差分故障攻击的方法.对于SKINNY-64-64和SKINNY-64-128,在算法倒数第三轮注入随机半字节故障,理论上平均通过2.32次随机半字节故障注入即可得知连续两轮共4个半字节的信息.通过对多个位置的信息获取,理论上平均通过9.23次随机半字节故障注入即可恢复单轮的64 bit轮密钥,结合密钥扩展算法即可恢复全部64 bit的主密钥.利用类似的方法攻击SKINNY-128-128和SKINNY-128-256,在算法倒数第三轮注入随机字节故障,理论上平均通过2.4次随机字节故障注入即可得知连续两轮共4个半字节的信息,平均通过9.56次随机字节故障注入即可恢复128 bit的主密钥.攻击SKINNY-64-192或SKINNY-128-384时需要额外对倒数第五轮进行攻击,分别需要18.52次随机半字节故障注入和19.18次随机字节故障注入.在对SKINNY完成的差分故障分析的基础上,本文给出了一种对ForkAE进行密钥恢复的方法,理论上仅需要1次对故障加密机的询问即可恢复ForkAE的主密钥.

关键词： ForkAE算法 SKINNY算法差分故障攻击

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乡土文化促进城乡融合的作用机理及路径选择

扬州教育学院学报 2024年第03期42卷 81-85页

作者：谢敏温州大学

党的二十大强调把城乡融合发展作为实现共同富裕和民族复兴的重要抓手。处理好城乡文化关系是实现城乡融合的先决条件。然而长期以来，在“城市中心主义”现代化的影响下，乡土文化逐渐空心化、边缘化，导致城乡差距进一步扩大，严重阻... 详细信息

党的二十大强调把城乡融合发展作为实现共同富裕和民族复兴的重要抓手。处理好城乡文化关系是实现城乡融合的先决条件。然而长期以来，在“城市中心主义”现代化的影响下，乡土文化逐渐空心化、边缘化，导致城乡差距进一步扩大，严重阻碍城乡融合进程。基于此，从乡土文化推进城乡融合、弥合城乡文化认同、凝聚乡村建设动力、赋能乡村产业四个方面论述了乡土文化促进城乡融合的机制，并从党建引领、关注乡愁、凝神聚力、文化赋能四个视角提出有高度、有温度、有力量、有力度的城乡融合的具体实现路径。

关键词：城乡融合城乡关系乡土文化乡愁和谐

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碳酸水环境下隧道水泥基材料的抗侵蚀特性

建筑材料学报 2024年第5期27卷 408-417页

作者：李康邹敏王希谢永江刘娟红中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司高速铁路轨道系统全国重点实验室北京100081 中国铁道科学研究院集团有限公司铁道建筑研究所北京100081 北京科技大学土木与资源工程学院北京100083

对比了多种水泥基材料在碳酸水加速侵蚀前后的抗压强度、材料内部的物相迁移和孔结构特征.结果表明:碳酸水侵蚀后水泥基材料强度的发展受到限制,Ca(OH)_(2)和CaCO_(3)含量同时降低,孔径粗化且有害孔的比例增大;以水化硅酸钙凝胶和Ca(OH)... 详细信息

对比了多种水泥基材料在碳酸水加速侵蚀前后的抗压强度、材料内部的物相迁移和孔结构特征.结果表明:碳酸水侵蚀后水泥基材料强度的发展受到限制,Ca(OH)_(2)和CaCO_(3)含量同时降低,孔径粗化且有害孔的比例增大;以水化硅酸钙凝胶和Ca(OH)_(2)为主要水化产物的胶凝体系最容易受到碳酸水的侵蚀,且Ca(OH)_(2)含量越高,水泥基材料抗碳酸水侵蚀的能力越弱;以钙矾石为主要水化产物的胶凝体系抗碳酸水侵蚀的能力明显增强.

关键词：隧道水泥基材料碳酸水侵蚀物相分析孔结构 Rietveld法

Molecularly engineered lignin to polyphenol via organocatalysis as an active sunscreen ingredient

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Journal of Bioresources and Bioproducts 2024年第2期9卷 197-210页

作者： Yuanlong Guo Pengcheng Liu Lei Deng Changwei Lui Michael North Gang Hu Qitian Huang Zongbao Kent Zhao Haibo xie Department of Polymeric Materials&Engineering Guizhou UniversityGuiyang 550025China KZJ New Materials Group Guizhou Co.Ltd. Guizhou 551200China Green Chemistry Centre of Excellence Department of ChemistryUniversity of YorkYork YO105DDUK Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China

Phenolation is one of the effective strategies to synthesize lignin-based polyphenols,improve lignin’s properties,and extend its value-added applications in biological,medicinal and cosmetic ***,by taking the structural feature advantage of lignin,an effective and green strategy was developed to molecularly engineer lignin into a robust lignin-3-(2-hydroxyphenyl)propionate ester(LPPE)derivative via a transesterification reaction between 3,4-dihydrocoumarin(DHC)and the aliphatic hydroxyls in lignin under *** strategy is optimized and the novel derivative was systematically characterized by ^(1)H,^(13)C and ^(31)P nuclear magnetic resonance(NMR)and Fourier transform infrared(FT-IR)*** findings indicated that the successful introduction of 3-(2-hydroxyphenyl)propionate groups using a OH groups/DHC/organic base mo-lar ratio of 1꞉1꞉0.3 at 120℃ for 6 h increased the content of phenolic hydroxyl groups from 1.7931 to 3.0179 mmol/g,and the LPPE exhibited excellent ultraviolet-absorbing and antioxidant per-formance with up to 90%free radical scavenging activity within 20 min using 5 mg/mL of *** addition,good biocompatibility and a high Sun protection factor(SPF)value of 40.9 were achieved at 5%(w)dosage of LPPE in the cream,indicating its significant application potential in sunscreen.

关键词： Phenolation of lignin Organocatalysis 3,4-dihydrocoumarin Antioxidant Sunscreen cream

Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu ZHANG Zi Yu LI Xin Xin LU Yao ZHANG Lu LIU Ru Yu CHANG min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei xie Yao LI ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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县区级医院创面修复学科建设探索

中华烧伤与创面修复杂志 2024年第8期40卷 781-784页

作者：丁伟马涛谢加兵杨民皖南医学院弋矶山医院创面修复外科芜湖241000 皖南医学院弋矶山医院手足外科芜湖241000 皖南医学院弋矶山医院骨科芜湖241000

县区级医院创面修复学科建设作为中国特色创面修复学科体系建设的重要组成部分之一,目前尚缺乏可借鉴的成熟建设经验和模式。该文以中国特色创面修复学科体系建设理论为基础,结合皖南创面修复专科联盟建设实践经验和体会,就如何在县区... 详细信息

县区级医院创面修复学科建设作为中国特色创面修复学科体系建设的重要组成部分之一,目前尚缺乏可借鉴的成熟建设经验和模式。该文以中国特色创面修复学科体系建设理论为基础,结合皖南创面修复专科联盟建设实践经验和体会,就如何在县区级医院开展创面修复学科建设进行探讨。

关键词：伤口愈合医院科室创面修复学科学科建设县区级医院皖南创面修复专科联盟

Impact of ursodeoxycholic acid therapy in autoimmune liver disease patients with COVID-19 and its clinical prognosis

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Biosafety and Health 2024年第3期6卷 165-170页

作者： minghui Li Weihua Cao Tingting Jiang Wen Deng Shiyu Wang Shuling Wu Lu Zhang Yao Lu min Chang Ruyu Liu Xiaoyan Ding Ge Shen Yuanjiao Gao Hongxiao Hao Xiaoxue Chen Leiping Hu Mengjiao Xu Yuyong Jiang Wei Yi Yao xie Rui Song Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Medical Oncology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

To explore the impact of ursodeoxycholic acid(UDCA)on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and clinical outcomes in patients with autoimmune liver disease(AILD).Patients diagnosed with AILD were enrolled and divided into a UDCA group and a non-UDCA group based on whether they received UDCA *** data were collected regarding AILD diagnosis,treatment,biochemical indicators,and imaging *** incidence of SARS-CoV-2 infection and the prognosis of AILD patients were observed.A total of 1,138 patients completed *** usage rate of hormone(P=0.003)and immunosuppressant(P=0.001)used for treating AILD in the non-UDCA group was markedly lower than in the UDCA *** UDCA usage rate was markedly lower in SARS-CoV-2 infected patients than in uninfected patients(P=0.003).The rate of SARS-CoV-2 infection in the non-UDCA group was significantly higher than in the UDCA group(P=0.018).Logistic regression analysis showed that UDCA use(P=0.003)was correlated to a lower incidence of SARS-CoV-2,while immunosuppressant use(P=0.017)increased the *** time from SARS-CoV-2 infection was markedly longer for those receiving UDCA treatment than those in the non-UDCA group(P=0.018).UDCA is associated with low SARS-CoV-2 incidence in AILD patients,while immunosuppressant increases its incidence *** receiving UDCA treatment have a longer recovery time after being infected.

关键词： Ursodeoxycholic acid(UDCA) Autoimmune liver disease(AILD) Coronavirus disease 2019(COVID-19) Primary biliary cholangitis(PBC) Autoimmune hepatitis(AIH)

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6-羟基己酸甲酯高效催化加氢制备1,6-己二醇的工艺研究

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现代化工 2024年第5期44卷 219-223页

作者：范丽敏谢传欣青岛科技大学环境与安全工程学院山东青岛266042

在釜式反应器内进行6-羟基己酸甲酯加氢制备1,6-己二醇的工艺研究,考察了反应温度、反应压力、催化剂质量分数和反应时间等因素对催化加氢过程的影响,并采用气相色谱仪分析监测6-羟基己酸甲酯催化加氢制备1,6-己二醇的反应进程,得到最... 详细信息

在釜式反应器内进行6-羟基己酸甲酯加氢制备1,6-己二醇的工艺研究,考察了反应温度、反应压力、催化剂质量分数和反应时间等因素对催化加氢过程的影响,并采用气相色谱仪分析监测6-羟基己酸甲酯催化加氢制备1,6-己二醇的反应进程,得到最优工艺条件:温度为200℃、压力为7 MPa、催化剂质量分数为8%、反应时间为6 h。进一步采用核磁共振氢谱和红外光谱等分析手段对产品进行结构确认,结果表明,6-羟基己酸甲酯的转化率达99%,1,6-己二醇选择性最高可达86%。

关键词： 6-羟基己酸甲酯加氢工艺铜基催化剂 1,6-己二醇

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

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Science China(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin Zhuang min-Sheng Peng Ya-Jun Guo Wei-Zhu Qian Newton OOtecko Wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-Shi Chen Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration