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Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice

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Journal of Genetics and Genomics 2022年第1期49卷 63-73页

作者： Shicheng Zhu Hanjing Song Liangjun zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang zhong-min dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu Institute of Life Sciences College of Life and Environmental SciencesKey Laboratory of Mammalian Organogenesis and RegenerationHangzhou Normal UniversityHangzhouZhejiang 311121China The Affiliated Hospital Hangzhou Normal UniversityHangzhouZhejiang 310015China

Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate.

关键词： Cleft palate Conditional knock-in Mouse model Msx1 Organ development

Metagenomics reveals the microbial community and functional metabolism variation in the partial nitritation-anammox process:From collapse to recovery

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Journal of Environmental Sciences 2024年第1期135卷 210-221页

作者： Hong Wang Hui Gong Xiaohu dai min Yang State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China BIOMATH Department of Data Analysis and Mathematical ModellingGhent UniversityGhent 9000Belgium

Mainstream partial nitritation-anammox(PNA)process easily suffers from performance instability and even reactor collapse in ***,it is of great significance to unveil the characteristic of performance recovery,understand the intrinsic mechanism and then propose operational *** this study,we combined long-term reactor operation,batch tests,and metagenomics to reveal the succession of microbial community and functional metabolism variation from system collapse to *** aeration control(0.10-0.25mg O_(2)/L)was critical for performance *** was also found that Candidatus Brocadia became the dominant flora and its abundance increased from 3.5%to 11.0%.Significant enhancements in carbon metabolism and phospholipid biosynthesis were observed during system recovery,and the genes abundance related to signal transduction was dramatically *** up-regulation of sdh and suc genes showed the processes of succinate dehydrogenation and succinyl-CoA synthesis might stimulate the production of amino acids and the synthesis of proteins,thereby possibly improving the activity and abundance of AnAOB,which was conducive to the performance ***,the increase in abundance of hzs and hdh genes suggested the enhancement of the anammox *** in the abundance of key genes involved in nitrogen metabolism indicated that nitrogen removal pathway was more diverse after system *** achievement of performance recovery was driven by anammox,nitrification and denitrification coupled with dissimilatory nitrate reduction to *** results provide deeper insights into the recovery mechanism of PNA system and also provide a potential regulation strategy for the stable operation of the mainstream PNA process.

关键词： Partial nitritation-anammox Metagenomics Microbial community Functional metabolism Recovery

Multi-stream signals separation based on space-time-isomeric (SPATIO) array using metasurface antennas

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Science China(Information Sciences) 2024年第2期67卷 181-200页

作者： Yangming LOU Liang JIN Huiming WANG Zhou zhong Junyan dai PLA Strategic Support Force Information Engineering University School of Information and Communications Engineering Xi'an Jiaotong University 3. State Key Laboratory of Millimeter WavesSoutheast University

In spatial domain signal processing, it is necessary to equip more antennas at the receiver to improve spatial demultiplexing capability. However, increasing the number of antennas under restricted space will reduce antenna spacing and raise the channel correlation, making the number of signal streams spatially demultiplexed much smaller than that of antennas. This paper proposes a method to design a space-timeisomeric(SPATIO) array based on metasurface antennas under wireless multipath conditions. Each antenna in this array has a different pattern and varies independently with time, reducing the channel correlation by superposing multipath at distinct positions and moments. Based on the SPATIO array, we present an array parameter design scheme based on infinity norm minimization, which can maximize the received energy of each stream while separating multi-stream received signals. Simulation results illustrate the performance of the SPATIO array for multi-stream signal reception. Compared with conventional multiple-input multipleoutput arrays, the proposed array can reduce the bit error rate by one order of magnitude under the same simulation conditions.

关键词： multiple-input multiple-output metasurface antenna space-time-isomeric array multipath channel degree of freedom

Astrocyte syncytium:from neonatal genesis to aging degeneration

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Neural Regeneration Research 2024年第2期19卷 395-396页

作者： min Zhou Shiying zhong Alexei Verkhratsky Department of Neuroscience Ohio State University Wexner Medical CenterColumbusOHUSA Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achücarro Basque Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain

Modern neuroscience began from all reaching and fierce conflict between“neuronismo and reticulismo”——between neuronal and reticular theories of the organization of the nervous system;the conflict culminated in December of 1906 in Stockholm where Santiago Ramon y Cajal(the proponent of the neuronal doctrine)and Camillo Golgi(who advocated the syncytial reticular organization of neural networks)delivered their Noble prize lectures(Verkhratsky,2009).

关键词： degeneration neonatal aging

Broadband Dual-Input Doherty Power Amplifier Design Based on a Simple Adaptive Power Dividing Ratio Function

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China Communications 2024年第5期21卷 97-112页

作者： dai Zhijiang zhong Kang Li mingyu Pang Jingzhou Jin Yi School of Microelectronics and Communication Engineering Chongqing UniversityChongqing 400044China Xi’an Branch of China Academy of Space Technology Xi’an 710100China

In this paper,a simple adaptive power dividing function for the design of a dual-input Doherty power amplifier(DPA)is *** the presented approaches,the signal separation function(SSF)at different frequency points can be characterized by a *** in the practical test,the coefficients of SSF can be determined by measuring a small number of data points of input *** as other dualinput DPAs,the proposed approach can also achieve high output power and back-off efficiency in a broadband operation band by adjusting the power distribution ratio ***,a 1.5-2.5 GHz highefficiency dual-input Doherty power amplifier is implemented according to this *** test results show that the peak power is 48.6-49.7d Bm,and the 6-d B back-off efficiency is 51.0-67.0%,and the saturation efficiency is 52.4-74.6%.The digital predistortion correction is carried out at the frequency points of 1.8/2.1GHz,and the adjacent channel power ratio is lower than-54.5d *** and experiment results can verify the effectiveness and correctness of the proposed method.

关键词： broadband doherty power amplifier dualinput efficiency enhancement load modulation

Extracorporeal membrane oxygenation as a bridging therapy for patients with thiamine deficiency-induced pulmonary arterial hypertension

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World Journal of Emergency Medicine 2024年第2期15卷 147-149页

作者： Fangfang Qiu Weixing dai Tengyue Huang min Li Department of Intensive Care Unit the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Department of Intensive Care Unit the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Thiamine deficiency is characterized by a deficiency of thiamine(vitamin B1),lactic acidosis,pulmonary arterial hypertension(PAH),right-sided heart failure,and peripheral nerve *** deficiency is easily misdiagnosed and missed during clinical practice and is associated with death in severe cases.[1,2]Here we reported a patient who was admitted to the hospital with severe metabolic acidosis and pulmonary hypertension and finally diagnosed with thiamine deficiency by detecting plasma vitamin B1 *** clinically obvious thiamine deficiency is rare,and cases of thiamine deficiency requiring extracorporeal membrane oxygenation(ECMO)treatment are rarer,we believe that our case will be helpful for emergency clinicians.

关键词： vitamin hypertension arterial

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin Hai-Yan Yu Ye dai Zhi-min dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

Sliding behaviors of the trapezoidal roof rock block under a lateral dynamic disturbance

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 741-760页

作者： Feng dai Wancheng Zhu min Ren Shunchuan Wu Leilei Niu Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming650093China Center for Rock Instability and Seismicity Research Department of Mining EngineeringSchool of Resource and Civil EngineeringNortheastern UniversityShenyang110819China

The surrounding rock of underground space is always affected by external dynamic disturbance from the side position,such as blasting vibration from a stope at the same level or seismic waves from adjacent strata.A series of laboratory tests,numerical simulations and theoretical analyses were carried out in this study to disclose the sliding mechanism of roof rock blocks under lateral ***,the experiments on trapezoidal key block under various clamping loads and disturbance were conducted,followed by numerical simulations using the fast Lagrangian analysis of continua(FLAC3D).Then,based on the conventional wave propagation model and the classical shear-slip constitutive model,a theoretical model was proposed to capture the relative displacement between blocks and the sliding displacement of the key *** results indicate that the sliding displacement of the key block increased linearly with the disturbance energy and decreased exponentially with the clamping load when the key block was disturbed to slide(without instability).Meanwhile,when the key block was disturbed to fall,two types of instability process may appear as immediate type or delayed *** addition,the propagation of stress waves in the block system exhibited obvious low-velocity and lowfrequency characteristics,resulting in the friction reduction effect appearing at the contact interface,which is the essential reason for the sliding of rock *** results can be applied to practical underground engineering and provide valuable guidance for the early detection and prevention of rockfalling disasters.

关键词： Lateral dynamic disturbance Trapezoidal rock block system Low-velocity and low-frequency wave Friction reduction effect Instability mode

Data-driven Wasserstein distributionally robust chance-constrained optimization for crude oil scheduling under uncertainty

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Chinese Journal of Chemical Engineering 2024年第5期69卷 152-166页

作者： Xin dai Liang Zhao Renchu He Wenli Du Weimin zhong Zhi Li Feng Qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Process System Engineering Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

Crude oil scheduling optimization is an effective method to enhance the economic benefits of oil *** uncertainties,including uncertain demands of crude distillation units(CDUs),might make the production plans made by the traditional deterministic optimization models infeasible.A data-driven Wasserstein distributionally robust chance-constrained(WDRCC)optimization approach is proposed in this paper to deal with demand uncertainty in crude oil ***,a new deterministic crude oil scheduling optimization model is developed as the basis of this *** Wasserstein distance is then used to build ambiguity sets from historical data to describe the possible realizations of probability distributions of uncertain demands.A cross-validation method is advanced to choose suitable radii for these ambiguity *** deterministic model is reformulated as a WDRCC optimization model for crude oil scheduling to guarantee the demand constraints hold with a desired high probability even in the worst situation in ambiguity *** proposed WDRCC model is transferred into an equivalent conditional value-at-risk representation and further derived as a mixed-integer nonlinear programming *** case studies from a real-world refinery are conducted to show the effectiveness of the proposed ***-of-sample tests demonstrate that the solution of the WDRCC model is more robust than those of the deterministic model and the chance-constrained model.

关键词： Distributions Model Optimization Crude oil scheduling Wasserstein distance Distributionally robust chance constraints