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MicroRNAs:protective regulators for neuron growth and development

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Neural Regeneration Research 2023年第4期18卷 734-745页

作者： Zhi-Xuan Ma Zhen Liu Hui-Hui Xiong Zong-Pu zhou Li-Si Ouyang Fu-Kang Xie Ya-Mei Tang zhong-Dao Wu Ying Feng School of Medicine South China University of TechnologyGuangzhouGuangdong ProvinceChina zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of Tropical Disease Control Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

MicroRNAs(miRNAs)play an important regulatory role in neuronal growth and *** mi RNAs target different genes to protect neurons in different ways,such as by avoiding apoptosis,preventing degeneration mediated by conditional mediators,preventing neuronal loss,weakening certain neurotoxic mechanisms,avoiding damage to neurons,and reducing inflammatory damage to *** high expression of mi RNAs in the brain has significantly facilitated their development as protective targets for therapy,including neuroprotection and neuronal *** RNA is indispensable to the growth and development of neurons,and in turn,is beneficial for the development of the brain and checking the progression of various diseases of the nervous *** can thus be used as an important therapeutic target for models of various *** review provides an introduction to the protective effects of mi RNA on neurons in case of different diseases or damage models,and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.

关键词： brain damage miRNA neurodegenerative disorders neuronal apoptosis neuronal protection

Preventive Effect of Perioperative Management Using Oral Clopidogrel on Postoperative Rebleeding in Patients with Spontaneous Intracerebral Hemorrhage

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Journal of Cerebrovascular Disease 2019年第1期2卷 11-14页

作者： Tao Yang zhong-Xiao lin Xi-lin Zhang Xing-Ming zhong Department of Neurosurgery Huzhou First People’s HospitalHuzhou 313000China Department of Neurosurgery The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325027China Central Laboratory Huzhou First People’s HospitalHuzhou 313000China

Background: With the aging society in China and the increasing incidence of cardiovascular and cerebrovascular diseases,spontaneous cerebral hemorrhage with the use of oral clopidogrel has become common in patients. Owing to its inhibition of platelet aggregation,oral clopidogrel results in a high incidence of postoperative intracranial rebleeding,and the prognosis is poor. The purpose of this study is to determine the effect of perioperative management of spontaneous intracerebral hemorrhage (SICH) using oral clopidogrel on postoperative rebleeding. Methods: From January 2010 to June 2018,64 patients with SICH who took clopidogrel orally and finally received surgical treatment were selected from Huzhou First People’s Hospital and the Second Affiliated Hospital of Wenzhou Medical University. The influencing factors of postoperative rebleeding were analyzed via a case-control study. Results: All patients with SICH were divided into two groups according to the standard time of drug withdrawal before surgery: drug withdrawal at < 3 days and ≥ 3 days. The incidence of postoperative rebleeding after drug withdrawal at ≥ 3 days was significantly lower than that after drug withdrawal at < 3 days. Thereafter,all patients were divided into two groups according to the adenosine diphosphate (ADP) inhibition rate detected using a thromboelastography monitor: ADP inhibition rate of < 60% and ≥ 60%. The incidence of postoperative rebleeding in the ADP inhibition rate of < 60% group was significantly lower than that in the ADP inhibition rate of ≥ 60% group. In addition,drug withdrawal at ≥ 3 days and ADP inhibition rate of < 60% had a synergistic effect on the prevention of postoperative rebleeding. Conclusions: Patients with drug withdrawal at ≥ 3 days can undergo active early surgery. The ADP inhibition rate of ≥ 60% can be used as the predictive index of high-risk postoperative rebleeding in patients with SICH taking oral clopidogrel. By reducing the ADP inhibition rate to < 6

关键词： Spontaneous intracerebral hemorrhage Clopidogrel Adenosine diphosphate Perioperative management

Effect of organophosphorus pesticide pollution on soil animals

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Journal of Environmental Sciences 2000年第1期12卷 49-58页

作者： Wang, Zhen-zhong Zhang, You-Mei Guo, Yong-Can Li, zhong-Wu Resource and Environment Department Hunan Normal University Changsha 410081 China

This paper studied the change in soil animal community in contaminated and irrigated area by organophosphorus pesticide waste water and its mechanism was discussed. The results showed that the species and quantities of soil animals decreased with organophosphorus pesticide pollution degree increasing. The species of soil animals decreased with average and rare population mainly decreasing, while the amount change was associated with that of the dominant population of Acarina, Collembola and Nematoda. Toxicity experiment demonstrated that the respiration intensity of soil animal was restrained obviously by pesticide pollution. After observation of SEM, the effect of pesticide pollution on the earthworm (\%Pheretima robusta)\% stomach intestinal mucosa damage has been observed, which showed the pesticide contamination may damage the earthworms bodies. Ulcerous focus and perforation on stomach mucosa were usually seen. The stomach microvilli appeared atrophic and disordered especially in the bodies of these earthworms growing in seriously polluted soil, bad atrophic phenomena were seen not only on the stomach mucosa microvilli but also on the cilia of the intestinal mucosa which appeared swollen as a spheroid. Under TEM, RER and Golgi compound dilatation, chondrisome swell and ridge disappearance were observed on cells of stomach epithelium mucosa of \%***\% collected from heavy polluted area. By calculation, the safety concentration of earthworm in methamidophos pesticide is 0\^2517 ml/L.

关键词： pesticide pollution soil animal respiration intensity pathological changes LC 50 CLC number: X592 Document code: A

Gene therapy in pancreatic cancer

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World Journal of Gastroenterology 2014年第37期20卷 13343-13368页

作者： Si-Xue Liu zhong-Sheng Xia Ying-Qiang zhong Department of Gastroenterology Sun Yat-sen Me-morial HospitalSun Yat-sen University Department of Gastro-enterology Sun Yat-sen Memorial HospitalSun Yat-sen Univer-sity

Pancreatic cancer(PC) is a highly lethal disease and notoriously difficult to treat. Only a small proportion of PC patients are eligible for surgical resection, whilst conventional chemoradiotherapy only has a modest effect with substantial toxicity. Gene therapy has become a new widely investigated therapeutic approach for *** article reviews the basic rationale, gene delivery methods, therapeutic targets and developments of laboratory research and clinical trials in gene therapy of PC by searching the literature published in English using the PubMed database and analyzing clinical trials registered on the Gene Therapy Clinical Trials Worldwide website(http://www. ***/genmed/ clinical). Viral vectors are main gene delivery tools in gene therapy of cancer, and especially, oncolytic virus shows brighter prospect due to its tumor-targeting *** therapeutic targets for gene therapy include tumor suppressor gene p53, mutant oncogene K-ras,anti-angiogenesis gene VEGFR, suicide gene HSK-TK,cytosine deaminase and cytochrome p450, multiple cytokine genes and so on. Combining different targets or combination strategies with traditional chemoradiother-apy may be a more effective approach to improve the efficacy of cancer gene therapy. Cancer gene therapy is not yet applied in clinical practice, but basic and clinical studies have demonstrated its safety and clinical benefits. Gene therapy will be a new and promising field for the treatment of PC.

关键词： Pancreatic cancer Gene therapy Tumor suppressor Suicide Anti-angiogenesis Immunotherapy Oncogene Multidrug resistance Clinical trial

The silt stalactite——a peculiar kind of sedimentary structures

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Chinese Science Bulletin 1997年第23期42卷 1974-1977,2025页

作者： zhong, JH Ma, ZP Univ Petr China Dongying 257062 Peoples R China

THE Yellow River, with its huge amount of silt charge from the Loess Plateau, is the secondlargest river in China. Its lower reach has become a famous hanging river because of serioussilting up, and the magnitude of discharge changes much from season to season. As a result ofsilting, migration of the stream channel happens frequently. Lateral erosion of channel or pointbars, and scarp slopes forming during the erosion may be often observed. The silt stalactite,hitherto not reported, usually forms on surfaces of the slope. As a newly found kind of sedirnen-tary structure, the silt stalactite may have some significance to the study of sedimentary envi-ronments and paleoclimate.

关键词： silt stalactite sedimentary structure the Yellow River Delta.

First generation solar adaptive optics system for 1-m New Vacuum Solar Telescope at Fuxian Solar Observatory

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Research in Astronomy and Astrophysics 2016年第2期16卷 19-26页

作者： Chang-Hui Rao Lei Zhu Xue-Jun Rao Lan-Qiang Zhang Hua Bao Xue-An Ma Nai-Ting Gu Chun-lin Guan Dong-Hong Chen Cheng Wang Jun lin Zen-Yu Jin zhong Liu Key Laboratory on Adaptive Optics Chinese Academy of Sciences Laboratory on Adaptive Optics Institute of Optics and Electronics Chinese Academy of Sciences Yunnan Astronomical Observatories Chinese Academy of Sciences

The first generation solar adaptive optics （AO） system, which consists of a fine tracking loop with a tip-tilt mirror （TTM） and a correlation tracker, and a high-order correction loop with a 37-element deformable mirror （DM）, a correlating Shack-Hartmann （SH） wavefront sensor （WFS） based on the ab- solute difference algorithm and a real time controller （RTC）, has been developed and installed at the 1-m New Vacuum Solar Telescope （NVST） that is part of Fuxian Solar Observatory （FSO）. Compared with the 37-element solar AO system developed for the 26-cm Solar Fine Structure Telescope, administered by Yunnan Astronomical Observatories, this AO system has two updates： one is the subaperture arrangement of the WFS changed from square to hexagon; the other is the high speed camera of the WFS and the corre- sponding real time controller. The WFS can be operated at a frame rate of 2100 Hz and the error correction bandwidth can exceed 100 Hz. After AO correction, the averaged residual image motion and the averaged RMS wavefront error are reduced to 0.06＂ and 45 nm, respectively. The results of on-sky testing obser- vations demonstrate better contrast and finer structures of the images taken with AO than those without AO.

关键词： adaptive optics -- high angular resolution -- sunspots -- granulation

Relaxation Property and Stability Analysis of the Quasispecies Models

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Communications in Theoretical Physics 2009年第10期52卷 726-734页

作者： FEGN Xiao-Li LI Yu-Xiao GU Jian-zhong ZHUO Yi-zhong School of Physical Engineering Zhengzhou University Zhengzhou 450052 China Center for Computational and System Biology Institute of Biophysics Chinese Academy of Science Beijing 100101 China China Institute of Atomic Energy P.O. Box 275（18） Beijing 102413 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 China

The relaxation property of both Eigen model and Crow-Kimura model with a single peak fitness landscape is studied from phase transition point of view. We first analyze the eigenvalue spectra of the replication mutation matrices. For sufficiently long sequences, the almost crossing point between the largest and seeond-largest eigenvalues locates the error threshold at which critical slowing down behavior appears. We calculate the critical exponent in the limit of infinite sequence lengths and compare it with the result from numerical curve fittings at sufficiently long sequences. We find that for both models the relaxation time diverges with exponent 1 at the error （mutation） threshold point. Results obtained from both methods agree quite well. From the unlimited correlation length feature, the first order phase transition is further confirmed. Finally with linear stability theory, we show that the two model systems are stable for all ranges of mutation rate. The Igigen model is asymptotically stable in terms of mutant classes, and the Crow-Kimura model is completely stable.

关键词： relaxation time critical exponent error threshold

Organic Light Emitting Diode Using Inorganic Material as Electron Transport Layer

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Chinese Physics Letters 1997年第12期14卷 946-948页

作者： YANG Xiao-hui HUA Yu-lin TENG Feng HOU Yan-bing XU Xu-rong HUANG zhong-hao Department of Physics Northern Jiaotong UniversityReijing 100044 Institute of Material Physics Tianjin Institute of TechnologyTianjin 300191 Department of Chemistry Northeast Normal UniversityChangchun 130024

In this letter we report a new kind of organic light emitting diode in which an inorganic material was used as electron transport *** incorporation of this inorganic material layer increased the brightness in one order.

关键词： diode inorganic Electron

Generalized Persistence of Entropy Weak Solutions for System of Hyperbolic Conservation Laws

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Chinese Annals of Mathematics,Series B 2022年第4期43卷 499-508页

作者： Yi zhou School of Mathematical Sciences Fudan UniversityShanghai 200433China

Let u(t,x)be the solution to the Cauchy problem of a scalar conservation law in one space *** is well known that even for smooth initial data the solution can become discontinuous in finite time and global entropy weak solution can best lie in the space of bounded total *** is impossible that the solutions belong to,for example,H^(1) because by Sobolev embedding theorem H^(1) functions are Holder ***,the author notes that from any point(t,x),he can draw a generalized characteristic downward which meets the initial axis at y=α(t,x).If he regards u as a function of(t,y),it indeed belongs to H^(1) as a function of y if the initial data belongs to H^(1).He may call this generalized persistence(of high regularity)of the entropy weak *** main purpose of this paper is to prove some kinds of generalized persistence(of high regularity)for the scalar and 2×2 Temple system of hyperbolic conservation laws in one space dimension.

关键词： Quasilinear hyperbolic system Cauchy problem Entropy weak solution Vanishing viscosity method