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The transcorneal electrical stimulation as a novel therapeutic strategy against retinal and optic neuropathy: a review of experimental and clinical trials

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 914-919页

作者： Ye Tao Tao Chen Bei Liu Li-Qiang Wang Guang-Hua Peng Li-Min Qin zhong-jun yan Yi-Fei Huang Department of Ophthalmology Ophthalmology & Visual Science Key Lab of PLAGeneral Hospital of Chinese PLA Department of Clinical Aerospace Medicine the Fourth Military Medical University Department of Neurosurgery and Institute for Functional Brain Disorders Tangdu Hospitalthe Fourth Military Medical University

Transcorneal electrical stimulation （TES） is a novel therapeutic approach to activate the retina and related downstream structures. TES has multiple advantages over traditional treatments, such as being minimally invasive and readily applicable in a routine manner. Series of animal experiments have shown that TES protects the retinal neuron from traumatic or genetic induced degeneration. These laboratory evidences support its utilization in ophthalmological therapies against various retinal and optical diseases including retinitis pigmentosa （RP）, traumatic optic neuropathy, anterior ischemic optic neuropathy （AION）, and retinal artery occlusions （RAOs）. Several pioneering explorations sought to clarify the functional mechanism underlying the neuroprotective effects of TES. It seems that the neuroprotective effects should not be attributed to a solitary pathway, on the contrary, multiple mechanisms might contribute collectively to maintain cellular homeostasis and promote cell survival in the retina. More precise evaluations y/a functional and morphological techniques would determine the exact mechanism underlying the remarkable neuroprotective effect of TES. Further studies to determine the optimal parameters and the long-term stability of TES are crucial to justify the clinical significance and to establish TES as a popularized therapeutic modality against retinal and optic neuropathy.

关键词： transcorneal electrical stimulation therapeutic strategy retinal disease optic neuropathy

基于Poisson过程与分布的股票价格过程

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北京交通大学学报 2006年第3期30卷 97-99,110页

作者：钟艳君王军北京交通大学理学院

根据概率论中的Poisson过程,Poisson分布和渗流理论,研究证卷市场中的股票价格波动过程,通过建立相应的金融收益模型,构造出股价的随机过程.再利用价格过程的特征函数,研究股价过程概率分布的收敛问题.同时还讨论了在不同时段内股价波... 详细信息

根据概率论中的Poisson过程,Poisson分布和渗流理论,研究证卷市场中的股票价格波动过程,通过建立相应的金融收益模型,构造出股价的随机过程.再利用价格过程的特征函数,研究股价过程概率分布的收敛问题.同时还讨论了在不同时段内股价波动的性质和状态.

关键词： Poisson过程 Poisson分布渗流理论 Black—Scholes公式特征函数

Massive hemoptysis and hemothorax： a rare but fatal complication of intralobar sequestration

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Chinese Medical Journal 2012年第14期125卷 2638-2640页

作者： WANG Hong-wei LU Jiang-yang SUN jun-zhong, XIAO yan WEN Bo Department of Patlaology First Affiliated Hospital of General Hospital of People's Liberation Army Beijing 100048 China Department of OncologyFirst Affiliated Hospital of General Hospital of People's Liberation Army Beijing 100048 China Respiratory Center First Affiliated Hospital of General Hospitalof People's Liberation Army Beijing 100048 China Department ofRadiology First Affiliated Hospital of General Hospitalof People's Liberation Army Beijing 100048 China

Intralobar sequestration （ILS） is an uncommon abnormality that accounts for 75% of all pulmonary sequestrations. Over the years there have been several reports of various presenting signs of which hemoptysis was commonly described, however, massive hemoptysis and hemothorax is extremely rare in literature. We present a case of a 45-year-old man who died of fatal complication from an ILS. This case report shows an uncommon presentation of ILS with massive hemoptysis and hemothorax resulting in a dramatic course of disease and a fatal outcome, and for this reason in the absence of trauma or other causes for massive hemoptysis, hemothorax, or lung hematoma, this possibility should be kept in mind so as to avoid misdiagnosis, and resection of the sequestered tissue should be considered in all patients.

关键词： hemoptysis hemothorax bronchopulmonary sequestration, autopsy

EDTA辅助水热法制备性能优异的棒状LiFePO_4/C材料(英文)

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无机化学学报 2013年第10期29卷 2257-2264页

作者：董静钟本和钟艳君唐艳刘恒郭孝东四川大学化学工程学院成都610065 四川大学材料科学与工程学院成都610065

以乙二胺四乙酸为配位剂采用水热法制备了棒状LiFePO4/C材料.采用X射线衍射、扫描电镜、透射电镜、循环伏安、交流阻抗和恒电流充放电测试等对材料进行表征.结果表明：乙二胺四乙酸对材料的形貌和电性能均有很大影响.通过加入乙二胺四乙... 详细信息

以乙二胺四乙酸为配位剂采用水热法制备了棒状LiFePO4/C材料.采用X射线衍射、扫描电镜、透射电镜、循环伏安、交流阻抗和恒电流充放电测试等对材料进行表征.结果表明：乙二胺四乙酸对材料的形貌和电性能均有很大影响.通过加入乙二胺四乙酸,材料的形貌由不规则的颗粒变为棒状的颗粒且颗粒的厚度由140～200 nm减少至40～90 nm,材料的表面包覆约3.5nm的均匀碳层,且该材料极化较小且界面阻抗较低.0.1C放电比容量为167 mAh·g-1（接近理论容量170 mAh·g-1）.

关键词：材料科学水热法循环伏安锂电池 LiFePO4 乙二胺四乙酸

混合溶剂对溶胶-凝胶法制备的Li_3V_2(PO_4)_3/C高倍率性能的影响

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物理化学学报 2011年第4期27卷 869-874页

作者：唐艳钟本和郭孝东刘恒钟艳君聂翔唐红四川大学化学工程学院成都610065 四川大学材料科学与工程学院成都610065

以有机-水为混合溶剂,采用溶胶-凝胶法制备锂离子电池正极材料Li3V2(PO4)3/C,选取乙醇、乙二醇和1,2-丙二醇为有机溶剂,聚丙烯酸(PAA)为碳源和螯合剂.通过X射线衍射(XRD)、扫描电镜(SEM)、恒流充放电以及循环伏安测试等方法,研究了产物... 详细信息

以有机-水为混合溶剂,采用溶胶-凝胶法制备锂离子电池正极材料Li3V2(PO4)3/C,选取乙醇、乙二醇和1,2-丙二醇为有机溶剂,聚丙烯酸(PAA)为碳源和螯合剂.通过X射线衍射(XRD)、扫描电镜(SEM)、恒流充放电以及循环伏安测试等方法,研究了产物的结构形貌及电化学性能.XRD测试结果表明所有溶剂制备的样品结晶良好,有机溶剂的加入不影响Li3V2(PO4)3材料的晶型结构.恒流充放电结果表明有机溶剂的加入改善了材料的电化学性能.以1,2-丙二醇-水为溶剂的样品电化学性能最好,在3.0-4.5V电压范围内,0.1C(1C=150mA·g-1)倍率首次放电比容量为132.89mAh·g-1,10C倍率首次放电比容量达125.42mAh·g-1,循环700周后容量保持率为95.79%,具有良好的倍率性能与循环性能;在3.0-4.8V电压范围内倍率性能较差.扫描电镜结果表明混合溶剂制备的样品呈片状和针状,这种形状有利于锂离子的扩散,因此提高了材料的电化学性能.

关键词：锂离子电池正极材料 Li3V2(PO4)3 溶胶-凝胶法混合溶剂

Li_3V_2(PO_4)_3/C正极材料在不同电压区间的电化学行为及容量衰减原因(英文)

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物理化学学报 2015年第2期31卷 277-284页

作者：唐艳钟艳君欧庆祝刘恒钟本和郭孝东王辛龙四川大学材料科学与工程学院成都610065 四川大学化学工程学院成都610065

采用溶胶-凝胶法制备锂离子电池正极材料Li_3V_2(PO_4)_3/C.通过恒电流充放电测试、循环伏安(CV)、电化学阻抗谱(EIS)等方法,研究了Li_3V_2(PO_4)_3/C在不同电压区间的电化学行为(3.0-4.5 V和3.0-4.8 V).结果表明,3.0-4.8 V电压区间的... 详细信息

采用溶胶-凝胶法制备锂离子电池正极材料Li_3V_2(PO_4)_3/C.通过恒电流充放电测试、循环伏安(CV)、电化学阻抗谱(EIS)等方法,研究了Li_3V_2(PO_4)_3/C在不同电压区间的电化学行为(3.0-4.5 V和3.0-4.8 V).结果表明,3.0-4.8 V电压区间的循环性能和倍率性能均不及3.0-4.5 V电压区间的.3.0-4.5 V区间0.1C(1C=150m A·g^(-1))倍率首次放电比容量为127.0 mAh·g^(-1),循环50次后容量保持率为99.5%,而3.0-4.8 V区间的分别为168.2 mAh·g^(-1)和78.5%.经过高倍率测试后再回到0.1C倍率充放电,3.0-4.5 V和3.0-4.8 V的放电比容量分别为初始0.1C倍率的99.0%和80.7%.经过3.0-4.8 V电压区间测试后,少部分第三个锂离子能够在低于4.5V的电压脱出,使3.0-4.5 V电压区间的放电比容量提升了7.4%.CV结果表明3.0-4.8 V区间的容量损失主要表现为第一个锂离子的不可逆损失.极片的X射线衍射(XRD)和X射线光电子能谱(XPS)分析测试结果表明经过3.0-4.8 V测试后,Li_3V_2(PO_4)_3的结构发生了轻微的改变.电感耦合等离子体(ICP)测试结果表明循环后的电解液中含有少量的V.结构变形和V溶解可能是Li_3V_2(PO_4)_3在3.0-4.8 V区间容量衰减的主要原因.

关键词： Li3V2(PO4)3/C 电化学行为电压区间容量衰减

CYP2E1-dependent oxidative damage by chronic ethanol treatment in rat brain

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CYP2E1-dependent oxidative damage by chronic ethanol treatme...

冷备状态下两个相同部件并联的可修系统解的渐近性质

中国药理学会第十一次全国学术会议

作者： zhong yan-jun,YUE Jiang (Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 430071,China)

OBJECTIVE Ethanol-inducible cytochrome P450 2E1(CYP2E1) has been shown to be involved in the metabolism of ethanol in both brain and *** enhanced levels of CYP2E1 were found in alcoholics’brain,and oxidative stress is implicated in ethanol-induced brain *** objective of the study was to determine the contribution of CYP2E1-mediated reactive oxygen species (ROS) generation to toxic effects of chronic ethanol treatment in rat brain *** Adult male Wistar rats(about 250 g) were treated intragastrically with ethanol at 3.0 g·kg in sucrose solution(1%,W/V) for 30 d or received sucrose solution a-lone. Brain damage was assayed by measurement of lactate dehydrogenase(LDH) and histopathological *** CYP2E1 protein and mRNA levels were assessed by immunoblotting,quantitative quantum dot immunohistochemistry,and real-time RT-PCR. CYP2E1 activities probed by chlorzoxazone hydroxylation(CZXH) were determined by *** levels in brain regions were deter-mined by laser confocal scanning *** Chronic ethanol treatment induced the damage to neural cells in hippocampus, cerebellum and brain stem,indicated by both lactate dehydrogenase activity and histopathological *** with control rats,CYP2E1 proteins were increased in hippocampus(1.56-fold,P<0.05),cerebellum(1.23-fold,P<0.01) and brain stem (1.43-fold,P<0.05) in ethanol-treated ***2E1 mRNA levels were significantly increased by chronic ethanol treatment in hippocampus and in *** increase in CYP2E1 proteins was found to be accompanying an increase in CYP2E1 catalytic activities in hippocampus,cerebellum and brain stem after chronic ethanol ***2E1 activities were positively correlated with LDH levels in hippocampus(r = 0.746,P = 0.005 ),cerebellum(r = 0.837,P = 0.010) and brain stem(r = 0.861,P = 0.006).ROS levels induced by ethanol were associated with the increased CYP2E1 levels in specific regions assayed by immunohistochemical analysis. C

关键词： cytochrome P450 2E1 ethanol brain reactive oxygen species

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信阳师范学院学报（自然科学版） 2006年第2期19卷 141-143页

作者：仲彦军张萍新疆大学数学与系统科学学院新疆乌鲁木齐830046 信阳师范学院数学与信息科学学院河南信阳464000

本文当修复率μ(x)满足0<μ≤μ(x)≤μ<∞时,通过讨论对应于该系统的主算子的谱特征,得到该系统的时间依赖解是强渐近稳定的.

关键词：特征值预解案渐近稳定

不同碳源合成Na2MnPO4F／C及其作为锂离子电池正极材料的性能

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物理化学学报 2013年第9期29卷 1989-1997页

作者：钟艳君李君涛吴振国钟本和郭孝东黄令孙世刚四川大学化学工程学院成都610065 厦门大学能源研究院固体表面与物理化学国家重点实验室化学化工学院福建厦门361005

采用湿法球磨和原位热解碳包覆相结合的方法,分别以硬脂酸、柠檬酸、聚乙二醇-6000(PEG-6000)、β-环糊精为碳源,制备了不同结构的Na_2MnPO_4F/C复合材料,并研究了它们作为锂离子电池正极材料的电化学行为.通过X射线衍射(XRD)、扫描电镜... 详细信息

采用湿法球磨和原位热解碳包覆相结合的方法,分别以硬脂酸、柠檬酸、聚乙二醇-6000(PEG-6000)、β-环糊精为碳源,制备了不同结构的Na_2MnPO_4F/C复合材料,并研究了它们作为锂离子电池正极材料的电化学行为.通过X射线衍射(XRD)、扫描电镜(SEM)、BET比表面积测试、恒流充放电等表征手段,比较和分析了产物的结构、形貌及电化学性能.研究结果表明,由不同碳源制备的材料在形貌和颗粒尺寸上有明显差异,进而对它们的电化学性能造成很大影响.影响电化学性能的关键因素在于材料一次颗粒的大小.其中,以柠檬酸为碳源制备的样品呈现出典型的微纳结构和最小的一次颗粒(10-40 nm).并给出最佳的电化学性能:在1.5-4.8 V电压范围内,以5mA·g^(-1)充放电电流获得的首次放电比容量约为80mAh·g^(-1),且循环稳定性良好.

关键词：锂离子电池正极材料 Na_2MnPO_4F/C 碳源形貌