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sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： Song-Man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng jin-Jun Chen zhong-ji meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi jia Shang Ruo-Chan Chen Yan Huang Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1 in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at *** enrolled patients were followed-up for at least 1 *** In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD ***,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

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Definition and classification of acute-on-chronic liver diseases

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World Journal of Clinical Cases 2022年第15期10卷 4717-4725页

作者： Yuan-Yao Zhang zhong-ji meng Postgraduate Training Basement of jinzhou Medical University Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Institute of Biomedical Research Hubei Key Laboratory of Embryonic Stem Cell ResearchTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Infectious Diseases Hubei Clinical Research Center for Precise Diagnosis and Therapy of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina

Patients with chronic liver diseases(CLDs)develop acute liver injury and/or acute decompensation under the attack of various precipitants and present with significantly elevated alanine aminotransferase and/or total bilirubin levels,liver failure,or acute decompensation of liver cirrhosis,which is called acute-on-CLD(AoCLD).AoCLD accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** is complicated by various clinical types,the severity of the disease,and may pose a high risk of *** date,the definition of AoCLD is still vague,and a consensus concept of the clinical classification is *** review aimed to define the concept and clinical types of AoCLD based on related studies and the literature.

关键词： Chronic liver disease Acute-on-chronic liver disease Acute liver injury Acute decompensation Acute-on-chronic liver failure

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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan Liu Wei Yuan Xue Mei jing Li Tao Li Rong-jiong Zheng Xin-Yi Zhou Jun Zhao zhong-ji meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

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Identifying Three New AGNs among Fermi Unidentified Gigaelectronvolt Sources

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Research in Astronomy and Astrophysics 2024年第7期24卷 260-270页

作者： Shun-Hao ji zhong-Xiang Wang Qiang-meng Huang Ruo-Heng Yang Department of Astronomy School of Physics and AstronomyYunnan University Shanghai Astronomical Observatory Chinese Academy of Sciences

We report our identification of three gigaelectronvolt γ-ray sources, 4FGL J0502.6+0036, 4FGL J1055.9+6507,and 4FGL J1708.2+5519, as Active Galactic Nuclei(AGNs). They are listed in the latest Fermi-Large Area Telescope source catalog as unidentified ones. We find that the sources all showed γ-ray flux variations in recent years. Using different survey catalogs, we are able to find a radio source within the error circle of each source's position. Further analysis of optical sources in the fields allows us to determine the optical counterparts, which showed similar variation patterns to those seen in γ-rays. The optical counterparts have reported redshifts of 0.6,1.5, and 2.3, respectively, estimated from photometric measurements. In addition, we also obtain an X-ray spectrum of 4FGL J0502.6+0036 and a flux upper limit on the X-ray emission of 4FGL J1055.9+6507 by analyzing the archival data. The broadband spectral energy distributions of the three sources from radio to γ-rays are constructed. Comparing mainly the γ-ray properties of the three sources with those of different sub-classes of AGNs, we tentatively identify them as blazars. Followup optical spectroscopy is highly warranted for obtaining their spectral features and thus verifying the identification.

关键词： (galaxies:) BL Lacertae objects: general (galaxies:) quasars: general gamma-rays: galaxies

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Kilometer-resolution three-dimensional crustal deformation of Tibetan Plateau from InSAR and GNSS

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Science China Earth Sciences 2024年第6期67卷 1818-1835页

作者： Chuanjin LIU Lingyun ji Liangyu ZHU Caijun XU Chaoying ZHAO zhong LU Qingliang WANG School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China The Second Monitoring and Application Center China Earthquake AdministrationXi’an 710054China College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Roy M.Huffington Department of Earth Sciences Southern Methodist UniversityDallasTX 75025USA

Located at the forefront of the collision between the Indian and Eurasian Plates,the Tibetan Plateau experiences intense crustal *** ground-based geodetic monitoring,such as GNSS and leveling,is challenging,due to factors such as high altitude and harsh climate,making it difficult to accurately determine a high-resolution crustal deformation field of the *** by ground observation conditions,InSAR technique has key advantages for obtaining extensive and high-resolution crustal deformation *** makes it indispensable for crustal deformation monitoring on the Tibetan *** study used Sentinel-1 data from 2014 to 2020 to compute the ascending and descending InSAR deformation fields for the Tibetan *** was conducted with a measurement accuracy of approximately 3 mm/*** upon this,we integrated InSAR and GNSS data to yield kilometer-resolution three-dimensional(3D)crustal deformation and strain rate fields for the Tibetan Plateau.A spherical wavelet analysis was used to decompose the 3D deformation field and separate the nontectonic crustal deformation to increase the strength of the tectonic deformation ***-wavelength(110 km)deformation mainly results from subsidence in the central plateau and uplifts along the Himalayan *** indicates that the Tibetan Plateau may have stopped the entire uplift and entered a local collapse ***,the deformation fields at different spatial scales reveal that the plateau exhibits discontinuous deformation in short wavelengths and continuous deformation in long *** findings of this study contribute to resolving the controversy between the Block and Continuum Deformation models of the Tibetan Plateau.

关键词： Tibetan Plateau InSAR GNSS 3D Deformation Deformation Model

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Phylogeographic relationships of the southern green stink bug Nezara viridula （Hemiptera： Pentatomidae）

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Insect Science 2010年第5期17卷 448-458页

作者： Min Li zhong-Hua Fan ji-meng Hua Chun-jing Niu Chun-Xuan Li Wen-Jun Bu Institute of Entomology College of Life Sciences Nankai University Tianjin China

The sequences of 16S rDNA, cytochrome oxidase subunit I （CO1） and cytochrome b （Cyt b） genes from nine field collections （seven provinces in China： Guangxi, Hubei, Guangdong, Guizhou, Zhejiang, Hunan, jiangxi, and also southern and northern part oflran）, plus the sequences of Africa, Europe, Americas and Japan obtained form GenBank were used to re-analyse the genetic variation in the southern green stink bug Nezara viridula （Linnaeus）. The phylogeographic re-analysis by using four algorithms （N J, MP, ML and Bayesian） showed three main lineages. The Iranian haplotypes fell into lineage II formed from Europe and America, rather than in lineage III from Asia; the Chinese haplotypes fell into the Asian clade. Our results suggested that African and non-African gene pools have been isolated since the Miocene era with the molecular clock calibrations for Heteroptera mtDNA, and not since the Pliocene as mentioned previously. The corresponding age of the separation of the eastern and western Asia clades is estimated to be 4.0-1.6 million years ago, coinciding with the Pliocene-Pleistocene epoch and with acute rising events in the Tibet Plateau locates in the western China, which may have formed the barriers observed today.

关键词： COI Cyt b 16S rDNA Nezara viridula phylogeographie

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A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

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Petroleum Science 2024年第1期21卷 244-251页

作者： ji-Lin Fan Feng Zhang Qian Chen Hao-Chen Song Lu-Yu zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

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Characterization of rock thermophysical properties and factors affecting thermal conductivity−A case study of Datong Basin,China

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Journal of Groundwater Science and Engineering 2024年第1期12卷 4-15页

作者： meng-lei ji Shuai-chao Wei Wei Zhang Feng Liu Yu-zhong Liao Ruo-xi Yuan Xiao-xue Yan Long Li Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China China University of Geosciences(Beijing) Beijing 100083China

Rock thermal physical properties play a crucial role in understanding deep thermal conditions,modeling the thermal structure of the lithosphere,and discovering the evolutionary history of sedimentary *** advancements in geothermal exploration,particularly the identification of high-temperature geothermal resources in Datong Basin,Shanxi,China,have opened new *** study aims to characterize the thermal properties of rocks and explore factors influencing thermal conductivity in basins hosting high-temperature geothermal resources.A total of 70 groups of rock samples were collected from outcrops in and around Datong Basin,Shanxi *** property tests were carried out to analyze the rock properties,and the influencing factors of thermal conductivity were studied through experiments at different temperature and water-filled *** results indicate that the thermal conductivity of rocks in Datong,Shanxi Province,typically ranges from 0.690 W/(m·K)to 6.460 W/(m·K),the thermal diffusion coefficient ranges from 0.441 mm^(2)/s to 2.023 mm^(2)/s,and the specific heat capacity of the rocks ranges from 0.569 KJ/(kg·℃)to 1.117 KJ/(kg·°C).Experimental results reveal the impact of temperature and water saturation on the thermal conductivity of the *** thermal conductivity decreases with increasing temperature and rises with high water saturation.A temperature correction formula for the thermal conductivity of different lithologies in the area is proposed through linear *** findings from this study provide essential parameters for the assessment and prediction,development,and utilization of geothermal resources in the region and other basins with typical high-temperature geothermal resource.

关键词： Datong Basin Rock thermal conductivity Thermal diffusivity Specific heat capacity Influencing factors

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A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

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Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： Yi-Xuan Li Liang-Ying Wu Yan Yang Yao-zhong Lu zhong-Ying ji Yu-Xiong Guo Xiao-Long Wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability

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Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model

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Virologica Sinica 2008年第2期23卷 107-115页

作者： Ina Schulte E-juan ZHANG zhong-ji meng Rong-juan PEI mengji LU Michael Roggendorf Institute of Virology University Hospital Essen University of Duisburg-Essen 45122 Essen Germany Department of Microbiology Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China State Key Lab of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan430071 China

The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

关键词：美洲旱獭细胞基因免疫系统

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