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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu Jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Study on Nonuniform Deformation of Tailor Rolled Blank During Uniaxial Tension

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Acta Metallurgica Sinica(English Letters) 2015年第9期28卷 1198-1204页

作者： hua-Wei Zhang Xiang-hua liu Li-zhong liu Ping Hu Jia-Lu Wu School of Mechanical Engineering and Automation Northeastern University Research Institute of Science and Technology Northeastern University School of Automotive Engineering Dalian University of Technology

The deformation characteristics of tailor rolled blank （TRB） in the course of uniaxial tension were studied by means of analysis, test and simulation. The mechanical analytical model of TRB during uniaxial tension was set up, and the deformation formulae for the thinner side and for the thicker side were derived to quantify the deformation of TRB. On this basis, uniaxial tension tests on TRB and ordinary blanks （the thinner side and the thicker side of TRB） were conducted. Lagrange polynomial interpolation method was adopted to construct the stress-strain fields of unannealed and annealed TRBs for solving TRB material parameters, and then, uniaxial tension simulation on TRB was completed. Deformations and properties of unannealed TRB were compared with those of annealed TRB, and the thinner side and the thicker side were also compared. Finally, the research results were explained by metallurgical structure. The results show that nonuniform deformation happens in TRB during uniaxial tension, and the necking occurs on the thinner side. The agreement of analysis, test and simulation confirms the correctness of the analytical model and the deformation formulae. The findings of this paper can lay the foundation for the future study on TRB stamping formability and provide a way for TRB modeling.

关键词： Tailor rolled blank (TRB) Nonuniform deformation Uniaxial tension Annealing Metallographical

Enhanced breakdown strength of BaTiO_(3)-based multilayer ceramic capacitor by structural optimization

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Rare Metals 2023年第8期42卷 2552-2561页

作者： Qian liu hua Hao Qing-Hu Guo zhong-Hui Shen Jian Wang Ming-He Cao zhong-hua Yao Han-Xing liu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Material Science and EngineeringWuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528220China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China International School of Material Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and DevicesWuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Material Science and EngineeringWuhan University of TechnologyWuhan 430070China

0.5 wt%Nb_(2)O_(5)doped 0.12BiAlO_(3)-0.88BaTiO_(3)(12BA5N)multilayer ceramic capacitor(MLCC-1)was prepared,which satisfied EIA X7R specification(where X is the minimum temperature,R is the percentage of capacitance variation limit)at 1 *** distribution of internal electric field under breakdown voltage was simulated by finite element method(FEM),indicating that the electric field strength increased significantly at the terminal of internal *** areas may become the headstream of breakdown for MLCC-1 due to the shape *** order to improve the breakdown performance of MLCC-1,it was optimized by 12BA5N+2G green sheets(prepared by 12BA5N ceramic powder with 2 wt%B-Al-Si glass additive),then MLCC-2 was obtained which satisfied EIA X8R *** BDS rose from 20 to29.4 kV·mm^(-1),and the electric field distribution of dielectric layer was also analyzed by ***,it was also found that the grain size and the dielectric constants of"core"and"shell"parts for the 12BA5N+2G dielectric layer both contributed to the enhanced BDS of MLCC-2according to the simulation results from FEM.

关键词： Multilayer ceramic capacitor(MLCC) Breakdown strength(BDS) Simulation Grain size Dielectric constant

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我国护理学硕士研究生培养能力的研究

中国实用护理杂志 2006年第12期22卷 4-6页

作者：单伟颖安文忠刘亚莉封桂英何仲承德医学院中国协和医科大学护理学院中国协和医科大学护理学院 067000

目的本研究旨在探讨培养适合我国国情的护理专业硕士研究生的方案。方法采用Delphi技术。结果“科研型”硕士研究生培养能力按照百分比从高到低依次为:专业基础知识、临床知识、科研能力、社会适应能力、教学能力、管理能力、社区护理能... 详细信息

目的本研究旨在探讨培养适合我国国情的护理专业硕士研究生的方案。方法采用Delphi技术。结果“科研型”硕士研究生培养能力按照百分比从高到低依次为:专业基础知识、临床知识、科研能力、社会适应能力、教学能力、管理能力、社区护理能力;“临床型”硕士研究生培养能力依次为:专业基础知识、临床知识、社会适应能力、管理能力、科研能力、教学能力和社区护理能力。结论根据我国目前的情况,专家认为护理专业硕士研究生的能力培养不可忽视专业基础知识、临床知识和技能。

关键词：护理教育 Delphi技术

RESEARCH ON THE FLOW PROPERTY IN THREE DIMENSIONAL CAVITY OF MICRO-CHANNEL

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Journal of Hydrodynamics 2006年第1期18卷 20-25页

作者： BAO Fu-bing LIN Jian-zhong liu Yan-hua Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China China Jiliang University Hangzhou 310018 China

The vortical property in a three dimensional cavity of micro-channel flow, which is very important, was investigated numerically. The results show that the rotation direction of vortex in the cavity depends on the dimension and shape of the cavity as well as the viscosity of the fluid. With the dimension and shape of the cavity fixed, there exists a critical inlet velocity. When the inlet velocity is less than the critical value, the rotation direction of vortex in the cavity will change. The critical velocity is directly proportional to the vis- cosity of the fluid, and inversely proportional to square of the thickness, length and depth of cavity. For the ratio of length and depth of cavity equals to one, there is a critical dimensionless parameter Recr , when Recr＇ is less than Recr＇ , the rotation direction of vortex will change too. Recr＇ is equal to 11.8 approximately.

关键词： micro channel cavity flow vortex numerical simulation

Single Peak Solutions for a Schr?dinger Equation with Variable Exponent

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Acta Mathematica Sinica,English Series 2023年第11期39卷 2207-2218页

作者： zhong Yuan liu Peng LUO hua Fei XIE School of Mathematics and Statistics He’nan UniversityKaifeng 475004P.R.China School of Mathematics and Statistics&Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan 430079P.R.China School of Mathematics and Statistics Nanyang Normal UniversityNanyang 473061P.R.China

We study the following Schr?dinger equation with variable exponent−Δu+u=u^(p+∈a)(x),u>0 in R^(N),where∈>0,1 详细信息

We study the following Schr?dinger equation with variable exponent−Δu+u=u^(p+∈a)(x),u>0 in R^(N),where∈>0,1

关键词： Single peak solutions Schr?dinger equation variable exponent

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Role of miR-132/methyl-CpG-binding protein 2 in the regulation of neural stem cell differentiation

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Neural Regeneration Research 2021年第2期16卷 345-349页

作者： Dong Chen Jie liu zhong Wu Shao-hua Li Department of Orthopedics Shanghai Tenth People’s HospitalTongji UniversityShanghaiChina

Methyl-CpG-binding protein 2(MeCP2)is a well-known transcription repressor,and mutations in MECP2 cause serious neurological *** studies have suggested that Me CP2 is involved in neural maturation only,and have not reported its role in neural stem cell *** the present study,we investigated this possible role of Me CP2 in neural stem *** used two different differentiation methods to explore how Me CP2 influences neural stem cell *** we transfected Me CP2-overexpressing lentivirus into neural stem cells,astrocytic differentiation was *** impaired astrocytic differentiation occurred even in conditions of 20%fetal bovine serum,which favored astrocytic *** addition,mi R-132 had the largest expression change after differentiation among several central nervous system related mi RNAs.A luciferase assay confirmed that mi R-132 directly targeted Me CP2,and that mi R-132 was able to reduce Me CP2 expression at both the RNA and protein *** upregulation of mi R-132 by mi RNA mimics promoted astrocytic differentiation,which was fully recovered by Me CP2 *** results indicate that mi R-132 regulates cell lineage differentiation by reducing Me *** study was approved by the Ethics Committee of Shanghai Tenth People's Hospital of Tong Ji University,China(approval ***-2018-4748)on March 10,2018.

关键词： astrocytes factor model pathways stem cell

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红花尔基沙地樟子松天然林枯立木特征分析

林业科学研究 2017年第5期30卷 788-796页

作者：赵中华刘灵王宏翔王千雪胡艳波张吉利王春来惠刚盈中国林业科学研究院林业研究所国家林业局林木培育重点实验室北京100091 国家林业局哈尔滨林业机械研究所黑龙江哈尔滨150086 红花尔基林业局森林调查大队内蒙古海拉尔021112

[目的]了解沙地樟子松天然纯林中枯立木的数量及空间结构特征,探究枯立木形成的原因,为樟子松林的保护和经营提供依据。[方法]在沙地樟子松天然纯林中设置2块1 hm^2的大样地,用全站仪对样地中所有胸径大于5 cm的立木进行定位并进行全面... 详细信息

[目的]了解沙地樟子松天然纯林中枯立木的数量及空间结构特征,探究枯立木形成的原因,为樟子松林的保护和经营提供依据。[方法]在沙地樟子松天然纯林中设置2块1 hm^2的大样地,用全站仪对样地中所有胸径大于5 cm的立木进行定位并进行全面调查;对调查样地的基本特征,枯立木的数量特征及径级分布进行了分析,提出了用于表达林分中枯立木微环境的活立木比的概念,并采用林分空间结构参数一元分布和二元分布分析方法,对枯立木与其最近4株相邻木的关系进行分析。[结果]2块不同密度的樟子松天然纯林下更新幼苗和枯立木数量相差较大,密度较小(样地1)的样地更新幼苗和枯立木较少,而密度较大的样地(样地2)中枯立木达到200棵,林下更新幼苗数量达到15 280株·hm^(-2);樟子松天然纯林样地内枯立木主要以小径级木为主,胸径集中在11 cm以下;样地1枯立木径级连续分布,幅度较窄;样地2中的枯立木径级幅度较宽,但在20 22 cm缺刻,有2株大于23 cm的枯立木;2块样地中枯立木的分布格局均为随机分布,样地1中枯立木周围的4株相邻立木大多为活立木,且胸径较枯立木大;样地2中,只有一半的枯立木周围的最近4株立木为活立木,且有三分之一以上的枯立木胸径不是最小的,枯立木有连续分布的现象。2块样地中枯立木的角尺度-大小比数二元分布特征的差异不明显,而角尺度-活立木比二元分布特征和大小比数-活立木比二元分布特征差异明显,样地1中枯立木的最近4株随机分布于其周围的相邻木为活立木且胸径大于枯立木的比例明显高于样地2,而枯立木最近4株随机分布于其周围的相邻木有枯立木的比例明显小于样地2。[结论]樟子松天然纯林枯立木以小径级林木为主,枯立木的数量与林分密度相关,林木竞争是林木死亡的主要原因,密度过大也会产生病虫害,因此,对天然樟子松纯林要进行适度经营,保持合理密度。

关键词：沙地樟子松天然纯林枯立木红花尔基

A new species of Malus in China,Malus shizongensis liu ***

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Journal of Integrative Agriculture 2020年第10期19卷 2451-2457页

作者： liu Zhen-zhong LI zhong-xing GAO hua BAO Cha-na College of Horticulture Northwest A&F UniversityYangling 712100P.R.China State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China

Based on morphological,molecular biological,and molecular systematic studies,we describe here a new species of Malus from Yunnan,*** compared the morphology of this new species,Malus shizongensis liu ***,with three Malus species,including ***,***,and *** the appearance of *** was similar to these three species,it differed in height,branch color,branch hair,and flower *** better identify the taxonomy of this new species,genome of *** and that of seven Malus species,including ***,***,***,***,***,***,and *** were analyzed.A phylogenetic tree based on genome analysis indicated that *** was close to ***,*** had its species-specific SNPs,and the number of species-specific SNPs was similar to that of three close species(***,***,and ***).Based on the above information,we named this new species as *** liu ***.

关键词： Malus new species taxonomy