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Delayed diagnosis of prosopagnosia following a hemorrhagic stroke in an elderly man:A case report

World Journal of Clinical Cases 2020年第24期8卷 6487-6498页

作者： Yin Yuan Feng Huang Jia-Xin Xiao Yue-Er Yang Peng-Li Zhu zhong-hai gao Wen-Chao Cai Department of Geriatric Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350100Fujian ProvinceChina Fujian Provincial Institute of Clinical Geriatrics Fuzhou 350001Fujian ProvinceChina Fujian Provincial Key Laboratory of Geriatrics Fuzhou 350001Fujian ProvinceChina Fujian Provincial Center for Geriatrics Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Radiology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Acquired prosopagnosia is a rare condition characterized by the loss of familiarity with previously known faces and the inability to recognize new *** usually occurs after the onset of brain lesions such as in a *** initial identification of prosopagnosia generally relies on a patient’s self-report,which can be challenging if it lacks an associated chief *** were few cases of prosopagnosia presenting purely as eye symptoms in the previous literature confirmed by functional magnetic resonance imaging(MRI).CASE SUMMARY We present a case of delayed diagnosis of prosopagnosia after a right hemisphere stroke in an elderly man whose chief complaint was persistent and progressive"blurred vision"without facial recognition *** tests revealed a homonymous left upper quadrantanopia,with normal visual *** was found by accident to barely recognize familiar *** patient showed severe deficit in face recognition and perception tests,and mild memory loss in neuropsychological *** functional MRI revealed the visual recognition deficits were *** behavioral intervention,the patient started to rely on other cues to compensate for poor facial *** prosopagnosia showed no obvious improvement eight months after the stroke,which had negative impact on his social *** Our case demonstrates that the presentation of prosopagnosia can be atypical,and visual difficulties might be a clinical manifestation solely of prosopagnosia,which emphasizes the importance of routinely considering face recognition impairment among elderly patients with brain lesions.

关键词： Prosopagnosia Blurred vision Stroke Diagnosis Functional magnetic resonance imaging Elderly Case report

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin zhong Wenwen Yang Peng gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing hai-Dong Qian Qiao gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Organometal halide perovskite quantum dots:synthesis,optical properties,and display applications

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Chinese Chemical Letters 2016年第8期27卷 1124-1130,1464页

作者： gao-Ling Yang hai-Zheng zhong Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems School of Materials Science & Engineering

In recent two years,organometal halide perovskites quantum dots are emerging as a new member of the nanocrystals *** the chemical point of view,these perovskites quantum dots can be synthesized either by classical hot-injection technique for inorganic semiconductor quantum dots or the reprecipitation synthesis at room temperature for organic *** a physical point of view,the observed large exciton binding energy,well self-passivated surface,as well as the enhanced nonlinear properties have been of great interest for fundamental *** the application point of view,these perovskites quantum dots exhibit high photoluminescence quantum yields,wide wavelength tunability and ultra-narrow band emissions,the combination of these superior optical properties and low cost fabrication makes them to be suitable candidates for display *** this short review,we introduce the synthesis,optical properties,the prototype light-emitting devices,and the current important research tasks of halide perovsktie quantum dots,with an emphasis on CH_3NH_3PbX_3（X= CI,Br,I） quantum dots that developed in our group.

关键词： Halide perovskite Quantum dots Photoluminescence Electroluminescence Display

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基于无人机平台的复合绝缘子检测方法

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自动化技术与应用 2018年第3期37卷 111-115,119页

作者：张德钦庞玉海钟宇高冰洁广西电网有限责任公司北海供电局广西北海536000

复合绝缘子以其优异的憎水性和机械性能而被广泛用于超高压输电线路中,因此研究复合绝缘子带电检测和故障定位对保证电网可靠运行具有重大意义。为此基于无人机平台设计了一种基于全球定位系统(GPS)的实时动态(RTK)定位技术的复合绝缘... 详细信息

复合绝缘子以其优异的憎水性和机械性能而被广泛用于超高压输电线路中,因此研究复合绝缘子带电检测和故障定位对保证电网可靠运行具有重大意义。为此基于无人机平台设计了一种基于全球定位系统(GPS)的实时动态(RTK)定位技术的复合绝缘子检测和定位系统。利用经纬M600六旋翼无人机替代人工带电作业的方式,运用电场法和憎水性分级法对复合绝缘子实施检测,并利用GPS精准定位故障绝缘子。对此,本文基于无人机平台和GPS定位技术的复合绝缘子检测和定位系统的分析结果表明,该装置能提高检测效率,定位准确,安全可靠。

关键词：无人机 RTK定位复合绝缘子红外测温法电场法憎水性分级法

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Regioselective Polymerizations of α-Olefins with an α-Diamine Nickel Catalyst

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Chinese Journal of Polymer Science 2019年第10期37卷 959-965,I0003页

作者： Heng Liao Jie gao Liu zhong hai-Yang gao Qing Wu School of Materials Science and Engineering PCFM Lab GD HPPC Lab Sun Yat-sen University

Polymerizations of linear α-olefins(CnH2n, CH2=CH―R, R = Cn-2) catalyzed by early transition metals typically afford amorphous polymers with alkyl chains(Cn-2), while chain-straightening polymerizations of α-olefins with nickel-based catalysts produce semicrystalline polyolefins. Polymerizations of various α-olefins were carried out using an α-diamine nickel catalyst with a significantly distorted chelating ring. The influences of temperature, monomer concentration, and chain length of α-olefins on polyolefin microstructure were examined in detail. The α-diamine nickel catalyst realized highly regioselective 2,1-insertion of α-olefins regardless of reaction temperature and monomer concentration. Increased chain length of α-olefins led to the formation of more linear *** polyolefins with high melting temperatures(Tm) were made from α-olefins through highly regioselective 2,1-insertion and precise chain-straightening.

关键词： Nickel catalyst α-Olefin Polymerization Regioselectivity Chain walking

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2D sandwich-like nanosheets of ultrafine Sb nanoparticles anchored to graphene for high-efficiency sodium storage

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Nano Research 2017年第12期10卷 4360-4367页

作者： Xiaowu Liu Man gao hai Yang Xiongwu zhong Yan Yu CAS Key Materiels for Energy Conversion Department of Materials Science and Engineering University of Science and Technology of Chine Hefei 230026 China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Tianjin 300071 China State Key Laboratory of Fire Science University of Science and Technology of China Hefei 230026 China

Sb is considered a promising anode material for high-performance sodium-ion batteries （NIBs） owing to its high theoretical specific capacity （660 mAh-g-1）. However, Sb shows a very large volume change （-200%） during sodiation and desodiation, leading to poor electrochemical performance. Here, we designed and tested a sandwich-like graphene-supported Sb nanocomposite （denoted Sb@RGO@Sb）, in which ultrafine Sb nanoparticles are uniformly anchored on a reduced graphene oxide （RGO） surface. The ultrafine Sb nanocrystals anchored on the RGO surface minimize the aggregation of Sb and inhibit restacking of the RGO sheets, leading to a minimum transport length for both ions and electrons. The graphene layer not only accommodates the large volume variation of Sb during cycling but also promotes the electron conductivity of the whole electrode. Owing to its unique structure, this sandwich-like composite exhibits superior sodium storage properties.

关键词： Sb/graphene composites sodium ion battery anode sandwich-like structure

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人参皂苷 Rg3激活线粒体功能改善慢性疼痛的机制

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中国药理学通报 2025年第1期41卷 94-100页

作者：张培根朱海丽高卉湖北科技学院医学部药学院湖北咸宁437100

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参... 详细信息

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参皂苷Rg3给药;记录小鼠痛觉行为变化;HE染色、尼氏染色、免疫印迹及免疫组化检测各组PFC脑组织神经和线粒体损伤情况;分子对接探究人参皂苷Rg3的作用靶点;Mito-Tracker检测线粒体膜电位;ATP试剂盒分析ATP含量。结果与假手术组相比,模型组小鼠表现为痛觉过敏和运动能力受损;PFC内神经及线粒体损伤(P<0.05)。与模型组相比,人参皂苷Rg3给药可增加小鼠机械痛阈值、热缩足潜伏期和转棒停留时间;同时降低PFC内炎性细胞、尼氏小体及Dnm1l阳性细胞数,下调c-Fos、IL-1β和Dnm1l蛋白表达水平(P<0.05)。分子对接显示人参皂苷Rg3可结合Dnm1l。在细胞水平,人参皂苷Rg3给药可升高线粒体膜电位和ATP含量(P<0.05)。结论人参皂苷Rg3可通过调控降低PFC内炎症因子和线粒相关蛋白表达,改善线粒体功能,缓解CCI小鼠痛觉过敏。

关键词：人参皂苷Rg3 慢性神经性疼痛线粒体前额叶皮层 CCI PFC

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Thermal-flow-electric coupling performance analysis of a liquid-immersed battery thermal management system

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Science China Technological Sciences 2025年第1期 157-176页

作者： Qiang gao Jun TIAN Chujin BAO Yangfan zhong Chengbin ZHANG Yongping CHEN School of Energy and Environment Southeast University Battery Testing Center China North Vehicle Research Institute Zhejiang Immertech Co. Ltd. Alibaba Cloud Computing Co. Ltd.

Ensuring the safety and performance of lithium-ion batteries(LIBs) is a significant challenge for electric *** tackle this issue, an innovative liquid-immersed battery thermal management system(LIBTMS) using bionic baffles with fish-like perforations is developed. The thermal-flow-electric coupling characteristics of LIBTMSs with different baffle structures(no baffle, conventional baffle, baffle with circular perforations and baffle with fish-like perforations) are systematically investigated using experimental and numerical methods. The results indicate that the forced flow scheme exhibits better thermal management performance and voltage equalization than static flow. Moreover, the LIB temperatures and voltage deviations of different LIBTMSs increase quickly with increasing discharge rates. More importantly, the innovative LIBTMS exhibits the best thermoelectric performance due to its excellent thermoelectric equilibrium behavior caused by high electrical and temperature consistency, as well as the best overall performance involving the balance between the pressure loss and heat transfer capacity of the system. Compared with other structures, the innovative LIBTMS using baffles with fish-like perforations exhibits a maximum reduction of 10.1%, 15.2%, 25.8% and 9.0% in LIB maximum temperature, maximum temperature difference, system pressure drop and voltage deviation, respectively, under the same operating ***, for the LIBTMS using baffles with fish-like perforations, the bottom inlet and top outlet configuration and coolant precooling are suggested to enhance cooling performance.

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High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： Yong-xin Wang Ya-ge Li Ya-bo gao zhong Huang hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

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