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Science China Chemistry 2025年

作者： Qiong Liu Qiyun Deng Changxu Zhu Kongqi chen Lidan chen Zhaohui Sun Ben zhong Tang Zhiming Wang AIE Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province South China University of Technology Department of Laboratory Medicine General Hospital of Southern Theater Command School of Life Sciences The Chinese University of Hong Kong Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong HKUST-Shenzhen Research Institute

The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging *** this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge *** a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these ***,the probe TPhIQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission (AIE) effect,and the ability to distinguish tumor cells from normal ***,it efficiently generated reactive oxygen species (ROS) and specifically labeled lipid droplets,enabling the precise staining and killing of cancer *** study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy (PDT) by harnessing the unique properties of AIE materials.

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组合方式对煤岩组合体力学特性和冲击倾向性影响实验研究

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西安科技大学学报 2017年第5期37卷 655-661页

作者：秦忠诚陈光波秦琼杰山东科技大学矿业与安全工程学院山东青岛266590

为探讨组合方式对煤岩组合体力学特性和冲击倾向性的影响,基于煤岩单体试件单轴压缩实验,对自主构建的二元、三元组合体开展单轴压缩实验研究,探讨不同组合体力学特性和冲击倾向性规律。结果表明:组合体呈"碎状"、"锥形"、"Y形"破坏;应... 详细信息

为探讨组合方式对煤岩组合体力学特性和冲击倾向性的影响,基于煤岩单体试件单轴压缩实验,对自主构建的二元、三元组合体开展单轴压缩实验研究,探讨不同组合体力学特性和冲击倾向性规律。结果表明:组合体呈"碎状"、"锥形"、"Y形"破坏;应力应变曲线对比明显,有煤参与的组合体,压密阶段明显,无煤参与的组合体,弹、塑性阶段显著;组合体强度受中间试件和上下试件接触面积的影响:中间试件相同时,上下试件接触面积越大,组合体强度越小;组合体中弹性模量小的软弱岩层是能量积聚的主要载体;组合体组分之间硬度差别越大,冲击能量指数越大,冲击倾向性越强。

关键词：冲击地压组合方式煤岩组合体冲击能量指数

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong zhong Qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： zhong-Sheng Nong Hao-Fan Qian Ying-Chun chen Pu-Sheng Wang Liu-Zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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Immunization with Chlamydial Plasmid Protein pORF5 DNA Vaccine Induces Protective Immunity against Genital Chlamydial Infection in Mice

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Immunization with Chlamydial Plasmid Protein pORF5 DNA Vacci...

Peri-centrosomal localization of small interfering RNAs in C. elegans

2008年中国微生物学会学术年会

作者： Li zhong-Yu~(1)),Wu Yi-Mou~(1)),WANG Shi-Ping~(2)),zhong guang-Ming~(3)),chen Ding~(3)) 1) Department of Microbiology and Immunology,University of South China,Hengyang 421001,China 2) Xiangya School of Medicine,Central South University,Changsha 410078,China 3) University of Texas Health Science Center at San Antonio,TX 78229,USA

To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this *** this study,pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial *** of BALB/c mice were immunized intranasally with pORF5 DNA *** and cell mediated immune responses were evaluated.

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Science China Life Sciences 2025年

作者： Qile Jin Xuezhu Feng Minjie Hong Ke Wang Xiangyang chen Jiewei cheng Yan Kuang Xiaoyue Si Mingjing Xu Xinya Huang Shouhong guang chengming Zhu Department of Obstetrics and Gynecology The First Affiliated Hospital of USTC The USTC RNA Institute Hefei National Research Center for Physical Sciences at the Microscale School of Life Sciences Division of Life Sciences and Medicine Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China School of Basic Medicine Anhui Medical University

The centrosome is the microtubule-organizing center and a crucial part of cell division. Centrosomal RNAs(cnRNAs) have been reported to enable precise spatiotemporal control of gene expression during cell division in many species. Whether and how cnRNAs exist in C. elegans are unclear. Here, using the nuclear RNAi Argonaute protein NRDE-3 as a reporter, we observed potential peri-centrosome localized small interfering(si)RNAs in C. elegans. NRDE-3 was previously shown to associate with pre-mRNAs and pre-rRNAs via a process involving the presence of complementary siRNAs. We generated a GFP-NRDE-3 knock-in transgene through CRISPR/Cas9 technology and observed that NRDE-3 formed peri-centrosomal foci neighboring the tubulin protein TBB-2, other centriole proteins and pericentriolar material(PCM)components in C. elegans embryos. The peri-centrosomal accumulation of NRDE-3 depends on RNA-dependent RNA polymerase(RdRP)-synthesized 22G siRNAs and the PAZ domain of NRDE-3, which is essential for siRNA binding. Mutation of eri-1, ergo-1, or drh-3 significantly increased the percentage of pericentrosome-enriched NRDE-3. At the metaphase of the cell cycle, NRDE-3 was enriched in both the peri-centrosomal region and the spindle. Moreover, the integrity of centriole proteins and pericentriolar material(PCM) components is also required for the peri-centrosomal accumulation of NRDE-3. Therefore, we concluded that siRNAs could accumulate in the pericentrosomal region in C. elegans and suggested that the peri-centrosomal region may also be a platform for RNAi-mediated gene regulation.

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG chen LIN zhong LUJI HUANG FU chenG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

不同应力状态下热轧带钢表面氧化皮的剥离及酸洗速率

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机械工程材料 2016年第11期40卷 58-62,102页

作者：叶东东陈建钧张新宇王忠建陈广阴子良华东理工大学机械与动力工程学院上海200237

利用自主设计的拉矫机对热轧带钢施加不同的压下量或张紧力进行拉矫破鳞试验,使试验钢表面获得不同的应力状态,观察了破鳞前后氧化皮/基体的界面形貌;采用拉伸试验研究了不同应力状态下氧化皮/基体界面的结合强度;采用电位导数首零方法... 详细信息

利用自主设计的拉矫机对热轧带钢施加不同的压下量或张紧力进行拉矫破鳞试验,使试验钢表面获得不同的应力状态,观察了破鳞前后氧化皮/基体的界面形貌;采用拉伸试验研究了不同应力状态下氧化皮/基体界面的结合强度;采用电位导数首零方法对试验钢进行酸洗试验,研究了应力状态对酸洗速率的影响。结果表明:不论是拉应力还是压应力,随着应力值的增大,氧化皮的全剥落率不断增大,且压应力时的全剥落效果好于拉应力时的,最终受压应力面和受拉应力面氧化皮的全剥落率稳定值分别为24.1%和6.3%;当全剥落率相同或相近时,拉应力对氧化皮/基体结合强度的降低效果和对酸洗速率的提升效果都好于压应力的;当压下量相同或相近时,压应力对酸洗速率的提升效果好于拉应力的。

关键词：拉矫氧化皮拉应力压应力酸洗速率

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-Ming Mo Xu chen Shu-Hua zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi Lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： Long Pan Guoqiang Li Xiaoyan Wang Ming Jin Xinrong He Luo Qin zhong Wang Wenwei Zhao Chunzhu chen Yuanlu Liu Jin Yang Lele Shu Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Lanzhou University College of Earth Sciences， chengdu University of Technology School of Geographic Science， Nantong University Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the Late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi Lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi Lake salinity varied between 2 g/L and 47 g/L during the Late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the Late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi Lake has a low salinity of average value of ～15 g/L. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and Little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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