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Journal of Rare Earths 2017年第11期35卷 1092-1101页

作者： Qi wang Meisheng Cui Xiaowei huang Yongke Hou Mei Yue Qiang zhong YongqiZhang General Research Institute for Non-Ferrous Metals Beijing 100088 China Grirem Advanced Materials Co. Ltd Beijing 100088 China

In this study,two series of cerium zirconium mixed oxides CeZrLaPrOwere prepared under traditional co-precipitation and oxidation co-precipitation methods respectively. The physicochemical properties of the samples were compared under these two methods and assessed by XRD,Raman,BET,TEM,HTPR,OSC,XPS and catalysts measurements. The formation of homogeneity phase structure can be facilitated by changing the precipitating properties of Ce3+ under oxidation coprecipitation method, which is helpful to enhance the homogeneity of Ce and Zr at atomic ***’s more, it is conducive to remove impurities Na~+ and Cl~-by oxidation co-precipitation with hydrogen peroxide. The catalysts activities are related to both the redox properties and the textural properties of mixed oxides. The Pd-only TWCs supported on the CZLP-H-F exhibits better catalytic performance and thermal stability with wider air/fuel ratio operation window, lower light-off and full conversion temperatures of CHand NO. The homogeneity of phase structure for cerium zirconium mixed oxide can be predicted and deduced from detecting the atomic distribution uniformity of its precursor. So this work not only provides insights into the mechanisms for phase segregation of cerium zirconium mixed oxide, but also provides a guidance to improve homogeneity of cerium zirconium mixed oxide by adding additives.

关键词： Cerium zirconium mixed oxides Co-precipitation Hydrogen peroxide Catalytic performance

特殊人群中成药精细化用药规则在处方审核系统的建立与应用

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中国医院药学杂志 2024年第9期44卷 1088-1092页

作者：李佳乐舒蓉钟秀秀邹文清钟丽红陈怡祿和凡黄兆耆莫小兰广州医科大学附属妇女儿童医疗中心药学部广东广州510620

目的:为保障特殊人群合理规范使用中成药,开发并不断优化处方审核系统中成药精细化用药规则。方法:根据药品说明书、最新用药指南及专家共识等设立特殊人群中成药精细化用药规则,对广州医科大学附属妇女儿童医疗中心的合理用药处方审核... 详细信息

目的:为保障特殊人群合理规范使用中成药,开发并不断优化处方审核系统中成药精细化用药规则。方法:根据药品说明书、最新用药指南及专家共识等设立特殊人群中成药精细化用药规则,对广州医科大学附属妇女儿童医疗中心的合理用药处方审核系统进行功能补充和规则优化,保障用药合理安全有效。统计中成药精细化用药规则建立后的处方审核拦截率、审核类型分布等。对审核规则进行不断优化,同时通过弹窗提示等功能提高门诊特殊人群中成药处方合格率,规范临床合理用药。结果:特殊人群中成药精细化用药规则能够实现对用法、用量及给药途径不适宜,禁用、慎用、忌用情况、过敏用药,相互作用和重复用药等错误的审核,审核拦截率适宜(4.45%),审核成功率较高(94.83%)。特殊人群中成药精细化用药规则设置前后审核准确率具有显著性差异(P<0.01)。结论:对中成药用药规则进行精细化设置,促进了专科医院处方审核工作的有效开展,规范了特殊人群中成药合理使用。

关键词：特殊人群中成药精细化设置用药规则

星点设计-效应面法优化pH值依赖型岩黄连碱口服结肠靶向纳米粒

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中草药 2024年第6期55卷 1935-1945页

作者：曾勇珠郭魏张裕彦钟华帅苏晓丹朱煜周燕黄秋洁叶勇广西医科大学药学院广西南宁530021 广西医科大学第二附属医院广西南宁530007 广西中医药大学药学院广西南宁530001 广西生物活性分子研究与评价重点实验室广西南宁530021

目的采用星点设计-效应面法(central composite design-response surface methodology,CCD-RSM)优化pH值依赖型岩黄连碱口服结肠靶向纳米粒(dehydrocavidine-chitosan/pectin-nanoparticles,DC-CS/PT-NPs)制备工艺,并对其进行质量表征及体外释放行为评价。方法采用离子凝胶法制备DC-CS/PT-NPs,以粒径、PDI、ζ电位、包封率、载药量作为评价指标,采用单因素考察和CCD-RSM优化DC-CS/PT-NPs制备工艺。通过透射电子显微镜(transmission electron microscope,TEM)、扫描电子显微镜(scanning electron microscope,SEM)、傅里叶红外光谱(Fourier transform infrared spectroscopy,FTIR)、差示扫描量热法(differential scanning calorimetry,DSC)和X射线衍射法(X-ray diffraction,XRD)对DC-CS/PT-NPs进行表征,并进行体外释放性能评价。结果最佳处方为壳聚糖质量浓度为1.5 mg/mL,果胶质量浓度为1.5 mg/mL,TPP质量浓度为2.0 mg/mL,壳聚糖pH值为5.0。DC-CS/PT-NPs包封率为(61.64±1.77)%,载药量为(8.05±0.18)%,粒径为(418.65±4.92)nm,ζ电位为(−14.14±0.22)mV。DC-CS/PT-NPs呈均匀的球形或类球形;制备成纳米粒后,药物的晶型发生了改变;体外释药结果表明,DC-CS/PT-NPs在人工胃液中2 h仅释放24.35%,在人工小肠液中4 h累积释放率85%。结论CCD-RSM所建立的模型可用于DC-CS/PT-NPs处方优化,DC-CS/PTNPs具有良好的体外结肠释药特征。

关键词：岩黄连碱星点设计-效应面法结肠靶向壳聚糖果胶 pH值依赖纳米粒体外释放离子凝胶法

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类液体聚合物表面的研究进展

涂料工业 2024年第6期54卷 76-81页

作者：黄艳轶张振强李瑜罗忠马春风张广照华南理工大学材料科学与工程学院广州510641 海军工程大学基础部武汉430033 海军工程大学舰船与海洋学院武汉430033

类液体表面对各种液体具有动态排斥性,液体能轻易在表面滑落,同时表现出极低的接触角滞后。近年来,制备成本低、环保、高效、性能稳定、可大规模应用的类液体聚合物表面成为研究热点。类液体聚合物表面独特的拒液性能与分布在表面的聚... 详细信息

类液体表面对各种液体具有动态排斥性,液体能轻易在表面滑落,同时表现出极低的接触角滞后。近年来,制备成本低、环保、高效、性能稳定、可大规模应用的类液体聚合物表面成为研究热点。类液体聚合物表面独特的拒液性能与分布在表面的聚合物分子结构紧密相关。介绍了类液体聚合物表面的拒液作用机制和制备基本准则以及具有类液体性质的聚合物材料和类液体聚合物表面的制备方法;总结了类液体聚合物功能材料最新的代表性应用研究成果,包括防冰、耐沾污、减阻、无损液滴定向传输等;讨论了类液体聚合物功能材料仍然面临的挑战,并展望了其未来应用前景。

关键词：类液体聚合物表面湿润性动态排斥低黏附力

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鄱阳湖草洲景观连通性对植物多样性的影响

地理学报 2024年第1期79卷 259-278页

作者：张成陈文波黄芳芳东华理工大学测绘与空间信息工程学院南昌330013 东华理工大学南昌市景观过程与国土空间生态修复重点实验室南昌330013 江西农业大学国土资源与环境学院南昌330045 浙江广厦建设职业技术大学建筑工程学院东阳322100

在全球景观破碎化不断加剧的背景下,剖析景观连通度对生物多样性的影响机制对恢复生态过程和保护生物多样性具有深远意义。本文以鄱阳湖草洲为研究对象,综合考虑水位变化与物种扩散生态过程,在识别不同水位梯度下草洲分布格局的基础上,... 详细信息

在全球景观破碎化不断加剧的背景下,剖析景观连通度对生物多样性的影响机制对恢复生态过程和保护生物多样性具有深远意义。本文以鄱阳湖草洲为研究对象,综合考虑水位变化与物种扩散生态过程,在识别不同水位梯度下草洲分布格局的基础上,通过景观格局指数和基于图论的景观连通度指数相结合的方法,分析不同水位草洲景观结构连通度和功能连通度的动态变化,揭示草洲景观连通度对植物多样性的影响及其尺度效应,比较结构连通度与功能连通度对植物多样性格局的相对解释力。研究结果表明:①鄱阳湖草洲呈现“水落滩出、水进草退”的景观格局特征,随着水位的增加,草洲同时面临水体的淹没效应和分割效应,面积萎缩和破碎化并存;②随着水位的增加,草洲斑块面积不断减小、形状趋于简单、密度降低、破碎化加剧,景观结构连通度下降,难以连接的独立组分增加、斑块连通的可能性降低,景观功能连通度下降;③草洲景观连通度越高,景观尺度上的植物物种丰富度越高,斑块尺度上的植物群落相似性越大,功能连通度比结构连通度更加能解释植物多样性格局。本文研究结果可从景观连通度的新视角为湖泊地区景观格局优化和植物多样性保护提供参考。

关键词：鄱阳湖草洲景观连通度植物多样性尺度效应

基于Transformer编码器的超短期光伏发电功率预测

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智慧电力 2024年第5期52卷 16-22,59页

作者：黄莉甘恒玉刘兴举寇仲李筠王亚辉顾波贵州乌江水电开发有限责任公司贵州贵阳550002 华北水利水电大学电气工程学院河南郑州450045

针对现有光伏发电功率预测方法对于气象数据特征间的内在耦合关联特性挖掘不足的问题,提出基于Transformer编码器的超短期光伏发电功率预测方法。首先,基于历史气象数据和数值天气预报数据重构输入矩阵;然后,采用多层感知机或一维卷积... 详细信息

针对现有光伏发电功率预测方法对于气象数据特征间的内在耦合关联特性挖掘不足的问题,提出基于Transformer编码器的超短期光伏发电功率预测方法。首先,基于历史气象数据和数值天气预报数据重构输入矩阵;然后,采用多层感知机或一维卷积滤波器生成输入嵌入,并添加时序信息嵌入和时间特征嵌入,再通过多头自注意力机制对数据特征间的内在耦合关系进行自动挖掘;最后,通过解码层生成功率预测序列。算例结果表明所提预测方法对于超短期光伏发电功率的预测精度更高,并且具有较好的鲁棒性。

关键词：光伏发电功率预测自注意力机制特征嵌入

Comparison of canaloplasty and trabeculectomy for open angle glaucoma：a Meta-analysis

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1814-1819页

作者： zhong-Jing Lin Shuo Xu Shou-Yue huang Xiao-Bin Zhang Yi-Sheng zhong Department of Ophthalmology Ruijin Hospital Affiliated Medical School Shanghai Jiao Tong University Shanghai 200025 China Department of Ophthalmology Hubei University of Science and Technology Xialming 437100 Hubei Province China

AIM： To evaluate the advantage of canaloplasty compared to trabeculectomy for patients with open angle ***： Potentially relevant studies were systematically searched using various databases from inception until December 2015. The outcome analyses performed automatically using Revman 5.3 included intraocular pressure reduction （IOPR）, postoperative success rate, anti-glaucoma medications reduction and the incidence of adverse ***： We included four qualified studies incorporating a total of 215 eyes for quantitative synthesis. The weighted mean difference （WMD） of IOPR between canaloplasty and trabeculectomy from baseline to 12mo was -2.33 （95%CI： -4.00, -0.66）. There was not significant improvement in the complete or qualified success rate （OR： 0.58, 95%CI： 0.26, 1.31; OR： 0.50, 95%CI： 0.10, 2.44, respectively）. Similarly, no statistically significance was observed in anti-glaucoma mediations reduction （WMD： -0.54, 95%CI： -1.18, 0.09）. Sensitivity analysis of the primary outcome estimate confirmed the stability of the Meta-analysis ***： Trabeculectomy seems to be more effective in lowering IOP up to 12mo when comparing with canaloplasty. Canaloplasty does not seem to be inferior to trabeculectomy considering the postoperative success rate or the number of postoperative anti-glaucoma medications. Meanwhile, it has an advantage of less bleb related complications.

关键词： canaloplasty trabeculectomy open angle glaucoma Meta-analysis

Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

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Food Science and Human Wellness 2024年

作者： Yanyan Pan Gang Yang Dan Wu Yan Wei Shijun Fan Lin Xia Qian Chen Qianying huang Yongling Lu Xi Peng Clinical Medical Research Center， Southwest Hospital， Third Military Medical University (Army Medical University) Burn Department， Ningbo No.2 Hospital nstitute of Burn Research， State Key Laboratory of Trauma and Chemical Poisoning， Southwest Hospital， Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

关键词：

超高效液相色谱-串联质谱法同时测定食用农产品(水果)中14种甜味剂含量

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食品科技 2024年第4期49卷 315-321页

作者：钟永生万承波朱钦程丽美章明管鹏黄磊江西省检验检测认证总院工业产品检验检测院江西南昌330029

目的:建立了超高效液相色谱-串联质谱法测定食用农产品(水果)中14种甜味剂的分析方法。方法:水果样品经50%(V/V)甲醇水溶液提取后,萃取液经HLB(Hydrophilic lipophilic balance)固相萃取柱净化和氮吹浓缩,采用Acquity UPLC HSS T3色谱柱... 详细信息

目的:建立了超高效液相色谱-串联质谱法测定食用农产品(水果)中14种甜味剂的分析方法。方法:水果样品经50%(V/V)甲醇水溶液提取后,萃取液经HLB(Hydrophilic lipophilic balance)固相萃取柱净化和氮吹浓缩,采用Acquity UPLC HSS T3色谱柱(2.1 mm×100 mm,1.8μm)进行分离,以甲醇-10 mmol/L乙酸铵水溶液为流动相进行梯度洗脱,柱温35℃,流速为0.35 mL/min,利用电喷雾离子源多反应监测模式对14种甜味剂进行定性离子、定量检测。结果:14种甜味剂在相应的浓度范围内线性关系良好(R2≥0.994),方法检出限在0.09~1.65μg/L之间,定量限在0.17~4.89μg/L之间。3个不同加标浓度水平的回收率在84.7%~107.5%之间,相对标准偏差(n=6)在3.2%~8.5%之间。结论:该方法样品前处理简单、重现性好、灵敏度高、准确度高,可适用于食用农产品(水果)中14种甜味剂的同时测定。

关键词：超高效液相色谱-串联质谱甜味剂食用农产品水果同时测定

Focus control of wide-angle metalens based on digitally encoded metasurface

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Opto-Electronic Advances 2024年第8期7卷 26-41页

作者： Yi Chen Simeng Zhang Ying Tian Chenxia Li Wenlong huang Yixin Liu Yongxing Jin Bo Fang Zhi Hong Xufeng Jing Institute of Optoelectronic Technology China Jiliang UniversityHangzhou 310018China Centre for THz Research China Jiliang UniversityHangzhou 310018China College of Metrology&Measurement Engineering China Jiliang UniversityHangzhou 310018China College of Information Engineering China Jiliang UniversityHangzhou 310018China

Based on the principle of super-symmetric lens with quadratic phase gradient transformation, combined with the principle of digital coding of metasurface, we propose a wide-angle coded metalens for focusing control in two-dimensional space. This metalens achieves focus shift in the x-direction by changing the oblique incidence angle of the incident wave,and focus control in the y-direction by combining with the convolution principle of the digitally coded metasurface to achieve flexible control of light focusing in the two-dimensional plane. The metasurface unit is mainly composed of threelayer of metal structure and two layers of medium, and the transmission phase is obtained by changing the middle layer of metal structure, which in turn obtains the required phase distribution of the metalens. The design of the metalens realizes the function of the lens with a large viewing angle at the x-polarized incidence, and realizes two-dimensional focus control. Experimentally, we prepared the designed coding metalens and tested the focus control function of the wide-angle coding metalens. The experimental results are in good agreement with the design results.

关键词： metasurface metalens wide-angle coding