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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo ang Guo Xiaona Zhu Huifang zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12.13-Di HODE,14,2.-Di HDHA,prostaglandin D2.and Lyso PA(18:2.showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

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Effects of longitudinal magnetic field on primary dendrite spacing and segregation of directionally solidified single crystal superalloy

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Progress in Natural Science:Materials International 2024年第1期34卷 26-36页

作者： Congjiang Zhang Yilin Zhou Chen Shen Weili Ren Xiaotan Yuan Biao Ding Haibiao Lu Zuosheng Lei Yunbo {2. ang Zhang State Key Laboratory of Advanced Special Steel College of Materials Science and Engineering Shanghai University National Engineering Research Center for Magnesium Alloys Natural Key Laboratory of Advanced Casting Technologies College of Materials Science and EngineeringChongqing University

The primary dendrite spacing(PDS) and segregation of directionally solidified single crystal(SC) superalloy under the longitudinal magnetic field(LMF) were investigated based on the analysis of the whole cross-sectional microstructure at different solidification distances. The results show that the PDS under the LMF remains basically unchanged at different solidification distances, and it is greater than that under no LMF. With the increase of magnetic field intensity, the PDS increases and the macrosegregation decreases. The increasing PDS and reducing segregation under the LMF can be attributed to the increase of solute boundary layer, which expands the non-equilibrium freezing temperature range and brings the effective partition coefficient closer to 1. The increase of the solute enrichment layer thickness could be caused by the downward secondary circulation generated by the thermoelectric magnetic convection(TEMC) near the interface, which drives the migration of solutes towards the interdendritic region. This work not only clarifies the mechanism of LMF controlling PDS and reducing segregation by TEMC, but also provides theoretical guidance for producing high-quality SC superalloys using magnetic fields.

关键词： Primary dendrite spacing Segregation Single crystal superalloy Directional solidification Magnetic field Thermoelectric magnetic convection

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Reconcile the contradictory wettability requirements for the reduction and oxidation half-reactions in overall CO_(2. photoreduction via alternately hydrophobic surfaces

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Journal of Energy Chemistry 2024年第6期93卷 202-212,I0006页

作者： Hailing Huo Ting Hu Chengxi Huang Fang Wu Tongyu Wang Xuan Liu Liang Zhang Qiang Ju Zhiqing zhong Hongbin Xing Erjun Kan ang Li MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing Nanjing University of Science and TechnologyNanjing 210094JiangsuChina College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037JiangsuChina

The overall photocatalytic CO_(2. reduction reaction(OPCRR)that can directly convert CO_(2. and H_(2.O into fuels represents a promising renewable energy conversion *** a typical redox reaction,the OPCRR involves two half-reactions:the CO_(2. reduction half-reaction(CRHR)and the water oxidation half-reaction(WOHR).Generally,both half-reactions can be promoted by adjusting the wettability of ***,there is a contradiction in wettability requirements for the two ***,CRHR prefers a hydrophobic surface that can accumulate more CO_(2. molecules on the active sites,ensuring the appropriate ratio of gas-phase(CO_(2.)to liquid-phase(H_(2.O)***,the WOHR prefers a hydrophilic surface that can promote the departure of the gaseous product(O_(2.)from the catalyst surface,preventing isolation between active sites and the reactant(H_(2.O).Here,we successfully reconciled the contradictory wettability requirements for the CRHR and WOHR by creating an alternately hydrophobic *** was achieved through a selectively hydrophobic modification method and a charge-transfer-control ***,the collaboratively promoted CRHR and WOHR led to a significantly enhanced OPCRR with a solar-to-fuel conversion efficiency of 0.186%.Notably,in ethanol production,the catalyst exhibited a 10.64-fold increase in generation rate(2.1.44μmol g^(-1)h~(-1))and a 4-fold increase in selectivity(55.77%)compared to the benchmark *** innovative approach holds great potential for application in universal overall reactions involving gas participation.

关键词： Hydrophobic Hydrophilic Gas transport Overall CO_(2.photoreduction Z-scheme

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改进变分自编码器的工业时序数据异常检测

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计算机工程与设计 2024年第1期45卷 17-23页

作者：张志昂廖光忠武汉科技大学计算机科学与技术学院湖北武汉430065 武汉科技大学智能信息处理与实时工业系统湖北省重点实验室湖北武汉430065

为解决传统的异常检测模型对工业时序数据异常点检测方面误判率大和抗干扰性差的问题,提出一种改进的变分自编码器模型。考虑到工业时序数据的不规律性,使用变分自编码器模型作为基础架构;由于变分自编码器本身存在难以准确检测出异常... 详细信息

为解决传统的异常检测模型对工业时序数据异常点检测方面误判率大和抗干扰性差的问题,提出一种改进的变分自编码器模型。考虑到工业时序数据的不规律性,使用变分自编码器模型作为基础架构;由于变分自编码器本身存在难以准确检测出异常时序数据的问题,在编码和解码过程中分别引入时间卷积网络和通道注意力机制,实现扩大感受野和增强特征权重;对数据时序数据使用随机森林进行特征排序,提高检测的准确性。通过进行对比测试实验,验证了该模型可以有效提高对异常工业时序数据点检测的准确性和可靠性。

关键词：异常检测时间卷积网络变分自编码器通道注意力机制时序数据随机森林感受野

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推进剂药柱自动化装袋技术

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兵工自动化 2024年第8期43卷 93-95,100页

作者：李昂余海勇钟顺金程林中国兵器装备集团自动化研究所有限公司智能制造事业部四川绵阳621000

针对药柱装袋依赖人工操作,存在人机不隔离、有安全隐患等问题,在民用产品自动化包装技术基础上,选择合适的自动化包装设备进行相应技术改造,实现推进剂药柱包装自动化。对比2.自动化包装设备用于推进剂药柱内包装的优缺点,确定改造点... 详细信息

针对药柱装袋依赖人工操作,存在人机不隔离、有安全隐患等问题,在民用产品自动化包装技术基础上,选择合适的自动化包装设备进行相应技术改造,实现推进剂药柱包装自动化。对比2.自动化包装设备用于推进剂药柱内包装的优缺点,确定改造点,进行相应的技术改造,并通过实际生产验证。应用结果表明:改造后的设备能够成功实现推进剂药柱装袋,各项安全隐患被消除。

关键词：推进剂药柱自动化装袋

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基于粪便代谢组学研究健脾化浊方对动脉粥样硬化小鼠的影响

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时珍国医国药 2024年第8期35卷 1827-1832页

作者：黄浪浪刘中勇刘言薇江西中医药大学附属医院江西南昌330006

目的基于液相色谱-质谱联用(LC-MS)研究健脾化浊方对动脉粥样硬化(AS)小鼠粪便代谢物的调节机制。方法采用高胆碱饮食建立AS动物模型,观察小鼠主动脉斑块病理变化,运用LC-MS技术分析小鼠粪便样品代谢轮廓,结合主成分分析(PCA)、正交... 详细信息

目的基于液相色谱-质谱联用(LC-MS)研究健脾化浊方对动脉粥样硬化(AS)小鼠粪便代谢物的调节机制。方法采用高胆碱饮食建立AS动物模型,观察小鼠主动脉斑块病理变化,运用LC-MS技术分析小鼠粪便样品代谢轮廓,结合主成分分析(PCA)、正交最小偏二乘判别分析(OPLS-DA)等手段鉴定并筛选出小鼠粪便差异代谢物及代谢通路。结果健脾化浊方可抑制小鼠AS斑块形成,调节血清脂质水平,并回调77种与AS相关的潜在生物标志物、10种关键生物标志物以及8条代谢通路(维生素B6代谢、硫胺素代谢、类固醇生物合成、甘油磷脂代谢、嘌呤代谢、精氨酸和脯氨酸代谢、初级胆汁酸生物合成、类固醇激素生物合成)。结论健脾化浊方发挥治疗AS的作用机制可能是通过调节AS小鼠维生素代谢、核苷酸代谢、脂质代谢以及氨基酸代谢等过程来实现。

关键词：健脾化浊方动脉粥样硬化粪便代谢组学

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Simulation on effect of throat contraction ratio and strake stagger angle on flow field and aerodynamic performance of scrampressor

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航空动力学报 2017年第5期32卷 1183-1194页

作者： Yang Ling zhong Jing-jun HAN Ji-ang Marine Engineering College Dalian Maritime University

The design methods of typical supersonic aircraft intakes and shock wave compression technology have been applied to ram-rotor,an attractive compression system.A ram-rotor is of a typical structure including the compression ramp,the throat and the subsonic diffuser;a scrampressor is similar to ram-rotor,the only difference is that scrampressor has no subsonic *** work was the continuation of the preparatory *** order to further study the effect of throat contraction ratio and strake stagger angle on the flow field and performance of a scrampressor,the flow field of a scrampressor with a three-dimensional flow path was numerically simulated with different throat contraction ratios and strake stagger *** results indicated that the optional aerodynamic performance of a scrampressor could be achieved with an adiabatic efficiency of 0.8413atotal pressure recovery coefficient of 0.8446,a total pressure ratio of 7.14 and a static pressure ratio of 5.17for a throat contraction ratio of 0.6 and a strake stagger angle of 12..It was therefore concluded that an appropriate decrease in throat contraction ratio and an increase in strake stagger angle could help the comprehensive improvement of a scrampressor in performance.

关键词： scrampressor flow field aerodynamic performance throat contraction ratio strake stagger angle

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面向波动可再生能源的质子交换膜电制氢系统最优压强运行

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电力自动化设备 2024年第8期44卷 210-217页

作者：刘元肖碧涛卢昂刘文昕钟治垚方家琨王辉黄蕾国电南京自动化股份有限公司江苏南京210032 华中科技大学强电磁技术全国重点实验室湖北武汉430074

为提升质子交换膜电制氢系统在波动可再生能源输入下的制氢效率,提出面向最大效率的质子交换膜电制氢系统最优压强运行模式。介绍质子交换膜电制氢系统,提出基于压强控制的协调运行原理;对质子交换膜电制氢系统的压强特性和功率特性进... 详细信息

为提升质子交换膜电制氢系统在波动可再生能源输入下的制氢效率,提出面向最大效率的质子交换膜电制氢系统最优压强运行模式。介绍质子交换膜电制氢系统,提出基于压强控制的协调运行原理;对质子交换膜电制氢系统的压强特性和功率特性进行建模,从而建立面向最大效率的压强优化模型。在波动电流输入算例下检验最优压强运行模式的制氢效果,结果表明,相较于恒定压强模式,最优压强运行模式下的质子交换膜电制氢系统平均制氢能耗得到有效降低,系统性能得到明显提升。

关键词：可再生能源质子交换膜电制氢系统压强特性建模最大制氢效率最优压强运行

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Effect of Meridional Characteristic angle on Aerodynamic Performance of Ram-Rotor

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Journal of Thermal Science 2020年第3期29卷 753-762页

作者： HAN Ji'ang GUAN Jian zhong Jingjun CHEN Luting Naval Architecture and Ocean Engineering College Dalian Maritime UniversityDalian 116026China Merchant Marine College Shanghai Maritime UniversityShanghai 201306China

A kind of meridional concept which has a shape of contraction-expansion(Con-Exp)was applied to the ram-rotor in the paper,and detailed numerical simulation to understand the impact of meridional shape and geometric characteristic angle on the aerodynamic behavior of ram-rotors has been *** to baseline,there was a positive effect in intensifying shock train and suppressing low momentum fluid in Con-Exp scheme,and the pressure ratio and efficiency of Con-Exp scheme increased by 2.075%and 3.160%,*** the contracting angle was increasing,supersonic flow at and after throat region accelerated remarkably,and the static pressure rise was decreased *** terminating shock train was transformed to terminating shock,and the efficiency of ram-rotor was unfavorable to improve due to low throttle *** expanding angle rose,the terminating shock moved forward and turned to shock train *** pressure rise capacity and throttling ability of ram-rotor were *** low momentum fluid was accumulated near the middle and upper flow-path,yielding greater flow loss at large expanding angle.

关键词： ram-rotor meridional shape contracting angle expanding angle numerical simulation

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Effect of Vane Opening on Aerodynamic Performance of the Ram-rotor Test System

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Journal of Thermal Science 2016年第3期25卷 207-215页

作者： HAN Ji-ang GUAN Jian zhong Jingjun YUAN Chenguang Marine Engineering College Dalian Maritime University

In order to research the influence of adjustable vane on the aerodynamic performance of the ram-rotor test system, FLUENT soft-ware has been adopted to simulate the flow passage of the ram-rotor test system numerically. The vane opening is controlled by changing the stagger angle of the vane blades. Results show that flow uniformity of vane outlet is influenced by the vane openings, which has an impact on the aerodynamic loss to some extent. Total pressure ratio, adiabatic efficiency and mass flow rate can be regulated by different openings of the vane. Compared with -8° vane opening, top efficiency of the ram-rotor increases by about 13.8% at ＋6° opening. And total pressure ratio drops by 5.87%. The rising opening increases the relative Mach number at inlet of the ram-rotor and weakens the intensity of the tip clearance leakage, which comes to a decreasing aerodynamic loss.

关键词： adjustable vane ram-rotor test system aerodynamic performance numerical simulation

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