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Prognostic significance of erythropoietin and erythropoietin receptor in gastric adenocarcinoma

World Journal of Gastroenterology 2011年第34期17卷 3933-3940页

作者： lin Wang Hai-Gang Li zhong-Sheng Xia Jian-Ming wen Jun Lv Department of Pathology Sun Yat- Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China Department of Gastroenterology Sun Yat- Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China Department of Pathology the First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 Guangdong Province China Department of Nephrology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China

AIM: To investigate the expression of Erythropoietin (Epo) and its receptor (EpoR) in gastric adenocarcinoma (GAC) and the correlation with angiogenesis and clinicopathological features. METHODS: The expressions of Epo, EpoR and vascular endothelial growth factor (VEGF), as well as mi-crovessel density were evaluated in 172 GAC biopsies by immunohistochemical staining. The correlations between these parameters and patient’s clinicopathological features were analyzed statistically. RESULTS: The proportion of Epo and EpoR alterations in GAC was higher than that in adjacent normal mucosa (P = 0.035 and 0.030). Epo high-expression was associ-ated with EpoR high-expression, Lauren type, extensivelymph node metastasis and advanced stage of GAC (P = 0.018, 0.018, 0.004 and 0), while EpoR expression was linked with older age, World Health Organization type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.013, 0.008 and 0.001). VEGF high expression was significantly correlated with EpoR low-expression, Lauren type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.001, 0.001 and 0.007). The expression of Epo or EpoR was associated with microvessel density (P = 0.004 and 0.046). On multivariate analysis, only lymph node metastasis, abnormal Epo expression and tumor nodes metastases stage were independently associated with survival. In addition, a strong association with the immunohistochemical expression of EpoR and the angiogenic protein, VEGF, was noted. CONCLUSION: Increased expression of Epo and EpoR may play a signif icant role in the carcinogenesis, angiogenesis and progression of GAC. Epo may be an inde-pendent prognostic factor.

关键词： Erythropoietin Erythropoietin receptor Gas- tric adenocarcinoma Immunohistochemistry Prognosis

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Study on biomass catalytic pyrolysis for production of bio-gasoline by on-line FTIR

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Chinese Chemical Letters 2007年第4期18卷 445-448页

作者： Chang Bo Lu Jian zhong Yao Wei Gang lin wen Li Song Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

The pyrolysis of biomass is a promising way for production of bio-gasoline if the stability and quality problems of the bio-crudeoil can be solved by catalytic cracking and reforming. In this paper, an on-line infrared spectrum was used to study the characteristics of catalytic pyrolysis with the following preliminary results. The removal of C=O of organic acid is more difficult than that of aldehydes and ketones. HUSY/γ-Al2O3 and REY/γ-Al2O3 catalysts exhibited better deoxygenating activities while HZSM-5/γ-Al2O3 catalyst exhibited preferred selectivities for production of iso-alkanes and aromatics. Finally, possible mechanisms of biomass catalytic pyrolysis are discussed as well.

关键词： Biomass Pyrolysis Catalyst Bio-gasoline

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Regulation of influenza virus infection by microRNAs

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Journal of Integrative Agriculture 2019年第7期18卷 1421-1427页

作者： ZOU zhong GONG wen-xiao HUANG Kun SUN Xiao-mei JIN Mei-lin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070P R.China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070P.R. China Key Laboratory of Development of Veterinary Diagnostic Products Ministry of Agriculture and Rural AffairsWuhan 430070P.R. China

MicroRNAs(miRNAs) are small noncoding RNAs of 18–25 nucleotides(nt) in length that represent key regulators of many normal cellular functions through the inhibition of mRNA translation and mRNA *** date,over 2 500 mature miRNAs have been identified in plants,animals and several types of *** A virus(IAV),which is a negativesense,single-stranded RNA virus,does not encode viral ***,IAV infection can alter the expression of host miRNAs,either in cell culture or in *** turn,host miRNAs regulate IAV life cycle through directly binding to IAV genome or indirectly targeting host factors associated with viral *** this review,we briefly summarized the role and significance of miRNA in relation to IAV *** the role of cellular miRNAs during viral infection may be beneficial to the identification of novel therapeutic strategies to block IAV replication.

关键词： microRNAs influenza A virus pathogenesis therapeutic strategies

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化学模拟生物固氮——Ⅶ.乙炔选择性还原成乙烯作为原子簇活性中心多核络合活化底物的一种判据

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厦门大学学报(自然科学版) 1980年第2期 50-56页

作者：张藩贤林正忠许志文林国栋蔡启瑞厦门大学固氮研究组厦门大学固氮研究组厦门大学物理化学研究所

系统地比较了FeMo-co和固氮酶的各种模拟体系在KBH4还原乙炔为乙烯的反应中的催化活性和选择性。FeMo-co（活性:转变数为34;选择性:99％C2H4）和本实验室合成的模型化合物（活性:转变数为20～30;选择性;91～95％）比其它固氮酶的模拟体... 详细信息

系统地比较了FeMo-co和固氮酶的各种模拟体系在KBH4还原乙炔为乙烯的反应中的催化活性和选择性。FeMo-co（活性:转变数为34;选择性:99％C2H4）和本实验室合成的模型化合物（活性:转变数为20～30;选择性;91～95％）比其它固氮酶的模拟体系(MoO42--CySH;MoO42-—CySH—Fe2+;MoOS42-—胰岛素;[Fe4S4（SCH2Φ）4]2-;和MoS42-)具有较高的活性和选择性;这可作为FeMo—co及其合成模拟物的原子簇活性中心多核络合活化底物分子的一种判据.

关键词：络合活性中心原子簇乙炔炔烃判据底物

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A Review on Shale Reservoirs as an Unconventional Play--The History,Technology Revolution,Importance to Oil and Gas Industry,and the Development Future

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1887-1902页

作者： lin wen McMaster University Hamilton L8S4L8 Ontario Canada

As a milestone of the entire energy industry,unconventional resources have inevitably swept the world in the last decade,and will certainly dominate the global oil and gas industry in the near ***,the ＂unconventional＂ will become ＂conventional＂.Along with the rapid development,however,some issues have emerged,which are closely related to the viability of unconventional resources *** the current circumstances of low crude oil and gas price,coupled with the prominent environmental concerns,the arguments about the development and production of unconventional resources have been recently heated *** work introduced the fullblown aspects of unconventional resources especially shale reservoirs,by discussing their concepts and definitions,reviewing the shale gas and shale oil development history and necessity,analyzing the shale plays＇ geology and petroleum systems with respects to key hydrocarbon accumulation elements and mechanisms,and summarizing the technology *** study also discussed the relevant key issues,including significant estimation uncertainty of technically recoverable resources,the equivocal understanding of complex geology preventing the production and technologies implementation optimization,the difficulties of experiences and technologies global expanding,and the corresponding risks and *** addition,based on the latest production and exploration data,the future perspective of the unconventional resources was depicted from global unconventional resources assessments,technology development,and limitations constraining the development.

关键词： unconventional resources shale gas shale oil technology uncertainties

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The untold story between enhancers and skeletal muscle development

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Journal of Integrative Agriculture 2020年第9期19卷 2137-2149页

作者： ZHANG Yong-sheng LU Dan LIU Yu-wen YI Guo-qiang TANG zhong-lin Shenzhen Branch Guangdong Laboratory for lingnan Modern Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124P.R.China Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124P.R.China College of Animal Science and Technology Yunnan Agricultural UniversityKunming 650201P.R.China State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Currently,enhancers have key transcriptional regulatory roles in muscle *** muscle formation involves various molecules,and in animals,enhancers are one of the main types of transcriptional regulatory regions that are of great importance to regulate myogenic gene *** muscle development,enhancers can generate enhancer RNAs(eRNAs)that are involved in the regulation of gene *** regulation of gene expression by eRNAs offers great potential in improving animal production *** we comprehensively review the roles of enhancers in muscle formation and its potential function in skeletal muscle *** review will describe the future application of enhancers in skeletal muscle development and discuss the prospects that enhancer studies offer for agriculture,biotechnology,and animal breeding.

关键词： animal enhancer eRNA skeletal muscle growth and development

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Strong Coupling of Light with Extremely Thin Non-Close-Packing Colloidal Crystals:Experimental and Theoretical Studies

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Chinese Physics Letters 2013年第4期30卷 217-220页

作者： HUANG zhong DONG wen Department of Physics and Jiangsu Key Laboratory of Thin Films Soochow UniversitySuzhou 215006

Single and double layers of non-close-packing silica colloidal crystals are prepared using the self-assembly and chemical etching methods.A modulation of size reduction of 21%of silica particles is reported while sustaining the ordering of the *** a result of the coupling between light and the two-dimensional(2D)photonic structures,several dips are clearly observed in the measured optical transmission *** decreasing the dielectric particle size,the transmission dips undergo blue shifts and simultaneously become *** measured transmission spectra are in good agreement with the theoretical calculations by taking the energy dissipation of the semi-infinite dielectric substrate for the 2D photonic crystals.

关键词： spectra. methods. dielectric

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Survey of traditional Dai medicine reveals species confusion and potential safety concerns: a case study on Radix Clerodendri Japonicum

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Chinese Journal of Natural Medicines 2017年第6期15卷 417-426页

作者： DUAN Bao-zhong FANG Hai-Lan LI Xi-wen HUANG lin-Fang WANG Ping CHEN Shi-lin College of Pharmaceutical Sciences Hubei University of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences College of Pharmaceutical Sciences Dali University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College

The adulteration of herbal products is a threat to consumer safety. In the present study, we surveyed the species composition of commercial Radix Clerodendri Japonicum products using DNA barcoding as a supervisory method. A reference database for plant-material DNA-barcode was successfully constructed with 48 voucher samples from 12 Clerodendrum species. The database was used to identify 27 Radix Clerodendri Japonicum decoction piece samples purchased from drug stores and hospitals. The DNA sequencing results revealed that only 1 decoction piece(3.70%) was authentic C. japonicum, as recorded in the Dai Pharmacopeia, whereas the other samples were all adulterants, indicating a potential safety issue. The results indicate that decoction pieces that are available in the market have complex origins and that DNA barcoding is a suitable tool for regulation of Dai medicines.

关键词： Dai medicine DNA barcode Radix Clerodendri Japonicum Adulterants ITS 2

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Wideband angle of arrival estimation of chirp signals using virtual Wignerville distribution

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Journal of Systems Engineering and Electronics 2007年第2期18卷 243-248页

作者： wen zhong Li Liping Zhang Xixiang School of Electronic Engineering Univ. of Electronic Science and Technology of ChinaChengdu 610054 P. R. China

To estimate the angle of arrivals （AOA） of wideband chirp sources, a new timo-frequency algorithm is proposed. In this method, virtual sensors are constructed based on the fact that the steering vectors of wideband chirp signals are linear and vary with time. And the randon Wignersville distribution （RWVD） of real sensors and virtual sensors are calculated to yield the new time-invariable steering vectors, furthermore, the noise and cross terms are suppressed. In addition, the multiple chirp signals are selected by their time-frequency points. The cost of computation is lower than the common AOA estimation methods of wideband sources due to nonrequirement of frequency focusing, interpolating and matrix decomposition, including subspace decomposition. Under the lower signal noise ratio （SNR） condition, the proposed method exhibits better precision than the method of frequency focusing （FF）. The proposed method can be further applied to nonuniform linear array （NLA） since it is not confined to the array geometry. Simulation results illustrate the efficacy of the proposed method.

关键词： Array signal processing Angle of arrivals Wignerville distribution Wideband chirp signal.

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Recent Advances in High‑Efficiency Electrocatalytic Water Splitting Systems

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Electrochemical Energy Reviews 2023年第1期6卷 1-38页

作者： Xian‑Wei Lv wen‑wen Tian zhong‑Yong Yuan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin 300350China

Electrocatalytic water splitting driven by renewable energy input to produce clean hydrogen(H_(2))has been widely considered a prospective approach for a future hydrogen-based ***,the development of industrial alkaline water electrolyzers is hindered due to their unfavorable thermodynamics with high overpotential for delivering the whole process,caused by sluggish kinetics involving four-electron *** exploration of water electrolysis with low energy consumption and high efficiency is urgently required to meet the ever-growing energy storage and portfolio *** review emphasizes the strategies proposed thus far to pursue high-efficiency water electrolysis systems,including from the aspects of electro-catalysts(from monofunctional to bifunctional),electrode engineering(from powdery to self-supported),energy sources(from nonrenewable to renewable),electrolytes(from pure to hybrid),and cell configurations(from integrated to decoupled).Critical appraisals of the pivotal electrochemistry are highlighted to address the challenges in elevating the overall efficiency of water ***,valuable insights for the future development directions and bottlenecks of advanced,sustainable,and high-efficiency water splitting systems are outlined.

关键词： Electrocatalytic water splitting Hydrogen-based society Electrode engineering Cell configurations Challenges and perspectives

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