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Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 54-66页

作者： Jiaxin Li Haozhang zhong Bojun Cao Zhaoyang Ran Jia tan Liang Deng Yongqiang Hao Jinglong Yan Department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Materials Modification and Modeling Shanghai Jiao Tong UniversityShanghai200240China

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone *** the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of *** this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3D *** study observed the proliferation and differentiation of MC3T3-E1 cells during surface culture of the three types of *** also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical *** trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two *** results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

关键词： Porous titanium scaffolds Geometric morphology Cell proliferation Structural design

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激光陀螺实验中谐振腔调节的分析与讨论

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大学物理 2024年第4期43卷 49-55页

作者：张燚谭中奇袁杰梁永辉江奇渊孙兵锋国防科技大学前沿交叉学科学院湖南长沙410073 国防科技大学南湖之光实验室湖南长沙410073

本文在非傍轴近似条件下利用几何光学理论推导了激光陀螺实验中谐振腔大小、反射镜曲率及偏转角度等因素与腔内自再现谐振激光空间位置关系的公式,比较了其与通常傍轴近似下矩阵光学结果的差异,讨论了实验时调节反射镜偏转角度对谐振腔... 详细信息

本文在非傍轴近似条件下利用几何光学理论推导了激光陀螺实验中谐振腔大小、反射镜曲率及偏转角度等因素与腔内自再现谐振激光空间位置关系的公式,比较了其与通常傍轴近似下矩阵光学结果的差异,讨论了实验时调节反射镜偏转角度对谐振腔有效腔长、光路面积、陀螺比例因子及激光出光位置的影响规律,对激光陀螺实验中谐振腔的调节有指导意义.

关键词：激光陀螺谐振腔调节非傍轴近似自再现

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基于指纹图谱和网络药理学的经典名方三化汤质量标志物预测

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中国现代中药 2024年第1期26卷 68-79页

作者：倪天婷谈仲川梅佳钰罗鑫朱靓婷高洁干国平湖北中医药大学药学院湖北武汉430065 湖北省中药炮制工程技术研究中心湖北武汉430065

目的:建立三化汤的指纹图谱,利用网络药理学方法筛选质量控制指标性成分。方法:建立15批三化汤的高效液相色谱法(HPLC)指纹图谱,采用“中药色谱指纹图谱相似度评价系统”(2012A版)进行相似度评价后确定共有峰;通过与对照药材、对照品比... 详细信息

目的:建立三化汤的指纹图谱,利用网络药理学方法筛选质量控制指标性成分。方法:建立15批三化汤的高效液相色谱法(HPLC)指纹图谱,采用“中药色谱指纹图谱相似度评价系统”(2012A版)进行相似度评价后确定共有峰;通过与对照药材、对照品比对,对峰进行归属和指认;并采用正交偏最小二乘法-判别分析(OPLS-DA)对15批三化汤进行质量评价;利用网络药理学筛选三化汤的核心作用靶点和通路,通过分子对接将核心靶点与13个成分进行对接验证,筛选出三化汤质量控制的指标性成分。结果:三化汤物质基准的HPLC指纹图谱共标定17个共有峰,相似度均大于0.97;共指认13个色谱峰,分别为辛弗林、柚皮苷、橙皮苷、新橙皮苷、芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚、厚朴酚、和厚朴酚、紫花前胡苷、异欧前胡素,其中含量排名前4的成分为柚皮苷、新橙皮苷、辛弗林、紫花前胡苷;OPLS-DA将样品分为3类,通过变量重要性投影得出新橙皮苷、柚皮苷、紫花前胡苷、大黄酸对三化汤物质基准影响较大;网络药理学预测13个成分可能通过肿瘤蛋白P53 (TP53)、蛋白激酶B1 (Akt1)、90 kDa热休克蛋白αA1 (HSP90AA1)、非受体酪氨酸激酶(SRC)、磷脂酰肌醇3-激酶催化亚基α (PIK3CA)等38个核心靶点,作用于内分泌抵抗、脂质和动脉粥样硬化、前列腺癌、PI3KAkt1信号通路、结直肠癌等157条主要通路发挥药效作用,度值前5位的成分为大黄素、大黄酚、大黄素甲醚、和厚朴酚、厚朴酚。分子对接结果显示,13个成分均能与Akt1稳定地结合。结论:通过整合含量测定、化学计量学、网络药理学,共筛选出新橙皮苷、柚皮苷、紫花前胡苷、大黄酸、辛弗林、大黄素、大黄酚、大黄素甲醚、和厚朴酚、厚朴酚10个成分可能为三化汤的质量标志物。

关键词：三化汤经典名方化学计量学指纹图谱网络药理学

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Studies of Laser-induced-MOCVDZinc Oxide Films

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Chemical Research in Chinese Universities 1994年第3期10卷 240-243页

作者： REN Peng-cheng, tan zhong-ke and LUO Wen-xiu(Ceiiter for Functional Materials Research, Qingdao Institute of Chemical Technology,Qingdao,266042)

hin films of ZnO were prepared using the double photobeams ultraviolet laserinduced-metallorganic chemical vapour deposition (MOCVD)technique. The struc-ture and transparent photoconductive properties of these films were investigated us-ing X-ray diffraction (XRD) , reflecting electron diffraction (RED) .scanning elec-tron microscopy (SEM) and ultraviolet visible absorption spectrometry (UV) .Theexperiments showed that the technique produced superior quality films of polycrys-tal ZnO_(1-x) (the O-vacancies in the ZnO lattice) , and possessed higher depositionrate, lower growth temperature conipared with CVD or MOCVD technique and thethin films had far better transparent photoconductive properties than tliose grownby the conventional CVD or MOCVD technique.

关键词： Double-photobeams ultraviolet laser induction . Metallorganic chemicalvapour tleposition(MOCVD) Zinc oxide film

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Characteristic of the equivalent impedance for an mxn RLC network with an arbitrary boundary

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Frontiers of Information Technology & Electronic Engineering 2017年第12期18卷 2070-2081页

作者： Zhi-zhong tan Hong ZHU Jihad H. ASAD Chen XU Hua tanG Department of Physics Nantong University Nantong 226019 China College of Science Changzhou Institute of Technology Changzhou 213002 China Department of Physics Palestine Technical University Tulkarm p.o. Box 7 Palestine School of Electronics and lnformation Nantong University Nantong 226019 China Departrnent of Physics Yunhe Teachers College Pizhou 221300 China

Considerable progress has been made recently in the development of techniques to determine exactly two-point resistances in networks of various topologies. In particular, a general resistance formula of a non-regular mxn resistor network with an arbitrary boundary is determined by the recursion-transform （RT） method. However, research on the complex impedance network is more difficult than that on the resistor network, and it is a problem worthy of study since the equivalent impedance has many different properties from equivalent resistance. In this study, the equivalent impedance of a non-regular mxn RLC network with an arbitrary boundary is studied based on the resistance formula, and the oscillation characteristics and resonance properties of the equivalent impedance are discovered. In the RLC network, it is found that our formula leads to the occurrence of resonances at the boundary condition holding a series of specific values with an external alternating current source. This curious result suggests the possibility of practical applications of our formula to resonant circuits.

关键词： RLC network Resonance properties Oscillation characteristics Amplitude-frequency

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Efficient and rapid capture of uranium(Ⅵ) in wastewater via multiamine modified β-cyclodextrin porous polymer

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Chinese Journal of Chemical Engineering 2024年第4期68卷 144-155页

作者： Xing zhong Yubin tan Siyuan Wu Caixia Hu Kai Guo Yongchuan Wu Neng Yu Mingyang Ma Ying Dai School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China

It is quite important to ensure the safety and sustainable development of nuclear energy for the treatment of radioactive wastewater. To treat radioactive wastewater efficiently and rapidly, two multi-amine β-cyclodextrin polymers(diethylenetriamine β-cyclodextrin polymer(DETA-TFCDP) and triethylenetetramine β-cyclodextrin polymer(TETA-TFCDP)) were prepared and applied to capture uranium. Results exhibited that DETA-TFCDP and TETA-TFCDP displayed the advantages of high adsorption amounts(612.2and 628.2 mg·g-1, respectively) and rapid adsorption rates, which can reach(88 ± 1)% of their equilibrium adsorption amounts in 10 min. Moreover, the adsorbent processes of DETA-TFCDP and TETATFCDP on uranium(Ⅵ) followed the Langmuir model and pseudo-second-order model, stating they were mainly chemisorption and self-endothermic. Besides, TETA-TFCDP also showed excellent selectivity in the presence of seven competing cations and could be effectively reused five times via Na2CO3as the desorption reagent. Meanwhile, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy illustrated that the enriched multi-amine groups and oxygen-containing functional groups on the surface of TETA-TFCDP were the main active sites for capturing uranium(Ⅵ). Hence, multi-amine β-cyclodextrin polymers are a highly efficient, rapid, and promising adsorbent for capturing uranium(Ⅵ)from radioactive wastewater.

关键词： Adsorption Waste water Pollution Uranium(VI) b-Cyclodextrin

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Genomic Characterization of a Streptococcus suis Serotype 2 Isolated from a Human Patient

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Biomedical and Environmental Sciences 2022年第8期35卷 760-763页

作者： GUO Geng Lin GAO Hua Sheng WANG Zhuo Hao tan zhong Ming HAN Ming Xiao CHEN Qi DU Hong ZHANG Wei ZHANG Hai Fang College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095JiangsuChina Key Lab of Animal Bacteriology Ministry of AgricultureNanjing 210095JiangsuChina OIE Reference Lab'for Swine Streptococcosis Nanjing 210095JiangsuChina Department of Clinical Laboratory The Second Affliated Hospital of Soochow UniversitySuzhou 215004JiangsuChina NHC Key Laboratory of Enteric Pathogenic Microbiology Jjiangsu Provincial Center for Disease Control and PreventionNanjng 210009JiangsuChina

Streptococcus suis(S. suis) is a Gram-positive zoonotic pathogen. S. suis infection in humans commonly causes meningitis, septicemia, arthritis,and streptococcal toxic shock-like syndrome(STSLS). S. suis has 29 serotypes, of which S. suis serotype 2(SS2) has the highest clinical isolation rate and strongest pathogenicity and causes most S. suis human *** 1,000 different sequence types(STs)were identified in *** based on multilocus sequence typing(MLST).Among these,STs,ST1,and ST7 belong to serotype 2 and are the major hazards of *** 1998 and 2005,two cases of SS2 human infection outbreak were reported in Jiangsu and Sichuan,China,causing 14 deaths and 38 deaths,respectively.

关键词： suis Streptococcus Human

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Interfacial modification using the cross-linkable tannic acid for highly-efficient perovskite solar cells with excellent stability

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Journal of Energy Chemistry 2024年第4期91卷 236-244页

作者： Xing Gao Lirong Rong Fei Wu Yen-Hung Lin Ye Zeng Junhong tan Rongxing He Cheng zhong Linna Zhu Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy School of Materials&EnergySouthwest UniversityChongqing 400715China Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Department of ChemistryWuhan UniversityWuhan 430072HubeiChina Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloon 999077Hong KongChina State Key Laboratory of Advanced Displays and Optoelectronics Technologies The Hong Kong University of Science and TechnologyClear Water BayKowloon 999077Hong KongChina

Although the performance of perovskite solar cells(PSCs)has been dramatically increased in recent years,stability is still the main obstacle preventing the PSCs from being *** device instability can be caused by a variety of reasons,including ions diffusion,surface and grain boundary defects,*** this work,the cross-linkable tannic acid(TA)is introduced to modify perovskite film through post-treatment *** numerous organic functional groups(–OH and C=O)in TA can interact with the uncoordinated Pb^(2+)and I^(-)ions in perovskite,thus passivating defects and inhibiting ions *** addition,the formed TA network can absorb a small amount of the residual moisture inside the device to protect the perovskite ***,TA modification regulates the energy level of perovskite,and reduces interfacial charge ***,following TA treatment,the device efficiency is increased significantly from 21.31%to 23.11%,with a decreased hysteresis ***,the treated device shows excellent air,thermal,and operational *** light of this,the readily available,inexpensive TA has the potential to operate as a multipurpose interfacial modifier to increase device efficiency while also enhancing device stability.

关键词： tannic acid Defect passivation lons diffusion Hydrophilic Stability Perovskite solar cells

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Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2013年第47期19卷 8895-8901页

作者： zhong-Ming tan Bei-Cheng Sun Liver Transplantation Center of the First Affiliated Hospital Nanjing Medical University The Key Laboratory of Living Donor Liver Transplantation Ministry of Health

Chronic hepatitis B virus(HBV)infection is the key driving force of liver disease progression,resulting in the development of hepatic dysfunction,cirrhosis and hepatocellular carcinoma(HCC).The primary aim of therapy is to suppress or eliminate HBV replication to reduce the activity of hepatitis,thus reducing the risk of,or slowing the progression of,liver ***(t)ide analogues(Nucs)may result in rapid suppression of HBV replication with normalization of serum transaminases and restore liver function,thus increasing survival in patients with hepatic ***-term Nuc therapy may result in histological improvement or reversal of advanced fibrosis and reduction in disease progression,including the development of *** long-term benefits of a finite course of interferon(IFN)-αtherapy also include a sustained and cumulative response,as well as hepatitis B surface antigen seroclearance and reduction in the development of cirrhosis and/or *** IFN and newer Nucs may achieve better long-term outcomes because of improved efficacy and a low risk of drug ***,treatment outcomes are still far from *** the effects of anti-HBV treatment against HCC incidence and recurrence after hepatectomy or liver transplantation is required for further improvement of outcome.

关键词： Hepatocelluar carcinoma Antiviral therapy Carcinogenesis Recurrence Nucleos(t)ide analogues Interferon Retrospective study Clinical trial

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热电联产对电厂经济效益的影响

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中国电力 2000年第2期33卷 18-20页

作者：谭中翔长春热电二厂吉林长春130031

针对现行热电联产效益核算方法存在的主要问题提出一种新的核算方法，并详细介绍新方法的３个阶段，即经济指标核定、各项费用核定及利润总额核定。进一步分析热电联产对电厂经济效益的影响，指出热电联产的效益只有在热电价格比达到一... 详细信息

针对现行热电联产效益核算方法存在的主要问题提出一种新的核算方法，并详细介绍新方法的３个阶段，即经济指标核定、各项费用核定及利润总额核定。进一步分析热电联产对电厂经济效益的影响，指出热电联产的效益只有在热电价格比达到一定程度才可以实现。

关键词：城市集中供热热电联产电厂经济效益

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