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Sodium intake:a double-edged sword wielded by the brain

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Science China(Life Sciences) 2024年第7期67卷 1545-1547页

作者： Lingyu Xu Xiaolong ma Yi Wang zhong Chen Key Laboratory of Neuropharmacology and Pharmaceutical Sciences Zheiiang Chinese Medical UniversityHangzhou 310053China Institute of Pharmacology&Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Taste receptors on the tongue discriminate between five fundamental tastes:sour,sweet,bitter,salty,and umami(Chandrashekar et al.,2006).Typically,stimuli that evoke bitterness and acidity prompt aversive responses by animals,whereas sweet and umami flavors are appetitive and *** is unique in that it transitions from an appetitive to an aversive stimulus with increasing concentrations.

关键词： prompt sweet sword

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Micro/nanosystems for controllable drug delivery to the brain

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The Innovation 2024年第1期5卷 139-157页

作者： Mingzhen Tian Zhichao ma Guang-zhong Yang Institute of Medical Robotics School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Drug delivery to the brain is crucial in the treatment for central nervous system *** significant progress has been made in recent years,there are still major challenges in achieving controllable drug delivery to the *** clinical needs arise from various factors,including controlled drug transport,handling large drug doses,methods for crossing biological barriers,the use of imaging guidance,and effective models for analyzing drug *** advances in micro/nanosystems have shown promise in addressing some of these *** include the utilization of microfluidic platforms to test and validate the drug delivery process in a controlled and biomimetic setting,the development of novel micro/nanocarriers for large drug loads across the blood-brain barrier,and the implementation of micro-intervention systems for delivering drugs through intraparenchymal or peripheral *** this article,we present a review of the latest developments in micro/nanosystems for controllable drug delivery to the *** also delve into the relevant diseases,biological barriers,and conventional *** addition,we discuss future prospects and the development of emerging robotic micro/nanosystems equipped with directed transportation,real-time image guidance,and closed-loop control.

关键词： equipped doses barriers

A new method for evaluating wedges of steel plates and strips

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Journal of Iron and Steel Research International 2024年第7期31卷 1719-1735页

作者： Xiao-bao ma Xiao-xin ma Tao Wang zhong-kai Ren Yu-cheng Ren College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Ministry of Education Engineering Research Center of Advanced Metal Composite Forming Technology and Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina China National Heavy machinery Research Institute Co. Ltd.Xi'an 710018ShaanxiChina Faculty of Mechanical Engineering Hebei University of ArchitectureZhangjiakou 075000HebeiChina

To overcome the inaccuracy problem of the traditional wedge evaluation of steel plates and strips caused by the ran-domness of the thicknesses of two local points and improve the reliability of the wedge index,the double-centroid method for the wedge evaluation was proposed,and a model based on the centroid theory was ***,an integral model for the discrete thickness values of the cross-section profiles was *** discussion focused on the distinct characteristics of the two-point method,asymmetric method,and double-centroid method in evaluating the asymmetric distribution of *** three methods were employed to evaluate the wedge values of both the theoretical and measured cross-sections of steel plates and strips,and the accuracies of three wedge evaluation models were analyzed and *** results showed that the double-centroid method objectively reflects the degree and variation characteristics of the wedge values of the cross-sections of steel plates and strips,and this method is feasible,reliable,and outstanding.

关键词： Steel plate and strip Wedge Two-point method Double-centroid method Reliability

A novel DPSS filter optimization scheme to reduce the intrinsic interference of FBMC-QAM systems

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High Technology Letters 2024年第1期30卷 68-74页

作者：董琪阳 ma Tianming JIN Jie WU zhong School of Electrical and Electronic Engineering Shanghai University of Engineering ScienceShanghai 201620P.R.China

In order to reduce the intrinsic interference of the filter bank multicarrier-quadrature amplitude modulation(FBMC-QAM)system,a novel filter optimization scheme based on discrete prolate spheroidal sequences(DPSS)is ***,a prototype filter function based on DPSS is designed,since the eigenvalue can be used as an indicator of the energy concentration of DPSS,so a threshold is set,and the sequence with the most concentrated energy is selected under the threshold,that is,the sequence with the eigenvalue higher than the threshold,and the prototype filter function is rewritten as a weighted sum function of multiple *** the energy constraints of the filter,the relationship between the eigenvectors and the intrinsic interference function is established,and the function problem is transformed into an optimization problem for the weighted *** the interior point method,the most suitable weight is found to obtain the minimum intrinsic interference *** analysis and simulation results show that compared with the prototype filters such as Type1 and CaseC,the DPSS filter applying the proposed optimization algorithm can effectively suppress the intrinsic interference of the system and obtain a better bit error rate(BER)performance.

关键词： filter bank multicarrier-quadrature amplitude modulation(FBMC-QAM) intrinsic interference discrete prolate spheroidal sequences(DPSS) interior point method

Activation Redistribution Based Hybrid Asymmetric Quantization Method of Neural Networks

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工程与科学中的计算机建模(英文) 2024年第1期138卷 981-1000页

作者： Lu Wei zhong ma Chaojie Yang R&D Innovation Center Xi’an Microelectronics Technology InstituteXi’an710065China

The demand for adopting neural networks in resource-constrained embedded devices is continuously *** is one of the most promising solutions to reduce computational cost and memory storage on embedded *** order to reduce the complexity and overhead of deploying neural networks on Integeronly hardware,most current quantization methods use a symmetric quantization mapping strategy to quantize a floating-point neural network into an integer ***,although symmetric quantization has the advantage of easier implementation,it is sub-optimal for cases where the range could be skewed and not *** often comes at the cost of lower *** paper proposed an activation redistribution-based hybrid asymmetric quantizationmethod for neural *** proposedmethod takes data distribution into consideration and can resolve the contradiction between the quantization accuracy and the ease of implementation,balance the trade-off between clipping range and quantization resolution,and thus improve the accuracy of the quantized neural *** experimental results indicate that the accuracy of the proposed method is 2.02%and 5.52%higher than the traditional symmetric quantization method for classification and detection tasks,*** proposed method paves the way for computationally intensive neural network models to be deployed on devices with limited computing *** will be available on https://***/ycjcy/Hybrid-Asymmetric-Quantization.

关键词： Quantization neural network hybrid asymmetric accuracy

Grating-free autofocus for single-pixel microscopic imaging

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Photonics Research 2024年第6期12卷 1313-1321页

作者： GUAN WANG HUAXIA DENG YU CAI MENGCHAO ma XIANG zhong XINGLONG GONG CAS Key Laboratory of Mechanical Behavior and Design of materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China School of Instrument Science and Opto-electronics Engineering Hefei University of TechnologyHefei 230009China

As a computational technology,single-pixel microscopic imaging(SPMI)transfers the target’s spatial information into a temporal *** traditional focusing method of imaging before evaluation is not applicable to the SPMI *** propose a grating-free autofocus strategy derived from the physical mechanism of optical *** the amplitude information of just one high-frequency point in the spectrum is all that is needed to achieve fast autofocus with the SPMI ***,only four patterns need to be cyclically projected,enabling efficient localization of the focal plane based on the measurement *** demonstrate SPMI autofocus experiments at micrometer and even nanometer depths of *** proposed method can be extended to achieve SMPI autofocus with invisible optical pattern illumination.

关键词： optical system. illumination

Transition-metal-catalyzed remote meta-C-H alkylation and alkynylation of aryl sulfonic acids enabled by an indolyl template

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Chinese Chemical Letters 2024年第8期35卷 254-259页

作者： Pengfei Zhang Qingxue ma Zhiwei Jiang Xiaohua Xu zhong Jin College of Chemistry State Key Laboratory of Elemento-organic ChemistryNankai UniversityTianjin 300071China Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resource Chemistry College of Chemistry and Environmental SciencesKashi UniversityKashgar 844007China

Transition-metal-catalyzed remote sp^(2)C-H functionalization of aryl sulfonic acids was hardly ever real-ized owing to competitive ortho-C-H functionalization of aryl sulfonates and electron-deficient nature of phenyl ***,with the assistance of a practical biaryl indolyl directing template,palladium-catalyzed remote sp^(2)C-H alkylation of aryl sulfonic acids have been achieved in moderate to good yields with exclusive meta ***,remote meta-selective C-H alkynylation of aryl sulfonic acids was also accomplished with a rhodium *** meta-C-H functionalized products proved to be the superior synthetic precursors,which are difficult to access using the conventional strategy.

关键词： C-H functionalization Aryl sulfonic acid Site-selectivity Transition-metal catalysis Alkylation Alkynylation

Reinforcement Learning Based Quantization Strategy Optimal Assignment Algorithm for Mixed Precision

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Computers, materials & Continua 2024年第4期79卷 819-836页

作者： Yuejiao Wang zhong ma Chaojie Yang Yu Yang Lu Wei Xi’an Microelectronics Technology Institute Xi’an710065China

The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to databit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determinethe optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantizationcan effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In thispaper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bitwidth is proposed, and reinforcement learning is used to automatically predict the mixed precision that meets theconstraints of hardware resources. In the state-space design, the standard deviation of weights is used to measurethe distribution difference of data, the execution speed feedback of simulated neural network accelerator inferenceis used as the environment to limit the action space of the agent, and the accuracy of the quantization model afterretraining is used as the reward function to guide the agent to carry out deep reinforcement learning training. Theexperimental results show that the proposed method obtains a suitable model layer-by-layer quantization strategyunder the condition that the computational resources are satisfied, and themodel accuracy is effectively *** proposed method has strong intelligence and certain universality and has strong application potential in thefield of mixed precision quantization and embedded neural network model deployment.

关键词： Mixed precision quantization quantization strategy optimal assignment reinforcement learning neural network model deployment

Bubble dynamics properties of B-particles in a quasi-2D gas-solid fluidized bed:Computational particle fluid dynamics numerical simulation and post-processed by digital image analysis technique

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Particuology 2024年第3期86卷 223-238页

作者： Zemin Yuan zhong Huang Guotao Qin Guanjia Zhao Suxia ma Hairui Yang Guangxi Yue Key Laboratory of Clean and Efficient Combustion and Utilization in the Circulating Fluidized Bed Taiyuan University ofTechnologyTaiyuan030024China Department of Energy and Power Engineering Tsinghua UniversityBeijing100084.China

Bubble dynamics properties play a crucial and significant role in the design and optimization of gas-solid fluidized *** this study,the bubble dynamics properties of four B-particles were investigated in a quasi-two-dimensional(quasi-2D)fluidized bed,including bubble equivalent diameter,bubble size distribution,average bubble density,bubble aspect ratio,bubble hold-up,bed expansion ratio,bubble radial position,and bubble *** studies were performed by computational particle fluid dynamics(CPFD)numerical simulation and post-processed with digital image analysis(DIA)technique,at superficial gas velocities ranging from 2u_(mf) to 7u_(mf).The simulated results shown that the CPFD simulation combining with DIA technique post-processing could be used as a reliable method for simulating bubble dynamics properties in quasi-2D gas-solid fluidized ***,it seemed not desirable for the simulation of bubble motion near the air distributor at higher superficial gas velocity from the simulated average bubble density *** superficial gas velocity significantly affected the bubble equivalent diameter and evolution,while it had little influence on bubble size distribution and bubble aspect ratio distribution for the same *** time-averaged bubble hold-up and bed expansion ratio increased with the increase of superficial gas *** core-annular flow structures could be found in the fluidized bed for all *** average bubble rising velocity increased with the increasing bubble equivalent *** bubble lateral movement,the smaller bubbles might be more susceptible,and superficial gas velocity had a little influence on the absolute lateral velocity of *** simulated results presented a valuable and novel approach for studying bubble dynamics *** comprehensive understanding of bubble dynamics behaviors in quasi-2D gas-solid fluidized beds would provide support in the design,operation,and optimization of gas-solid

关键词： Bubble dynamics properties CPFD simulation Quasi-2D gas-solid fluidized bed Digital image analysis