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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian ding Chun Chen Heng Zhao Bin Dai lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong zhong Qiang Liu Fanglian Chen Ping lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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基于似三棱柱的长大货物联运路径优化方法

物流科技 2017年第3期40卷 60-65,70页

作者：张英贵李明忠雷定猷王海凤中南大学交通运输工程学院湖南长沙410000

以长大货物多式联运路径优化问题为研究对象,深入分析长大货物联运可行性因素与合理性因素,统筹考虑长大货物运到期限、碳排放和线路可改造等特性,以长大货物多式联运总运输成本和碳排放量最低为优化目标,构建基于线路限界、桥梁承重能... 详细信息

以长大货物多式联运路径优化问题为研究对象,深入分析长大货物联运可行性因素与合理性因素,统筹考虑长大货物运到期限、碳排放和线路可改造等特性,以长大货物多式联运总运输成本和碳排放量最低为优化目标,构建基于线路限界、桥梁承重能力、换装设备能力制约的长大货物多式联运路径多目标优化模型,设计基于运输节点与运输方式的不规则棱柱模型,提出一种基于似三棱柱网络与遗传算法的长大货物联运路径优化算法。算例结果表明:文章所提出的方法较单一优化目标相比具有明显优势,能有效地解决长大货物联运路径优化问题。

关键词：综合交通运输长大货物联运路径优化似三棱柱碳排放

污水处理行业的减污降碳探索——嘉兴港区工业污水处理有限公司的绿色转型

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中国环保产业 2024年第2期 9-11页

作者：郭慧钟丁磊薛懂何舒文姚海勇浙江巨能环境工程有限公司浙江桐乡314503 浙江数翰科技有限公司浙江桐乡314503 嘉兴港区工业污水处理有限公司浙江平湖314201

嘉兴港区工业污水处理有限公司通过技术创新、协同增效的方式,采用高浓度厌氧颗粒污泥床技术,“硫代碳”脱氮技术,人工智能(AI)运维决策控制系统集中化、协同化及数智化为污水处理厂提供绿色低碳转型的新思路。

关键词：污水处理减污降碳技术创新协同增效

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Electric Field Driven Surface Ion Transport in Hydrophobic Nanopores

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Chinese Journal of Chemistry 2021年第6期39卷 1511-1516页

作者： Xin-lei ding Zeng-Qiang Wu zhong-Qiu Li Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China

Water behavior in nanoconfined hydrophobic environment is different from that in the bulk,which greatly influences mass *** switching of nanopores showing great potential for controlled water or ion transport has been realized through several methods,especially the voltage-triggered wetting/dewetting inspired by biological ion ***,in the hydrophobic silanized nanopores,the finite ionic current is still observed and the ion transport mechanism is not yet ***,we explore the ion transport behavior in the hydrophobic silanized anodic aluminum oxide(AAO).Ion transport through this hydrophobic membrane is confirmed,although no aqueous pathway was *** show that ions transport through the cross-linked silane layer on the inner *** is revealed that metal ions,not just the protons or hydroxide ions,are involved in the ion transport driven by external electric *** study provides a new insight into the ion transport in nanoconfined hydrophobic environment which is helpful to understand the biological processes and design new nanofluidic devices.

关键词： Hydrophobic interface Surface ion transport Nanotechnology Surface chemistry Silanes

Summer extreme precipitation patterns and synoptic-scale circulation precursors over the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyuan ding Yao HA zhong zhong College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of global warming,the extreme summer precipitation over the Tibetan Plateau(TP)has changed *** this study,the summer(June–August)extreme precipitation on the TP was classified into three spatial types by applying the K-means clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipitation dataset(TPHi Pr,1979–2020).The characteristics of the circulation anomalies and precursors corresponding to the extreme precipitation on the TP in summer during 1979–2020 were *** results showed that the summer extreme precipitation of the TP can be categorized into northwestern(NW),southeastern(SE),and southern Himalayan(HS)types based on extreme precipitation *** NW and SE types are mainly influenced by anomalous signals in the mid-to-high latitude regions upstream of them,whereas the HS type is controlled by the localized subtropical anomalous *** the 8th day before the onset of the NW type,an anomalous cyclone was observed in the western Atlantic Ocean(60°W,50°N),which triggered the west-to-east quasi-latitudinal propagation of Rossby *** the onset day of the NW type,the upper troposphere showed positive-negative-positive geopotential height anomalies along the latitudinal 40°N from the Caspian Sea,the western part of Xinjiang,to the northeastern *** entered from the Arabian Sea along the southeastern edge of the anomalous cyclone on the southwestern TP and converged in the northwestern *** to the NW type,the precursors of the SE type appeared at higher latitudes and were more *** the 8th day before the onset of the SE type,an anomalous cyclone occurred near Greenland(60°W,70°N)and excited Rossby waves propagating *** the onset day of the SE type,the upper troposphere showed negative-positive-negative geopotential height anomalies across Eurasia from the Ural Mountains and the Iranian Plateau to the northern TP in the northwest-southeast directi

关键词： Tibetan Plateau Summer extreme precipitation Atmospheric circulation anomaly Precursor Teleconnection wave train

Advanced Policy Learning Near-Optimal Regulation

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 743-749页

作者： ding Wang Xiangnan zhong IEEE the Faculty of Information Technology Beijing University of Technology and also with the Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing University of Technology the Department of Electrical Engineering University of North Texas

Designing advanced design techniques for feedback stabilization and optimization of complex systems is important to the modern control field. In this paper, a near-optimal regulation method for general nonaffine dynamics is developed with the help of policy learning. For addressing the nonaffine nonlinearity, a pre-compensator is constructed, so that the augmented system can be formulated as affine-like form. Different cost functions are defined for original and transformed controlled plants and then their relationship is analyzed in detail. Additionally, an adaptive critic algorithm involving stability guarantee is employed to solve the augmented optimal control problem. At last, several case studies are conducted for verifying the stability, robustness, and optimality of a torsional pendulum plant with suitable cost.

关键词： Adaptive critic algorithm learning control neural approximation nonaffine dynamics optimal regulation

On the vortex filament in 3-spaces and its generalizations

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Science China Mathematics 2021年第7期64卷 1331-1348页

作者： Qing ding Shiping zhong School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematics and Computer Sciences Gannan Normal UniversityGanzhou 341000China

In this article,we devote to a mathematical survey on the theory of the vortex filament in 3-dimensional spaces and its *** shall present some effective geometric tools applied in the study,such as the Schrodinger flow,the geometric Korteweg-de Vries(KdV)flow and the generalized bi-Schrodinger flow,as well as the complex and para-complex *** should be mentioned that the investigation in the imaginary part of the octonions looks very fascinating,since it relates to almost complex structures and the G2 structure on S^(6).As a new result in this survey,we describe the equation of generalized bi-Schr?dinger flows from R1 into a Riemannian surface.

关键词： moving curve bi-Schrdinger flow para-complex structure almost complex structure