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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI zhong-hao PU Xiao-qi LI Sha-sha DONG Xiao-ke ZHANG Guo-qiang WANG Yu LIU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3.5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P3.kinase(PI3.)/protein kinase B(AKT)pathway were increased by TRQ(P3./AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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A V-CYCLE MUTIGRID FOR QUADRILATERAL ROTATED Q_1 ELEMENT WITH NUMERICAL INTEGRATION

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Journal of Computational Mathematics 2003年第5期21卷 545-554页

作者： zhong-ci Shi Xue-jun Xu(LSEC, institute of Computational Mathematics, academy of Mathematics and System {3., chinese academy of sciences, Beijing 100080, china) 中科院数学与系统科学院 LSEC CAS 北京 100080

In this paper, a V-cycle multigrid method is presented for quadrilateral rotated elements with numerical integration.

关键词： Multigrid Rotated Q1 elements Numerical integration.

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Microsegregation and Improved Methods of Squeeze Casting 2024 Aluminium Alloy

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Journal of Materials Science & Technology 2003年第5期19卷 413-416页

作者： Yong zhong, Guoyue SU and Ke YANGThe National Engineering Research Center, the institute of Metal Research, chinese academy of sciences, Shenyang 110016,{3. Natl. Eng. Res. Ctr. Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

The squeeze casting of a 2024 Al alloy was carried out to investigate the effect on microsegregation in the alloy of the application of pressure followed by diffusion annealing. The experimental results indicate that an optimum applied pressure followed by an optimum diffusion annealing process can markedly reduce the degree of microsegregation and improve the mechanical properties to a degree that can approach the level of forged 2024 Al alloy.

关键词： 2024 Al alloy Squeeze casting Microsegregation Diffusion annealing

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Investigation of gravity influence on EOR and CO_(2) geological storage based on pore-scale simulation

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Petroleum Science 2024年第2期21卷 987-1001页

作者： Yong-Mao hao Gui-Cheng Wu Zong-Fa Li zhong-Hui Wu Yong-Quan Sun Ran Liu Xing-Xing Li Bo-Xin Pang Nan Li Key Laboratory of Unconventional Oil&Gas Development(china University of Petroleum(East china)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Dongsheng Jinggong Petroleum Development Group Co. LtdShengli Oilfield CompanySINOPECDongying257001ShandongChina

Gravity assistance is a critical factor influencing CO_(2)-Oil mixing and miscible flow during EOR and CO_(2)geological *** on the Navier-Stokes equation,component mass conservation equation,and fluid property-composition relationship,a mathematical model for pore-scale CO_(2) injection in oilsaturated porous media was developed in this *** model can reflect the effects of gravity assistance,component diffusion,fluid density variation,and velocity change on EOR and CO_(2) *** nonhomogeneous porous media,the gravity influence and large density difference help to minimize the velocity difference between the main flow path and the surrounding area,thus improving the oil recovery and CO_(2) *** CO_(2) injection angles and oil-CO_(2) density differences can increase the oil recovery by 22.6% and 4.2%,respectively,and increase CO_(2) storage by 3..9% and 4.7%,*** diffusion facilitates the transportation of the oil components from the low-velocity region to the main flow path,thereby reducing the oil/CO_(2) concentration difference within the porous *** diffusion can increase oil recovery and CO_(2) storage by 5.7% and 6.9%,*** addition,combined with the component diffusion,a low CO_(2) injection rate creates a more uniform spatial distribution of the oil/CO_(2) component,resulting in increases of 9.5% oil recovery and 15.7% CO_(2) storage,*** study provides theoretical support for improving the geological CO_(2) storage and EOR processes.

关键词： Gravity Flow simulation CO_(2)-oil mixing Enhanced oil recovery(EOR) Geological storage

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PARALLEL ChaoTIC MULTISPLITTING ITERATIVE METHODS FOR THE LARGE SPARSE LINEAR COMPLEMENTARITY PROBLEM

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Journal of Computational Mathematics 2001年第3期19卷 281-292页

作者： zhong-zhi Bai (State Key Laboratory of Scientific/Engineering Competing institute of Computational Mathematics and Scientific/Engineering Computing, academy of Mathematics and Systems {3., chinese academy of sciences, Beijing 100080, china) 中科院计算数学与工程计算数学所科学与工程计算国家重点实验室北京 100080

Focuses on a study which presented a parallel chaotic multisplitting method for solving the large sparse linear complementarity problem. Preliminaries of the study; Equations of the parallel chaotic multisplitting met... 详细信息

关键词： linear complementarity problem matrix multisplitting chaotic iteration relaxed method convergence property

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Wetting front migration model of ion-adsorption rare earth during the multi-hole unsaturated liquid injection

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 483-496页

作者： Yu Wang Xiaojun Wang Yuchen Qiu hao Wang Gang Li Kaijian Hu Wen zhong zhongqun Guo Bing Li Chunlei Zhang Guangxiang Ye Jiangxi Key Laboratory of Mining Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhou341000China School of Civil Engineering and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou341000China Ganzhou Nonferrous Metallurgy Research institute Ganzhou341000China

In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still ***,wetting front migration distance and leaching time are usually required to optimize the leaching *** this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head *** the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were *** the postintersection stage,the intersection accelerated the wetting front *** using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the ***,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was *** analysis results showed that the proposed model can accurately simulate the infiltration process under experimental *** research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.

关键词： Ion-adsorption rare earth ore Multi-hole unsaturated liquid injection In situ leaching Intersection effect Calculation model

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Systematic distortion in cosmic microwave background maps

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Science china(Physics,Mechanics & Astronomy) 2009年第5期52卷 804-808页

作者： LIU hao 1,3.&LI TiPei 1,2 1Key Laboratory of Particle Astrophysics,institute of High Energy Physics,chinese {3. of {3.,Beijing 100049,china 2Center for Astrophysics,Tsinghua University,Beijing 100084,china 3.Graduate University of chinese academy of sciences,Beijing 100049,china Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing China Graduate University of chinese academy of sciences Beijing China Center for Astrophysics Tsinghua University Beijing China

To minimize instrumentally the induced systematic errors,cosmic microwave background(CMB)anisotropy experiments measure temperature differences across the sky using pairs of horn antennas, temperature map is recovered from temperature difference obtained in sky survey through a map-making *** inspect and calibrate residual systematic errors in the recovered temperature maps is important as most previous studies of cosmology are based on these *** analyzing pixel-ring coupling and latitude dependence of CMB temperatures,we find notable systematic devia- tion from CMB Gaussianity in released Wilkinson Microwave Anisotropy Probe(WMAP)*** detected deviation cannot be explained by the best-fit LCDM cosmological model at a confidence level above 99%and cannot be ignored for a precision cosmology study.

关键词： cosmology cosmic microwave background methods data analysis

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Discovery of seep carbonate nodules as new evidence for gas venting on the northern continental slope of South china Sea

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chinese Science Bulletin 2006年第10期51卷 1228-1237页

作者： CHEN zhong1,2,3. YAN Wen1,2,3. CHEN Muhong1,3. WANG Shuhong1,2,3. LU Jun1,3. ZHANG Fan1,3. XIANG Rong1,3. XIAO Shangbin1,3. YAN Pin1,2,3.& GU Senchang1,2,3.1. South china Sea institute of Oceanology, {3. academy of Sci-ences, Guangzhou 5103.1, china 2. Guangzhou Center for Gas Hydrate Research, chinese academy of sciences, Guangzhou 5103.1, china 3. Key Laboratory of Marginal Sea Geology, South china Sea institute of Oceanology and Guangzhou institute of Geochemistry, chinese academy of sciences, Guangzhou 5103.1, china South china Sea institute of Oceanology Chinese Academy of Science Guangzhou China Guangzhou Center for Gas Hydrate Research Chinese Academy of Sciences Guanzhou China Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology and Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China

Seep carbonate nodules were firstlycollected from the southwestern Dongsha area onnorthern continental slope of South china Sea formineralogical and geochemical studies. The resultsof X-ray diffraction show that carbonate nodules arecomposed of Fe-rich domolite,siderite and a few cal-cite and aragonite, as well as a small quantity ofnon-carbonate minerals such as goethite, quartz andclay minerals. Fe-rich dolomite and siderite charac-terized by euhedral microcrystalline structure weredirectly precipitated at cold seeps. The δ 13. valuesfor Fe-rich dolomite and siderite in the bulk nodulesvary from ?18.24‰ to ?3..07‰, and the δ 18O valuesrange from 0.42 to 2.76‰. Their moderate depleted13. reflects that carbon origin is possibly thermoge- netic gas or mixed gas, which is evidence of gasventings in the seafloor. Moreover, massive wormtube fossils related to cold seeps were found on thesurfaces of carbonate nodules, and the conduitsand/or channels in semi-solidified nodules whichwere not filled by carbonate or sediment were alsoobserved. A preliminary conclusion is that activemicro gas venting with a conduit/channel diameterrange from 200 μm to 600 μm possibly exists inmodern seafloor of the carbonate nodule area.

关键词：渗出碳酸盐节碳氧同位素甲烷渗漏天然气水化物

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Prediction method for October 2003.solar storm

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Science china(Technological sciences) 2006年第5期49卷 629-640页

作者： XIE Yanqiong1, 2, 3. WEI Fengsi1, FENG Xueshang1 & zhong Dingkun1, 2 1. State Key Laboratory of Space Weather, Center for Space Science and Applied Research, chinese academy of sciences, Beijing 100080, china 2. Graduate School, chinese academy of sciences, Beijing 10003., china 3. institute of Meteorology, PLA University of Science and Technology, Nanjing 211101, china State Key Laboratory of Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Graduate School Chinese Academy of Sciences

Aiming at two intense shock events on October 28 and 29, 2003. this paper presents a two-step method, which combines synoptic analysis of space weather ——“observing” and quantitative prediction ——“palpating”, and then uses it to test predictions. In the first step of “observing”, on the basis of observations of the solar source surface magnetic field, interplanetary scintillation (IPS) and ACE spacecraft, we find that the propagation of the shocks is asymmetric relative to the normal direction of their solar sources, and the Earth is located near the direction of the fastest speed and the greatest energy of the shocks. As the two fast ejection shock events, the fast explosion of coronal mass of the extremely high temperature, the strong magnetic field, and the high speed background solar wind are also helpful to their rapid propagation. In the second step of “palpating”, we adopt a new membership function of the fast shock events for the ISF method. The predicted results show that for the onset time of the geomagnetic disturbance, the relative errors between the observational and the predicted results are 1.8% and 6.7%; and for the magnetic disturbance magnitude, the relative errors are 4.1% and 3.1%, re- spectively. Furthermore, the comparison among the predicted results of our two-step method with those of five other prevailing methods shows that the two-step method is advantageous. The results tell us that understanding the physical features of shock propagation thoroughly is of great importance in improving the prediction precision.

关键词： solar storm, interplanetary shock, interplanetary scintillation, two-step method, ISF method.

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Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

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Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi Yang Wei Xu Yongjie Xu Yu Zhang Zixuan Cheng Yizhang Wu Xuetao Gan Wei zhong Yan Liu Genquan Han Yue hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China INRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic ***,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane ***,we acquired clear evidences of ferromagnetic behavior at room *** structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and *** a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room *** addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

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