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ZnPcS2P2-based Photodynamic Therapy Induces Mitochondria-dependent Apoptosis in K562 Cells

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 488-494页

作者： Hui-Fang HUANG yuan-zhong CHEN yong WU Fujian Institute of Hematology,Union Hospital,Fujian Medical University,Fuzhou 350001,China Fujian Institute of Hematology Union Hospital Fujian Medical UniversityFuzhou 350001 China

Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumorchemotherapeutic and other toxic *** therapy （PDT） exerts significant cellular killingefficacy through either an apoptotic or necrotic cell death *** study investigated the mechanismunderlying the killing effects of a novel amphipathic photosensitizer [di-sulfonated di-phthalimidomethylphthalocyanine zinc （ZnPcS2P2）]-mediated photodynamic therapy （ZnPcS2P2-PDT） on K562 *** evident in the post-PDT cells through the TdT-mediated dUTP nick end labeling （TUNEL） method andDNA fragmentation *** ZnPcS2P2-PDT,K562 cells underwent mitochondria-dependent apoptosisas evidenced by the release of cytochrome c from mitochondria into cytosol,accompanied by mitochondrialmembrane potential （ΔΨm） reduction,indicating the opening of the mitochondrial permeability transitionpore （PTP）.The activities of protease from the caspase family and caspase-3 were also significantly ***,ZnPcS2P2-PDT down-regulated the expression of chimaeric Bcr-Abl oncoprotein,which isthe molecular hallmark of chronic myelogenous leukemia （CML）.

关键词： photodynamic therapy zinc phthalocyanine apoptosis mitochondria K562 cell

State-of-the-Art Technology in the Construction of Sea-Crossing Fixed Links with a Bridge, Island, and Tunnel Combination

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Engineering 2019年第1期5卷 15-21页

作者： Yaojun Ge yong yuan State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China

In general, two kinds of structures are used to provide a way across a river, canal, sea, or other obstacle: bridge structures that pass over the obstacle, and tunnel structures that pass below the obstacle. Although the construction of both bridges and tunnels can be traced back over thousands of years, bridge–tunnel combinations that use an island as a sea-crossing fixed link (SCFL) have only been built over the past 82 years. The first such combination was probably the 6.4 km long San Francisco–Oakland Bay Bridge in the United States, which was completed in 1936. The most recently constructed SCFL combining a bridge, tunnel, and island is the Hong Kong–Zhuhai–Macao (HZM) Bridge, which opened for traffic on October 24, 2018 with the longest SCFL combination in the world, at a total length of 29.6 km.

关键词： kinds of structures provide a way across combinations

Characteristics and origin of a new type of polyhalite potassium ore in the Lower Triassic Jialingjiang Formation, Puguang area, northeastern Sichuan Basin, SW China

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Journal of Palaeogeography 2021年第1期10卷 112-124页

作者： Wen-Jun Shang Mian-Ping Zheng yong-Sheng Zhang Jia-Ai zhong En-yuan Xing yuan Peng Bao-Ling Gui Kong Li Institute of Mineral Resources Chinese Academy of GeosciencesBeijing 100037China Key Laboratory of Salt Lake Resources and Environment Ministry of Natural ResourcesBeijing 100037China Key Laboratory of Mineralization and Resource Evaluation Ministry of Natural ResourcesBeijing 100037China The 5th Detachment of Gold Force of the Chinese People's Armed Police Force Xi'an 710199Shaanxi ProvinceChina

A new type of polyhalite potassium ore(NTPPO) was found in the Lower Triassic Jialingjiang Formation, NE Sichuan Basin, SW China. It is water soluble, therefore can be exploited using the water-solution method, and is of great potential of economic value and research significance. Based on cores, thin sections, energy spectrum and SEM analyses, its microfeatures, macrofeatures and origin are discussed, and a genetic model is established to provide a scientific basis for future evaluation, prediction and exploration of potassium ore in the Sichuan Basin. It is proposed that the NTPPO was caused by storm activities:(1) the storm broke the original sedimentary polyhalite–gypsum beds, whose fragments were transported into the salt basin with high content of K+ and Mg2+;(2) in the basin, the polyhalite continued to be formed from gypsum by metasomatism with K-and Mg-rich brine;(3) during diagenesis, under high temperature and high pressure, K–Mg-rich brine from halite continued to replace anhydrite(or gypsum) to form polyhalite.

关键词： Puguang area Lower Triassic New type of polyhalite potassium ore Microfeatures and macrofeatures Storm event deposition

Spatiotemporal changeof vegetationcoverage recovery and its driving factors in the Wenchuan earthquake-hit areas

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Journal of Mountain Science 2021年第11期18卷 2854-2869页

作者： SUN Xiao-fei yuan Lin-guo ZHOU Ying-zhi SHAO Huai-yong LI Xian-feng zhong Ping Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China College of Earth Science Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau of Nanchong Nanchong 637000China Department of Geography National University of SingaporeKent Ridge 117570Singapore

Vegetation coverage recovery after the Wenchuan earthquake has important implications for preventing post-seismic geohazards and soil ***,spatiotemporal changes in vegetation coverage recovery and its driving factors have not been sufficiently studied in the quake-hit *** paper aims to analyze vegetation coverage recovery and its driving factors in the quake-hit areas using monadic linear regression,coefficient of variation,and geographical ***,we used Moderate-resolution Imaging Spectroradiometer(MODIS)data to calculate the vegetation coverage from 2008 to 2018 in the quake-hit ***,we assessed the trend and stability of vegetation recovery in the quake-hit areas based on vegetation ***,combined with topography,climate,soil type,vegetation type,and human activities in the quake-hit areas,the driving factors affecting vegetation coverage recovery were *** results showed that the vegetation coverage level in the quake-hit areas recovered about 90%of that before the *** coverage recovery was mainly improved in a stepwise manner:increasing and then stabilizing,then increasing and stabilizing ***,soil type,and road density were the main factors affecting vegetation coverage recovery,and the interaction among all factors positively strengthened their impacts on vegetation coverage *** addition,the results also revealed the categories that were conducive to vegetation coverage recovery among the same environmental factors and can provide a scientific reference for vegetation coverage recovery in the quake-hit areas.

关键词： Wenchuan earthquake Vegetation coverage recovery Geographical detector Driving factors

Memristor-Based Genetic Algorithm for Image Restoration

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Journal of Electronic Science and Technology 2022年第2期20卷 149-158页

作者： yong-Bin Yu Chen Zhou Quan-Xin Deng yuan-Jing-Yang zhong Man Cheng Zheng-Fei Kang the School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054 the School of Computer Science Chengdu College of University of Electronic Science and Technology of ChinaChengdu 611731

This paper explores a way of deploying the classical algorithm named genetic algorithm(GA) with the memristor. The memristor is a type of circuit device with both characteristics of storage and computing, which provides the similarity between electronic devices and biological components, such as neurons, and the structure of the memristor-based array is similar to that of chromosomes in genetics. Besides, it provides the similarity to the image gray-value matrix that can be applied to image restoration with GA. Thus, memristor-based GA is proposed and the experiment about image restoration using memristor-based GA is carried out in this paper. And parameters,such as the size of initial population and the number of iterations, are also set different values in the experiment,which demonstrates the feasibility of implementing GA with memristors.

关键词： Image image similarity

Sub-lethal effects of Beauveria bassiana(Balsamo) on field populations of the potato tuberworm Phthorimaea operculella Zeller in China

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Journal of Integrative Agriculture 2018年第4期17卷 911-918页

作者： yuan Hui-guo WU Sheng-yong LEI zhong-ren Silvia I.Rondon GAO Yu-lin State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Department of Crop and Soil Sciences Hermiston Agricultural Research and Extension Center Oregon State University

The potato tuberworm Phthorimaea operculella Zeller, is one of the most important potato pests worldwide including China. Several reports indicate that P. operculella could be controlled biologically by the use of beneficial fungus such as Beauveria bassiana(Bals.-Criv) Vuill. However, limited information is available under growing conditions in China. Thus, this study evaluated the sub-lethal effects of B. bassiana on the offspring of P. operculella by the age-stage, two-sex life table. First instar larva of P. operculella were treated with 1×107 conidia m L–1 of the fungus, and several biological parameters were evaluated. The fecundity, duration of the egg stage, all larval stages, pre-adult stage, and total pre-oviposition period, were significantly shorter than the control treatment. Offspring of treated parents, presented a net reproductive rate and mean generation time of 17.43 per day and 24.98 days, respectively, compared to 65.79 per day and 26.51 days for the untreated ones. This study provides basic information to help understanding the potential long-term effects of entomopathogenic fungi on P. operculella.

关键词： potato tubermoth sub-lethal effects biological control management

Effects of sleeve gastrectomy with jejuno-jejunal or jejuno-ileal loop on glycolipid metabolism in diabetic rats

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World Journal of Gastroenterology 2016年第32期22卷 7332-7341页

作者： Ming-Wei zhong Shao-Zhuang Liu Guang-yong Zhang Xiang Zhang San-yuan Hu Department of General Surgery Qilu Hospital of Shandong University

AIM To explore the effect of sleeve gastrectomy(SG) with jejuno-jejunal or jejuno-ileal loop on glycolipid metabolism in diabetic *** Diabetic rats, which were induced by high-fat diet(HFD), nicotinamide and low-dose streptozotocin, underwent sham operations, SG, SG with jejuno-ileal loop(SG-JI) and SG with jejuno-jejunal loop(SG-JJ) followed by postoperative HFD. Then, at the time points of baseline and 2, 12 and 24 wk postoperatively, we determined and compared several variables, including the area under the curve for the results of oral glucose tolerance test(AUCOGTT), serum levels of triglyceride, cholesterol and ghrelin in fasting state, homeostasis model assessment of insulin resistance(HOMA-IR), body weight, calorie intake, glucagon-like peptide(GLP)-1 and insulin secretions after glucose gavage at dose of 1 g/*** At 2 wk postoperatively, rats that underwent SG, SGJJ and SG-JI, compared with sham-operated(SHAM)rats, demonstrated lower body weight, calorie intake and ghrelin(P < 0.05 vs SHAM), enhanced secretion of insulin and GLP-1 after glucose gavage(P < 0.05 vs SHAM), improved AUCOGTT, HOMA-IR, fasting serum triglyceride and cholesterol(AUCOGTT: 1616.9 ± 83.2, 837.4 ± 83.7, 874.9 ± 97.2 and 812.6 ± 81.9, P < 0.05 vs SHAM; HOMA-IR: 4.31 ± 0.54, 2.94 ± 0.22, 3.17 ± 0.37 and 3.41 ± 0.22, P < 0.05 vs SHAM; Triglyceride: 2.35 ± 0.17, 1.87 ± 0.23, 1.98 ± 0.30 and 2.04 ± 0.21 mmol/L, P < 0.05 vs SHAM; Cholesterol: 1.84 ± 0.21, 1.53 ± 0.20, 1.52 ± 0.20 and 1.46 ± 0.23 mmol/L). At 12 wk postoperatively, rats receiving SG-JJ and SG-JI had lower body weight, reduced levels of triglyceride and cholesterol and elevated level of GLP-1 compared to those receiving SG(P < 0.05 vs SG). At 24 wk after surgery, compared with SG, the advantage of SG-JJ and SG-JI for glucolipid metabolism was still evident(P < 0.05 vs SG). SG-JI had a better performance in lipid metabolism and GLP-1 secretion of rats than did *** SG combined with intestinal loop ind

关键词： Sleeve gastrectomy Jejuno-jejunal loop Jejuno-ileal loop Diabetes Glucolipid metabolism

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

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Oncology Research 2024年第6期32卷 1079-1091页

作者： CHAO TANG CHUNYU zhong JUNHAO ZHU FENG yuan JIN YANG yong XU CHIyuan MA Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(GHPAs)harbor somatic activating mutations in GNAS(αsubunit of stimulatory G protein).Mutations in GNAS are associated with clinical features of smaller and less invasive ***,the role of GNAS mutations in the invasiveness of GHPAs is *** mutations were detected in GHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEG3)was evaluated with ***3 was manipulated in GH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEG3 on tumor growth and *** invasiveness of GHPAs was significantly decreased in mice with mutated GNAS compared with that in mice with wild-type ***,the invasiveness of mutant GNASexpressing GH3 cells ***3 is uniquely expressed at high levels in GHPAs harboring mutated ***,MEG3 upregulation inhibited tumor cell invasion,and conversely,MEG3 downregulation increased tumor cell ***,GNAS mutations inhibit EMT in ***3 in mutated GNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that GNAS mutations may suppress cell invasion in GHPAs by regulating EMT through the activation of the MEG3/Wnt/β-catenin signaling pathway.

关键词： GHPAs GNAS mutation MEG3 β-catenin EMT

Pyrolysis Empirical Modeling of Polyester Glass Fiber Reinforced Plastics Using Sestak-Berggren Model Method

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Journal of Thermal Science 2024年第2期33卷 725-738页

作者： NAN Wei JI Wenhui yuan Yanping yuan zhongyuan SUN yong School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China CRRC Changchun Railway Vehicles Co. LtdChangchun130062China

Polyester Glass Fiber Reinforced Plastic(Polyester GFRP),a thermosetting plastic comprised of glass fiber and polyester polymer compounds,is extensively utilized in high-speed *** its pyrolysis mechanism is crucial as it significantly influences the combustion characteristics and fire safety ***,kinetic research on polyester GFRP primarily focuses on employing the Coats-Redfern method to derive a theoretical kinetic ***,the pyrolysis process of polyester GFRP is complex and the aforementioned theoretical model fails to accurately describe the pyrolysis ***,this study seeks to utilize the Sestak and Berggren(SB) model as a methodological approach to reveal the complex reaction mechanism during the pyrolysis *** on thermogravimetric analysis,the entire pyrolysis process of polyester GFRP is divided into two primary ***,model-free methods are employed to ascertain the activation energy and pre-exponential *** results show that the fitted empirical models of the two main pyrolysis stages are f(α)=(1-α)^(1.47)[-ln(1-α)]^(1.50) and f(α)=(1-α)^(1.77)[-ln(1-α)]^(1.72),*** predicted results are in good agreement with experimental data under different heating rates,which indicates that the empirical model can sufficiently describe the pyrolysis process of polyester GFRP.

关键词： polyester GFRP model-fitting methods empirical models pyrolysis