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Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:A meta-analysis

World Journal of Gastroenterology 2010年第23期16卷 2931-2942页

作者： Miao, Ruo-Yu Zhao, Hai-Tao Yang, Hua-Yu Mao, Yi-Lei Lu, Xin Zhao, Yi Liu, Chang-Ning zhong, shou-xian Sang, Xin-Ting Huang, Jie-Fu Chinese Acad Med Sci Dept Liver Surg Peking Union Med Coll Hosp Beijing 100730 Peoples R China Peking Union Med Coll Beijing 100730 Peoples R China Chinese Acad Sci Bioinformat Res Grp Inst Comp Technol Beijing 100190 Peoples R China

AIM:To investigate the impact of postoperative antiviral treatment on tumor recurrence and survival of patients with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection-related primary hepatocellular carcinoma(HCC) after curative ***:We performed a meta-analysis of randomized and non-randomized control trials from electronic search and manual *** fixed effect model of Mantel-Haenszel method and the random effect model of Der Simonian and Laird method were used for homogeneous and heterogeneous studies,*** HCV-related studies,three HBV-related studies and three studies on HBV or HCV-related HCC were ***:A total of 1224 patients were included in this *** estimated odds ratios(OR) for the 1-,2-,3-and 5-year recurrence were 0.54 [15.4% vs 24.1%,95% confidence interval(CI):0.32-0.89,P=0.02],0.42(36.9% vs 58.0%,95% CI:0.19-0.90,P=0.03),0.37(47.9% vs 63.8%,95% CI:0.19-0.71,P=0.003),and 0.32(66.7% vs 74.3%,95% CI:0.15-0.66,P=0.002),respectively;and the OR for the 1-,2-,3-,5-and 7-year mortality were 0.23(1.2% vs 9.1%,95% CI:0.07-0.71,P=0.01),0.31(6.4% vs 22.1%,95% CI:0.12-0.79,P=0.01),0.43(12.7% vs 20.8%,95% CI:0.21-0.89,P=0.02),0.42(25.1% vs 42.0%,95% CI:0.27-0.66,P=0.0002) and 0.28(31.9% vs 52.2%,95% CI:0.13-0.59,P=0.0008).CONCLUSION:This meta-analysis indicates the postoperative antiviral therapy,interferon in particular,may serve as a favorable alternative to reduce recurrence and mortality in patients with HBV/HCV related HCCs.

关键词： Antiviral therapy Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Recurrence Survival

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Effect of Phase Separation Size on the Properties of Self-healing Elastomer

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Chinese Journal of Polymer Science 2024年第6期42卷 798-804页

作者： Jun Xu Lei Zhu xian-Qi Feng Cong Sui Wen-Peng Zhao shou-Ke Yan School of Chemical Engineering Qingdao University of Science&TechnologyQingdao266042China College of Engineering Yanching institute of TechnologyLangfang065210China Key Laboratory of Rubber-plastics Qingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Regulation of phase structure has been recognized as one of the most effective ways to fabricate self-healing polymers with high mechanical *** mechanical properties of the resultant polymers are certainly affected by the size of separated phase ***,the study on this aspect is absence,because it can hardly exclude the influence of variation in monomer proportion required for tuning the separated phase ***,we report the first study on tuning the phase size through reversible addition-fragmentation chain transfer(RAFT)polymerization without changing the proportion of *** expected,the size of separated phase has been successfully mediated from 15 nm to 9 nm by tuning the molecular weight of the chain transfer *** is found that the mechanical strength and the self-healing efficiency of the resultant polymers increase simultaneously with the decrease of phase *** study on the formation kinetics of hydrogen bonds reveals that the decrease of phase size can facilitate the re-bonding rate of hydrogen bonds,even if the migration of polymer chains is restricted.

关键词： Self-healing polymers Phase separation Reversible addition-fragmentation chain transfer

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老年人胆囊炎胆石症（附105例临床分析）

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中华老年医学杂志 1994年第4期13卷 215-217页

作者：邱辉忠钟守先北京协和医院外科

报道１０５例６５岁以上老年人胆结石手术治疗的结果。其中急性胆褒炎胆囊结石３５例，急性化脓性胆管炎１０例。６９例（６５．７％）有并存症，其中以心血管疾病最常见；并存两种疾病以上者３２例（３０．４％）。１０５例手术中，胆... 详细信息

报道１０５例６５岁以上老年人胆结石手术治疗的结果。其中急性胆褒炎胆囊结石３５例，急性化脓性胆管炎１０例。６９例（６５．７％）有并存症，其中以心血管疾病最常见；并存两种疾病以上者３２例（３０．４％）。１０５例手术中，胆囊切除术６２例，胆囊切除加胆总管探查术３９例，胆囊造瘘术４例。术后并发症：急诊组与择期组均以肺部感染及伤口感染为主。术后死亡５例，总病死率为４．７％；急诊组４例，为１３．３％，择期组１例，为１．３％。我们认为对有症状的老年胆结石患者应尽早地施行择期手术，以降低急诊手术率。

关键词：胆囊疾病胆石症胆囊切除术

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Interpretation and characterization of rate of penetration intelligent prediction model

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Petroleum Science 2024年第1期21卷 582-596页

作者： Zhi-Jun Pei xian-Zhi Song Hai-Tao Wang Yi-Qi Shi shou-Ceng Tian Gen-Sheng Li College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Petroleum Resources and Prospecting Beijing102249China Kunlun Digital Technology Co. Ltd.Beijing102206China

Accurate prediction of the rate of penetration(ROP)is significant for drilling *** the intelligent ROP prediction model based on fully connected neural networks(FNN)outperforms traditional ROP equations and machine learning algorithms,its lack of interpretability undermines its *** study proposes a novel interpretation and characterization method for the FNN ROP prediction model using the Rectified Linear Unit(ReLU)activation *** leveraging the derivative of the ReLU function,the FNN function calculation process is transformed into vector *** FNN model is linearly characterized through further simplification,enabling its interpretation and *** proposed method is applied in ROP prediction scenarios using drilling data from three vertical wells in the Tarim *** results demonstrate that the FNN ROP prediction model with ReLU as the activation function performs exceptionally *** relative activation frequency curve of hidden layer neurons aids in analyzing the overfitting of the FNN ROP model and determining drilling data *** the well sections with similar drilling data,averaging the weight parameters enables linear characterization of the FNN ROP prediction model,leading to the establishment of a corresponding linear representation ***,the quantitative analysis of each feature's influence on ROP facilitates the proposal of drilling parameter optimization schemes for the current well *** established linear characterization equation exhibits high precision,strong stability,and adaptability through the application and validation across multiple well sections.

关键词： Fully connected neural network Explainable artificial intelligence Rate of penetration ReLU active function Deep learning Machine learning

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Chiral multiple-resonance thermally activated delayed fluorescence materials based on chiral spiro-axis skeleton for efficient circularly polarized electroluminescence

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Science China Chemistry 2024年第7期67卷 2257-2264页

作者： Shi-Quan Song Xiao Han zhong-zhong Huo Ching-Fai Yip xian-Fang Hong Meng-Ning Ding You-Xuan Zheng State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Chiral luminescence materials have potential applications in the field of three-dimensional displays due to their circularly polarized luminescence(CPL)***,the further development of circularly polarized organic light-emitting diodes(CP-OLEDs)needs to meet the requirements of high efficiency,high color purity,low cost,and high dissymmetry factor(gPLor gEL),chiral multiple resonance thermally activated delayed fluorescence(MR-TADF)materials are considered as candidates in these ***,based on a pair of chiral spirofluorene precursors,two pairs of high-performance chiral MR-TADF emitters((R/S)-p-Spiro-DtBuCzB and(R/S)-m-Spiro-DtBuCzB)are developed,which exhibit strong emissions peaking at 491 and 502 nm in toluene with full-width at half-maximum values of 25 and 33 nm,*** addition,small singlet–triplet energy gaps of 0.15 and 0.10 eV with high absolute photoluminescence efficiencies of 95.0%and 96.7%are observed for p-Spiro-DtBuCzB and m-Spiro-DtBuCzB molecules,*** based on p-Spiro-DtBuCzB and m-Spiro-DtBuCzB display high maximum external quantum efficiencies of 29.6%and 33.8%,*** importantly,CP-OLEDs present symmetric circularly polarized electroluminescence spectra with|gEL|factors of 3.36×10^(-4)and 7.66×10^(-4)for devices based on(R/S)-p-Spiro-DtBuCzB and(R/S)-m-Spiro-DtBuCzB enantiomers,respectively.

关键词： chiral spiro-axis skeleton-based material multiple resonance thermally activated delayed fluorescence circularly polarized electroluminescence dissymmetry factor external quantum efficiency

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Progress in processing of porous titanium:a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang xian-Feng Du Zhi-Lin Xu zhong-Shuai Liang Li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi'an Jiaotong UniversityXi'an 710049China

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace,marine engineering and biomedical fields due to their high corrosion resistance,low density,good biocompatibility and excellent mechanical ***,in this paper,a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes)for fabricating porous titanium is firstly covered in terms of their working principles,capabilities,shortcomings and ***,the influencing factors of various methods on final pore structure of porous Ti are ***,a summary of the chemical methods(CM)to obtain the porous Ti is also provided,such as dealloying method and reduction ***,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI xian xian Veronica Lim CHEN Qi ZHAO zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Reaction mechanism between Al_(2)O_(3)–MgO refractory materials and rare earth high-carbon heavy rail steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1153-1163页

作者： Yi Wang Guang-jie Song Ping Shen Jian-zhong He Da-xian Zhang Jian-xun Fu Center for Advanced Solidification Technology(CAST) School of Materials Science and EngineeringState Key Laboratory of Advanced Special SteelShanghai UniversityShanghai200444China State Key Laboratory of Baiyunebo Rare Earth Resources Research and Comprehensive Utilization Baotou014030Inner MongoliaChina Inner Mongolia Baotou Steel Union Co. Ltd.Baotou014030Inner MongoliaChina

Submerged entry nozzle(SEN)clogging is a major problem affecting the production quality of rare earth steel,and finding a suitable refractory outlet can significantly reduce production *** explore the relationship between refractory composition and interface interaction,unprotected coated Al_(2)O_(3)–MgO refractories and SiO2-coated Al_(2)O_(3)–MgO refractories were added to rare earth high-carbon heavy rail steel under laboratory conditions,and the Al_(2)O_(3)–MgO refractory was found to be more *** results show that,from the epoxy resin side to the refractory side,the contour of the refractory interface reaction layer can be divided into two main layers:an iron-rich reaction layer and an iron-poor reaction *** based on the spherical model suggest that the adhesion force is proportional to the size of the refractory particles and inclusions,and the same result applies to the surface *** the inclusions at a smaller size has a specific effect on alleviating the erosion of *** with the erosion mechanism of Al_(2)O_(3)–MgO refractories,the interface reaction mechanism between Al_(2)O_(3)–MgO refractories and molten steel was proposed,which provides ideas for solving SEN clogging.

关键词： Rare earth high-carbon heavy rail steel Al_(2)O_(3)-MgO refractory Adhesion Surface tension Interface interaction

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重症急性胰腺炎研究方向的几点建议

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中国普通外科杂志 2005年第5期14卷 321-322页

作者：钟守先中国医学科学院中国协和医科大学北京协和医院外科北京100730

近十余年来,随着对重症急性胰腺炎(severe acute pancreatitis,SAP)基础研究的不断深入,医疗技术的快速发展,有效的新药不断出现,SAP的疗效已取得了较好的进展,但是有关SAP发病、诊治和预后等多个方面的问题尚未解决,其死亡率还在20%左... 详细信息

近十余年来,随着对重症急性胰腺炎(severe acute pancreatitis,SAP)基础研究的不断深入,医疗技术的快速发展,有效的新药不断出现,SAP的疗效已取得了较好的进展,但是有关SAP发病、诊治和预后等多个方面的问题尚未解决,其死亡率还在20%左右,这与其他炎性疾病相比还是很高的.因此,要取得突破性进展,必须在SAP的发生和发展的机制上作更进一步的深入研究,在众多的因素中找到其关键的因素,才有可能及早阻断导致病情发展的恶性循环链,使疗效得到根本性的提高.因此笔者拟在SAP的基础和临床研究方面提出几个观点与大家商榷.

关键词：胰腺炎/病理生理学急性病综述文献

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胰腺体尾部癌的根治清扫范围

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外科理论与实践 2005年第3期10卷 206-207页

作者：钟守先中国医学科学院中国协和医科大学北京协和医院外科

胰腺体尾部癌占胰腺癌的20%～30%.由于胰腺体尾部癌早期无任何特异性症状,因而发现往往较晚,使手术的切除率很低.近年影像学的发展使胰腺癌的诊断率有所提高,但其切除率仍低于30%.胰腺癌的生物学特性是淋巴转移早且易向周围的脂肪神经... 详细信息

胰腺体尾部癌占胰腺癌的20%～30%.由于胰腺体尾部癌早期无任何特异性症状,因而发现往往较晚,使手术的切除率很低.近年影像学的发展使胰腺癌的诊断率有所提高,但其切除率仍低于30%.胰腺癌的生物学特性是淋巴转移早且易向周围的脂肪神经组织浸润,即使能切除亦往往达不到根治性的要求,因此胰腺体尾部癌病人的预后甚至比胰头癌还差,5年生存率一般不超过10%.然胰体尾切除术的手术难度比Whipple术低,并发症亦少,且病例亦相对较少,因此没有治疗胰头癌那样得到大家的重视,有关如何能更合理地进行根治以提高远期疗效的讨论很少.本文根据自巳的经验提出胰体尾部癌手术需廓清的范围和方法,与大家商榷,期望能改善治疗的预后.

关键词：胰腺肿瘤外科手术方法

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