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Long non-coding RNA: The functional regulator of mesenchymal stem cells

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World Journal of Stem Cells 2019年第3期11卷 167-179页

作者： zhong-Yu xie Peng Wang Yan-Feng Wu Hui-Yong Shen Department of Orthopedics The Eighth Affiliated Hospital Sun Yat-sen University Center for Biotherapy Sun Yat-sen Memorial Hospital Sun Yat-sen University

Mesenchymal stem cells(MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for ***, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA(LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently,multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.

关键词： Mesenchymal stem cells Long non-coding RNA Regulator Multipotent stroma cells

Human menstrual blood-derived stem cells as immunoregulatory therapy in COVID-19:A case report and review of the literature

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World Journal of Clinical Cases 2021年第7期9卷 1705-1713页

作者： Juan Lu zhong-Yang xie Dan-Hua Zhu Lan-Juan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)caused by novel coronavirus 2019 in December 2019 has spread all around the globe and has caused a *** is still no current effective guidance on the clinical management of *** stem cell therapy has been shown to be one of the therapeutic approaches to alleviate pneumonia and symptoms through their immunomodulatory effect in COVID-19 *** SUMMARY We describe the first confirmed case of COVID-19 in Hangzhou to explore the role of human menstrual blood-derived stem cells(MenSCs)in the treatment of ***,we review the immunomodulation effect including nonspecific and specific immune functions of MenSCs for the therapy of *** MenSCs can be helpful to find a promising therapeutic approach for COVID-19.

关键词： COVID-19 Human menstrual blood-derived stem cells Immunoregulatory therapy Inflammatory response Cytokine storm Case report

等离子体空气消毒机对幼儿园室内空气动静态消毒效果研究

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中国消毒学杂志 2024年第4期41卷 259-260,263页

作者：李晔谢中艺蔡冉潘协商许激林军明浙江省疾病预防控制中心浙江杭州310051

目的研究一种等离子体空气消毒机对动态有人和静态无人室内空气消毒效果。方法选择一间幼儿园教室,用等离子体空气消毒机分别在教室有人和无人时消毒,比较消毒前后空气中浮游菌、沉降菌、颗粒物和微生物负荷,综合评估等离子体空气消毒... 详细信息

目的研究一种等离子体空气消毒机对动态有人和静态无人室内空气消毒效果。方法选择一间幼儿园教室,用等离子体空气消毒机分别在教室有人和无人时消毒,比较消毒前后空气中浮游菌、沉降菌、颗粒物和微生物负荷,综合评估等离子体空气消毒效果。结果在无人室内,消毒60 min时室内空气自然菌消亡率>90%;在有人室内,尽管人员活动持续污染空气,空气消毒仍达到50%以上的自然菌消亡率。无论室内是否有人活动,消毒后空气中沉降菌、颗粒物和微生物负荷均下降。结论该等离子体空气消毒机可以有效消除空气中细菌和颗粒物,能够在有人时使用,为预防经空气传播疾病在室内传播提供有效消毒方法。

关键词：等离子体空气消毒机室内空气消毒效果法

Self-assembled graphene oxide/polyethyleneimine films as high-performance quartz crystal microbalance humidity sensors

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Rare Metals 2021年第6期40卷 1597-1603页

作者： Zhen Yuan Hui-Ling Tai Yuan-Jie Su Guang-zhong xie Xiao-Song Du Ya-Dong Jiang State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China

As humidity is one of the most widely demanded environmental parameters,the precision of its detection is *** advanced humidity sensor will improve the validity of the humidity monitoring *** this study,a facile chemical layer-by-layer self-assembly(CLS)method was developed for fabricating graphene oxide(GO)/polyethyleneimine(PEI)multilayer *** to the chemical bonding between the PEI and GO,and the intrinsic stickiness of the PEI,layered films with different numbers of layers were successfully prepared using the CLS method and confirmed through ultraviolet-visible(UV-Vis)spectroscopy and the mass loading of quartz crystal microbalance(QCM).Morphological measurements revealed that the roughness and thickness of the films increased exponentially with the number of *** GO/PEI films were deposited on QCM electrodes using the CLS method to produce the humidity *** humidity measurement results showed a high sensitivity(37.84 Hz/%RH)and rapid response/recovery(<5 s/8 s)of the optimal sensor,which was superior to that of recently developed QCM sensors.

关键词： Humidity sensors Quartz crystal microbalance Graphene oxide Polyethyleneimine Self-assembly

Physiological and pathological insights into exosomes in the brain

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Zoological Research 2020年第4期41卷 365-372页

作者： Xiao-Hui Li Juan Zhang Ding-Feng Li Wei Wu zhong-Wen xie Qiang Liu Institute on Aging and Brain Disorders The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineHefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life SciencesUniversity of Science and Technology of ChinaHefeiAnhui230001China State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefeiAnhui 230036China Neurodegenerative Disease Research Center University of Science and Technology of ChinaHefeiAnhui 230026China Organ Transplantation Center The First Affiliated Hospital of University of Science and Technology of ChinaHefeiAnhui 230026China CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhui 230029China CAS Key Laboratory of Brain Function and Disease University of Science and Technology of ChinaHefeiAnhui 230026China

Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or *** in the brain have considerable impact on neuronal development,activation,and *** addition,exosomes are reported to be involved in the onset and propagation of various neurodegenerative *** this review,we discuss the content of exosomes derived from major cell types in the brain,and their function under physiological and pathological conditions.

关键词： pathological Exosomes insight

Microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents during heat treatments

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Rare Metals 2024年第4期43卷 1786-1792页

作者： Yuan-Feng xie Xing-Cheng xie zhong-Wu Li Rui-Jun Cao zhong-Kun Lin Qing Li Chen-Guang Lin Powder Metallurgy and Special Materials Research Department General Research Institute for Nonferrous MetalsBeijing100088China

The effects of cryogenic treatment(CT)and tempering-cryogenic treatment(TCT)on the microstructure and properties of coarse-grained WC-10Co cemented carbides with different carbon contents were *** binder phase,WC mean grain sizes,W solubility in the binder,relative magnetic s aturation,densities,hardness,wear resistance and second phase precipitation of cemented carbides with different heat treatments were *** results show that there are significant changes of microstructure and properties in the samples with CT and TCT,especially due to the precipitation of metastable nanoparticles W_(x)Co_(y)C_(z) in the binder during the heat treatments of CT and *** the simultaneous combination of microstructure and nanoparticle-reinforced binder,a dramatically improved combination of hardness and wear resistance of the samples after TCT has been achieved.

关键词： Cryogenic treatment Tempering Coarsegrained cemented carbide Carbon content Nanoparticlereinforced binder

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基于XLNet的多数据源中文地名匹配方法

地理空间信息 2024年第8期22卷 59-63,88页

作者：郑诗语邱芹军谢忠陶留锋李伟杰中国地质大学(武汉)计算机学院湖北武汉430074 地理信息系统国家地方联合工程实验室湖北武汉430074 自然资源部城市国土资源监测与仿真重点实验室广东深圳518000

地址作为社会发展中重要的基础性数据资源,已成为城市地理空间数据化建设的重要组成部分。地名匹配旨在比较表示相同真实世界位置的配对字符串。当前地名匹配方法依赖于字符串相似性独立或多种混合相似性度量方法,这些方法无法有效地捕... 详细信息

地址作为社会发展中重要的基础性数据资源,已成为城市地理空间数据化建设的重要组成部分。地名匹配旨在比较表示相同真实世界位置的配对字符串。当前地名匹配方法依赖于字符串相似性独立或多种混合相似性度量方法,这些方法无法有效地捕捉长句子上下文信息,不能充分理解地址含义。因此,提出一种基于XLNet算法的地名匹配方法,利用深度神经网络将一对地名分类为匹配或不匹配。该方法利用长程记忆并使用双信息流注意力掩码对事件序列进行重构,以利用其双向信息建立表征。实验结果表明,该方法可解决长地址匹配问题,模型能较好地理解上下文语义信息,优于先前研究的单个相似度量及基于监督机器学习的方法。

关键词：地名匹配地名实体 XLNet Softmax 回归模型

Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep:A Neuroscience Exploration

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Neuroscience Bulletin 2024年第6期40卷 852-854页

作者： Zhe zhong Fuling Yan Chunming xie Department of Neurology School of MedicineAffiliated Zhongda HospitalSoutheast UniversityNanjing210009China Institute of Neuropsychiatry Affiliated Zhongda HospitalSoutheast UniversityNanjing210009China The Key Laboratory of Developmental Genes and Human Disease Southeast UniversityNanjing210009China

Imagine that,in the future,you could enhance your memory by applying a mild electric current to your brain during *** might sound like science fiction,but it is based on cutting-edge neuroscience *** is widely recognized as a crucial factor for long-term memory consolidation,but the exact mechanisms by which the brain coordinates neural activity across different regions during sleep to reorganize and integrate memories are unknown[1,2].

关键词： Sleep integrate applying

Mathematic principles of interrupted-sampling repeater jamming (ISRJ)

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Science in China(Series F) 2007年第1期50卷 113-123页

作者： WANG XueSong LIU JianCheng ZHANG WenMing FU QiXiang LIU zhong xie XiaoXia School of Electronics Science and Engineering National University of Defense Technology Changsha410073 China

Coherent Jamming is one of the Important trends in modern radar electronic warfare. High-speed sampling of wldeband radio frequency （RF） signals and high isolatlon of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to enginserlng application. In this paper, a novel repeater Jamming based on interrupted sampling technique is presented. For a Jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the Jamming signal feed the matched flltar of a pulse compression radar. For the case of the Ilnser frequency modulated （LFM） pulse compression radars, mathematic principles of the *** repeater jamming Is developed, and then the efficiency of the jamming is described and stated as expressions of key parameters which are also beneficial to the Jamming design for other coherent radars.

关键词： interrupted-sampling repeater jamming ambiguity function pulse compression linear frequency modulated signal