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Advances in Bioscience and Biotechnology 2013年第1期4卷 1-5页

作者： zhon-min huang Yi-Te Chiang min-Che Tung Chia-Chang Wu Kuan-Chou Chen ming-Te huang Yuan-Hung Wang Cheng-huang Shen Department of Urology Chia-Yi Christian Hospital Chiayi City Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Urology Tung’s Taichung MetroHarbor Hospital Taichung County Taiwan Division of General Surgery Department of Surgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan Division of General Surgery Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Survivin is an inhibitor of apoptosis protein and also plays a important role in the development of several malignancies. To investigate the association between survivin promoter –31 G/C (rs9904341) polymorphism and bladder cancer (BC) risk. A total of 200 pathologically confirmed BC cases and 200 unrelated cancer-free controls were recruited in Chiayi Christian Hospital from August 2002 to May 2009. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the –31 G/C polymorphism at survivin promoter region. There was a significant difference in the frequency distribution of survivin promoter –31 G/C polymorphism in BC cases as compared to controls. Among BC cases, individuals with the C/C genotype of survivin promoter have a significantly higher prevalence of invasive (T2-T4) or high-grade (G2-G3) tumors as compared to those who carried the G/G genotype. In conclusion, our findings suggest that the survivin promoter –31 G/C polymorphism was not only associated with clinical stage and pathological grade but also involved in the development of bladder cancer.

关键词： Survivin Bladder Cancer Polymorphism Apoptosis

Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： min Zhou Shi Li Chuan huang School of Life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

Association between human glutathione S-transferase omega rs4925 polymorphism and bladder cancer

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Advances in Bioscience and Biotechnology 2013年第1期4卷 62-66页

作者： Su-Wei Hu Yen-Hao Su zhon-min huang Hsin-An Chen Wei-Tang Kao Yuan-Hung Wang Chia-Chang Wu Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Urology Tung’s Taichung MetroHarbor Hospital Taichung County Taiwan Division of General Surgery Department of Surgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan

Glutathione S-transferases (GSTs) play an important role in the detoxification of polycyclic aromatic hydrocarbons and aromatic amines, the toxic substances contained in cigarettes. GST Omega 1 (GSTO1) not only utilizes glutathione in conjugation reaction but also contributes to the biotransformation of several xenobiotics. A single nucleotide polymorphism (Ala-140Asp) of GSTO1 gene causing variations in enzyme activity may influence individual susceptibility to bladder cancer (BC). It is hypothesized that genetic polymorphism of GSTO1 gene has an effect on BC risk in particular by interacting with cigarette smoking. A total of histopathologically confirmed 300 BC patients and 300 cancer-free controls were recruited from February 2002 to February 2009. Genotyping of the GSTO1 Ala140Asp polymorphism was determined using a polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were calculated as a measure of the combined effect of cigarette smoking and the GSTO1 Ala140Asp polymorphism on BC risk. We found that study subjects with the GSTO1 Ala/Ala genotype have a significantly increased BC risk (OR = 1.5;95% CI = 1.1 - 2.7). A statistically significant increased BC risk was also found in ever smokers with the GSTO1 Ala/Ala genotype (OR = 4.9;95%CI = 2.8 - 9.7). In conclusion, this study provides an epidemiologic evidence of a significantly increased BC risk among ever smokers with the GSTO1 Ala/Ala genotype.

关键词： Bladder Cancer Cigarette Smoking GSTO1 Polymorphism

Discovering deaminases using AlphaFold2:a strategy to search for tool proteins for gene editing

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Signal Transduction and Targeted Therapy 2024年第3期9卷 822-824页

作者： Yongye huang Jianxin Jiang min Wu Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNortheastern UniversityShenyang 110169China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University WenzhouZhejiang 325000China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China The Joint Research Center Affiliated Xiangshan Hospital of Wenzhou Medical UniversityNingboChina

A recent study by huang et *** in Cell reported the application of AlphaFold2 to forecast the structures of deaminase proteins and cluster them based on structural similarity,creating a truncated Sdd that can be used as a cytosine base editor(CBE)to be integrated into a single adeno-associated virus(AAV)1 This ground-breaking study aided by the artificial intelligence system would largely broaden the utility of tool proteins for gene editing.

关键词： CBE Alpha editor

Quantum vector DC magnetometry via selective phase accumulation

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 12-22页

作者： min Zhuang Sijie Chen Jiahao huang Chaohong Lee Institute of Quantum Precision Measurement State Key Laboratory of Radio Frequency Heterogeneous IntegrationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China Laboratory of Quantum Engineering and Quantum Metrology School of Physics and AstronomySun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Precision measurement of magnetic fields is a crucial issue in both fundamental scientific research and practical sensing *** sensitive detection of a vector magnetic field poses a significant challenge in quantum magnetometry,particularly in estimating a vector DC magnetic field with high ***,we propose a comprehensive protocol for quantum vector DC magnetometry,utilizing selective phase accumulation in both non-entangled and entangled quantum *** upon the principles of Ramsey interferometry,our protocol enables the selective accumulation of phase for a specific magnetic field component by incorporating a meticulously designed pulse *** the individual measurement scheme,we employ three individual quantum interferometries to independently estimate each of the three magnetic field ***,in the simultaneous measurement scheme,the application of a pulse sequence along different directions enables the simultaneous estimation of all three magnetic field components using only one quantum ***,by employing an entangled state(such as the Greenberger-Horne-Zeilinger state)as the input state,the measurement precisions of all three components may reach the Heisenberg *** study not only establishes a general protocol for measuring vector magnetic fields using quantum probes,but also presents a viable pathway for achieving entanglement-enhanced multi-parameter estimation.

关键词： magnetometry quantum interferometry entanglement-enhanced quantum metrology

Constraining the Earth-mass Primordial Black Hole Mergers Model of the Non-repeating FRBs Using the First CHIME/FRB Catalog

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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： min Meng Qiu-Ju huang Can-min Deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for q

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter

Digital twin driven and intelligence enabled content delivery in end-edge-cloud collaborative 5G networks

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Digital Communications and Networks 2024年第2期10卷 328-336页

作者： Bo Yi Jianhui Lv Xingwei Wang Lianbo Ma min huang College of Computer Science and Engineering Northeastern UniversityShenyang110169China Pengcheng Lab. Shenzhen518055China College of Software Northeastern UniversityShenyang110819China College of Information Science and Engineering Northeastern UniversityShenyang110819China

The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low ***,these massive devices will lead to explosive traffic growth,which in turn cause great burden for the data transmission and content *** challenge can be eased by sinking some critical content from cloud to *** this case,how to determine the critical content,where to sink and how to access the content correctly and efficiently become new *** work focuses on establishing a highly efficient content delivery framework in the IoE *** particular,the IoE environment is re-constructed as an end-edge-cloud collaborative system,in which the concept of digital twin is applied to promote the *** on the digital asset obtained by digital twin from end users,a content popularity prediction scheme is firstly proposed to decide the critical content by using the Temporal Pattern Attention(TPA)enabled Long Short-Term Memory(LSTM)***,the prediction results are input for the proposed caching scheme to decide where to sink the critical content by using the Reinforce Learning(RL)***,a collaborative routing scheme is proposed to determine the way to access the content with the objective of minimizing *** experimental results indicate that the proposed schemes outperform the state-of-the-art benchmarks in terms of the caching hit rate,the average throughput,the successful content delivery rate and the average routing overhead.

关键词： Digital twin IoE Content delivery Caching Routing

Rice canopy temperature is affected by nitrogen fertilizer

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Journal of Integrative Agriculture 2024年第3期23卷 824-835页

作者： min Jiang Zhang Chen Yuan Li Xiaomin huang Lifen huang zhongyang Huo Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology/Agricultural College Yangzhou UniversityYangzhou 225009China Jiangsu Co-lnnovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009China

Canopy temperature strongly influences crop yield formation and is closely related to plant physiological ***, the effects of nitrogen treatment on canopy temperature and rice growth have yet to be comprehensively examined. We conducted a two-year field experiment with three rice varieties(HD-5, NJ-9108, and YJ-805) and three nitrogen treatments(zero-N control(CK), 200 kg ha~(–1)(MN), and 300 kg ha~(–1)(HN)). We measured canopy temperature using a drone equipped with a high-precision camera at the six stages of the growth period. Generally,canopy temperature was significantly higher for CK than for MN and HN during the tillering, jointing, booting, and heading stages. The temperature was not significantly different among the nitrogen treatments between the milky and waxy stages. The canopy temperature of different rice varieties was found to follow the order: HD-5>NJ-9108>YJ-805, but the difference was not significant. The canopy temperature of rice was mainly related to plant traits, such as shoot fresh weight(correlation coefficient r=–0.895), plant water content(–0.912), net photosynthesis(–0.84), stomatal conductance(–0.91), transpiration rate(–0.90), and leaf stomatal area(–0.83). A structural equation model(SEM) showed that nitrogen fertilizer was an important factor affecting the rice canopy *** study revealed:(1) A suite of plant traits was associated with the nitrogen effects on canopy temperature,(2) the heading stage was the best time to observe rice canopy temperature, and(3) at that stage, canopy temperature was negatively correlated with rice yield, panicle number, and grain number per panicle. This study suggests that canopy temperature can be a convenient and accurate indicator of rice growth and yield prediction.

关键词： canopy temperature rice physiological and biochemical characteristics yield

Time-History Dynamic Characteristics of Reinforced Soil-Retaining Walls

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Structural Durability & Health Monitoring 2024年第6期18卷 853-869页

作者： Lianhua Ma min huang Linfeng Han Department of Building and Environmental Safety Chongqing Vocational Institute of Safety&TechnologyChongqing404120China National Engineering Research Center for Inland Waterway Regulation Chongqing Jiaotong UniversityChongqing400074China

Given the complexities of reinforced soil materials’constitutive relationships,this paper compares reinforced soil composite materials to a sliding structure between steel bars and soil and proposes a reinforced soil constitutive model that takes this sliding into account.A finite element dynamic time history calculation software for composite response analysis was created using the Fortran programming language,and time history analysis was performed on reinforced soil retaining walls and gravity retaining *** vibration time histories of reinforced soil retaining walls and gravity retaining walls were computed,and the dynamic reactions of the two types of retaining walls to vibration were compared and *** dynamic performance of reinforced earth retaining walls was evaluated.

关键词： Reinforced earth retaining walls time history dynamic analysis finite element

Changes in Leaf Stomatal Properties in Rice with the Growing Season

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 807-817页

作者： Jiana Chen Fangbo Cao min huang Rice and Product Ecophysiology Key Laboratory of Ministry of Education for Crop Physiology and Molecular BiologyHunan Agricultural UniversityChangsha410128China National Engineering Research Center of Rice Hunan Agricultural UniversityChangsha410128China

Transplanting rice varieties grown in different seasons can lead to different yields due to different dry matterproduction. Early-season rice varieties transplanted in the late season can obtain high yields with short-growthduration and higher yields driven by higher dry matter production. To make clear the variations in dry matterproduction across seasons, four early-season rice varieties were chosen for late-season transplantation. The grainyield, dry matter accumulation, leaf photosynthetic, and leaf stomatal properties were studied. It was observedthat the average yields of these four varieties in the late season were 33% greater, despite a reduced growth periodof 13 days in comparison with the early season. Furthermore, there was a notable increase in both total and postheadingdry matter production during the late season. The leaf net photosynthetic rate, stomatal area, stomatalwidth, and stomatal length were higher in the late season. Despite no significant difference in stomatal densitybetween seasons, strong positive linear relationships were observed between net photosynthetic rate and stomatalconductance, and between stomatal conductance and area. These relationships demonstrate that the increase ofthe stomatal width and length of the leaves in the late season leads to an increase in the stomatal area, therebyincreasing the stomatal conductance and enhancing the photosynthesis of the leaves. Consequently, this leads togreater dry matter production and a higher yield compared to the early season. Therefore, when breeding newhigh-yielding and short-growing varieties, the large stomatal area can be used as a reference index.

关键词： Photosynthesis rice stomatal properties season yield