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基于红细胞的仿生载体用于光热剂递送和肿瘤光热治疗的研究进展

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中国医药工业杂志 2022年第1期53卷 28-36页

作者：冯之资沈诗洋莫然中国药科大学高端药物制剂与材料研究中心江苏南京210009

光热疗法是一种借助光热剂的光热转换特性,通过升高局部温度杀死肿瘤细胞的新型治疗手段。纳米递送系统的应用能够显著改善光热剂的稳定性和体内分布,提高光热疗法的治疗效率。但人工合成的纳米材料往往存在生物相容性差等安全性问题。... 详细信息

光热疗法是一种借助光热剂的光热转换特性,通过升高局部温度杀死肿瘤细胞的新型治疗手段。纳米递送系统的应用能够显著改善光热剂的稳定性和体内分布,提高光热疗法的治疗效率。但人工合成的纳米材料往往存在生物相容性差等安全性问题。以天然红细胞作为光热剂递送系统能提高生物相容性并延长体内循环时间。将红细胞膜提取并整合至纳米载体表面或以红细胞膜形成的囊泡作为递送载体,也能够降低免疫原性。这类基于红细胞的仿生载体实现了光热剂的高效递送,增强了肿瘤光热疗法的治疗效果。本研究针对红细胞和红细胞膜仿生载体在光热剂递送和肿瘤光热疗法中的相关研究进展进行了归纳总结,以期为相关研究者提供参考和借鉴。

关键词：光热疗法光热剂红细胞红细胞膜仿生载体

铁氮掺杂生物质/聚苯胺衍碳氧还原催化剂研究

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新疆大学学报（自然科学版）（中英文） 2022年第3期39卷 314-322页

作者：姚智子冯欢欢董森李源马俊红新疆大学化工学院新疆乌鲁木齐830017

研究高性价比的非贵金属氧还原反应(ORR)催化剂对清洁能源的大规模开发有重要意义,本研究以聚苯胺(PANI)和生物质废弃物豆渣共同作为碳/氮前驱体材料,g-C_(3)N_(4)为辅助氮源和致孔剂,氯化铁作为氧化剂和铁源制备得到了一种具有多孔结... 详细信息

研究高性价比的非贵金属氧还原反应(ORR)催化剂对清洁能源的大规模开发有重要意义,本研究以聚苯胺(PANI)和生物质废弃物豆渣共同作为碳/氮前驱体材料,g-C_(3)N_(4)为辅助氮源和致孔剂,氯化铁作为氧化剂和铁源制备得到了一种具有多孔结构的铁氮共掺杂生物质/聚苯胺衍碳材料(Fe-N-C_(B)/C_(PANI)).系统考察了氯化铁用量对催化剂样品结构及ORR催化性能的影响,优化后的催化剂样品Fe-N-C_(B)/C_(PANI)-2对ORR具有良好的催化活性,其起始电势相对商业催化剂Pt/C正移50 m V,抗甲醇性能和稳定性明显优于Pt/C.

关键词：氧还原反应催化剂生物质聚苯胺铁氮掺杂碳

Effects of zhizi Chuanxiong Capsule (栀子川芎胶囊) on Abnormal Methylation in Rabbits with Atherosclerosis

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Chinese Journal of Integrative Medicine 2018年第7期24卷 512-517页

作者： ZHOU Qing-bing WU Li-qi ZHANG Yin ZHANG Zhi-fang XU feng-qin Institute of Geriatric Medicine Xiyuan Hospital China Academy of Chinese Medical Sciences

Objective： To investigate the effects of zhizi Chuanxiong Capsule（ZCC, 栀子川芎胶囊） on abnormal DNA methylation in a rabbit model of atherosclerosis（AS）. Methods： After 1 week of adaptive feeding, 48 New Zealand white rabbits were randomly divided into 4 groups： a control group（n=12） fed with normal diet for 22 weeks; a model group（n=12） fed with high fat diet for 14 weeks followed by 8 weeks of normal diet feeding; a low-dose ZCC group（n=12） fed with high fat diet and low-dose ZCC for 14 weeks, followed by 8 weeks of normal diet and low-dose drug; a high-dose ZCC group（n=12） fed with high fat diet and high-dose drug for 14 weeks, followed by 8 weeks of normal diet and high-dose drug. After 22 weeks of feeding, blood samples were taken from the rabbit ear vein, and the genomic DNA was extracted for methylation immunoprecipitation sequencing（Medip-seq）. The aorta tissues were collected for hematoxylin-eosin（HE） staining. Results： Eight rabbits died during the feeding process. HE staining showed that the size of the lipid deposition on vessel wall and atherosclerotic plaque formation were reduced in both low-and high-dose group. The Medip-seq results showed that there were 146 abnormally methylated genes（including both hypermethylated gene and hypomethylated genes） in the model group, compared with the control group. Gene Ontology（GO） and Pathway analysis showed that these abnormally methylated genes were found to be involved in multiple AS-related functions and pathways, such as protein kinase C activity, cholesterol transport, mitogen-activated protein kinase（MAPK） signaling pathway, peroxisome proliferater-activated receptor signaling pathway, vascular smooth muscle contraction, inflammation and so on. The abnormal methylated genes in AS model group were altered in both low-and high-dose groups： low-dose ZCC could change 72 of the 146 abnormally methylated genes, highdose ZCC could change 71. Through GO and Pathway analysis, these altered methylated genes were involved

关键词： detoxifying and activating blood circulation atherosclerosis methylation stasis and toxin zhizi Chuanxiong capsule

栀子甘草豉汤的LC-PDA-MS/MS分析及抗抑郁作用研究

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中国药科大学学报 2009年第4期40卷 342-347页

作者：乐文冯芳王娅中国药科大学药物分析教研室南京210009

目的:建立栀子甘草豉汤的LC-PDA-MS/MS分析方法,研究该传统经方的化学组成;初步探讨该经方的抗抑郁作用。方法:通过LC-PDA-MS/MS系统分离分析化合物,色谱柱为ODS C18柱(250 mm×4.6 mm,5μm);流动相为1%乙酸水溶液和甲醇;梯度洗脱;利用E... 详细信息

目的:建立栀子甘草豉汤的LC-PDA-MS/MS分析方法,研究该传统经方的化学组成;初步探讨该经方的抗抑郁作用。方法:通过LC-PDA-MS/MS系统分离分析化合物,色谱柱为ODS C18柱(250 mm×4.6 mm,5μm);流动相为1%乙酸水溶液和甲醇;梯度洗脱;利用ESI-MS/MS技术和UV特征光谱归属主要色谱峰对应的化合物;采用小鼠悬尾实验(TST)和强迫游泳实验(FST)模型,考察栀子甘草豉汤的抗抑郁作用。结果:有效分离了栀子甘草豉汤中的成分,鉴定出其中10个化合物,这些成分分别属于环烯醚萜苷类、黄酮类和三萜皂苷类;首次发现该经方在小鼠悬尾和强迫游泳模型中具有抗抑郁作用。结论:LC-PDA-MS/MS方法能有效分离和鉴定栀子甘草豉汤中的主要化学成分;栀子甘草豉汤具有抗抑郁作用,其药效物质成分与已识译出的化学成分群之间的关系有待进一步探讨。

关键词：栀子甘草豉汤化学成分 LC-PDA-MS/MS 抗抑郁

Effect of Tongluojiunao injection made from Sanqi(Radix Notoginseng) and zhizi(Fructus Gardeniae) on brain microvascular endothelial cells and astrocytes in an in vitro ischemic model

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Journal of Traditional Chinese Medicine 2014年第6期34卷 725-732页

作者： Weihong Li Xingguang Li Qinghong Du feng Li Yuan zhu Yang Liu Jie Ma Liangqin Wan Fanghe Li Sai Zhang School of Preclinical Medicine Beijing University of Chinese Medicine Encephalopathy Center Jiangsu Province Hospital of Traditional Chinese Medicine Medical Affairs Novartis Pharmaceuticals (China)

OBJECTIVE: To explore the effect of Tongluojiunao injection(TLJN) prepared with Sanqi(Radix Notoginseng) and zhizi(Fructus Gardeniae) on the interaction between brain microvascular endothelial cells(BMECs) and astrocytes in an in vitro ischemic ***: First, an in vitro model of cerebral ischemia in BMECs or astrocytes was established by oxygen-glucose deprivation(OGD). TLJN was used as a medicine of intervention. The OGD-injuredBMECs were cultured in various astrocyte-conditioned media. Cell activity, alkaline phosphatase(AKP) and γ-glutamyl transpeptidase(γ-GT) activity,interleukin-1 beta(IL-1β), and tumor necrosis factor alpha(TNF-α) content in BMECs were ***, OGD-injured astrocytes were cultured in various BMEC-conditioned media. Cell activity, as well as expression of brain-derived neurotrophic factor(BDNF) and glial cell-derived neurotrophic factor(GDNF) in astrocytes, were ***: The results of paracrine signaling of normal BMECs or astrocytes showed a protective effect on each other: conditioned media from normal astrocytes improved cell viability, AKP, and γ-GT activity, and reduced IL-1β and TNF-α content of injured BMECs; conditioned media from normal BMECs improved cell viability and expression of BDNF and GDNF in injured astrocytes. However, once the BMECs or astrocytes were injured by OGD, the protective effect decreased or disappeared. The above-mentioned protective induction was effectively recovered by TLJN ***: The therapeutic benefit of TLJN was achieved by recovering two-way induction between BMECs and astrocytes, enhancing activity of injured BMECs and astrocytes, stabilizing enzymatic barriers, promoting expression of neurotrophic factors, and inhibiting inflammatory cytokines.

关键词： Endothelial cells Astrocytes Paracrine communication Oxygen-glucose-deprivation Ton-gluojiunao injection

A randomized controlled clinical study on treatment of hand, foot and mouth disease in children with Reduning injection

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Chinese Medical Journal 2013年第13期126卷 2585-2586页

作者： XU Hua-shan ZHUO Zhi-qiang CHEN Bao-chuan J1NG Jiao ZHAO Guo-rong WU Jun-feng XIAO Wei Quanzhou Children's Hospital Teaching Hospital of Fujian Medical University Quanzhou Fujian 362000 China Jiangsu Kangyuan Pharmaceutical Corporation Ltd. Lianyungang Jiangsu 22200 I China

Hand, foot and mouth disease （HFMD） has become a major public health problem in China since 2008,which has been widely prevalent in children under 5 years of age. According to the data of the Ministry of Health, the number of cases with HFMD exceeded 1 million during the recent 4 years. The major etiologic agent of HFMD is enterovirus 71 and coxsackievirus A 16. The main clinical manifestations of the disease include fever, maculopapular skin vesicles on the hand, foot and buttock, oral herpes, ulcer; ation severe cases there can be central nervous system infection and/or pulmonary hemorrhage, which are mostly caused by EV71 and may be life-threatening with a fatality rate of 0.3 to 0.5 per thousand cases. There are no specific antiviral drugs, nor vaccine against EV71.~ The difficult problem of the treatment is how to reduce the severe cases and mortality. Reduning injection is a preparation of traditional Chinese herbal medicine composed of Qinghao （Artemisiae annuae）, Jinyinhua （Flos lonicerae） and zhizi （Gardenia jasminoides）, which was listed among the therapies for HFMD in the 2010 guidelines of the Ministry of Health for diagnosis and treatment of HFMD.2 We now reported the results of our study on the efficacy of Reduning injection in treatment of 81 patients with HFMD. We selected 81 cases who were inpatients treated in 2010 in the Department of Infectious Diseases of Quanzhou Chidren＇s Hospital. The inclusion criteria were as follows： 1. Patients who met either the clinical diagnostic criteria for HFMD ordinary clinical type or the clinical diagnostic criteria for confirmed cases of HFMD （etiologically confirmed cases must account for more than 1/3 of the cases）. 2. The axillary temperature is _〉37.5~C, within 48 hours after onset of the disease; 3. Skin changes such as the rashes and vesicles occurred in no more than 48 hours; 4. Range of age is between 1 and 13 years; 5. Patients or their parents or guardians are willing to participate in the study and si

关键词： hand foot and mouth disease Reduning injection children

Network pharmacology studies on Reduning injection in treatment of COVID-19

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Asian Toxicology Research 2020年第3期2卷 85-96页

作者： Zhi-Hua Yang Yi-Hua Fan Yi-Fei Ma Ping Xin Yuan-Yuan Liu Lin Wang Hai-feng Yan Ting-Ting Lv First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China The Fourth Clinical Medical College of Xinjiang Medical University Urumqi 830000China Tianjin University of Traditional Chinese Medicine Tianjin301617China Jiangsu College of Nursing Huai’an 223005China

Background:Network pharmacology was used to explore the mechanism of the Chinese patent medicine Reduning injection in the treatment of corona virus disease ***:The chemical constituents and targets of Qinghao(Artemisiae annuae herba),Jinyinhua(Lonicerae japonicae flos),zhizi(Gardeniae fructus)in the Chinese patent medicine Reduning injection were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the target related to corona virus disease 2019 was searched in GeneCards database,then perform Venn analysis on the targets of corona virus disease 2019 and the Chinese patent medicine Reduning injection,to screen the compounds and targets of the Chinese patent medicine Reduning injection in the treatment of corona virus disease *** String platform was used to construct the protein-protein interaction network,and key targets were *** 3.5.1 was used to construct the active traditional Chinese medicine-chemical composition-target-disease network to screen the key active components,and the gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed on the common target through DAVID(6.8)online analysis data tool to predict the mechanism of ***:Fifty-two active ingredients and 232 targets were selected from the Chinese patent medicine Reduning injection,including 44 targets related to corona virus disease 2019.A total of 310 gene ontology biological processes and 94 Kyoto Encyclopedia of Genes and Genomes signaling pathways were obtained,which were mainly involved in inflammation,viral infection,bacterial infection,immune response and substance metabolism,et ***:The mechanism of the Chinese patent medicine Reduning injection in the treatment of corona virus disease 2019 may be related to antivirus,bacteriostasis,anti-inflammatory and antifebrile,immune regulation and metabolism regulation,et al.

关键词： Network pharmacology SARS-CoV-2 Reduning injection COVID-19

栀子厚朴汤配伍变化对柚皮素与橙皮素药代动力学的影响

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中国药科大学学报 2011年第5期42卷 431-435页

作者：孙丽丽冯芳赵孝蕊中国药科大学药物分析教研室南京210009 中国药科大学药物质量与安全预警教育部重点实验室南京210009

研究大鼠灌胃给予枳实、枳实-栀子、枳实-厚朴和栀子厚朴汤4种配伍汤剂后柚皮素与橙皮素在血浆中的药代动力学。将SD大鼠随机分为4组,分别灌胃枳实、枳实-栀子、枳实-厚朴、栀子厚朴汤剂10.83 mL/kg,采用HPLC法测定各汤剂给药后的血药浓... 详细信息

研究大鼠灌胃给予枳实、枳实-栀子、枳实-厚朴和栀子厚朴汤4种配伍汤剂后柚皮素与橙皮素在血浆中的药代动力学。将SD大鼠随机分为4组,分别灌胃枳实、枳实-栀子、枳实-厚朴、栀子厚朴汤剂10.83 mL/kg,采用HPLC法测定各汤剂给药后的血药浓度,计算药代动力学参数。结果表明4种不同配伍方给药后,柚皮素与橙皮素的药代动力学参数有差异。栀子厚朴汤不同配伍对柚皮素与橙皮素在大鼠血浆中的药代动力学存在不同的影响。栀子或厚朴能够延缓柚皮素与橙皮素的达峰时间;厚朴能够显著地增加橙皮素的AUC0-24 h;枳实、栀子、厚朴3味药材共同配伍应用时减少了柚皮素与橙皮素的达峰时间,使柚皮素的AUC0-24 h降低,同时使橙皮素的AUC0-24 h增加,但增加程度低于枳实-厚朴组。实验结果显示药材配伍对相同成分的药代动力学行为有影响。

关键词：栀子厚朴汤配伍柚皮素橙皮素 HPLC 药代动力学

A Feasible Strategy for Quantitative Determination of Different Structural Type Multi-components in zhizi Jinhua Pill

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A Feasible Strategy for Quantitative Determination of Differ...