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Numerical Validations of the Tangent Linear Model for the Lorenz Equations

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Computer Modeling in Engineering & Sciences 2019年第7期120卷 83-104页

作者： Tengjin Zhao Jing zhang Zhilin Li zhiyue zhang School of Mathematical Sciences Jiangsu Provincial Key Laboratory for Numerical Simulation of Large Scale Complex SystemsNanjing Normal UniversityNanjing210023China Department of Mathematics North Carolina State UniversityRaleighNC 27695-8205USA

The validity of the tangent linear model(TLM)is studied numerically using the example of the Lorenz equations in this *** relationship between the limit of the validity time of the TLM and initial perturbations for the Lorenz equations is investigated using the Monte Carlo sampling method.A new error function between the nonlinear and the linear evolution of the perturbations is ***,numerical sensitivity analysis is carried to establish the relationship between parameters and the validity of the TLM,such as the initial perturbation,the prediction time,the time step size and so on,by the method of mathematical statistics.

关键词： Lorenz model tangent linear model nonlinear model Monte Carlo

Release characteristics of mercury in chemical looping combustion of bituminous coal

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Journal of Environmental Sciences 2020年第8期32卷 197-203页

作者： Ling Ji Qianwen Wang zhiyue zhang Hao Wu Changsong Zhou Hongmin Yang Engineering Laboratory of Energy System Process Conversion and Emission Reduction Technology of Jiangsu Province School of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210042PR China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast UniversityNanjing210096China

This study evaluated the release characteristics of mercury from bituminous coal in chemical looping combustion(CLC)using Australian iron ore as the oxygen carrier in a fixed bed *** effects of several parameters,such as temperature in the fuel reactor(FR)and air reactor(AR),gasification medium in the FR,and reaction atmosphere in the AR,on mercury release characteristics,were *** mercury speciation and release amount in the FR and AR under different conditions were further *** results indicate that most of the mercury in coal was released in the FR,while the rest of it was released in the ***0 was found to be the major species in the released *** results also indicate that a higher temperature in the FR led to an increase in the total mercury release amount and a decrease in Hg0 ***,a higher temperature in the AR resulted in a decrease in the total mercury release amount and Hg 0 *** increase in the H2O/CO2 ratio of gasification mediums in the FR was beneficial for the increase in the total mercury release amount and Hg 0 proportion.A higher O2 concentration in reaction atmosphere in AR had a negligible effect on the total mercury release amount,but a positive effect on Hg0 oxidization.

关键词： Chemical looping combustion Mercury Release amount Distribution

Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis

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Asian Journal of Pharmaceutical Sciences 2018年第3期13卷 229-238页

作者： Xiuping zhang Yang Shi zhiyue zhang Zhenlei Yang Guihua Huang Department of Pharmaceutical Science Shandong University

Tetramethylpyrazine(TMP) is a traditional Chinese herbal medicine with strong antiinflammatory and cartilage protection activities, and thus a promising candidate for treating osteoarthritis. However, TMP is rapidly cleared from the joint cavity after intra-articular injection and requires multiple injections to maintain efficacy. The aim of this study was to encapsulate TMP into poly(lactic-co-glycolic acid)(PLGA) microspheres to enhance the TMP retention in the joint, reducing injection frequencies and decreasing dosage. TMP microspheres were prepared by emulsion/solvent evaporation method. The intra-articular retention of the drug was assessed by detecting the drug concentration distributed in the joint tissue at different time points. The therapeutic effect of TMP microspheres was evaluated by the swelling of knee joints and histologic analysis in papain-induced OA rat model. The prepared freezedried microspheres with a particle size of about 10 μm can effectively prolong the retention time of the drug in the articular cavity to 30 d, which is 4.7 times that of the TMP ***-articular injection of TMP microspheres efficiently relieved inflammatory symptoms,improved joint lesions and decreased the depletion of proteoglycan. In conclusion, intraarticular injection of TMP loaded microspheres was a promising therapeutic method in the treatment of OA.

关键词： Osteoarthritis Tetramethylpyrazine Intra-articular injection PLGA microspheres Retention Pharmacodynamics

Effects of dietary Clostridium butyricum and rumen protected fat on meat quality,oxidative stability,and chemical composition of finishing goats

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Journal of Animal Science and Biotechnology 2024年第2期15卷 911-924页

作者： Meimei zhang zhiyue zhang Xinlong zhang Changming Lu Wenzhu Yang Xiaolai Xie Hangshu Xin Xiaotan Lu Mingbo Ni Xinyue Yang Xiaoyang Lv Peixin Jiao College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030People’s Republic of China Lethbridge Research and Development Centre Lethbridge T1J 4B1Canada School of Agriculture and Food Sciences The University of QueenslandGattonQLD 4343Australia International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement Yangzhou 225009China

Background Clostridium butyricum(CB)is a probiotic that can regulate intestinal microbial composition and improve meat *** protected fat(RPF)has been shown to increase the dietary energy density and provide essential fatty ***,it is still unknown whether dietary supplementation with CB and RPF exerts beneficial effects on growth performance and nutritional value of goat *** study aimed to investigate the effects of dietary CB and RPF supplementation on growth performance,meat quality,oxidative stability,and meat nutritional value of finishing ***-two goats(initial body weight,20.5±0.82 kg)were used in a completely randomized block design with a 2 RPF supplementation(0 vs.30 g/d)×2 CB supplementation(0 vs.1.0 g/d)factorial treatment *** experiment included a 14-d adaptation and 70-d data and sample collection *** goats were fed a diet consisted of 400 g/kg peanut seedling and 600 g/kg corn-based concentrate(dry matter basis).Result Interaction between CB and RPF was rarely observed on the variables measured,except that shear force was reduced(P<0.05)by adding CB or RPF alone or their combination;the increased intramuscular fat(IMF)content with adding RPF was more pronounced(P<0.05)with CB than without CB *** pH24h(P=0.009),a*values(P=0.007),total antioxidant capacity(P=0.050),glutathione peroxidase activities(P=0.006),concentrations of 18:3(P<0.001),20:5(P=0.003)and total polyunsaturated fatty acids(P=0.048)were increased,whereas the L*values(P<0.001),shear force(P=0.050)and malondialdehyde content(P=0.044)were decreased by adding ***,CB supplementation increased essential amino acid(P=0.027),flavor amino acid(P=0.010)and total amino acid contents(P=0.024)as well as upregulated the expression of lipoprotein lipase(P=0.034)and peroxisome proliferator-activated receptorγ(PPARγ)(P=0.012),and downregulated the expression of stearoyl-CoA desaturase(SCD)(P=0.034).The RPF supplementation increased dry

关键词： Chemical composition Clostridium butyricum Goats Meat quality Oxidative stability Rumen protected fat

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有限体积元数值方法在大气污染模式中的应用

计算物理 2009年第5期26卷 656-664页

作者：王平张志跃南京师范大学数学科学学院江苏南京210046 连云港师范高等专科学校数学系江苏连云港222006

运用有限体积元方法分析求解大气污染模型问题,分别选取试探函数空间和检验函数空间为一次元函数空间和分片常数函数空间,并且给出L2估计和H1估计,通过数值实验与有限差分方法进行分析与比较,说明其有效性.为改善大气污染问题的模拟提... 详细信息

运用有限体积元方法分析求解大气污染模型问题,分别选取试探函数空间和检验函数空间为一次元函数空间和分片常数函数空间,并且给出L2估计和H1估计,通过数值实验与有限差分方法进行分析与比较,说明其有效性.为改善大气污染问题的模拟提供实用有效的方法.

关键词：大气污染模型有限体积元方法 L2估计 H1估计

Krill oil activates NRF2 to prevent diabetic endothelial injury in part through astaxanthin-induced inhibition of KEAP1

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Food Science and Human Wellness 2024年

作者： Huali Meng Xiaoli Huang Jian Zhou Yan Zheng Lei Du Hui Li zhiyue zhang Linlin Xu Hao Wu Department of Nutrition and Food Hygiene， School of Public Health， Cheeloo College of Medicine， Shandong University Research Center of Translational Medicine， Jinan Central Hospital， Shandong University Department of Nutrition， Qilu Hospital， Cheeloo College of Medicine， Shandong University Medical Center of Gastrointestinal Surgery， Weifang People's Hospital NMPA Key Laboratory for Technology Research and Evaluation of Drug Products， Key Laboratory of Chemical Biology (Ministry of Education)， Department of Pharmaceutics， School of Pharmaceutical Sciences， Cheeloo College of Medicine， Shandong University Department of Neurology， The Second Hospital， Cheeloo College of Medicine， Shandong University

Objective: Diabetes mellitus (DM) is a severe chronic disease that results in high morbidity and mortality. DM causes endothelial injury， such as endothelial inflammation， oxidative stress and dysfunction， as a basis for cardiovascular complications of DM. Therefore， blockage of DM-induced endothelial injury (DEI) is a viable strategy for the prevention of DM-caused adverse outcomes. However， few effective approaches have been developed for the intervention of DEI. Krill oil (KO) has been reported to have anti-inflammatory and anti-oxidative activities， but its effect on DEI is unknown. Hence， the aims of this study were to investigate the effect and molecular mechanism of KO on ***: To investigated the preventive effect of krill oil (KO) on DEI， streptozotocin and high-fat diet-induced mice model of type 2 DM were fed with KO for 6months. RNA sequencing for endothelial cells (ECs) was used to explore the mechanism of KO’s protective function. To clarify the role of NRF2 signaling in KO’s protective function on DEI， KO was given to Nfe2l2 gene-silenced ECs or knockout mice. Molecular docking assay and surface plasmon resonance assay were carried out to reveal the ability of the main components of KO to bind KEAP1. Results: KO significantly alleviated DEI and aortic pathological injury in the wild-type diabetic mice. RNA sequencing revealed that KO dramatically activated nuclear factor erythroid 2-related factor 2 (Nfe2l2/NRF2) antioxidant signaling in high glucose-challenged ECs， the effect of which was further confirmed in the diabetic aortas. Nfe2l2 gene deletion or silencing completely abolished KO’s protection against DEI in vivo and in vitro， demonstrating that NRF2 was required for KO’s action. Further， molecular docking assay and surface plasmon resonance assay identified that KO’s functional component astaxanthin (AST)， but not docosahexaenoic acid and eicosapentaenoic acid， was able to bind the Kelch domain of Kelch like ECH associated protein 1 (KE

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一类非线性发展方程的特征中心差分法

计算物理 2007年第6期24卷 637-646页

作者：郭双冰张志跃南京师范大学数学与计算机科学学院江苏南京210097

给出一类非线性发展方程的特征中心差分法,分别得到非规则网格上的位移u、速度ut及其对空间变量x的一阶导数项的差分解和误差估计.所讨论方法的计算量与基于线性插值的特征差分法相当,其近似解与基于二次插值的特征差分法的近似解具有... 详细信息

给出一类非线性发展方程的特征中心差分法,分别得到非规则网格上的位移u、速度ut及其对空间变量x的一阶导数项的差分解和误差估计.所讨论方法的计算量与基于线性插值的特征差分法相当,其近似解与基于二次插值的特征差分法的近似解具有相同阶的误差估计,u,ut对空间变量x的一阶导数近似均具有超收敛误差估计.数值试验说明了该方法的可行性和有效性.

关键词：非线性发展方程特征中心差分法误差估计