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Somatic CDKN2A copy number variations are associated with the prognosis of esophageal squamous cell dysplasia

Chinese Medical Journal 2024年第8期137卷 980-989页

作者： zhiyuan fan Jing Zhou Yuan Tian Yu Qin Zhaojun Liu Liankun Gu Sanford M.Dawsey Wenqiang Wei Dajun Deng National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(MOE/Beijing) Division of EtiologyPeking University Cancer Hospital and InstituteBeijing 100142China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMDUSA Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211166China

Background:Somatic copy number variations(SCNVs)in the CDKN2A gene are among the most frequent events in the dysplasia-carcinoma sequence of esophageal squamous cell ***,whether CDKN2A SCNVs are useful biomarkers for the risk stratification and management of patients with esophageal squamous cell dysplasia(ESCdys)is *** study aimed to investigate the characteristics and prognostic value of CDKN2A SCNVs in patients with mild or moderate(m/M)***:This study conducted a prospective multicenter study of 205 patients with a baseline diagnosis of m/M ESCdys in five high-risk regions of China(Ci County,Hebei Province;Yanting,Sichuan Province;Linzhou,Henan Province;Yangzhong,Jiangsu Province;and Feicheng,Shandong Province)from 2005 to *** DNA was extracted from paraffin biopsy samples and paired peripheral white blood cells from patients,and a quantitative polymerase chain reaction assay,P16-Light,was used to detect CDKN2A copy *** cumulative regression and progression rates of ESCdys were evaluated using competing risk ***:A total of 205 patients with baseline m/M ESCdys were *** proportion of ESCdys regression was significantly lower in the CDKN2A deletion cohort than in the diploid and amplification cohorts(18.8%[13/69]vs.35.0%[28/80]vs.51.8%[29/56],P<0.001).In the univariable competing risk analysis,the cumulative regression rate was statistically significantly lower(P=0.008),while the cumulative progression rate was higher(P=0.017)in ESCdys patients with CDKN2A deletion than in those without CDKN2A ***2A deletion was also an independent predictor of prognosis in ESCdys(P=0.004)in the multivariable ***:The results indicated that CDKN2A SCNVs are associated with the prognosis of ESCdys and may serve as potential biomarkers for risk stratification.

关键词： Somatic copy number variations Esophageal squamous cell carcinoma Esophageal neoplasms Squamous intraepithelial lesions DNA copy number variations Prognosis Prospective study

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Novel DNA methylation markers for early detection of gastric cardia adenocarcinoma and esophageal squamous cell carcinoma

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Science China Life Sciences 2024年

作者： zhiyuan fan Jiajie Hao Feifan He Hao Jiang Jinwu Wang Minjuan Li Xinqing Li Ru Chen Wenqiang Wei Office of National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Linzhou Cancer Hospital Department of Orthopedic Surgery Beijing Jishuitan HospitalCapital Medical University Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University

Gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC) present significant health challenges in China,often diagnosed at advanced stages with poor ***,effective biomarkers for early detection remain *** study aimed to integrate methylome and transcriptome data to identify DNA methylation markers for the early detection of GCA and *** the discovery stage,we conducted Infinium MethylationEPIC array analysis on 36 paired GCA and non-tumor adjacent tissues (NAT),identifying differentially methylated CpG sites (DMCs) between GCA/ESCC and NAT through combined analyses of in-house and publicly available *** the validation stage,targeted pyrosequencing and quantitative real-time RT-PCR were performed on paired tumor and NAT samples from 50GCA and 50 ESCC *** the application stage,an independent set of 438 samples,including GCA,ESCC,high-and low-grade dysplasia(HGD/LGD),and normal controls,was tested for selected DMCs using *** analysis validated three GCA-specific,two ESCC-specific,and one tumor-shared DMCs,exhibiting significant hypermethylation and decreased expression of target genes in tumor samples compared with *** these DMCs,we developed a GCA-specific 4-marker panel (cg27284428,cg11798358,cg07880787,and cg00585116) with an area under the receiver operating characteristic curve (AUC) of 0.917,effectively distinguishing between cardia HGD/GCA patients and cardia LGD/normal ***,an ESCC-specific 3-marker panel (cg14633892,cg04415798,and cg00585116)achieved an AUC of 0.865 in distinguishing esophageal HGD/ESCC ***,integrating cg00585116,age,and alcohol consumption yielded a tumor-shared logistic model with good discrimination for two cancer/HGD (AUC,0.767;95%confidence interval,0.720–0.813).The mean AUC of the model after 5-fold cross-validation was *** summary,our study identifies novel DNA methylation markers capable of accurately distinguishing

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基于相关变分模态分解和CNN-LSTM的变压器油中溶解气体体积分数预测

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高电压技术 2024年第1期50卷 263-273,I0020页

作者：范志远杜江河北省电磁场与电器可靠性重点实验室(河北工业大学) 天津300130 省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学) 天津300130

为解决变压器油中溶解气体实际监测数据中噪声信号对模型预测性能的影响以及单一长短期记忆神经网络(long short-term memory,LSTM)无法对数据间的深层特征进行有效提取的问题,提出了一种融合了相关变分模态分解(correlation variationa... 详细信息

为解决变压器油中溶解气体实际监测数据中噪声信号对模型预测性能的影响以及单一长短期记忆神经网络(long short-term memory,LSTM)无法对数据间的深层特征进行有效提取的问题,提出了一种融合了相关变分模态分解(correlation variational mode decomposition,CVMD)、1维卷积神经网络(one dimensional convolutional neural network,1D-CNN)和LSTM的组合预测模型。首先,利用CVMD去除原始气体序列中的噪声信号,并将去噪序列分解为1组相对平稳的子序列分量;然后,针对各子序列分量分别构建CNN-LSTM预测模型,利用1D-CNN挖掘数据间的深层特征形成特征向量,并将其输入到LSTM中进行预测;最后,对各子序列预测结果叠加重构,得到最终的气体预测值。并通过4组对比实验对所提模型进行了全方位、多角度的验证。算例研究结果表明,所提模型单步和多步预测的平均绝对百分比误差分别为1.53%和2.09%。相较于现有模型,该文所提模型在单步和多步预测性能上均有明显提升,为变压器在线监测和故障预警提供了重要技术支撑。

关键词：油中溶解气体相关变分模态分解 1维卷积神经网络长短期记忆神经网络气体体积分数预测

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Texture Evolution Behavior and Its Triggered Mechanical Anisotropy of CP Ti During Severe Cold Rolling and Subsequent Annealing

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1271-1282页

作者： Xiaohui Shi Zuhan Cao zhiyuan fan Junwei Qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

The texture evolution behavior and its triggered mechanical anisotropy of commercially pure titanium(CP Ti) during severe cold rolling and subsequent annealing are discussed based on the optical microscopy and the electron backscattered diffraction analyses. Some enlightening results are found. It is shown that planar textures exist under all treatments, namely the {11–29} under rolling state, the {11–27} under 300 °C annealing state and the {11–24} under 500 °C annealing state. This indicates that the crystal plane indices of planar texture change toward {-12–10} with increasing annealing temperature, which is a result of crystal lattice rotation. Planar texture triggers anisotropy of the mechanical properties for CP Ti sheets under all treatments. In particular, CP Ti sheets exhibit severe and similar anisotropy behavior under rolling and 300 °C annealing states. Generally speaking, the rolling direction(RD) specimens get relatively low yield strength, high ultimate tensile strength and good plasticity, and RD + 45° specimens show relatively high yield strength, low ultimate tensile strength and good plasticity. The transverse direction specimens, however, usually exhibit high yield strength and low plasticity. It is proved that the above anisotropy behavior is mainly determined by the Schmid factor distribution of the(10–10)[11–20] prismatic slip system in different directions. Due to the non-negligible influence exerted by the(0001)[11–20] basal slip system after 500 °C annealing, the anisotropy behavior under this state is obviously different.

关键词： Titanium Texture Severe cold rolling Annealing Anisotropy Schmid factor

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YB417C侧开式硬盒包装机内衬纸烟包自动装填装置的设计

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烟草科技 2024年第7期57卷 97-103页

作者：谭仕威范智源吴建军杨牧宸苏勇达上海烟草机械有限责任公司上海市201206 中国烟草机械集团有限责任公司北京市100055

为解决异型包装卷烟人工包装方式存在生产成本高、物料消耗大等问题,基于YB417C侧开式硬盒包装机的工艺流程,针对内衬纸烟包不完全包裹、未固定成型的特点,设计了一种内衬纸烟包自动装填装置。通过设计模盒、烟包料斗以及凸轮运动规律,... 详细信息

为解决异型包装卷烟人工包装方式存在生产成本高、物料消耗大等问题,基于YB417C侧开式硬盒包装机的工艺流程,针对内衬纸烟包不完全包裹、未固定成型的特点,设计了一种内衬纸烟包自动装填装置。通过设计模盒、烟包料斗以及凸轮运动规律,实现了将内衬纸烟包平稳、无损地装填入侧开式烟盒中。以上海烟草集团有限责任公司生产的“中华(金中支)”牌卷烟为对象对该装置进行测试,结果表明:该装填装置运行稳定可靠,运动规律符合设计要求,能够满足200包/min的生产速度要求,运行效率达到98.8%;在侧开式硬盒成型工艺流程中因装填装置引起的故障停机次数不超过1次/班次,避免了烟支损伤和散落。该技术可为提高卷烟包装设备生产效率和质量提供支持。

关键词： YB417C侧开式硬盒包装机内衬纸烟包烟组装填装置凸轮连杆机构

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Probing into the Yield Plateau Phenomenon in Commercially Pure Titanium During Tensile Tests

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 701-709页

作者： Xiaohui Shi Zuhan Cao zhiyuan fan Ruipeng Guo Junwei Qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China

To explain the intrinsic mechanism of the yield plateau phenomenon in commercially pure titanium,the tensile behaviors of commercially pure titanium specimens after 91.6%cryorolling and subsequent annealing at 280℃,335℃,450℃and 600℃have been *** results show that the yield plateau phenomenon is a result of dislocation behaviors controlled by grain size and thus only exists within a given range of mean grain size.αgrain boundaries are the main dislocation multiplication sources of commercially pure ***-grained microstructure could offer numerous dislocation multiplication locations during *** the applied stress is above the yielding strength,dislocations multiply rapidly and the mobile dislocation density is *** retrieve the imposed strain rate,the mean dislocation velocity is bound to be ***,it takes time for them to interact with each *** a result,the movement of dislocations is hardly blocked and the deformation could continue at a nearly constant applied ***,the so-called yield plateau behavior presents in the tensile *** disappearance of yield plateau phenomenon in coarse-grained and ultrafi ne-grained microstructures is attributed to the quick realization of the mutual interactions among dislocations at the initial stage of tensile test.

关键词： Yield plateau Commercially pure titanium Tensile test Grain size Dislocation

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Crashworthiness Optimization of Steel-Magnesium Hybrid Double-Hat-Shaped Tubes

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Automotive Innovation 2018年第3期1卷 247-254页

作者： Guojun Zheng zhiyuan fan Hui Zhang Ping Zhou School of Automotive Engineering Dalian University of TechnologyDalian 116024China German Aerospace Centre(DLR)-Institute of Vehicle Concepts Pfaffenwaldring 38-4070569 StuttgartGermany

The double-hat-shaped magnesium tube was difficult to use in actual applications due to its frangible material *** alloy and traditional steel were integrated into a new hybrid thin-walled double-hat-shaped tube to improve vehicle *** classes of hybrid tubes were examined,namely Hybrid-I(steel top hat and magnesium alloy bottom hat)and Hybrid-II(magnesium alloy top hat and steel bottom hat).The energy absorption characteristics and crashworthiness optimization of the thin-walled hybrid structures were investigated under three-point bending conditions through experiments and ***-objective optimization design for the two hybrid tubes was implemented to elucidate their lightweight *** showed that the specific energy absorption of Hybrid-I tube and Hybrid-II tube was approximately 44.7%and 12.7%higher than that of the double-hat-shaped DC04 tube,*** Hybrid-I tube had better crashworthiness and lightweight properties compared with Hybrid-II ***-I tube also had better lightweight properties than single-material steel tube and reduced wall thickness compared with magnesium alloy tube.

关键词： Lightweight design Magnesium alloy Hybrid double-hat-shaped tube Crashworthiness Steel

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Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

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Nano Research 2018年第10期11卷 5573-5583页

作者： zhiyuan fan Peter Y. Li Junjie Deng Stephen C. Bady Hao Cheng Department of Materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 USA Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences Wenzhou 325011 China

The controlled release of therapeutics from microparticles or nanoparticles （NPs） has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may induce inflammatory and foreign body responses to scaffold constructs, limiting their applications. Here we show that widely used poly（lactic-co-glycolic acid） nanoparticles （PLGA NPs） formed by double emulsion dramatically increased neutrophil infiltration and pro-inflammatory cytokines in alginate scaffolds 1 day after the subcutaneous injection of the scaffolds into mice. The coating of red blood cell （RBC） membranes on PLGA NPs completely eliminated these short-term inflammatory responses. For a longer term of 10 days, neither PLGA NPs nor RBC membrane-coated NPs exerted a significant effect on the infiltration of neutrophils or macrophages in alginate scaffolds, possibly due to the degradation and/or clearance of NPs by infiltrating cells. Despite the extensive exploration of cell membrane-coated NPs, our study is the first to investigate the effects of cell membrane coating on foreign body reaction to NPs. By harnessing the natural biocompatibility of cell membranes, our strategy of anti-inflammatory protection for scaffolds may be pivotal for many applications such as those relying on the recruitment of stem cells and/or progenitor ceils to scaffolds.

关键词： regenerative medicine wound healing drug delivery endothelial cell immune tolerance

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In-situ reduction of silver by surface DBD plasma:a novel method for preparing highly effective electromagnetic interference shielding Ag/PET

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Plasma Science and Technology 2021年第3期23卷 102-112页

作者： zhiyuan fan Lanbo DI Decai BU Tengda ZHANG Xiuling ZHANG College of Physical Science and Technology Dalian UniversityDalian 116622People's Republic of China

Electromagnetic interference(EMI)shielding composites with good flexibility and weatherability properties have attracted increased *** this study,we combined the surface modification method of sub-atmospheric pressure glow discharge plasma with in situ atmospheric pressure surface dielectric barrier discharge plasma(APSDBD)reduction to prepare polyethylene terephthalate supported silver(Ag/PET).Due to the prominent surface modification of PET film,mild plasma reduction,and effective control of the silver morphology by polyvinylpyrrolidone(PVP),a 3.32μm thick silver film with ultralow sliver loading(0.022 wt%)exhibited an EMI shielding efficiency(SE)of 39.45 d B at 0.01 GHz and 31.56 d B at 1.0 GHz(>30 d B in the range of 0.01–1.0 GHz).The SEM results and EMI shielding analysis indicated that the high performance originated from the synergistic effect of the formation of silver nanoparticles(Ag NPs)with preferentially oriented cell-like surface morphologies and layer-by-layer-like superimposed microstructures inside,which demonstrated strong microwave reflection *** transform infrared spectrometer and x-ray diffractometer showed that the surface structures of the heat-sensitive substrate materials were not destroyed by ***,APSDBD technology for preparing Ag/PET had no special requirements on the thickness,dielectric constant,and conductivity of the substrate,which provides an effective strategy for manufacturing metal or alloy films on surfaces of heat-sensitive materials at a relatively low cost.

关键词： Ag/PET atmospheric pressure cold plasma surface dielectric barrier discharge polyvinylpyrrolidone electromagnetic interference shielding

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Unmanned Aerial Vehicle Inspection Routing and Scheduling for Engineering Management

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Engineering 2024年第5期36卷 223-239页

作者： Lu Zhen zhiyuan Yang Gilbert Laporte Wen Yi Tianyi fan School of Management Shanghai UniversityShanghai 200444China Department of Decision Sciences HEC MontréalMontréalQC H3T 2A7Canada School of Management University of BathBath BA27AYUK Department of Building and Real Estate The Hong Kong Polytechnic UniversityHong Kong 999077China

Technological advancements in unmanned aerial vehicles(UAVs)have revolutionized various industries,enabling the widespread adoption of UAV-based *** engineering management,UAV-based inspection has emerged as a highly efficient method for identifying hidden risks in high-risk construction environments,surpassing traditional inspection *** on this foundation,this paper delves into the optimization of UAV inspection routing and scheduling,addressing the complexity introduced by factors such as no-fly zones,monitoring-interval time windows,and multiple monitoring *** tackle this challenging problem,we propose a mixed-integer linear programming(MILP)model that optimizes inspection task assignments,monitoring sequence schedules,and charging *** comprehensive consideration of these factors differentiates our problem from conventional vehicle routing problem(VRP),leading to a mathematically intractable model for commercial solvers in the case of large-scale *** overcome this limitation,we design a tailored variable neighborhood search(VNS)metaheuristic,customizing the algorithm to efficiently solve our *** numerical experiments are conducted to validate the efficacy of our proposed algorithm,demonstrating its scalability for both large-scale and real-scale *** experiments and a case study based on an actual engineering project are also conducted,providing valuable insights for engineering managers to enhance inspection work efficiency.

关键词： Engineering management Unmanned aerial vehicle Inspection routing and scheduling optimization Mixed-integer linear programming model Variable neighborhood search metaheuristic

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