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Light-driven high-precision cell adhesion kinetics

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Light(Science & Applications) 2022年第10期11卷 2256-2257页

作者： zhiyuan zhang Daniel Ahmed Acoustic Robotics Systems Laboratory Institute of Robotics and Intelligent SystemsDepartment of Mechanical and Process EngineeringETH ZurichS?umerstrasse 4CH-8803 ZurichSwitzerland

Existing single-cell adhesion kinetics methods are performed under conditions highly unlike the physiological cell adhesion ***,researchers have developed a new optical technique for high-precision measurement of cell... 详细信息

关键词： conditions. kinetics formed

Patient-derived xenograft platform of OSCC： a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

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Frontiers of Medicine 2016年第1期10卷 104-110页

作者： Shuyang Sun zhiyuan zhang Department of Oral and Maxillofacial-Head Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine'Shanghai Key Laboratory of Stomatology Shanghai 200011 China

Advances in next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamous cell carcinoma （OSCC）. Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancer and achieve the goal of personalized therapies. Patient-derived xenograft （PDX） models generated from human tumor samples that can retain the histological and genetic features of their donor tumors have been shown to be the preferred preclinical tool in translational cancer research compared with other conventional preclinical models. Specifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drug development and biomarker discovery. Recently, we have successfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer research. In this paper, we discuss the establishment, characterization, and preclinical applications of the PDX models. In particular, we focus on the classification and applications of the PDX models based on validated annotations, including clinicopathological features, genomic profiles, and pharmacological testing information. We also explore the translational value of this well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment optimization in the near future. Although various limitations still exist, this preclinical approach should be further tested and improved.

关键词： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral squamous cellcarcinoma

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Kill two birds with one stone: A novel dual-functional nanobiomaterial platform with a clear translational potential for bone regeneration

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Nano Research 2020年第9期13卷 2311-2312页

作者： Yu Shrike zhang zhiyuan zhang Division of Engineering in Medicine Department of MedicineBrigham and Womens HospitalHarvard Medical SchoolCambridgeMA02139USA Department of Oral and Maxillofacial Surgery Ninth Peoples HospitalShanghai Jiao Tong UniversityShanghai 200011China

Modulating healing of the bone has been a long-standing theme of both fundam ental and clinical research,which can be greatly aided using a biomaterials approach[1],designed to provide effective cues that are otherwise intrinsically lacking or insufficient in the wounded bone *** in Nano Research,Ye,Khademhosseini,and colleagues report a new nanobiom aterial strategy based on m esoporous silica rods with cone-shaped pores(MSR-CP),to minimize inflammation while maximizing regeneration,for the treatm ent of bone defects[2].

关键词： healing wound otherwise

Network autoregression model with grouped factor structures

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中山大学学报（自然科学版）（中英文） 2023年第5期62卷 24-37页

作者： zhang zhiyuan ZHU Xuening School of Data Science Fudan UniversityShanghai 200433China

Network autoregression and factor model are effective methods for modeling network time series *** this study,we propose a network autoregression model with a factor structure that incorporates a latent group structure to address nodal heterogeneity within the *** iterative algorithm is employed to minimize a least-squares objective function,allowing for simultaneous estimation of both the parameters and the group *** determine the unknown number of groups and factors,a PIC criterion is ***,statistical inference of the estimated parameters is *** assess the validity of the proposed estimation and inference procedures,we conduct extensive numerical *** also demonstrate the utility of our model using a stock dataset obtained from the Chinese A-Share stock market.

关键词： network autoregression factor structure heterogeneity latent group structure network time series

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Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

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Frontiers of Medicine 2011年第4期5卷 401-413页

作者： zhiyuan zhang Department of Oral and Maxillofacial Surgery Shanghai Key Laboratory of Stomatologythe Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200011China Oral Bioengineering/Regenerative Medicine Lab Shanghai Key Laboratory of Stomatologythe Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200011China

Clinical imperatives for the reconstruction of jaw bone defects or resorbed alveolar ridge require new therapies or procedures instead of autologous/allogeneic bone *** medicine,based on stem cell science and tissue engineering technology,is considered as an ideal alternative strategy for bone *** this paper,we review the current choices of cell source and strategies on directing the osteogenic differentiation of stem *** preclinical animal models for bone regeneration and the key translational points to clinical success in oral and maxillofacial region are also *** propose comprehensive strategies based on stem cell and tissue engineering researches,allowing for clinical application in oral and maxillofacial region.

关键词： bone regeneration animal models translational strategies oral and maxillofacial region

Stable expression and control parameters in the numerical simulation of unsaturated flow

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1501-1514页

作者： zhiyuan zhang Xu LI Yongkang WU Xiaokang LI Key Laboratory of Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

The Richards’equation describes the flow phenomenon in unsaturated porous media and is essential to hydrology and environmental *** study evaluated the numerical stability of two different forms of the Richards’*** analyses were performed to investigate the control parameters of the *** results show that the h-form Richards’equation has better applicability for calculating variable saturation flows than theθ-form Richards’*** the h-form Richards’equation,the hydraulic conductivity of the soil in the low-suction range and the specific moisture capacity in the high-suction range primarily influenced the *** addition,sensitivity analyses indicated that the saturated hydraulic conductivity,initial condition,and air-entry pressure have a higher sensitivity to the simulation results than the saturated water content,rainfall intensity,and decline rate of hydraulic ***,their correctness needs to be guaranteed first in numerical *** research findings can provide a helpful reference for improving the reliability of numerical simulations of unsaturated flows.

关键词： Richards’equation sensitivity analysis unsaturated soil hydraulic diffusivity seepage simulation

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Bioinspired Spiral Soft Pneumatic Actuator and Its Characterization

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Journal of Bionic Engineering 2021年第5期18卷 1101-1116页

作者： zhiyuan zhang Xueqian Wang Deshan Meng Bin Liang Shenzhen Key Laboratory of Intelligent Robotics Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Robotics and Intelligent Systems ETH Zurich8801 ZurichSwitzerland Research Institute of Tsinghua University at Shenzhen Shenzhen 518057China School of Aeronautics and Astronautics Sun Yat-Sen UniversityShenzhen 518107China

Soft robots have unique advantages over traditional rigid robots and have broad application prospects in many *** expand their bioinspired applications,we propose a novel Soft Pneumatic Actuator(SPA)associated with spiral configuration inspired by the structure and unwinding motion of the seahorse *** erent from bending motion of common soft actuators,the spiral SPA can generate unwinding motion as input air pressure ***,to explore the eff ect of diff erent initial spiral types on unwinding performance,three typical spiral SPAs are designed and simulated while keeping the outside arc of actuator body ***,a static model of the spiral SPA is established by combining the hyperelastic material model,geometric relationships,and virtual work *** improve model accuracy,two geometric correction parameters are employed and their physical significance is analyzed by finite element ***,a prototype of the logarithmic spiral SPA(Log_spiral SPA)is fabricated and a Fiber Bragg Grating(FBG)sensor array is designed to detect and reconstruct unwinding shapes of the ***,the unwinding performance,static model and output force capability of the prototype are tested and ***,we discuss prospects for this novel spiral SPA and test its practical applications in inchworm-like motion,assisting finger rehabilitation and object capture.

关键词： Soft robotics Spiral Soft actuator Virtual work principle Fiber Bragg grating

Promoting electrocatalytic alcohols oxidation coupled with H_(2) production via ligand intercalation strategy

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Nano Research 2023年第4期16卷 4596-4602页

作者： Li Li zhiyuan zhang Haotong Chen Fei Chen College of New Materials and Chemical Engineering Beijing Key Lab of Special Elastomeric Composite MaterialsBeijing Institute of Petrochemical TechnologyBeijing 102617China

Electrochemical alcohol oxidation,the alternate of oxygen evolution reaction,has been recognized as an effective way to produce value-added chemicals coupled with H2 ***,the current researches still suffer from the low reaction rate and Faradaic efficiency(FE)that limits the overall ***,we report a ligand intercalation strategy to enhance the current density of alcohol electrooxidation by intercalating sodium dodecyl sulfonate(SDS)in the interlayer of Co(OH)_(2)catalyst(Co(OH)_(2)-SDS).For instance,the Co(OH)_(2)-SDS shows obviously enhanced current density for glycerol electrooxidation than that of pure Co(OH)_(2).The corresponding glycerol conversion rate and H2 production rate reach 0.35 mmol·cm^(−2)·h^(−1)and 9.1 mL·cm^(−2)·h^(−1)at 1.42 V *** hydrogen electrode,which are 2.2-and 1.9-fold higher than that of Co(OH)_(2).The yield of formate reaches 86.6%with selectivity of 95.3%at high glycerol conversion of 95.1%(with FE of 83.3%for glycerol oxidation).The Co(OH)_(2)-SDS is demonstrated efficient for different alcohols with enhanced *** confirmed that the intercalation of SDS in Co(OH)_(2)can promote the generation and exposure of CoOOH reactive sites,and also facilitate the adsorption of alcohol,thus enabling high reaction rate.

关键词： electrocatalysis alcohol oxidation hydrogen cobalt hydroxide ligand intercalation

Complex RNA-DNA hybrid nanoshapes from iterative mix-andmatch screening

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Nano Research 2021年第1期14卷 46-51页

作者： Shi Chen zhiyuan zhang Eugene Alforque Thomas Hermann Department of Chemistry and Biochemistry University of CaliforniaSan DiegoCA 92093USA Center for Drug Discovery Innovation University of CaliforniaSan DiegoCA 92093USA Materials Science and Engineering Program University of CaliforniaSan DiegoCA 92093USA

Hybrid nucleic acid nanostructures partition architectural and functional roles between ribonucleic acid(RNA)joints and deoxyribonucleic acid(DNA)*** self-assemble from nucleic acid modules through synergistic stabilization of marginally stable base pairing interactions within circularly closed ***,we report the development of hybrid nanoshapes that include multiple different RNA modules such as internal loop and three-way junction(3WJ)*** iterative mix-and-match screening approach was used to identify suitable DNA connectors that furnished stable nanoshapes for combinations of different RNA *** resulting complex multicomponent RNA-DNA hybrid nanoshapes were characterized by atomic force microscopy(AFM)*** research provides proof of concept for modular design,assembly and screening of RNA-DNA hybrid nanoshapes as building blocks for complex extended nucleic acid materials with features at the sub-10 nm scale.

关键词： nucleic acid nanotechnology nanoshapes ribonucleic acid(RNA)three-way junction(3WJ) RNA deoxyribonucleic acid(DNA) sub-10 nm features