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Ignition processes and characteristics of charring conductive polymers with a cavity geometry in precombustion chamber for applications in micro/nano satellite hybrid rocket motors

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Defence Technology（防务技术） 2024年第2期32卷 55-66页

作者： zhiyuan zhang Hanyu Deng Wenhe Liao Bin Yu Zai Yu Nanjing University of Science and Technology Nanjing 210094China

The arc ignition system based on charring polymers has advantages of simple structure,low ignition power consumption and multiple ignitions,which bringing it broadly application prospect in hybrid propulsion system of micro/nano ***,charring polymers alone need a relatively high input voltage to achieve pyrolysis and ignition,which increases the burden and cost of the power system of micro/nano satellite in practical *** conductive substance into charring polymers can effectively decrease the conducting voltage which can realize low voltage and low power consumption repeated ignition of arc ignition *** this paper,a charring conductive polymer ignition grain with a cavity geometry in precombustion chamber,which is composed of PLA and multiwall carbon nanotubes(MWCNT)was *** detailed ignition processes were analyzed and two different ignition mechanisms in the cavity of charring conductive polymers were *** ignition characteristics of charring conductive polymers were also investigated at different input voltages,ignition grain structures,ignition locations and injection schemes in a visual ignition *** results demonstrated that the ignition delay and external energy required for ignition were inversely correlated with the voltages applied to ignition ***,the incremental depth of cavity shortened the ignition delay and external energy required for ignition while accelerated the propagation of *** the depth of cavity increased from 2 to 6 mm(at 50 V),the time of flame propagating out of ignition grain changed from 235.6 to 108 ms,and values of mean ignition delay time and mean external energy required for ignition decreased from 462.8 to 320 ms and 16.2 to 10.75 J,*** rear side of the cavity was the ideal ignition position which had a shorter ignition delay and a faster flame propagation speed in comparison to other ignition *** to direct injection scheme,swirlin

关键词： Micro/nano satellite hybrid propulsion Arc ignition Charring conductive polymer Ignition mechanism Ignition characteristic Repeated ignition

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FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression

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International Journal of Oral Science 2024年第2期16卷 333-348页

作者： Zhonglong Liu Xiaoyan Meng Yuxin zhang Jingjing Sun Xiao Tang zhiyuan zhang Liu Liu Yue He Department of Oral Maxillofacial&Head and Neck Oncology Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseaseShanghaiChina Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghaiChina Department of Oral Pathology Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral Disease ShanghaiShanghaiChina

SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor *** glycosylation has been intricately linked with immune escape and tumor ***7A is a highly glycosylated protein with five glycosylated *** underlying mechanisms of SEMA7A glycosylation and its contribution to immunosuppression and tumorigenesis are ***,we identify overexpression and aberrant N-glycosylation of SEMA7A in head and neck squamous cell carcinoma,and elucidate fucosyltransferase FUT8 catalyzes aberrant core fucosylation in SEMA7A at N-linked oligosaccharides(Asn 105,157,258,330,and 602)via a direct protein‒protein interaction.A glycosylated statue of SEMA7A is necessary for its intra-cellular trafficking from the cytoplasm to the *** EGF triggers SEMA7A N-glycosylation through increasing the binding affinity of SEMA7A toward FUT8,whereas TGF-β1 promotes abnormal glycosylation of SEMA7A via induction of epithelial–mesenchymal *** N-glycosylation of SEMA7A leads to the differentiation of CD8^(+)T cells along a trajectory toward an exhausted state,thus shaping an immunosuppressive microenvironment and being resistant immunogenic cell *** of SEMA7A significantly improves the clinical outcome of EGFR-targeted and anti-PD-L1-based ***,we also define RBM4,a splice regulator,as a downstream effector of glycosylated SEMA7A and a pivotal mediator of PD-L1 alternative *** findings suggest that targeting FUT8-SEMA7A axis might be a promising strategy for improving antitumor responses in head and neck squamous cell carcinoma patients.

关键词： aberrant squamous SEMA

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Design and test of the arc-shaped nail-tooth roller residual film recovery machine from the sowing layer

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 90-98页

作者： zhiyuan zhang Xuegeng Chen Xianfei Wang Shuaikang Xue Jingbin Li College of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832003XinjiangChina Xinjiang Production and Construction Corps Key Laboratory of Modern Agricultural Machinery Shihezi 832003XinjiangChina Key Laboratory of Northwest Agricultural equipment Ministry of Agriculture and Rural AffairsShihezi 832003XinjiangChina

Residual films on the sowing layer produced after mulching in Xinjiang farmland,harm the sowing quality and root growth of *** this study,a sowing layer residual film recovery machine based on a radial plate arc-shaped nail-tooth roller structure was ***,the key device structures were designed and the main working parameters were ***,taking the working depth,the forward speed of the machine and the rotation speed of the nail tooth roller as the test factors,and the film collection rate and film intertwining rate as the test indicators,the single factor tests and the Box-Behnken response surface tests were carried out to evaluate the performance of the sowing layer residual film recovery ***,the results showed that the order of significant factors was the working depth,the forward speed of the machine,and the rotation speed of the nail tooth ***,the optimal working parameters were determined,which the working depth,the forward speed of the machine,and the rotation speed of the nail tooth roller were 100 mm,4.8 km/h,and 49.3 r/min,***,the predicted value of the film collection rate was 69.20%.Finally,the verification test was taken with the optimal working parameter,and the results showed that the film collection rate was 66.84%,and the film intertwining rate was 1.39%.The relative error between the test value and the predicted value of the film collection rate was 3.40%.It indicated that the machine can perform the collection of sowing layer residual *** study can provide a theoretical basis and reference for the design of new sowing layer residual film machines.

关键词： residual film recycling machine mulching film pick-up device seedbed preparation

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Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma

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International Journal of Oral Science 2024年第1期16卷 110-121页

作者： Zheqi Liu Zhen zhang Yu zhang Wenkai Zhou Xu zhang Canbang Peng Tong Ji Xin Zou zhiyuan zhang Zhenhu Ren Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina Department of Oral and Maxillofacial Surgery Zhongshan HospitalFudan UniversityShanghaiChina School and Hospital of Stomatology Kunming Medical UniversityKunmingChina Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghaiChina Department of Pathology Jinshan HospitalFudan UniversityShanghaiChina Hainan Western Central Hospital Academician Zhang Zhiyuan Team Innovation CenterDanzhouChina

Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data. The metabolic activity of each spot was calculated using scMetabolism,and k-means clustering was used to classify all spots into hyper-, normal-, or hypometabolic regions. CD4T cell infiltration and TGF-βexpression is higher in the hypermetabolic regions than in the others. Through CellPhoneDB and NicheNet cell-cell communication analysis, it was found that in the hypermetabolic region, fibroblasts can utilize the lactate produced by glycolysis of epithelial cells to transform into inflammatory cancer-associated fibroblasts (iCAFs), and the increased expression of HIF1A in iCAFs promotes the transcriptional expression of CXCL12. The secretion of CXCL12 recruits regulatory T cells (Tregs), leading to Treg infiltration and increased TGF-β secretion in the microenvironment and promotes the formation of a tumor immunosuppressive microenvironment. This study delineates the coordinate work axis of epithelial cells-iCAFs-Tregs in OSCC using SC, ST and TCGA bulk data, and highlights potential targets for therapy.

关键词： CXCL12 microenvironment squamous

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Promising outcomes 5 weeks after a surgical cervical shunting procedure to unclog cerebral lymphatic systems in a patient with Alzheimer’s disease

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General Psychiatry 2024年第3期37卷 345-347页

作者： Xia Li Chenpeng zhang Yuan Fang Mei Xin Jianbo Shi zhiyuan zhang Zhen Wang Zhenhu Ren Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Alzheimer’s Disease and Related Disorders Center Shanghai Jiao Tong UniversityNational Center for Mental DisordersShanghaiChina Department of Nuclear Medicine Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Oral Maxillofacial-Head Neck Oncology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention ShanghaiChina

Recently,the glymphatic system has been recognised as an important‘waste solutes transport channel’within the brain.1 Studies have shown that blockage of the glymphatic system leads to increased beta-amyloid deposits,accelerating the onset and progression of Alzheimer’s disease(AD).12 Given that cervical lymph nodes receive cerebrospinal fluid from the brain’s glymphatic system,34 we speculated that decompression of the lymphatic trunk and cervical lymphatic-venous anastomosis(LVA)could facilitate the flow of cerebrospinal fluid in the cranial glymphatic system,potentially accelerating the clearance of harmful beta-amyloid and tau *** collaborated with surgeons who specialise in LVA supermicrosurgery for maxillofacial tumours and lymphoedema to develop a procedure to relieve the blockage of the glymphatic *** surgery employs supermicrosurgery techniques to create LVA connecting the bilateral cervical,deep lymphatic vessels to the veins,resulting in lymphatic trunk decompression,which allows the lymph fluid in the high-pressure lymphatic vessels to flow into the low-pressure venous *** goal of the minimally invasive surgery is to enhance the removal of proteins,such as beta-amyloid and tau,from the brain’s lymphatic systems to the maxillofacial lymphatic vessels,unclogging protein blockages within the *** extracranial procedure is safer than intracranial approaches.

关键词： lymphatic cervical Alzheimer

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行政违法检察监督的功能定位

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国家检察官学院学报 2024年第2期32卷 57-69页

作者：章志远华东政法大学

新时代行政违法检察监督的实践探索,将检察监督范围从诉讼领域拓展至行政领域,丰富了我国宪法关于法律监督的具体形态。检察机关作为行政机关依法行政监督者的角色定位,是习近平法治思想中严格执法理论的贯彻落实、党和国家监督体系贯... 详细信息

新时代行政违法检察监督的实践探索,将检察监督范围从诉讼领域拓展至行政领域,丰富了我国宪法关于法律监督的具体形态。检察机关作为行政机关依法行政监督者的角色定位,是习近平法治思想中严格执法理论的贯彻落实、党和国家监督体系贯通协调的生动实践,也是行政法律规范体系性解释的应有之义。检察机关作为行政争议实质化解促成者的角色定位,是对政法新兴话语兴起和行政诉讼程序空转现实的检察因应,也是服务保障高质量发展的外驱力量。检察机关作为行政法律统一适用助力者的角色定位,是与人民法院行政审判功能转型同频共振、实现从方法宣介向规则指引的转变,也是对行政基本法典编纂贡献的检察智慧。行政违法检察监督新脸谱的摹绘及其进一步实践,能够推动国家层面立法的积极回应。

关键词：行政违法检察监督依法行政实质化解法律统一适用

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工业文化赋能制造强国建设的内在机理及现实进路

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经济纵横 2024年第3期 98-107页

作者：张志元郭涛东北大学马克思主义学院辽宁沈阳110819

实施制造强国战略,推进新型工业化,既需要技术发展的刚性推动,也需要文化力量的柔性支撑。工业文化对国家工业化进程产生了深刻影响,是建设制造强国的强大精神动力。在价值定位上,工业文化作为塑造国家工业新形象的重要载体,为助推制造... 详细信息

实施制造强国战略,推进新型工业化,既需要技术发展的刚性推动,也需要文化力量的柔性支撑。工业文化对国家工业化进程产生了深刻影响,是建设制造强国的强大精神动力。在价值定位上,工业文化作为塑造国家工业新形象的重要载体,为助推制造业现代化转型提供了柔性力量,为加快制造强国建设创造了内生动力,是提升制造强国综合竞争力的有效支撑。伴随我国制造强国建设已进入深水区和关键阶段,要以习近平文化思想为指引,依托“第二个结合”活化工业文化,创新工业文化的话语体系及传播方式,通过融合工业文化提升制造业产品附加值,推动工业文化与工业遗产的空间性耦合,运用工业文化拓展高技能人才培养维度,全方位赋能制造强国建设。

关键词：制造强国工业文化高质量发展

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红色文艺赋能时代新人培育的逻辑理路

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思想政治教育研究 2024年第3期40卷 145-151页

作者：张志元郭涛东北大学马克思主义学院辽宁沈阳110819

红色文艺生成于中国共产党领导的革命实践,是以伟大建党精神为源头的中国共产党人精神谱系的真实写照,具有鲜明的政治立场和文化价值。红色文艺与思想政治教育的基本内涵高度契合,与社会主义核心价值观内在贯通,蕴含着坚定的革命理想和... 详细信息

红色文艺生成于中国共产党领导的革命实践,是以伟大建党精神为源头的中国共产党人精神谱系的真实写照,具有鲜明的政治立场和文化价值。红色文艺与思想政治教育的基本内涵高度契合,与社会主义核心价值观内在贯通,蕴含着坚定的革命理想和深厚的爱国主义情怀,为全面推进“大思政课”建设提供了丰富的红色滋养。红色文艺的审美意识形态属性在政治性与艺术性、情感性与说理性、传承性与创造性等关系思辨中展现出显著的育人优势,为培养担当民族复兴大任的时代新人提供了丰富“精神食粮”、打造了坚实“教育高地”、淬炼了有力“思想武器”。

关键词：红色文艺时代新人思想政治教育

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养老住房政策体系演进与多样化实施方法探究——以加拿大老年住房计划为例

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城市发展研究 2024年第4期31卷 74-81页

作者：张智源邓奕唐燕毛其智福州大学建筑与城乡规划学院清华大学建筑学院

目前全球老龄化日益严重，养老压力持续加大，在以美、日、芬三国为代表的世界各国总体呈现向居家养老发展的一致趋势下，分析得出加拿大的多样化养老经验对于我国最具可行性。宏观上分析加拿大自上而下的住房政策演进历程，其作为加拿... 详细信息

目前全球老龄化日益严重，养老压力持续加大，在以美、日、芬三国为代表的世界各国总体呈现向居家养老发展的一致趋势下，分析得出加拿大的多样化养老经验对于我国最具可行性。宏观上分析加拿大自上而下的住房政策演进历程，其作为加拿大福利制度的起源为后续进一步制定针对性的老年住房计划奠定了基础。老年住房计划中详细整理了针对加拿大全国13个省共18种多样化住房计划类型，总结出各省老年人住房政策方面共同的关注点，其多样化的本质是使政策实施更具针对性和人性化。微观上从申请者视角，以大不列颠哥伦比亚省为例检验了老年住房计划自下而上执行的可实施性。最终结合我国养老产业现状，得出加拿大养老住房政策对我国养老政策规划的启示。

关键词：养老住房政策体系老年住房计划个人申请自下而上加拿大

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甲基丙烯酸羟乙酯改性乙烯-α-烯烃共聚物封装胶膜

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高分子材料科学与工程 2024年第6期40卷 17-24页

作者：张志远徐梦楠陶家骏蒋姗常州大学材料科学与工程学院江苏常州213164

以甲基丙烯酸羟乙酯(HEMA)、苯乙烯(St)和γ-甲基丙烯酰氧丙基三甲氧基硅烷(KH570)为接枝单体,熔融接枝乙烯-α-烯烃共聚物(POE)制备POE-g-P(HEMA-co-St)(以下简称POE-g-PHS)和POE-g-P(HEMA-co-St-co-KH570)(以下简称POE-g-PHSK)。以过氧化-2-乙基己基碳酸叔丁酯(TBEC)为交联剂、POE-g-PHS和POE-g-PHSK为改性剂,分别加入POE基材中,经熔融共混和层压交联制备POE/POE-g-PHS胶膜和POE/POE-g-PHSK胶膜,研究了POE-g-PHS和POE-g-PHSK对胶膜的结构和性能的影响。结果表明,随着POE-g-PHS和POE-g-PHSK含量的增加,POE预制膜的防交联剂迁移能力明显提升;同时,POE胶膜交联度的提升和结晶度的变化也影响其综合性能。当POE-g-PHS和POE-g-PHSK质量分数分别为9%和6%时,综合性能最优。预制膜表面摩擦系数变化率从17.13%分别降低到0.53%和0.49%,胶膜交联度从86.28%分别提高至89.87%和90.91%,剥离强度从12.86 N/cm分别提升至20.86 N/cm和32.14N/cm,同时,抗紫外老化性能、力学性能和体积电阻率等性能均有提升。

关键词：乙烯-α-烯烃共聚物胶膜熔融接枝交联剂迁移表面摩擦系数

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