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Microglia activation,classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage

Neural Regeneration Research 2022年第7期17卷 1404-1411页

作者： Junfan Chen zhiyuan vera zheng Gang Lu Wai Yee Chan Yisen Zhang George Kwok Chu Wong Division of Neurosurgery Department of SurgeryThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Neurosurgery Hainan Branch of Chinese People’s Liberation Army General HospitalSanyaHainan ProvinceChina CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical Sciencesthe Chinese University of Hong KongHong Kong Special Administrative RegionChina Bioinformatics Unit SDIVF R&D CentreHong Kong Science and Technology ParksHong Kong Special Administrative RegionChina Department of Interventional Neuroradiology Beijing Neurosurgical InstituteBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity,despite advances in treating cerebral aneurysms.There has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage,but the results remain unsatisfactory.Microglia,the resident immune cells of the brain,are increasingly recognized as playing a significant role in neurological diseases,including subarachnoid hemorrhage.In early brain injury following subarachnoid hemorrhage,microglial activation and neuroinflammation have been implicated in the development of disease complications and recovery.To understand the disease processes following subarachnoid hemorrhage,it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and chemokines.In this review,we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage,including transcriptome changes and the neuroinflammatory signaling pathways.We also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome-based classification of microglia and the implications for microglial activation and neuroinflammation.

关键词： activation inflammation microglia modulator neuroinflammation sequencing signal pathway single-cell analysis stroke subarachnoid hemorrhage treatment

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Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage

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Stroke & Vascular Neurology 2022年第1期7卷 62-70页

作者： zhiyuan vera zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong Department of Surgery The Chinese University of Hong KongShatinHong Kong Department of Surgery Hainan General HospitalHaikouHainanChina School of Biomedical Science The Chinese University of Hong KongShatinHong Kong

Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as

关键词： STAT3 inflammation reversed

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Boron-doped high-entropy oxide toward high-rate and long-cycle layered cathodes for wide-temperature sodium-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 577-587页

作者： Yuzhen Dang Zhe Xu Yurong Wu Runguo zheng zhiyuan Wang Xiaopin Lin Yanguo Liu zheng-Yao Li Kai Sun Dongfeng Chen Dan Wang School of Materials Science and Engineering Northeastern University School of Resources and Materials Northeastern University at Qinhuangdao Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Neutron Scattering Laboratory Department of Nuclear Physics China Institute of Atomic Energy

03-type layered metal oxides hold great promise for sodium-ion batteries cathodes owing to their energy density advantage.However,the severe irreversible phase transition and sluggish Na+diffusion kinetics pose significant challenges to achieve high-performance layered cathodes.Herein,a boron-doped03-type high entropy oxide Na(Fe0.2Co0.15Cu0.05Ni0.2Mn0.2Ti0.2)B0.02O2(NFCCNMT-B0.02) is designed and the covalent B-O bonds with high entropy configuration ensure a robust layered structure.The obtained cathode NFCCNMT-B0.02exhibits impressive cycling performance（capacity retention of 95% and 82% after100 cycles and 300 cycles at 1 and 10 C,respectively） and outstanding rate capability(capacity of 83 mAh g-1at 10 C).Furthermore,the NFCCNMT-B0.02demonstrates a superior wide-temperature performance,maintaining the same capacity level(113,4 mAh g-1@-20℃,121 mAh g-1@25℃,and 119 mAh g-1@60℃) and superior cycle stability（90% capacity retention after 100 cycles at 1 C at-20℃）.The high-entropy configuration design with boron doping strategy contributes to the excellent sodium-ion storage performance.The high-entropy configuration design effectively suppresses irreversible phase transitions accompanied by small volume changes（ΔV=0.65 ?3）.B ions doping expands the Na layer distance and enlarges the P3 phase region,thereby enhancing Na+diffusion kinetics.This work offers valuable insights into design of high-performance layered cathodes for sodium-ion batteries operating across a wide temperature.

关键词： Born substitution High entropy oxide Na+ diffusion kinetics Phase transition Sodium-ion batteries

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An Aerial–Wall Robotic Insect That Can Land, Climb, and Take Off from Vertical Surfaces

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Research 2024年第1期2023卷 149-163页

作者： Qian Li Haoze Li Huan Shen Yangguang Yu Haoran He Xincheng Feng Yi Sun zhiyuan Mao Guangming Chen Zongjun Tian Lida Shen Xiangming zheng Aihong Ji College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjingChina

Insects that can perform flapping-wing flight,climb on a wall,and switch smoothly between the 2 locomotion regimes provide us with excellent biomimetic models.However,very few biomimetic robots can perform complex locomotion tasks that combine the 2 abilities of climbing and flying.Here,we describe an aerial–wall amphibious robot that is self-contained for flying and climbing,and that can seamlessly move between the air and wall.It adopts a flapping/rotor hybrid power layout,which realizes not only efficient and controllable flight in the air but also attachment to,and climbing on,the vertical wall through a synergistic combination of the aerodynamic negative pressure adsorption of the rotor power and a climbing mechanism with bionic adhesion performance.On the basis of the attachment mechanism of insect foot pads,the prepared biomimetic adhesive materials of the robot can be applied to various types of wall surfaces to achieve stable climbing.The longitudinal axis layout design of the rotor dynamics and control strategy realize a unique cross-domain movement during the flying–climbing transition,which has important implications in understanding the takeoff and landing of insects.Moreover,it enables the robot to cross the air–wall boundary in 0.4 s(landing),and cross the wall–air boundary in 0.7 s(taking off).The aerial–wall amphibious robot expands the working space of traditional flying and climbing robots,which can pave the way for future robots that can perform autonomous visual monitoring,human search and rescue,and tracking tasks in complex air–wall environments.

关键词： robot smoothly Vertical

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MnO-pillared graphene blocks enabling the ultrastable and ultrafast aqueous zinc ion batteries

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Science China Chemistry 2024年

作者： zheng Liu Zhipeng Qiu zhiyuan Li Tong Wei Zhuangjun Fan Huan Pang School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering China University of PetroleumQingdao

Due to the low cost, high theoretical capacity, and environmental friendliness, manganese-based cathodes are regarded as promising alternatives for aqueous zinc ion batteries（AZIBs）. However, the practicality of the zinc-manganese system is faced with great challenges, such as the inevitable structural collapse of the cathode and controversial energy storage mechanisms.Herein, we propose a novel concept of spatial deposition mechanism through the addition of MnSO4additives in the MnOpillared graphene blocks（G-MnO）. The covalent interface between MnO nanoparticles and multilayered graphene nanosheets can construct an in-built micro-electric field, which is beneficial for consecutive electron transfer（in both horizontal and vertical directions）. On this basis, the surficial activity of MnO confined in the interlayered nano-space is greatly enhanced and provides enough spatial deposition and subsequent reaction site for MnSO4additives, thus firstly extending the surficial controlled process to stereoscopic space, effectively improving the electrochemical performance of AZIBs. Therefore, the assembled Zn//G-MnO battery exhibits an excellent rate capability of 281.5 mAh g-1at 0.1 A g-1and 106 m Ah g-1at 20 A g-1, and impressive cycling stability(93 m Ah g-1remaining after 5,000 cycles). This finding may provide a new opportunity for the rational design of surficial controlled energy storage and conversion devices.

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Tungsten oxide-anchored Ru clusters with electron-rich and anti-corrosive microenvironments for efficient and robust seawater splitting

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SusMat 2024年第1期4卷 106-115页

作者： Yiming Zhang Weiqiong zheng Huijuan Wu Ran Zhu Yinghan Wang Mao Wang Tian Ma Chong Cheng zhiyuan Zeng Shuang Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduChina Department of Chemical and Biomolecular Engineering National University of SingaporeSingaporeSingapore Department of Materials Science and Engineering and State Key Laboratory of Marine PollutionCity University of Hong KongKowloonHong KongChina Shenzhen Research Institute City University of Hong KongShenzhenChina

Ruthenium(Ru)has been recognized as a prospective candidate to substitute platinum catalysts in water-splitting-based hydrogen production.However,minimizing the Ru contents,optimizing the water dissociation energy of Ru sites,and enhancing the long-term stability are extremely required,but still face a great challenge.Here,we report on creating tungsten oxide-anchored Ru clusters(Ru-WO_(x))with electron-rich and anti-corrosive microenvironments for efficient and robust seawater splitting.Benefiting from the abundant oxygen vacancy structure in tungsten oxide support,the Ru-WO_(x)exhibits strong Ru-O and Ru-W bonds at the interface.Our study elucidates that the strong Ru-O bonds in Ru-WO_(x)may accelerate the water dissociation kinetics,and the Ru-W bonds will lead to the strong metal-support interaction and electrons transfer fromWto Ru.The optimal Ru-WO_(x)catalysts exhibit a low overpotential of 29 and 218mVat the current density of 10 mA cm^(−2) in alkaline and seawater media,respectively.The outstanding long-term stability discloses that the Ru-WO_(x)catalysts own efficient corrosion resistance in seawater electrolysis.We believe that thiswork offers new insights into the essential roles of electron-rich and anti-corrosivemicroenvironments in Ru-based catalysts and provide a new pathway to design efficient and robust cathodes for seawater splitting.

关键词： hydrogen production microenvironment modulation noble metal catalysts seawater splitting tungsten oxide

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复合溶剂低温结晶法富集鱼油中的棕榈油酸

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中国食品学报 2024年第2期24卷 151-159页

作者：尹雪莲郑飞洋戴志远浙江工商大学海洋食品研究院杭州310012 浙江省水产品加工技术研究联合重点实验室杭州310012

为探究鱼油来源单不饱和脂肪酸的富集工艺,本研究以鳀鱼油为原料,采用复合溶剂-低温结晶法提纯POA。与单一溶剂相比,复合溶剂效果更佳。以POA含量及得率为指标,采用单因素实验对单一/复合溶剂种类、复合溶剂体积比、油溶比、结晶温度、... 详细信息

为探究鱼油来源单不饱和脂肪酸的富集工艺,本研究以鳀鱼油为原料,采用复合溶剂-低温结晶法提纯POA。与单一溶剂相比,复合溶剂效果更佳。以POA含量及得率为指标,采用单因素实验对单一/复合溶剂种类、复合溶剂体积比、油溶比、结晶温度、结晶时间进行优化。确定最佳工艺条件为丙酮-乙腈体积比为1∶10,鱼油与溶剂质量比为1∶6,结晶温度为-60℃,结晶时间为6 h,得到的混合脂肪酸中POA含量为(29.75±0.53)%。进一步进行放大试验,将得率提升至50%左右,总不饱和脂肪酸含量达79%以上。本研究为ω-7单不饱和脂肪酸的富集工艺提供了参考。

关键词：鳀鱼油复合溶剂低温结晶棕榈油酸

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基于IMPMMS并网的新能源电压稳定性分析

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电机与控制学报 2024年第3期28卷 66-74页

作者：郑军铭冯丽蔡志远张炳义沈阳工业大学电气工程学院辽宁沈阳110870 沈阳职业技术学院电气工程学院辽宁沈阳110033

新能源并网比例过高导致新能源电网电压稳定性低和机组脱网风险,永磁发电机组(IMPMMS)对系统具有电压补偿能力,能满足新能源电网无功需求。本文根据永磁发电机组的结构和工作原理,分析了永磁发电机组的电压补偿机理,推导影响无功调节能... 详细信息

新能源并网比例过高导致新能源电网电压稳定性低和机组脱网风险,永磁发电机组(IMPMMS)对系统具有电压补偿能力,能满足新能源电网无功需求。本文根据永磁发电机组的结构和工作原理,分析了永磁发电机组的电压补偿机理,推导影响无功调节能力的参数。结合新能源通过永磁发电机组并网的状态方程,建立电力系统仿真模型,对比不同程度电压跌落下永磁发电机组与传统机组的电压补偿能力及电压隔离作用,最后研制一台缩比样机。仿真和试验结果表明:网侧电压跌落幅度越大,永磁发电机组电压补偿能力越强,且永磁发电机组机械隔离可以隔离故障对新能源机组的影响,有效防止新能源脱网风险的发生,提高新能源发电系统的电压稳定性。

关键词：高比例新能源永磁发电机组无功补偿能力电压隔离电压稳定性

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基于平滑矩阵集优化的双基地MIMO雷达相干目标DOD和DOA联合估计

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北京航空航天大学学报 2024年第1期50卷 268-275页

作者：游致远胡国平周豪郑桂妹空军工程大学防空反导学院西安710051 空军工程大学研究生院西安710051

针对在进行相干目标测向时出现的协方差矩阵秩亏现象,双基地多输入多输出(MIMO)雷达探测相干目标会出现精度差、角度分辨率低等问题,提出一种基于分集平滑优化对相干目标波离方向角(DOD)和波达方向角(DOA)进行联合估计的算法。所提算法... 详细信息

针对在进行相干目标测向时出现的协方差矩阵秩亏现象,双基地多输入多输出(MIMO)雷达探测相干目标会出现精度差、角度分辨率低等问题,提出一种基于分集平滑优化对相干目标波离方向角(DOD)和波达方向角(DOA)进行联合估计的算法。所提算法能通过分集平滑降维协方差矩阵,构造更有效的平滑矩阵集对相干目标进行联合角度估计。将发射阵列和接收阵列进行分集平滑并构建发射子矢量,计算其协方差矩阵;将每个发射子矢量的协方差矩阵进行平滑重构而后进行加权处理得到前向平滑矩阵;对前向平滑矩阵进行共轭翻转等变换后,得到前后向平滑矩阵,再对其进行奇异值(SVD)分解;利用降维多重信号分类(RD-MUSIC)算法对信号进行空间谱估计并实现DOD和DOA自动配对。所提算法有效提高双基地MIMO雷达对相干目标的测向性能,并通过实验证明所提算法的可行性。

关键词：双基地雷达 MIMO雷达相干目标分集平滑角度联合估计

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贮藏温度对β-环糊精稳定南极磷虾油Pickering乳液的影响

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中国食品学报 2024年第2期24卷 239-247页

作者：蒋长兵黄程董烨郑振霄戴志远浙江工商大学管理工程与电子商务学院杭州310018 绿城农科检测技术有限公司杭州310052 浙江工商大学海洋食品研究院、浙江省水产品加工技术研究联合重点实验室、海洋食品精深加工关键技术省部共建协同创新中心杭州310012

为研究不同贮藏温度(4,25℃和37℃)对β-环糊精稳定南极磷虾油Pickering乳液的影响并确定其货架期,首先采用高速剪切的方法制备南极磷虾油Pickering乳液,乳液的粒径为13.64μm、电位为-38.14 mV,离心稳定性为85.34%。然后,以乳液的外观... 详细信息

为研究不同贮藏温度(4,25℃和37℃)对β-环糊精稳定南极磷虾油Pickering乳液的影响并确定其货架期,首先采用高速剪切的方法制备南极磷虾油Pickering乳液,乳液的粒径为13.64μm、电位为-38.14 mV,离心稳定性为85.34%。然后,以乳液的外观和微观变化、粒径、ζ-电位、离心稳定性、层析指数、过氧化物值(POV)和硫代巴比妥酸反应物(TBARS)为指标,研究不同贮藏温度对乳液的影响,结果表明:温度越高,乳滴分子的布朗运动越激烈,发生聚结的速率越快,乳液失稳所需时间越短。在4,25℃和37℃条件下,乳液贮存的货架期分别为28,16 d和8 d。本研究为南极磷虾资源的开发和利用提供了技术参考。

关键词：温度 β-环糊精南极磷虾油 Pickering乳液货架期

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