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Food Quality and Safety 2023年第2期7卷 300-308页

作者： Xudong Sun Chao Xu Chagen Luo Dongfu Xie Wei Fu zhiyuan gong Xinpeng Wang School of Mechatronics and Vehicle Engineering East China Jiaotong UniversityNanchangChina Key Laboratory of Conveyance Equipment(East China Jiaotong University) Ministry of EducationNanchangChina Nanchang Automotive Institute of Intelligence and New Energy(Tongji University) NanchangChina

Background and objectives:Current technology of X-ray imaging can recognize hard foreign materials(FMs)such as metal and high-density plastic.However,low-density foreign bodies are still a challenge for food quality and safety assessment.Materials and methods:An electromagnetic vibration feeder aided by terahertz time-domain spectroscopy(THz-TDS)and imaging was inves-tigated for non-destructively detecting tea stalk and insect FMs mixed with tea leaves.Results:THz time-domain signals were employed directly to develop the K-nearest neighbor model with a precision of 100%,accuracy of 95.6%and recall of 98.7%in predicting the unknown samples.High contrast THz-TDS images were obtained by the separation method for the samples using electromagnetic vibration feeder.The characteristic parameters of the ratio of maximum length(L)to maximum width(W)and hue extracted from THz-TDS images indicated significant difference between tea leaves and FMs.Conclusions:The results suggested that electromagnetic vibration feeder combination with THz-TDS was feasible for detecting FMs in fin-ishingteaproducts.

关键词： Terahertz spectroscopy imaging food foreign bodies

Genetically engineered bacterial-like particles induced specific cellular and humoral immunity as effective tick-borne encephalitis virus vaccine

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聚集体(英文)

聚集体(英文) 2023年第3期4卷 175-183页

作者： Mengyao Zhang Hongli Jin Yuanyuan Li Cuicui Jiao Pei Huang Yujie Bai zhiyuan gong Haili Zhang Shunjie Liu Hualei Wang Key Laboratory of Zoonosis Research Ministry of EducationCollege of Veterinary MedicineJilin UniversityChangchunChina

Tick-borne encephalitis(TBE)is a natural focal disease with fatal encephalitis induced by tick-borne encephalitis virus(TBEV),seriously threatening human and public health.Protection of TBE depends on vaccination with inactivated vaccine,which requires high cost and multiple immunizations.Here,we construct genetically engineered bacterial-like particles(BLPs)as an effective TBEV vaccine with simplified immunizations and improved immune efficacy.The TBEV BLPs involve the combination of the gram-positive enhancer matrix from Lactococcus lactis,and TBEV envelope(E)protein expressed by genetically engineered recombinant baculovirus.The prepared TBEV BLPs can effectively stimulate the activation of dendritic cells to present the TBEV E proteins to T and B cells,leading to strong and durable cellular and humoral immune responses in mice.Surprisingly,the serum levels of specific IgG antibodies in mice remain about 10^(6)at 6 months after the secondary immunization.Overall,the TBEV BLPs can be used as a potent vaccine candidate,laying the foundation for developing novel TBEV genetically engineered vaccines.

关键词： bacterial-like particles envelope protein genetically engineered vaccines gram-positive enhancer matrix tick-borne encephalitis virus

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安徽省气候变化和人类活动对草地物候的影响

应用生态学报 2024年第4期35卷 1092-1100页

作者：龚志远王春林董丹丹张蕊张曦安徽省·水利部淮河水利委员会水利科学研究院合肥230088

为了探究安徽省气候变化和人类活动对草地物候的影响,并且量化气候变化和人类活动对物候的贡献率,本研究基于2003—2020年安徽省归一化植被指数数据集提取草地物候——返青期(SOS)、枯黄期(EOS),采用slope趋势分析、Mann-Kendall非参数... 详细信息

为了探究安徽省气候变化和人类活动对草地物候的影响,并且量化气候变化和人类活动对物候的贡献率,本研究基于2003—2020年安徽省归一化植被指数数据集提取草地物候——返青期(SOS)、枯黄期(EOS),采用slope趋势分析、Mann-Kendall非参数检验与Hurst指数分析物候的时空变化特征及未来演变趋势,并结合年均气温、年降水量数据集,采用相关性分析和残差分析探讨气候变化和人类活动对物候的响应,并量化二者的贡献率。结果表明:2003—2020年,研究区SOS和EOS都表现为提前趋势,提前速率分别为0.8和0.7 d·a^(-1)。研究区南部SOS明显早于中部和北部地区;EOS从南向北逐渐提前。未来SOS和EOS都表现出提前趋势。SOS与年均气温主要表现为负相关性,与年降水量主要表现为正相关性;EOS与年均气温和年降水量都表现为负相关性。SOS由气候变化和人类活动共同驱动提前的区域面积占比为56.9%,EOS由气候变化和人类活动共同驱动提前的区域面积占比为48.3%,其中,人类活动是物候的主要驱动因素,气候变化为次要驱动因素。人类活动和气候变化对SOS的相对贡献率分别为66.4%和33.6%,对EOS的相对贡献率分别为61.2%和38.8%。人类活动对SOS和EOS的影响更强,主要导致SOS和EOS提前。

关键词：物候气候变化人类活动残差分析安徽省

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原始森林的概念、生态功能及研究进展

林业科学 2024年第4期60卷 173-182页

作者：龚金玉马致远胡琛李田雷静品中国林业科学研究院林业研究所、国家林业局和草原局林木培育重点实验室北京100091 南京林业大学南方现代林业协同创新中心南京210037

原始森林是指由乡土树种自然演替而成,没有明显人为干扰痕迹,生态过程没有受到明显影响的森林,其具有复杂的结构和生态功能,是自然界最稳定的碳储库和资源库,对全球气候调节及人类生存发展具有重要作用。在研究领域内明确、规范原始森... 详细信息

原始森林是指由乡土树种自然演替而成,没有明显人为干扰痕迹,生态过程没有受到明显影响的森林,其具有复杂的结构和生态功能,是自然界最稳定的碳储库和资源库,对全球气候调节及人类生存发展具有重要作用。在研究领域内明确、规范原始森林的概念和监测方法,有利于世界原始森林资源的清查、保护及监测。本研究在梳理国内外原始森林概念的基础上,归纳总结了原始森林特征,分析了国内外原始森林资源清查和监测的现状,综述了原始森林的重要生态功能:1)原始森林固碳能力存在的碳中性、碳源及碳库假说;2)原始森林具有优于其他森林的水文调节功能;3)原始森林是物种基因库,具有突出的生物多样性保护功能。基于目前对原始森林概念和监测中存在的问题,提出未来研究建议:在森林资源清查中将原始森林单独分类;加大对原始森林生态功能研究,开展原始森林固碳潜力、土壤呼吸的研究;增加原始森林水文调节能力研究,探索原始森林在缓解全球气候变化中的作用;探究原始森林生物多样性保护功能,减少全球生物多样性丧失。

关键词：原始森林天然林概念生态功能可持续经营

Exosome-mediated metabolic reprogramming:the emerging role in tumor microenvironment remodeling and its influence on cancer progression

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Signal Transduction and Targeted Therapy 2020年第1期5卷 421-433页

作者： Enli Yang Xuan Wang zhiyuan gong Miao Yu Haiwei Wu Dongsheng Zhang Department of Oral and Maxillofacial Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University324 Jingwu Road250021 JinanChina Department of Oral and Maxillofacial Surgery Shandong Provincial Hospital Affiliated to Shandong University324 Jingwu Road250021 JinanChina

Metabolic reprogramming is reported to be one of the hallmarks of cancer,which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.Recently,extracellular vesicles(EVs)known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment(TME).Meanwhile,the TME is a highly heterogeneous ecosystem incorporating cancer cells,fibroblasts,adipocytes,endothelial cells,mesenchymal stem cells,and extracellular matrix.Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells,which facilitate cancer progression,angiogenesis,metastasis,drug resistance,and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells.In this review,we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.In addition,we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis,and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy.Furthermore,a better understanding of the link between exosomes and metabolic reprogramming,and their impact on cancer progression,would provide novel insights for cancer prevention and treatment in the future.

关键词： metabolism prevention programming

Additive manufacturing of thin electrolyte layers via inkjet printing of highly-stable ceramic inks

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Journal of Advanced Ceramics 2021年第2期10卷 279-290页

作者： Zhongqi Zhu zhiyuan gong Piao Qu Ziyong Li Sefiu Abolaji Rasaki zhiyuan Liu Pei Wang Changyong Liu Changshi Lao Zhangwei Chen Additive Manufacturing Institute Shenzhen UniversityShenzhen518060China

Inkjet printing is a promising alternative for the fabrication of thin film components for solid oxide fuel cells(SOFCs) due to its contactless, mask free, and controllable printing process. In order to obtain satisfying electrolyte thin layer structures in anode-supported SOFCs, the preparation of suitable electrolyte ceramic inks is a key. At present, such a kind of 8 mol% Y_(2)O_(3)-stabilized ZrO_(2)(8 YSZ) electrolyte ceramic ink with long-term stability and high solid loading(> 15 wt%) seems rare for precise inkjet printing, and a number of characterization and performance aspects of the inks, such as homogeneity, viscosity, and printability, should be studied. In this study, 8 YSZ ceramic inks of varied compositions were developed for inkjet printing of SOFC ceramic electrolyte layers. The dispersing effect of two types of dispersants, i.e., polyacrylic acid ammonium(PAANH4) and polyacrylic acid(PAA), were compared. The results show that ultrasonic dispersion treatment can help effectively disperse the ceramic particles in the inks. PAANH4 has a better dispersion effect for the inks developed in this study. The inks show excellent printable performance in the actual printing process. The stability of the ink can be maintained for a storage period of over 30 days with the help of initial ultrasonic dispersion. Finally, micron-size thin 8 YSZ electrolyte films were successfully fabricated through inkjet printing and sintering, based on the as-developed high solid loading 8 YSZ inks(20 wt%). The films show fully dense and intact structural morphology and smooth interfacial bonding, offering an improved structural quality of electrolyte for enhanced SOFC performance.

关键词： inkjet printing water-based ceramic ink solid oxide fuel cell(SOFC)electrolyte 8YSZ ink stability rheological properties

Incorporation of Escherichia coli heat-labile enterotoxin B subunit into rabies virus particles enhances its immunogenicity in mice and dogs

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Biosafety and Health 2023年第5期5卷 308-319页

作者： zhiyuan gong Hailun Li Meichen Qian Yujie Bai Hongli Jin Jingxuan Sun Mengyao Zhang Cuicui Jiao Pei Huang Yuanyuan Li Haili Zhang Hualei Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of Zoonosisand College of Veterinary MedicineJilin UniversityChangchun 130062China Changchun Sino Biotechnology Co. Ltd.Changchun 130012China

Although inactivated vaccines against rabies have the advantage of high safety,effective protection against rabies virus(RABV)infection often requires multiple,high-dose immunization.Incorporating a molecular adjuvant into the viral particles has been found to be a useful strategy to promote the immune effectiveness of inactivated vaccines.In this study,we constructed a recombinant virus,rCVS11-LTB,which chimerically expresses a molecular adjuvant heat-labile enterotoxin B subunit(LTB)protein on the surface of the RABV particles.Immunogenicity in vivo was found to be promoted by rCVS11-LTB through the activation of dendritic cells(DCs).Our results demonstrated that inactivated rCVS11-LTB was able to induce higher levels of virusneutralizing antibodies(VNAs)in both mice and dogs than the parent virus rCVS11,to enhance the cellular immune response and T cell immune memory in mice,and was also able to provide 100%protection in mice from lethal doses of rabies virus,indicating its potential as a safe and effective inactivated rabies vaccine candidate.

关键词： RABV Inactivated vaccine Incorporation LTB Dendritic cells Activation

Molecular insights of organochlorine biocide-induced toxicity in zebrafish:Whole-adult-organism toxicogenomics,targeted gene expression and histological analyses

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Journal of Genetics and Genomics 2016年第8期43卷 525-528页

作者： eei yin lui caixia li zhi-hua li zhiyuan gong siew hong lam nus environmental research institute national university of singapore117411Singapore department of biological sciences national university of singapore117543Singapore yangtze river fisheries research institute chinese academy of fishery sciencesWuhan 430223China

Organochlorine biocides （OCBs）, such as lindane and dichlorodi- phenyltrichloroethane （DDT）, have been used for control of vector- borne diseases in public health and for insect pest control in agri- culture. These chemicals are extremely persistent in the environ- ment and they tend to bioaccumulate via food chains, thus posing risk to human and ecological health （Cooney et al., 2010; Wang et al., 2013）. Due to their persistence in the environment and continuous use in certain countries despite the banning of some of these chemicals, monitoring and studies of OCBs have continued intensely and remain relevant in foreseeable future （ Cohn et al.,

关键词： Molecular insights of organochlorine biocide-induced toxicity in zebrafish gene

基于有限体积法的功能梯度材料流固耦合传热一体化计算

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武汉科技大学学报 2024年第4期47卷 272-281页

作者：龚京风陈金梦宣领宽宫小朴江致远武汉科技大学汽车与交通工程学院湖北武汉430065 上汽通用汽车有限公司武汉分公司湖北武汉430208

为提高功能梯度材料(FGMs)流固耦合传热性能分析的准确性,本文提出了一种二维FGMs流固耦合传热问题一体化计算方法。基于有限体积法离散控制方程,将物性参数和变量储存在单元中心,把耦合面当成特殊的内部面处理,采用中心差分格式处理离... 详细信息

为提高功能梯度材料(FGMs)流固耦合传热性能分析的准确性,本文提出了一种二维FGMs流固耦合传热问题一体化计算方法。基于有限体积法离散控制方程,将物性参数和变量储存在单元中心,把耦合面当成特殊的内部面处理,采用中心差分格式处理离散方程中的面单元参数。通过FGMs圆环热传导算例,讨论了高斯法和最小二乘法两种梯度求解方法对于不同网格的适应性。结果表明,对于非结构化网格,最小二乘法比高斯法具有更好的适应性。对于结构化网格,两种方法都具有良好的适用性。因此,本文采用最小二乘法计算离散方程中的梯度,应用有限体积法求解FGMs方板热传导、自然对流和FGMs流固耦合传热问题。计算结果与文献或商用软件计算结果吻合良好,验证了本文方法的有效性。

关键词：有限体积法流固耦合传热功能梯度材料一体化计算中心差分

能量信息深度融合的移动网络架构及其技术挑战

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中国科学：信息科学 2024年第4期54卷 745-757页

作者：周盛孙宇璇姜之源龚杰常征牛志升清华大学电子工程系北京100084 北京交通大学电子信息工程学院北京100044 上海大学通信与信息工程学院上海200444 中山大学计算机学院广州510275 电子科技大学计算机科学与工程学院成都611731

5G的大规模部署伴随着网络能耗呈指数级增长,与此同时,国家提出了"碳达峰"与"碳中和"的"双碳"目标,因此移动网络的节能减排已刻不容缓.然而,一方面随着人工智能等技术的发展,未来6G网络中计算类业务预期将迎来大幅增长;另一方面,实现绿... 详细信息

5G的大规模部署伴随着网络能耗呈指数级增长,与此同时,国家提出了"碳达峰"与"碳中和"的"双碳"目标,因此移动网络的节能减排已刻不容缓.然而,一方面随着人工智能等技术的发展,未来6G网络中计算类业务预期将迎来大幅增长;另一方面,实现绿色低碳需要提升可再生能源的利用率,但绿色新能源供能不稳难以保证服务质量.为应对以上挑战,本文提出一种能量与信息服务深度融合的低碳网络架构,通过构建一个协调异质资源的智能控制面,充分利用并调度移动网络中泛在的算力、通信和储能,在保证6G个性化业务服务质量要求的同时,以期大幅降低网络能耗与碳排放.本文同时还讨论了该架构下的调度机制设计以及可能的未来研究方向.

关键词： 6G 低碳节能通信计算融合绿色能源