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基于Notch通路探究助阳补肺除痹颗粒治疗肺纤维化的临床研究

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吉林中医药 2024年第7期44卷 807-811页

作者：田治宇仕丽胡少丹孙峰曹政华长春中医药大学长春130117 长春中医药大学附属医院长春130021

目的观察助阳补肺除痹颗粒对肺纤维化肺肾亏虚、寒瘀阻络型患者症状改善情况,患者治疗前后血液中主要炎性因子及Notch通路相关指标表达情况的影响。方法选取肺纤维化肺肾亏虚、寒瘀阻络型患者80例,随机分为试验组与对照组,各40例,试... 详细信息

目的观察助阳补肺除痹颗粒对肺纤维化肺肾亏虚、寒瘀阻络型患者症状改善情况,患者治疗前后血液中主要炎性因子及Notch通路相关指标表达情况的影响。方法选取肺纤维化肺肾亏虚、寒瘀阻络型患者80例,随机分为试验组与对照组,各40例,试验组给予基础治疗加助阳补肺除痹颗粒,对照组给予基础治疗加百令胶囊,2组均治疗6周。统计2组患者临床疗效,以及治疗前后呼吸困难程度状况评分、肺功能、血气分析,采集患者治疗前后血清进行相关指标检测。结果经1个疗程治疗后,试验组总有效率为75%,对照组总有效率为55%。2组患者的临床症状、肺功能及血气分析较服药前均有所改善。治疗后患者血清中TGF-β_(1)、TNF-α表达下降;Notch通路主要指标Notch 1、Jagged 1、Hes 1表达降低,RBP-Jκ表达升高。结论助助阳补肺除痹颗粒可以不同程度改善肺纤维化患者临床症状,缓解呼吸困难程度,干预肺功能及血气分析,降低患者血清中TGF-β_(1)、TNF-α含量,调节Notch 1、Jagged 1、RBP-Jκ、Hes 1的表达。

关键词：助阳补肺除痹颗粒肺纤维化临床试验 Notch通路

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普朗铜矿岩体可爆性分级及炸药单耗预测研究

矿业研究与开发 2024年第3期44卷 28-32页

作者：曾庆田李洪超冯兴隆黄永辉王启新武旭阳张智宇云南迪庆有色金属有限责任公司云南迪庆藏族自治州674400 昆明理工大学城市学院云南昆明650051 昆明理工大学电力工程学院云南昆明650500 昆明理工大学公共安全与应急管理学院云南昆明650093 昆明理工大学国土资源工程学院云南昆明650093

为优化普朗铜矿地下采矿爆破参数,采用集对分析的理论与模型,以线性相关度较低,工程中较易获取的岩体密度、抗拉强度、抗压强度、岩体完整性系数为衡量指标,对该矿区东部、西部、南部所属岩体进行岩体可爆性分级。首先计算各岩体试样的... 详细信息

为优化普朗铜矿地下采矿爆破参数,采用集对分析的理论与模型,以线性相关度较低,工程中较易获取的岩体密度、抗拉强度、抗压强度、岩体完整性系数为衡量指标,对该矿区东部、西部、南部所属岩体进行岩体可爆性分级。首先计算各岩体试样的单因素联系度,并采取层次分析法确定每个衡量条件下的指标权系数,最终得到一个基于这4项指标的综合表达式进而确定岩体的可爆性等级。研究结果表明,西部区域岩体可爆性属于较难,东部区域和南部区域岩体的可爆性属于较易。在可爆性分级的基础上,对东部、南部、西部岩体进行了炸药单耗的预测,为爆破参数的选取提供一定的指导。

关键词：岩体可爆性集对分析模型层次分析法炸药单耗

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感染性心内膜炎的外科治疗

河南外科学杂志 2010年第6期16卷 1-3页

作者：柴守栋马增山马胜军董铭峰王建堂冯致余唐培哲山东聊城市人民医院心脏外科聊城252000

目的评价外科手术治疗感染性心内膜炎的经验和效果。方法回顾性分析15例感染性心内膜炎的外科治疗方法。先天性心脏病5例,风湿性心脏瓣膜病9例,右心室异物1例。术前超声检查赘生物形成14例,血培养阳性4例。全组病例中行心脏缺损矫正修补... 详细信息

目的评价外科手术治疗感染性心内膜炎的经验和效果。方法回顾性分析15例感染性心内膜炎的外科治疗方法。先天性心脏病5例,风湿性心脏瓣膜病9例,右心室异物1例。术前超声检查赘生物形成14例,血培养阳性4例。全组病例中行心脏缺损矫正修补5例,主动脉瓣置换术5例,二尖瓣置换术4例。结果全组病例均无术中死亡,1例术后因严重低心排综合征早期死亡,14例治愈出院,随访6个月～4a,预后良好,无复发及死亡病例。结论手术治疗感染性心内膜炎是一种有效的治疗措施,它降低了感染性心内膜炎的病死率。正确掌握手术时机,彻底清除感染病灶,恢复瓣膜功能以及围手术期应用有效抗生素是提高感染性心内膜炎治愈率的关键。

关键词：心内膜炎细菌性外科手术

Electron transfer in Cu/Cu_(2)O generated by disproportionation promoting efficient CO_(2)photoreduction

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Nano Research 2022年第8期15卷 7099-7106页

作者： Qian Zhu Kainan Zhu Minmin Cai Yaowen Zhang zhiyu Shao Mengpei Jiang Xiyang Wang Zhibin Geng Xiaofeng Wu Manrong Li Keke Huang Shouhua feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

Constructing a high-efficiency composite material for CO_(2)photoreduction is a key step to the achievement of carbon neutralization,but a comprehensive understanding of the factors that dictate CO_(2)reduction activity remains ***,we constructed a series of Cu in situ combined on Cu_(2)O(Cu/Cu_(2)O-1,-2,-3)via an acid disproportionation method with various processing *** optimal photocatalyst(Cu/Cu_(2)O-2)affords CO at a rate of 10.43μmol·g^(−1)·h^(−1),which is more than fourfold to that of pristine Cu_(2)*** transfer in the samples was detected by X-ray absorption spectroscopy(XAS)as well as X-ray photoelectron spectroscopy(XPS).Interestingly,the best photoreduction performance was not achieved by the sample possessing the most electron transfer(Cu/Cu_(2)O-1)but by the one with moderate electron transfer(Cu/Cu_(2)O-2).By virtue of density functional theory(DFT)calculations,a linear relationship between Bader charge variation(Δq)of the active sites and adsorption energy of CO_(2)reduction intermediates was discovered,wherein the moderate charge transfer corresponds to appropriate adsorption energy,which benefits CO_(2)photoreduction activity *** work provides guidance for the construction of composite catalysts for efficient CO_(2)photoreduction in a perspective of the quantity of electron transfer.

关键词： CO_(2)photocatalytic conversion charge transfer composite density functional theory(DFT)

血清脂蛋白a表达水平与原发性肺癌骨转移的关系

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中华生物医学工程杂志 2024年第3期30卷 207-210页

作者：沈孝镇舒创维张烽李智宇钟楚澄罗学平广州医科大学附属第五医院胸外科广州市加速康复腹部外科重点实验室广州

目的探讨原发性肺癌骨转移患者中血清脂蛋白a的表达水平, 为原发性肺癌骨转移的诊断和治疗提供新的思路和依据。方法选取2017年10月至2022年10月间400例就诊于广州医科大学附属第五医院原发性肺癌患者作为研究对象。其中280例为原发性... 详细信息

目的探讨原发性肺癌骨转移患者中血清脂蛋白a的表达水平, 为原发性肺癌骨转移的诊断和治疗提供新的思路和依据。方法选取2017年10月至2022年10月间400例就诊于广州医科大学附属第五医院原发性肺癌患者作为研究对象。其中280例为原发性肺癌骨转移组, 包括男性200例和女性80例, 年龄范围在28～85岁;其余120例为原发性肺癌无骨转移组, 包括90名男性和30名女性, 年龄范围在29～88岁。所有骨转移患者均接受了骨扫描及磁共振成像(MRI)检查。收集这些患者的临床一般资料, 测定纳入患者血浆中血清脂蛋白a的表达水平。结果原发性肺癌患者中, 有骨转移和无骨转移患者在性别分布、吸烟史和饮酒史方面差异无统计学意义(均P>0.05), 原发性肺癌骨转移患者血清脂蛋白a的表达水平较非骨转移患者明显升高(P<0.05)。结论原发性肺癌骨转移患者的血清脂蛋白a表达水平明显高于非骨转移组, 这可能为原发性肺癌骨转移的诊断和治疗提供新的思路和依据。

关键词：脂蛋白类原发性肺癌骨转移骨扫描磁共振成像

The host microbiota is associated with the occurrence and development of esophageal squamous cell carcinoma

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Protein & Cell 2023年第4期14卷 294-298页

作者： Jing Zuo Yanjun Liu Wenjing Lv Yudong Wang Zhisong Fan Long Wang Li feng Xue Zhang Jing Hani zhiyu Ni Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China The Affliated Hospital of Hebei University Baoding 071000China School of Basic Medical Science Hebei UniversityBaoding 071000China

DearEditor,Microecology is an emerging research area,particularly that of the digestive system(Marchesi et al.,2016;Wang et al.,2018).The intestinal microbiota contains a rich and complex microbial ecosystem that is in dynamic balance,the disruption of which can result in disease(Yatsunenko et al.,2012;Li et al.,2017;He et al.,2018).For example,studies have found that the esophagus has a variety of colonizing bacteria that may be related to esophageal cancer.

关键词： al. esophageal esophagus

Atmospheric fine particles in a typical coastal port of Yangtze River Delta

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Journal of Environmental Sciences 2020年第12期32卷 62-70页

作者： Qi Yuan Xiaomi Teng Shaoxuan Tu Binxin feng zhiyu Wu Hang Xiao Qiuliang Cai Yinxiao Zhang Qiuhan Lin Zhaoce Liu Mengmeng He Xiaokun Ding Weijun Li Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province Department of Atmospheric SciencesSchool of Earth SciencesZhejiang UniversityHangzhou 310027China Center for Excellence in Regional Atmospheric Environment&Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Environmental Processes and Pollution Control of Zhejiang Province Ningbo Urban Environment Observation and Research StationChinese Academy of SciencesNingbo 315830China School of Earth Science and Engineering Hebei University of EngineeringHandan 056038China Department of Chemistry Zhejiang UniversityHangzhou 310027China

In recent decades, coastal ports have experienced rapid development and become an important economic and ecological hub in China. Atmospheric particle is a research hotspot in atmospheric environmental sciences in inland regions. However, few studies on the atmospheric particle were conducted in coastal port areas in China, which indeed suffers atmospheric particle pollution. Lack of the physicochemical characteristics of fine particles serves as an obstacle toward the accurate control for air pollution in the coastal port area in China. Here, a field observation was conducted in an important coastal port city in Yangtze River Delta from March 6 to March 19, 2019. The average PM2.5 concentration was 63.7 ±27.8 μg/m^3 and NO3^-, SO4^2-, NH4^+, and organic matter accounted for ?60% of PM 2.5. Fe was the most abundant trace metal element and V as the ship emission indicator was detected. Transmission electron microscopy images showed that SK-rich, soot, Fe, SK-soot and SK-Fe were the major individual particles in the coastal port. V and soluble Fe were detected in sulfate coating of SK-Fe particles. We found that anthropogenic emissions, marine sea salt, and secondary atmosphere process were the major sources of fine particles. Backward trajectory analysis indicated that the dominant air masses were marine air mass, inland air mass from northern Zhejiang and inland-marine mixed air mass from Shandong and Shanghai during the sampling period. The findings can help us better understand the physicochemical properties of atmospheric fine particles in the coastal port of Eastern China.

关键词： Coastal port Water-soluble ion Organic matter Trace metal Individual particle

Dynamic Cantilever Magnetometry of Paramagnetism with Slow Relaxation

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Chinese Physics Letters 2022年第3期39卷 94-98页

作者： zhiyu Ma Kun Fan Qi Li feng Xu Lvkuan Zou Ning Wang Li-Min Zheng Fei Xue Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Dynamic cantilever magnetometry is a sensitive method that has been widely used in studying magnetic anisotropy in ferromagnetic materials and Fermi surface in quantum *** study a cobalt-iridium metal-metalloligand coordination polymer using dynamic cantilever *** experimental data of dynamic cantilever magnetometry are well explained using the proposed model for Langevin paramagnetism with slow *** on the proposed model,we calculate the magnetization and magnetic susceptibility of paramagnetic materials from frequency shifts of a *** extracted magnetization and magnetic susceptibility are consistent with those obtained from conventional DC and AC *** proposed slow relaxation picture is probably a general model for explaining dynamic cantilever magnetometry data of paramagnetic materials,including previously observed dynamic cantilever magnetometry data of paramagnetic metals[Gysin et al.2011 Nanotechnology22285715].

关键词： cantilever magnetization susceptibility

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基于文献计量的秸秆饲料化利用研究进展

中国农学通报 2024年第1期40卷 102-111页

作者：朱懿徐志宇孙仁华袁毅冯浩杰薛颖昊山东农业大学资源与环境学院山东泰安271018 农业农村部农业生态与资源保护总站北京100125

为整体分析农作物秸秆饲料化利用研究进展,选取2002—2021年Web of Science核心合集数据库和CNKI中国学术文献网络出版总库中秸秆饲料化研究的相关文献,采用CiteSpace软件进行可视化展示,主要对秸秆饲料化利用领域的国内外研究力量、研... 详细信息

为整体分析农作物秸秆饲料化利用研究进展,选取2002—2021年Web of Science核心合集数据库和CNKI中国学术文献网络出版总库中秸秆饲料化研究的相关文献,采用CiteSpace软件进行可视化展示,主要对秸秆饲料化利用领域的国内外研究力量、研究热点和研究前沿进行分析。结果表明,2002—2021年秸秆饲料化利用相关的中英文文献数量整体呈逐年上升态势,中国、美国、印度等国家研究体量较大;中英文发文量排名第一的科研机构分别是中国农业大学和印度农业研究理事会;中文主要发文作者间的合著关系由星型向网状结构过渡,英文主要发文作者间呈现星型、环型、树型、网状结构等多种合著关系;来自孔敬大学的Wanapat发文156篇,名列英文文献高产作者首位。秸秆饲料化利用领域中文文献研究热点为“乳酸菌”、“组合效应”、“青贮”、“发酵品质”和“生长性能”,研究前沿聚焦于反刍动物生产和生长性能、添加剂对青贮和微贮发酵品质的影响等方向。英文文献研究热点为“nutritive value”、“growth”、“rumen fermentation”、“dairy cow”和“degradation”,研究前沿聚焦于秸秆发酵和瘤胃发酵过程中微生物菌群的动态调节机制、添加剂对饲料养分利用率和动物能量代谢的综合影响等方面。上述研究结果可为秸秆饲料化利用领域学者凝练科学问题提供参考。

关键词：文献计量秸秆饲料 CiteSpace 研究热点前沿分析