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Chinese Journal of Chemical Engineering 2024年第2期66卷 310-331页

作者： Yao li Yuchun Zhang zhiyu li Huiyan Zhang Peng Fu College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255000China Key Laboratory of Energy Thermal Conversion and Control Ministry of EducationSchool of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Biomass-to-ethylene glycol is an effective means to achieve high-value utilisation of cellulose but is hindered by low conversion efficiency and poor catalyst activity and stability.Glucose and cellobiose are derivatives of cellulose conversion to ethylene glycol,and it is found that studying the reaction process of both can help to understand the reaction mechanism of cellulose.It is desirable to develop a reusable,highly active catalyst to convert cellulose into ethylene glycol.This ideal catalyst might have one or more active sites described the conversion steps above.Here,we discuss the catalyst development of celluloseto-ethylene glycol,including tungsten,tin,lanthanide,and other transition metal catalysts,and special attention is given to the reaction mechanism and kinetics for preparing ethylene glycol from cellulose,and the economic advantages of biomass-to-ethylene glycol are briefly introduced.The insights given in this review will facilitate further development of efficient catalysts,for addressing the global energy crisis and climate change related to the use of fossil fuels.

关键词： Ethylene glycol Cellulose Catalyst Retro-aldol condensation Hydrolysis Kinetics

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Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen li Jiali Huang Chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu zhiyu li Yi Ma Jinlei Bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such drugs.To address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation exposure.The optimized prodrug,DON-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell killing.Unlike the parent drug DON,DON-TK-BM3 exhibited no toxicity toward normal cells.Moreover,DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in mice.This study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

From risk control to resilience: developments and trends of urban roads designed as surface flood passages to cope with extreme storms

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 103-120页

作者： zhiyu Shao Yuexin li Huafeng Gong Hongxiang Chai College of Environment and Ecology Chongqing UniversityChongqing 400030China Key Laboratory of Ecological Environment of Ministry of Education of Three Gorges Reservoir Area Chongqing UniversityChongqing 400030China T.Y.lin International Engineering Consulting(China)Co.Ltd. Chongqing 400045China

Urban roads can be designated as surface flood passages to transport excess runoff during extreme storms, thereby preventing local flooding, which is known as the major drainage system. However, this practice poses significant risks, including human loss and property damage, due to the high flow rate and velocity carried by roads. Moreover, urban roads with low flood-resilience may significantly hamper the transportation function during severe storms, leading to dysfunction of the city. Therefore, there is an urgent need to transform risk-oriented flood passages into resilient urban road-based flood passages. This paper presents a systematic review of existing methodologies in designing a road network-based flood passage system, along with the discussion of new technologies to enhance system resilience. The study also addresses current knowledge gaps and future directions. The results indicate that flood management measures based on the urban road network should integrate accessibility assessment, lifeline and emergency planning to ensure human well-being outcomes. Furthermore, the special needs and features of vulnerable groups must be taken into serious consideration during the planning stage. In addition, a data-driven approach is recommended to facilitate real-time management and evaluate future works.

关键词： Major drainage Flood mitigation Resilient city Stormwater model Urban flooding

Harnessing overlapped temperature-salinity gradient in solar-driven interfacial seawater evaporation for efficient steam and electricity generation

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Journal of Energy Chemistry 2024年第8期95卷 694-700页

作者： Peida li Dongtong He Jingchang Sun Jieshan Qiu zhiyu Wang State Key Lab of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical Engineering Dalian University of Technology School of Physics and Electronic Technology Liaoning Normal University College of Chemical Engineering Beijing University of Chemical Technology

Solar-driven interfacial water evaporation（SIWE） offers a superb way to leverage concentrated solar heat to minimize energy dissipation during seawater desalination. It also engenders overlapped temperaturesalinity gradient（TSG） between water-air interface and adjacent seawater, affording opportunities of harnessing electricity. However, the efficiency of conventional SIWE technologies is limited by significant challenges, including salt passivation to hinder evaporation and difficulties in exploiting overlapped TSG simultaneously. Herein, we report self-sustaining hybrid SIWE for not only sustainable seawater desalination but also efficient electricity generation from TSG. It enables spontaneous circulation of salt flux upon seawater evaporation, inducing a self-cleaning evaporative interface without salt passivation for stable steam generation. Meanwhile, this design enables spatial separation and simultaneous utilization of overlapped TSG to enhance electricity generation. These benefits render a remarkable efficiency of90.8% in solar energy utilization, manifesting in co-generation of solar steam at a fast rate of 2.01 kg m-2-h-1and electricity power of 1.91 W m-2with high voltage. Directly interfacing the hybrid SIWE with seawater electrolyzer constructs a system for water-electricity-hydrogen co-generation without external electricity supply. It produces hydrogen at a rapid rate of 1.29 L h-1m-2and freshwater with 22 times lower Na+concentration than the World Health Organization（WHO） threshold.

关键词： Electricity generation Seawater Solar-driven interfacial water evaporation Steam generation

Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： zhiyu Chen Fang li Lei Fu Yu Xia Ying Luo Ang Guo Xiaona Zhu Huifang Zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the disease.We have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)children.Eight PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,respectively.Moreover,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as control.Thirty-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and TNBP.These results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

Hypertension and NAFLD risk:Insights from the NHANES 2017-2018 and Mendelian randomization analyses

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Chinese Medical Journal 2024年第4期137卷 457-464页

作者： Mengqin Yuan Jian He Xue Hu lichao Yao Ping Chen Zheng Wang Pingji liu zhiyu Xiong Yingan Jiang Lanjuan li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430000China Department of Gastroenterology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510010China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Centre for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310000China

Background:Hypertension and non-alcoholic fatty liver disease(NAFLD)share several pathophysiologic risk factors,and the exact relationship between the two remains unclear.Our study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey(NHANES)2017-2018 and Mendelian randomization(MR)analyses.Methods:Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES 2017-2018.Subsequently,a two-sample MR study was performed using the genome-wide association study(GWAS)summary statistics to identify the causal association between hypertension,systolic blood pressure(SBP),diastolic blood pressure(DBP),and NAFLD.The primary inverse variance weighted(IVW)and other supplementary MR approaches were conducted to verify the causal association between hypertension and NAFLD.Sensitivity analyses were adopted to confirm the robustness of the results.Results:A total of 3144 participants were enrolled for our observational study in NHANES.Weighted multivariable-adjusted logistic regression analysis suggested that hypertension was positively related to NAFLD risk(odds ratio[OR]=1.677;95%confidence interval[CI],1.159-2.423).SBP≥130 mmHg and DBP≥80 mmHg were also significantly positively correlated with NAFLD.Moreover,hypertension was independently connected with liver steatosis(β=7.836[95%CI,2.334-13.338]).The results of MR analysis also supported a causal association between hypertension(OR=7.203[95%CI,2.297-22.587])and NAFLD.Similar results were observed for the causal exploration between SBP(OR=1.024[95%CI,1.003-1.046]),DBP(OR=1.047[95%CI,1.005-1.090]),and NAFLD.The sensitive analysis further confirmed the robustness and reliability of these findings(all P>0.05).Conclusion:Hypertension was associated with an increased risk of NAFLD.

关键词： Hypertension Non-alcoholic fatty liver disease National Health and Nutrition Examination Survey Mendelian randomization analysis Causality

Steering surface reconstruction of hybrid metal oxides for efficient oxygen evolution reaction in water splitting and zinc-air batteries

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Journal of Energy Chemistry 2024年第5期92卷 383-393页

作者： Jie Zhu Junxue Chen Xida li Kun Luo Zewei Xiong zhiyu Zhou Wenyun Zhu Zhihong Luo Jingbin Huang Yibing li Key Lab of New Processing Technology for Nonferrous Metals and Materials Ministry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541000GuangxiChina The Key Laboratory of Rare Earth Functional Materials and Applications Zhoukou Normal UniversityZhoukou 466001HenanChina School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164JiangsuChina Wuhan Sunmoon Battery Co. LtdWuhan 430090HubeiChina

Surface reconstruction yields real active species in electrochemical oxygen evolution reaction(OER)conditions;however,rationally regulating reconstruction in a targeted manner for constructing highly active OER electrocatalysts remains a formidable challenge.Here,an electrochemical activation strategy with selective etching was utilized to guide the reconstruction process of a hybrid cobalt-molybdenum oxide(CoMoO_(4)/Co_(3)O_(4)@CC)in a favorable direction to improve the OER performance.Both in-situ Raman and multiple ex-situ characterization tools demonstrate that controlled surface reconstruction can be easily achieved through Mo etching,with the formation of a dynamically stable amorphous-crystalline heterostructure.Theoretical calculations together with experimental results reveal that the synergistic effects between amorphous CoOOH and crystalline Co_(3)O_(4) are crucial in enhancing the catalytic performance.Consequently,the reconstructed CoMoO_(4)/Co_(3)O_(4)@CC exhibits a low overpotential of 250 mV to achieve a current density of 10 mA cm^(-2) in 1 M KOH,and more importantly it can be practiced in electrolytic water splitting and rechargeable zinc-air batteries devices,achieving ultra-long stability for over 500 and 1200 h,respectively.This work provides a promising route for the construction of high-performance electrocatalysts.

关键词： Electrocatalyst Oxygen evolution reaction Surface reconstruction Selective etching Amorphous-crystalline heterostructures

GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

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Oncology Research 2024年第2期32卷 361-371页

作者： TINGTING li WEI ZHONG liU YANG zhiyu ZHAO li WANG CONG liU WANYUN li HAIYAN LV SHENGYU WANG JIANGHUA YAN TING WU GANG SONG FANGHONG LUO Cancer Research Center School of MedicineXiamen UniversityXiamen361000China Department of Pharmacy Xiamen Mental Health CenterXiamen Xianyue HospitalXiamen361000China

The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1)represents a therapeutic target and its regulating mechanism in GC.GIPC1 expression was elevated in GC tissues,liver metastasis tissues,and lymph node metastases.GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of GC cells.Conversely,GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted GC cell proliferation and migration.Furthermore,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPC1 expression.Moreover,GIPC1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPC1 overexpression had contrasting effects.Taken together,our findings suggest that GIPC1 functions as an oncogene in GC and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway.

关键词： GIPC1 PDGFR Gastric cancer Proliferation Migration

Personalized HRTF Prediction Based on light GBM Using Anthropometric Data

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China Communications 2023年第6期20卷 166-177页

作者： Yinliang Qiu Jing Wang zhiyu li School of Information and Electronics Beijing Institute of TechnologyBeijing 100876China

This paper proposes a personalized headrelated transfer function(HRTF)prediction method based on light GBM using anthropometric data.Considering the overfitting problems of the current training-based prediction methods,we use light GBM and a specific network structure to prevent over-fitting and enhance the prediction performance.By decomposing and combining the data to be predicted,we set up 90 light GBM models to separately predict the 90instants of HRTF in log domain.At the same time,the method of 10-fold cross-validation is used to score the accuracy of the model.For models with scores below 80 points,Bayesian optimization is used to adjust model hyperparameters to obtain a better model structure.The results obtained by light GBM are evaluated with spectral distortion(SD)which can show the fitting error between the prediction and the original data.The mean SD values of both ears on the whole test set are 2.32 d B and 2.28 d B respectively.Compared with the non-linear regression method and the latest method,SD value of light GBM-based method relatively decreases by 83.8%and 48.5%.

关键词： personalized HRTF anthropometric data lightGBM over-fitting

Enhanced electromagnetic wave absorption via optical fiber-like PMMA@Ti_(3)C_(2)T_(x)@SiO_(2) composites with improved impedance matching

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Nano Research 2024年第3期17卷 1676-1686页

作者： Huanhuan Niu Xuewen Jiang Wei li zhiyu Min Budi Riza Putra Wulan Tri Wahyuni Hailong Wang Rui Zhang Bingbing Fan School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Department of Materials and Earth Sciences Technical University of DarmstadtDarmstadt 64287Germany School of Material Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China Research Center for Metallurgy National Research and Innovation Agency(BRIN)PUSPIPTEK Gd.470South TangerangBanten 15315Indonesia Analytical Chemistry Division Department of ChemistryFaculty of Mathematics and Natural SciencesIPB UniversityWest Java 16680Indonesia

Ti_(3)C_(2)T_(x) nanosheets have attracted significant attention for their potential in electromagnetic wave absorption(EWA).However,their inherent self-stacking and exorbitant electrical conductivity inevitably lead to serious impedance mismatch,restricting their EWA application.Therefore,the optimization of impedance matching becomes crucial.In this work,we developed polymethyl methacrylate(PMMA)@Ti_(3)C_(2)T_(x)@SiO_(2) composites with a sandwich-like core–shell structure by coating SiO_(2) on PMMA@Ti_(3)C_(2)T_(x).The results demonstrate that the superiority of the SiO_(2) layer in combination with PMMA@Ti_(3)C_(2)T_(x),outperforming other relative graded distribution structures and meeting the requirements of EWA equipment.The resulting PMMA@Ti_(3)C_(2)T_(x)@SiO_(2) composites achieved a minimum reflection loss of-58.08 dB with a thickness of 1.9 mm,and an effective absorption bandwidth of 2.88 GHz.Mechanism analysis revealed that the structural design of SiO_(2) layer not only optimized impedance matching,but also synergistically enhanced multiple loss mechanisms such as interfacial polarization and dipolar polarization.Therefore,this work provides valuable insights for the future preparation of high-performance electromagnetic wave absorbing Ti_(3)C_(2)T_(x)-based composites.

关键词： polymethyl methacrylate(PMMA)@Ti_(3)C_(2)T_(x)@SiO_(2)composites impedance match SiO_(2)layer optical fiber-like structure interfacial polarization and dipolar polarization