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Investigating the interaction between umami peptides and umami receptor T1R1/T1R3-VFT: a computational approach

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Food Science and Human Wellness 2024年

作者： Hengli Meng zhiyong Cui Yingqiu Li Yanyang yu Shui Jiang yuan Liu Department of Food Science & Technology， School of Agriculture and Biology， Shanghai Shanghai Jiao Tong University Secondary College of Cereals and Tourism， Guangxi Vocational College of Technology and Business

The study of ligand-receptor interactions is of great significance in food flavor perception. In this study， a computer simulation method was used to investigate the mechanism of interaction between umami peptides and T1R1/T1R3-VFT receptor. The binding site， conformational changes， and binding free energy between umami peptides and T1R1/T1R3-VFT were analyzed through molecular modeling， molecular docking， and molecular dynamics simulations. The receptor model constructed using AlphaFold2 has the best rationality. The molecular docking results showed that umami peptides primarily bound to T1R1-VFT through hydrogen bonding， with key binding residues such as 149THR， 151ARG， and 108ASP. The binding of umami peptides led to a more stable complex system， and the positively charged amino acids contributed positively to the overall binding free energy. This study provides theoretical support for the development of a better understanding of the interaction between umami substances and the umami receptor.

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Playing,learning and having fun

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Changjiang Weekly 2022年第29期 8-9页

作者： Liu Jia Zhang Lin Zhou Chao Gao Yong Li Yonggang yu zhiyong 不详

During July 14 to 20o,although it was vacation time for schools in Wuhan,anyone who looked around would see the youth of the city engaged in many educational and challenging activities-tie-dyeing,museums,board games,g... 详细信息

关键词： dyeing sorting engaged

Effect of hypoxia on migration, invasion and adhesion to endothelium of human pulmonary adenocarcinoma A549 cells

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The Chinese-German Journal of Clinical Oncology 2008年第9期7卷 509-514页

作者： Weigan Shen Jun Zhu zhiyong yu Qingyu Xue Department of Cell Biology Medical College of Yangzhou University Yangzhou 225001 China Department of Biology Yangzhou Educational College Yangzhou 225000 China

Objective： To evaluate the effect of hypoxia on migration, invasion and adhesion to endothelium of human pulmo- nary adenocarcinoma A549 cells. Methods： Wound-healing and Transwell invasion assays were performed to study the effect of hypoxia on migration and invasion of A549 cells, and A549 cells were added to a monolayer of human umbilical vein endo-thelial cells （HUVECs） to test the ability to adhere to endothelium. Immunofluorescence assay and luciferase reporter gene assay were also used to evaluate the effect of hypoxia on distribution of E-cadherin, β-catenin, and actin, and hypoxia-inducible factor-1 （HIF-1）-dependent transcription, respectively. Results： Hypoxia facilitated A549 cell migration, invasion, and A549 cell-endothelial cells adhesion, and modulated the distribution of E-cadherin and β-catenin, and actin cytoskeleton rearrange-ment, and up-regulated HIF-l-dependent reporter gene expression in A549 cells. Conclusion： Promotion ofA549 cell migration, invasion, and adhesion on endothelium by hypoxia might be modulated through its up-regulating HIF-l-dependent gene expression, which then induced the redistribution of E-cadherin and β-catenin, and the actin cytoskeletal reorganization.

关键词： Hypoxia migration invasion adhesion A549 cell

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精密减速器回差试验台的精度特性

光学精密工程 2023年第16期31卷 2372-2382页

作者：俞志勇石照耀程慧明于渤张临涛北京工业大学材料与制造学部北京市精密测控技术与仪器工程技术研究中心

精密减速器回差试验台是非标设备，迄今对其精度特性缺乏系统性研究以至于还没有检定规程去评定该类测试设备的计量性能。为了评估精密减速器回差试验台的精度特性，提出了试验台精度的评定方法。首先，分析了精密减速器回差试验台的结... 详细信息

精密减速器回差试验台是非标设备，迄今对其精度特性缺乏系统性研究以至于还没有检定规程去评定该类测试设备的计量性能。为了评估精密减速器回差试验台的精度特性，提出了试验台精度的评定方法。首先，分析了精密减速器回差试验台的结构，确定了转矩传感器测量误差、角度传感器测量误差、转矩测量链摩擦转矩以及角度测量链弹性扭转角这四个因素是影响试验台精度的主要误差源。接着，研究了误差源的作用机理，提出了通过滞回曲线将转矩类误差转换为角度类误差的方法，统一了误差的类型。然后，提出了滞回曲线局部线性化的概念，实现了转矩类误差转换为角度类误差的简便计算。最后，根据回差的表达式给出了试验台精度的评定方法，并进行了测试实践。结果表明：几何回差的测试误差为±0.04′；弹性回差的测试误差为±0.06′；总回差的测试误差为±0.04′，回差试验台精度满足要求，本文提出的方法对评定试验台精度是有效的。另外，对精密减速器输出端一转范围内多处测试，能提升测试精度。

关键词：精密减速器试验台回差精度特性滞回曲线

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Tianshanbeilu and the Isotopic Millet Road: reviewing the late Neolithic/Bronze Age radiation of human millet consumption from north China to Europe

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National Science Review 2019年第5期6卷 1024-1039页

作者： Tingting Wang Dong Wei Xien Chang zhiyong yu Xinyu Zhang Changsui Wang Yaowu Hu Benjamin T.Fuller Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Palaeontology and PalaeoanthropologyChinese Academy of Sciences Institute of Archaeology and Cultural Relics of Xinjiang Uyghur Autonomous Region Research Center for Chinese Frontier Archaeology Jilin University Department of Anthropology School of Sociology and Anthropology Sun Yat-sen University Department of Archaeology and Anthropology University of Chinese Academy of Sciences

The westward expansion of human millet consumption from north China has important implications for understanding early interactions between the East and ***, few studies have focused on the Xinjiang Uyghur Autonomous Region, the vast geographical area directly linking the ancient cultures of the Eurasian Steppe and the Gansu Corridor of *** this study, we present the largest isotopic investigation of Bronze Age China(n = 110) on material from the key site of Tianshanbeilu, in eastern *** large range of δC values(–17.6 to –7.2; –15.5 ± 1.2) provides direct evidence of unique dietary diversity and consumption of significant Cresources(millets).The high δN results(10.3 to 16.7;14.7 ± 0.8) likely reflect sheep/goat and wild game consumption and the arid climate of the Taklamakan *** dates from four individuals indicate Tianshanbeilu was in use between 1940 and1215 cal *** Tianshanbeilu results are then analysed with respect to 52 Bronze Age sites from across Eurasia, to investigate the spread and chronology of significant human millet consumption and human *** isotopic survey finds novel evidence that the second millennium bc was a dynamic period,with significant dietary interconnectivity occurring between north China, Central Asia and ***,we argue that this ‘Isotopic Millet Road’ extended all the way to the Mediterranean and Central Europe, and conclude that these Cdietary signatures of millet consumption reflect early links(migration and/or resource transfer) between the Bronze Age inhabitants of modern-day China and Europe.

关键词： Inner Asian Mountain Corridor Silk Road Xinjiang Old World crop globalization Shang Dynasty

Structure and electrical properties of ternary BiFeO_(3)-BaTiO_(3)-PbTiO_(3) high-temperature piezoceramics

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Journal of Advanced Ceramics 2012年第3期1卷 227-231页

作者： Zhonghua YAO Ying LIU Zhe SONG Zhijian WANG Hua HAO Minghe CAO zhiyong yu Hanxing LIU State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and Key Laboratory of Advanced Technology for Specially Functional Materials Ministry of EducationWuhan University of TechnologyWuhan 430070China

In the current work,the bulk ternary(0.85-x)BiFeO3-xBaTiO3-0.15PbTiO3(BF-BTx-PT,x=0.08-0.35)system has been studied as a potential high-temperature *** with various content of BT were prepared via solid-state route,and pure perovskite phase was confirmed by X-ray *** temperature dependence of dielectric constants confirmed the decrease of Curie temperature with increasing BT *** was found that the morphotropic phase boundary(MPB)composition of BF-BTx-PT ceramics was in the vicinity of x=0.15,which exhibits optimal properties with piezoelectric constant d33 of 60 pC/N,high Curie temperature of 550℃,and low sintering temperature of 920℃.Measurements also showed that the depoling temperature was 300℃,about 150℃higher than that of commercialized PZT ceramics,which indicated good temperature ***-BTx-PT ceramics are promising candidates for high temperature applications.

关键词： ceramics piezoelectric materials barium titanate perovskite ferroelectrics

Risk Factors for Norovirus Outbreaks in Schools and Kindergartens — Beijing Municipality, China, July 2017–June 2022

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China CDC weekly 2024年第33期6卷 841-845页

作者： Baiwei Liu yu Wang Mengdi Tan Boran E Dongxue Zhang Hanqiu Yan Quanyi Wang Daitao Zhang Lei Jia zhiyong Gao Institute for Infectious Disease and Endemic Disease Control Beijing Center for Disease Prevention and ControlBeijingChina School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina School of Public Health Capital Medical UniversityBeijingChina Department of Endocrinology Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Summary What is already known on this topic?Norovirus is the leading cause of global acute gastroenteritis *** outbreaks mainly occur in schools and kindergartens in China,always causing public health *** is added by this report?Conditional logistic regression method was used to analyze the risk factors for norovirus outbreaks in schools and kindergartens,and found that students vomiting at school or kindergarten,case activity in public areas,and the first case’s classroom less than 5 meters from toilets were risk *** are the implications for public health practice?Effective measures to address these factors can help reduce the risk of norovirus outbreaks in schools and kindergartens.

关键词： let garten schools

Innovative 3D Microfluidic Intestinal Organoid Model for Assessing Cadmium Bioavailability in Food: Implications for Enhanced Exposure Risk Assessment

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Food Science and Human Wellness 2024年

作者： Yan Li Wen Sun Qiao Wang Wan Shi yu Chen zhiyong Gong Xiao Guo Xin Liu Yongning Wu Key Laboratory of Animal Biological Products & Genetic Engineering， Ministry of Agriculture and Rural， Sinopharm Animal Health Corporation Ltd. State Key Laboratory of Novel Vaccines for Emerging Infectious Diseases， China National Biotec Group Company Limited Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education)， College of Food Science and Engineering， Wuhan Polytechnic University Department of Oncology， Xiangya Hospital， Central South University NHC Key Laboratory of Food Safety Risk Assessment， China National Center for Food Safety Risk Assessment

Given the severe toxicity and widespread presence of cadmium (Cd) in staple foods such as rice， accurate dietary exposure assessments are imperative for public health. In vitro bioavailability is commonly used to adjust dietary exposure levels of risk factors; however， traditional planar Transwell models have limitations， such as cell dedifferentiation and lack of key intestinal components， necessitating a more physiologically relevant in vitro platform. This study introduces an innovative three-dimensional (3D) intestinal organoid model using a microfluidic chip to evaluate Cd bioavailability in food. Caco-2 cells were cultured on the chip to mimic small intestinal villi's 3D structure， mucus production， and absorption functions. The model's physiological relevance was thoroughly characterized， demonstrating the formation of a confluent epithelial monolayer with well-developed tight junctions (ZO-1)， high microvilli density (F-actin)， and significant mucus secretion (Alcian blue staining)， closely resembling the physiological intestinal epithelium. Fluorescent particle tracking confirmed its ability to simulate intestinal transport and diffusion. The Cd bioavailability in rice measured by the 3D intestinal organoid model (9.07% ± 0.21%) was comparable to the mouse model (12.82% ± 3.42%) but significantly lower than the Caco-2 monolayer model (26.97% ± 1.11%). This 3D intestinal organoid model provides a novel and reliable strategy for in vitro assessment of heavy metal bioavailability in food， with important implications for food safety and risk assessment.

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Hollow Multishelled Structure: Synthesis Chemistry and Application

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Chemical Research in Chinese Universities 2024年第3期40卷 346-393页

作者： MAO Dan WANG Chao LI Wei ZHOU Liang LIU Jian ZHENG Zjian ZHAO Yong CAO An-min WANG Shutao HUANG Jiaxing HUO Fengwei CHEN Hongyu MAI Liqiang yu Ranbo WANG Lianzhou LU yunfeng yu Chengzhong YANG Qihua YANG Zhenzhong ZENG Hua Chun ZHAO Hujun TANG zhiyong ZHAO Dongyuan WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChineseAcademy of SciencesBeijing 100190P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBejing 100190P.R.China School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong SARP.R.China Department of Chemistry Fudan UniversityShanghai 200433P.R.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070P.R.China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China School of Chemistry Beihang UniversityBejing 100191P.R.China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of Engineering Westlake UniversityHangzhou 310024P.R.China School of Flexible Electronics(Future Technologies) Nanjing Tech UniversityNanjing 211816P.R.China School of Science Westlake UniversityHangzhou 310024P.R.China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070P.R.China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083P.R.China School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072Australia College of Life Science and Technology Bejing University of Chemical TechnologyBejing 100029P.R.China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200241P.R.China College of Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China Department of Chemical Engineering Tsinghua UniversityBeijing 100

Hollow multishelled structure(HoMS),a promising and complex multifunctional structural system,features at least two shells that are separated by internal *** unique structure endows it with numerous advantages including low density,high loading capacity,large specific surface area,facilitated mass transport,and multiple spatial confinement *** the past twenty years,benefiting from the booming development of synthesis methods,various HoMS materials have been prepared and show promising applications in diverse areas.

关键词： Hollow multishelled structure Synthesis chemistry Energy storage Catalysis Electromagnetic wave absorption Drug delivery Sensor