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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He zhiyi zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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VIBRATION CONTROL OF FLUID-FILLED PRISMATIC SHELL WITH ACTIVE CONSTRAINED LAYER DAMPING TREATMENTS

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Chinese Journal of Mechanical Engineering 2008年第1期21卷 101-105页

作者： LIU Lijun zhang zhiyi HUAHongxing zhang Yi State Key Laboratory of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China 704 Research Department China Ship and Heavy Industry Group Corporation Shanghai 200030 China

Active constrained layer damping （ACLD） combines the simplicity and reliability of passive damping with the light weight and high efficiency of active actuators to obtain high damping over a wide frequency band. A fluid-filled prismatic shell is set up to investigate the validity and efficiency of ACLD treatments in the case of fluid-structure interaction. By using state subspace identification method, modal parameters of the ACLD system are identified and a state space model is established subsequently for the design of active control laws. Experiments are conducted to the fluid-filled prismatic shell subjected to random and impulse excitation, respectively, For comparison, the shell model without fluid interaction is experimented as well. Experimental results have shown that the ACLD treatments can suppress vibration of the fluid-free and fluid-filled prismatic shell effectively. Under the same control gain, vibration attenuation is almost the same in both cases.

关键词： Active constrained layer damping Subspace identification method Vibration control

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IMPROVED COVARIANCE DRIVEN BLIND SUBSPACE IDENTIFICATION METHOD

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Chinese Journal of Mechanical Engineering 2006年第4期19卷 548-553页

作者： zhang zhiyi FAN Jiangling HUA Hongxing State Key Laboratory of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China

An improved covariance driven subspace identification method is presented to identify the weakly excited modes. In this method, the traditional Hankel matrix is replaced by a reformed one to enhance the identifiability of weak characteristics. The robustness of eigenparameter estimation to noise contamination is reinforced by the improved Hankel matrix, in combination with component energy index （CEI） which indicates the vibration intensity of signal components, an alternative stabilization diagram is adopted to effectively separate spurious and physical modes. Simulation of a vibration system of multiple-degree-of-freedom and experiment of a frame structure subject to wind excitation are presented to demonstrate the improvement of the proposed blind method. The performance of this blind method is assessed in terms of its capability in extracting the weak modes as well as the accuracy of estimated parameters. The results have shown that the proposed blind method gives a better estimation of the weak modes from response signals of small signal to noise ratio （SNR）and gives a reliable separation of spurious and physical estimates.

关键词： Subspace identification method Weak modes Hankel matrix Component energy index (CEI) Stabilization diagram

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ANALYSIS AND SIMULATION ON THE MECHANISM OF A NOVEL DUAL-WAVE SHOCK TEST MACHINE

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Chinese Journal of Mechanical Engineering 2008年第1期21卷 94-100页

作者： WANG Gongxian zhang zhiyi CHU Deying SHEN Rongying Institute of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China School of Logistics Engineering Wuhan University of Technology Wuhan 430063 China

For qualifying the anti-shock performance of shipboard equipments and simulating actual underwater explosion environments, a novel dual-wave shock test machine is proposed to increase testing capability of shock test machines as well as to meet certain shock testing specification. The machine can generate a double-pulse acceleration shock for test articles according to specification defined in BV043/85. On the basis of the impact theory, a nonlinear dynamic model of the hydraulically-actuated test machine is established with thorough analysis on its mechanism which involves conversion of gas potential energy and dissipation of kinetic energy. Simulation results have demonstrated that the machine can produce a double-pulse acceleration shock in the time domain or a desired shock response spectrum in the frequency domain, which sets a theoretical base for the construction of the proposed machine.

关键词： Shock test machine Underwater explosion Velocity generator Pulse generator

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Non-coding RNA: a key regulator of the pathogenicity and immunity of Flaviviridae viruses infection

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Cellular & Molecular Immunology 2018年第2期15卷 185-186页

作者： zhiyi zhang Lifang Jiang Gucheng Zeng Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen UniversityGuangzhou510080China

Flaviviridae is a family of viruses that mainly spread through arthropod vectors,such as *** members of the Flaviviridae family include dengue virus(DENV),yellow fever virus,Zika virus(ZIKV),West Nile virus and hepatitis C virus(HCV).As Flaviviridae viruses remain a major global public health threat,elucidation of the exact mechanisms of pathogenesis during infection is required for the successful control of these deadly viruses.

关键词： immunity infection pathogenesis

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Raman spectroscopic study of DNA photodamage sensitized by hypocrellin B and 5-brominated-hypocrellin B

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Chinese Science Bulletin 1998年第13期43卷 1128-1135页

作者： Hongxia Zhao Yiming Xu zhiyi zhang Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China

Hypocrellin B (HB) is a highly effective photosensitizer. One of its derivatives, 5_brominated_hypocrellin B (5_Br_HB) has better photosensitive characteristics than it. Using Raman spectroscopy, the microcosmic photodamage to DNA sensitized by HB and 5_Br_HB was studied at molecular level. The results showed that when HB and 5_Br_HB were added to the solution of DNA and irradiated, the characteristic Raman frequencies and intensities of DNA changed to various degrees. The photodamage occurred on the whole DNA molecule, including phosphate backbone,deoxyribose and four bases. Not only the conformation but also the configuration of DNA was photodamaged: breakage of some H_bonds, disappearance of B_form conformation , scission of double or single strand and serious damage of four bases. The damage to A_T pairs was stronger than that to C_G pairs and DNA became polynucleotides finally. The 5_Br_HB_photosensitized damage to DNA was stronger than HB , which suggested the better photosensitive characteristics of 5_Br_HB in bioactive environment. The molecular mechanisms of photodamage to DNA sensitized by 5_Br_HB and HB were also elucidated.

关键词： hypocrellin B 5_brominated hypocrellin B calf thymus DNA photodamage Raman spectroscopy.

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Numerical modeling and analysis of the mechanism of a novel shock wave regulator for impact test

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High Technology Letters 2008年第2期14卷 187-192页

作者：王贡献 zhang zhiyi Wang Yu School of Logistics Engineering Wuhan University of Technology Wuhan 430063 P.R. China~ Naval Research Center Beijing~ 100973 P.R. China

Based on the concept of hydraulic dissipation of kinetic energy, a novel shock wave regulator, which is composed of a damper and an extemally triggered valve, is presented with thorough analyses on its working mechanism. By establishing motion equations of each component of the regulator and simulating the dynamic behavior of the whole system, the shock wave regulator is demonstrated numerically to be able to change the width and amplitude of shock pulses. Prompt and easy adjustment can be achieved by changing the equivalent flow area of damping orifices and consequently the closing velocity of the flow area of a valve, which makes it applicable to different impact testing.

关键词： impact test bumper shock pulse hydraulic braking

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Thermogalvanic hydrogel-based e-skin for self-powered on-body dual-modal temperature and strain sensing

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Microsystems & Nanoengineering 2024年第2期10卷 293-302页

作者： Zhaosu Wang Ning Li Xinru Yang zhiyi zhang Hulin zhang Xiaojing Cui College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China School of Physics and Information Engineering Shanxi Normal UniversityTaiyuan030031China

Sensing of both temperature and strain is crucial for various diagnostic and therapeutic ***,we present a novel hydrogel-based electronic skin(e-skin)capable of dual-mode sensing of temperature and *** thermocouple ion selected for this study is the iodine/triiodide(I−/I3−)redox couple,which is a common component in everyday *** leveraging the thermoelectric conversion in conjunction with the inherent piezoresistive effect of a gel electrolyte,self-powered sensing is achieved by utilizing the temperature difference between the human body and the external *** composite hydrogels synthesized from polyvinyl alcohol(PVA)monomers using a simple freeze‒thaw method exhibit remarkable flexibility,extensibility,and adaptability to human *** incorporation of zwitterions further augments the resistance of the hydrogel to dehydration and low temperatures,allowing maintenance of more than 90%of its weight after 48 h in the *** its robust thermal current response,the hydrogel was encapsulated and then integrated onto various areas of the human body,including the cheeks,fingers,and ***,the detection of the head-down state and the monitoring of foot movements demonstrate the promising application of the hydrogel in supervising the neck posture of sedentary office workers and the activity *** successful demonstration of self-powered on-body temperature and strain sensing opens up new possibilities for wearable intelligent electronics and robotics.

关键词： hydrogel modal utilizing

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NUMERICAL MODELING OF MULTI-CYLINDER ELECTRO-HYDRAULIC SYSTEM AND CONTROLLER DESIGN FOR SHOCK TEST MACHINE

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Chinese Journal of Mechanical Engineering 2007年第2期20卷 109-114页

作者： CHU Deying zhang zhiyi WANG Gongxian HUA Hongxing State Key Laboratory of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China

A high fidelity dynamic model of a high-energy hydraulically-actuated shock test machine for heavy weight devices is presented to satisfy the newly-built shock resistance standard and simulate the actual underwater explosion environments in laboratory as well as increase the testing capability of shock test machine. In order to produce the required negative shock pulse in the given time duration, four hydraulic actuators are utilized. The model is then used to formulate an advanced feedforward controller for the system to produce the required negative waveform and to address the motion synchronization of the four cylinders. The model provides a safe and easily controllable way to perform a ＂virtual testing＂ before starting potentially destructive tests on specimen and to predict performance of the system. Simulation results have demonstrated the effectiveness of the controller.

关键词： Shock test machine Negative shock pulse Actuator redundancy Feedforward controller Virtual testing

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An empirical study on constraint optimization techniques for test generation

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Science China(Information Sciences) 2017年第1期60卷 69-83页

作者： zhiyi zhang Zhenyu CHEN Ruizhi GAO Eric WONG Baowen XU State Key Laboratory for Novel Software Technology Nanjing University Department of Computer Science University of Texas at Dallas

Constraint solving is a frequent, but expensive operation with symbolic execution to generate tests for a program. To improve the efficiency of test generation using constraint solving, four optimization techniques are usually applied to existing constraint solvers, which are constraint independence, constraint set simplification, constraint caching, and expression rewriting. In this paper, we conducted an empirical study, using these four constraint optimization techniques in a well known test generation tool KLEE with 77 GNU Coreutils applications, to systematically investigate how these optimization techniques affect the efficiency of test generation. The experimental results show that these constraint optimization techniques as well as their combinations cannot improve the efficiency of test generation significantly for ALL-SIZED programs. Moreover, we studied the constraint optimization techniques with respect to two static metrics, lines of code(LOC) and cyclomatic complexity(CC), of programs. The experimental results show that the "constraint set simplification" technique can improve the efficiency of test generation significantly for the programs with high LOC and CC values. The"constraint caching" optimization technique can improve the efficiency of test generation significantly for the programs with low LOC and CC values. Finally, we propose four hybrid optimization strategies and practical guidelines based on different static metrics.

关键词： test generation symbolic execution constraint solving constraint optimization static metric

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