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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He zhiyi zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian Cancer Institute Handan 056500China Linzhou Cancer Hospital Linzhou 456550China Center for Disease Control and Prevention of Sheyang County Yancheng 224499China Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for Disease Control and Prevention Xinyang 464299China Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

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1990—2019年中国类风湿关节炎疾病负担的年龄-时期-队列模型分析及预测

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中华内科杂志 2025年第2期64卷 142-147页

作者：魏雪敏张娟李文静张志毅哈尔滨医科大学附属第一医院风湿免疫科哈尔滨150001

利用2019全球疾病负担研究数据库,采用Joinpoint回归模型分析中国类风湿关节炎发病率和标化伤残调整寿命年(DALY)率的变化趋势,基于年龄-时期-队列模型探讨年龄、时期和队列效应。采用灰色预测模型GM(1,1)对类风湿关节炎发病率及标化DAL... 详细信息

利用2019全球疾病负担研究数据库,采用Joinpoint回归模型分析中国类风湿关节炎发病率和标化伤残调整寿命年(DALY)率的变化趋势,基于年龄-时期-队列模型探讨年龄、时期和队列效应。采用灰色预测模型GM(1,1)对类风湿关节炎发病率及标化DALY率趋势进行拟合,并预测2020—2034年中国类风湿关节炎发病率及标化DALY率。结果显示,1990—2019年中国类风湿关节炎发病率、标化发病率及标化DALY率大体上呈现逐渐上升趋势,平均每年分别上升1.41%(95%CI 1.32%~1.44%,P<0.001)、0.10%(95%CI 0.01%~0.14%,P<0.001)、1.91%(95%CI 1.82%~2.12%,P<0.001)。年龄-时期-队列模型结果显示,1990—2019年中国类风湿关节炎发病率的纵向年龄曲线呈现先上升后下降的趋势,在60~64岁组达到高峰;标化DALY率纵向年龄曲线呈现逐渐上升的趋势,85~89岁组达到峰值。时期效应结果显示,1990—2019年中国类风湿关节炎发病风险呈先上升后下降趋势,2010—2014年发病风险最高,发病率风险RR=1.03(95%CI 1.00~1.06);DALY风险呈波动变化,表现为先下降后上升随后又下降的趋势,2005—2009年DALY风险最高RR=1.03(95%CI 1.02~1.05)。队列效应结果显示,出生越晚的人群发病风险和DALY风险越高。预测2020—2034年中国类风湿关节炎的发病率和标化DALY率呈现上升态势。类风湿关节炎仍然是重大公共卫生挑战,1990—2019年中国类风湿关节炎发病率、标化发病率及标化DALY率均呈现升高趋势,均不同程度地受年龄、时期效应及队列效应的影响。虽然中国类风湿关节炎负担低于全球平均水平,但仍然需要采取积极的预防措施以减轻类风湿关节炎的疾病负担。

关键词：关节炎类风湿发病率预测疾病负担年龄-时期-队列模型

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回指所致主被动不对应的认知语法分析

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外文研究 2025年第1期13卷 12-18,106页

作者：张智义南京师范大学江苏省南京市210046

由回指所导致的主被动不对应效应,既往研究较少涉及。生成语法自治的转换生成规则和成分统制规则,难以解释这种不对应。本研究基于认知语法,通过综合主被动构式认知语义、感知参照点和基线-加工模式分析,认为相关句式有两种基线构式,不... 详细信息

由回指所导致的主被动不对应效应,既往研究较少涉及。生成语法自治的转换生成规则和成分统制规则,难以解释这种不对应。本研究基于认知语法,通过综合主被动构式认知语义、感知参照点和基线-加工模式分析,认为相关句式有两种基线构式,不涉及回指的主动构式可以通过加工实现构式交替,涉及回指的主动构式由于感知参照点改变,指称意义改变,不能以加工实现构式交替。

关键词：主被动不对应基线-加工感知参照点构式交替

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基于细胞焦亡相关通路探讨中医药治疗糖尿病肾病的研究进展

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中国实验方剂学杂志 2025年第3期31卷 290-300页

作者：石锦涛张知宜卫芸菲韩佳瑞河南中医药大学第二临床医学院郑州450002 河南省中医院郑州450002

糖尿病肾病(DKD)是导致终末期肾脏病的主要原因之一,随着其患病率和死亡率逐年增加,俨然严重影响了患者的身心健康。细胞焦亡作为DKD发生发展的关键环节,可以通过活性氧(ROS)/硫氧还蛋白相互作用蛋白(TXNIP)/NOD样受体蛋白3(NLRP3)、Tol... 详细信息

糖尿病肾病(DKD)是导致终末期肾脏病的主要原因之一,随着其患病率和死亡率逐年增加,俨然严重影响了患者的身心健康。细胞焦亡作为DKD发生发展的关键环节,可以通过活性氧(ROS)/硫氧还蛋白相互作用蛋白(TXNIP)/NOD样受体蛋白3(NLRP3)、Toll样受体4(TLR4)/核转录因子-κB(NF-κB)/NOD样受体蛋白3(NLRP3)、核因子E_(2)相关因子2(Nrf2)/血红素氧合酶-1(HO-1)、丝裂原活化蛋白激酶(MAPK)/NOD样受体蛋白3(NLRP3)、缺氧诱导因子-1α(HIF-1α)/NOD样受体蛋白3(NLRP3)等信号通路的异常激活导致肾脏细胞损伤和炎症反应,加速DKD的进展。近年来,中医药凭借多靶点、多途径的优势,在DKD治疗中表现出显著的疗效。研究发现,中药单体苷类、黄酮类、多酚类、萜类、生物碱等多种化合物及清热解毒、补虚固本、祛瘀泄浊等类别的中药复方通过靶向相关信号通路,抑制细胞焦亡,干预DKD发展,为DKD的精准治疗提供了新的可能。该文系统梳理了细胞焦亡的相关通路,分析了近年来中药单体及复方在DKD细胞焦亡治疗中的研究成果及其作用机制,以期为中医药治疗DKD及研究提供了新的方向和思路,推动祖国医学现代化的进程和发展。

关键词：糖尿病肾病细胞焦亡信号通路中医药机制研究

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新疆寒区矿山重金属元素在冰雪冻融作用下的富集转化机理研究进展

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环境化学 2025年第2期44卷 469-484页

作者：侯大中张志义宋永泽苏慧新疆大学地质与矿业工程学院乌鲁木齐830046 新疆矿产资源绿色开发与生态修复省部共建协同创新中心乌鲁木齐830046 矿产资源生态环境保护性开采自治区高校重点实验室乌鲁木齐830046

冰川和雪山融水是新疆极为重要的水源补给来源,对区域社会经济可持续健康发展发挥着至关重要的作用.寒区矿山典型的冷热双岛效应会导致矿山重金属粉尘向外扩散,而冰雪冻融循环又为重金属元素富集转化提供了必要的环境,使得重金属元素随... 详细信息

冰川和雪山融水是新疆极为重要的水源补给来源,对区域社会经济可持续健康发展发挥着至关重要的作用.寒区矿山典型的冷热双岛效应会导致矿山重金属粉尘向外扩散,而冰雪冻融循环又为重金属元素富集转化提供了必要的环境,使得重金属元素随融水进入下游河流,对河流流经地区的人类生产生活及生态系统产生严重影响.为探究重金属元素在此冰雪冻融过程中的富集转化机理,本文综述了近年来有关重金属元素富集转化及其先导环节的研究进展,分别介绍了矿山粉尘运移扩散、矿山粉尘覆盖下的冰川消融以及重金属元素富集转化的国内外研究现状,并对新疆高寒地区矿山重金属元素在冰雪冻融作用下的富集转化机理研究的发展前景和应用价值进行了展望.

关键词：寒区矿山冰雪冻融重金属粉尘扩散重金属元素富集转化.

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VIBRATION CONTROL OF FLUID-FILLED PRISMATIC SHELL WITH ACTIVE CONSTRAINED LAYER DAMPING TREATMENTS

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Chinese Journal of Mechanical Engineering 2008年第1期21卷 101-105页

作者： LIU Lijun zhang zhiyi HUAHongxing zhang Yi State Key Laboratory of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China 704 Research Department China Ship and Heavy Industry Group Corporation Shanghai 200030 China

Active constrained layer damping （ACLD） combines the simplicity and reliability of passive damping with the light weight and high efficiency of active actuators to obtain high damping over a wide frequency band. A fluid-filled prismatic shell is set up to investigate the validity and efficiency of ACLD treatments in the case of fluid-structure interaction. By using state subspace identification method, modal parameters of the ACLD system are identified and a state space model is established subsequently for the design of active control laws. Experiments are conducted to the fluid-filled prismatic shell subjected to random and impulse excitation, respectively, For comparison, the shell model without fluid interaction is experimented as well. Experimental results have shown that the ACLD treatments can suppress vibration of the fluid-free and fluid-filled prismatic shell effectively. Under the same control gain, vibration attenuation is almost the same in both cases.

关键词： Active constrained layer damping Subspace identification method Vibration control

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IMPROVED COVARIANCE DRIVEN BLIND SUBSPACE IDENTIFICATION METHOD

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Chinese Journal of Mechanical Engineering 2006年第4期19卷 548-553页

作者： zhang zhiyi FAN Jiangling HUA Hongxing State Key Laboratory of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China

An improved covariance driven subspace identification method is presented to identify the weakly excited modes. In this method, the traditional Hankel matrix is replaced by a reformed one to enhance the identifiability of weak characteristics. The robustness of eigenparameter estimation to noise contamination is reinforced by the improved Hankel matrix, in combination with component energy index （CEI） which indicates the vibration intensity of signal components, an alternative stabilization diagram is adopted to effectively separate spurious and physical modes. Simulation of a vibration system of multiple-degree-of-freedom and experiment of a frame structure subject to wind excitation are presented to demonstrate the improvement of the proposed blind method. The performance of this blind method is assessed in terms of its capability in extracting the weak modes as well as the accuracy of estimated parameters. The results have shown that the proposed blind method gives a better estimation of the weak modes from response signals of small signal to noise ratio （SNR）and gives a reliable separation of spurious and physical estimates.

关键词： Subspace identification method Weak modes Hankel matrix Component energy index (CEI) Stabilization diagram

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ANALYSIS AND SIMULATION ON THE MECHANISM OF A NOVEL DUAL-WAVE SHOCK TEST MACHINE

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Chinese Journal of Mechanical Engineering 2008年第1期21卷 94-100页

作者： WANG Gongxian zhang zhiyi CHU Deying SHEN Rongying Institute of Vibration Shock and Noise Shanghai Jiaotong University Shanghai 200240 China School of Logistics Engineering Wuhan University of Technology Wuhan 430063 China

For qualifying the anti-shock performance of shipboard equipments and simulating actual underwater explosion environments, a novel dual-wave shock test machine is proposed to increase testing capability of shock test machines as well as to meet certain shock testing specification. The machine can generate a double-pulse acceleration shock for test articles according to specification defined in BV043/85. On the basis of the impact theory, a nonlinear dynamic model of the hydraulically-actuated test machine is established with thorough analysis on its mechanism which involves conversion of gas potential energy and dissipation of kinetic energy. Simulation results have demonstrated that the machine can produce a double-pulse acceleration shock in the time domain or a desired shock response spectrum in the frequency domain, which sets a theoretical base for the construction of the proposed machine.

关键词： Shock test machine Underwater explosion Velocity generator Pulse generator

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Non-coding RNA: a key regulator of the pathogenicity and immunity of Flaviviridae viruses infection

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Cellular & Molecular Immunology 2018年第2期15卷 185-186页

作者： zhiyi zhang Lifang Jiang Gucheng Zeng Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key Laboratory for Tropical Diseases Control of the Ministry of Education Sun Yat-sen UniversityGuangzhou510080China

Flaviviridae is a family of viruses that mainly spread through arthropod vectors,such as *** members of the Flaviviridae family include dengue virus(DENV),yellow fever virus,Zika virus(ZIKV),West Nile virus and hepatitis C virus(HCV).As Flaviviridae viruses remain a major global public health threat,elucidation of the exact mechanisms of pathogenesis during infection is required for the successful control of these deadly viruses.

关键词： immunity infection pathogenesis

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Raman spectroscopic study of DNA photodamage sensitized by hypocrellin B and 5-brominated-hypocrellin B

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Chinese Science Bulletin 1998年第13期43卷 1128-1135页

作者： Hongxia Zhao Yiming Xu zhiyi zhang Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China

Hypocrellin B (HB) is a highly effective photosensitizer. One of its derivatives, 5_brominated_hypocrellin B (5_Br_HB) has better photosensitive characteristics than it. Using Raman spectroscopy, the microcosmic photodamage to DNA sensitized by HB and 5_Br_HB was studied at molecular level. The results showed that when HB and 5_Br_HB were added to the solution of DNA and irradiated, the characteristic Raman frequencies and intensities of DNA changed to various degrees. The photodamage occurred on the whole DNA molecule, including phosphate backbone,deoxyribose and four bases. Not only the conformation but also the configuration of DNA was photodamaged: breakage of some H_bonds, disappearance of B_form conformation , scission of double or single strand and serious damage of four bases. The damage to A_T pairs was stronger than that to C_G pairs and DNA became polynucleotides finally. The 5_Br_HB_photosensitized damage to DNA was stronger than HB , which suggested the better photosensitive characteristics of 5_Br_HB in bioactive environment. The molecular mechanisms of photodamage to DNA sensitized by 5_Br_HB and HB were also elucidated.

关键词： hypocrellin B 5_brominated hypocrellin B calf thymus DNA photodamage Raman spectroscopy.

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