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USING DRIED BLOOD SPOTS IN COMBINATION WITH UHPLC AND ENHANCED ION GENERATION ESI TO STREAMLINE PHARMACOKINETIC ASSAYS

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USING DRIED BLOOD SPOTS IN COMBINATION WITH UHPLC AND ENHANC...

第十三届北京分析测试学术报告会暨展览会(BCEIA 2009)

作者： Herbert GODEL Stephan BUCKENMAIER zhixiu xu Agilent Technologies R&D and Marketing Gmb H & Co KG Agilent Technologies Shanghai

Pharmaceutical drug discovery includes generation of Pharmacokinetic data of potential drug candidate *** triple Quadrupole LCMSMS systems are considered to be instrument of choice for this particular analysis *** ord...

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专科医院护理人员对岗位管理的认知调查

护理学杂志 2020年第21期35卷 69-71页

作者：许志秀孙风丽淄博市妇幼保健院护理部山东淄博255000

目的了解专科医院护理人员对护士岗位管理的认知,为实施科学细化岗位管理提供参考。方法采用自行设计的护士岗位管理认知调查表对442名护理人员进行调查。结果临床护理人员对岗位管理的了解程度评分显著低于护理管理者(P<0.01),但两者... 详细信息

目的了解专科医院护理人员对护士岗位管理的认知,为实施科学细化岗位管理提供参考。方法采用自行设计的护士岗位管理认知调查表对442名护理人员进行调查。结果临床护理人员对岗位管理的了解程度评分显著低于护理管理者(P<0.01),但两者对了解护理岗位管理知识的需求程度及赞同程度均较高。结论临床护理和管理人员对护理岗位管理的赞同程度均较高;临床护理人员对护理岗位管理的认知程度相对较低,应加强针对性培训。

关键词：专科医院护士岗位管理认知绩效分配

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川芎嗪对大鼠脑缺血再灌注损伤的保护作用

实用中医药杂志 2007年第7期23卷 411-413页

作者：徐芝秀诸暨市人民医院浙江诸暨311800

目的:观察川芎嗪对大鼠脑缺血再灌注损伤的保护作用。方法:采用线栓法复制大鼠大脑中动脉脑缺血再灌注损伤模型,检测血液流变学指标,并测定再灌注后缺血侧脑组织中含水量、丙二醛(MDA)含量、总抗氧化能力(T-AOC)和超氧化物歧化酶(SOD)... 详细信息

目的:观察川芎嗪对大鼠脑缺血再灌注损伤的保护作用。方法:采用线栓法复制大鼠大脑中动脉脑缺血再灌注损伤模型,检测血液流变学指标,并测定再灌注后缺血侧脑组织中含水量、丙二醛(MDA)含量、总抗氧化能力(T-AOC)和超氧化物歧化酶(SOD)活性。结果:川芎嗪60mg/kg、30mg/kg、15mg/kg剂量均不同程度降低高、中、低切变率全血黏度、红细胞压积和血沉,能拮抗缺血脑组织脑含水量和MDA含量的增加,提高脑组织T-AOC、SOD含量。结论:川芎嗪对大鼠大脑中动脉缺血再灌注损伤具有明显保护作用。

关键词：大鼠川芎嗪脑缺血再灌注血液流变学脑水肿脂质过氧化

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

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小浪底水库对河道水质净化能力的影响

环境工程 2007年第1期25卷 74-75页

作者：师洋徐志修毛玉霞黄河水资源保护科学研究所河南郑州450004

依据《地表水环境质量标准》(GB3838-2002),采用单因子评价方法,分别对小浪底水库建成前3年和建成后4年的河道水质进行评价,结果表明,小浪底水库建成后,在库首断面水质持续恶化的情况下,小浪底坝下水质状况却明显好转,说明小浪底水库库... 详细信息

依据《地表水环境质量标准》(GB3838-2002),采用单因子评价方法,分别对小浪底水库建成前3年和建成后4年的河道水质进行评价,结果表明,小浪底水库建成后,在库首断面水质持续恶化的情况下,小浪底坝下水质状况却明显好转,说明小浪底水库库水对原水污染物有较强的净化能力,从而使下游河段水质得到改善。

关键词：小浪底水库水质评价单因子评价影响

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise

Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

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Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu Hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

Granting strength to aerogel fibers through encapsulation

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Science China Materials 2024年第4期67卷 1365-1366页

作者： Wenhui xu Department of Basic Chemistry School of PharmacyJiangxi University of Chinese MedicineNanchang 330004China

Aerogel fibers, distinguished by their lightweight nature, pronounced porosity, large surface area, and superior thermal insulation properties, have diversified applications in thermal management, energy devices, and environmental remediation[1]. However, compared with monolithic ones, these fibershaped aerogels exhibit limited mechanical strength and resilience due to their one-dimensional small size.

关键词： strength fibers thermal

Skeletal interoception in osteoarthritis

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Bone Research 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu Peng xu Department of Joint Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengdu 610041China

The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the *** its various forms,skeletal interoception specifically regulates the metabolic homeostasis of ***(OA)is a complex joint disorder involving cartilage,subchondral bone,and *** subchondral bone undergoes continuous remodeling to adapt to dynamic joint *** findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in *** skeletal interoception is also a potential mechanism for chronic synovial inflammation in *** this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral *** also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关键词： homeostasis inflammation releasing