检索结果-南通市图书馆

Coflex植入术治疗退行性腰椎管狭窄症41例的临床观察

在线全文

学校读者我要写书评

暂无评论

中华损伤与修复杂志（电子版） 2014年第4期9卷 43-47页

作者：王占长赵旭红梁宁曹轶伦苏志雄北京华信医院骨科 100016

目的探讨腰椎后路棘突间Coflex植入术治疗退行性腰椎管狭窄症(DLSS)的临床疗效。方法 2012年2月至2013年9月期间收治的74例DLSS患者,按愿意分为对照组33例和治疗组41例,其中对照组接受全椎板减压植骨融合内固定术,治疗组接受Coflex植入... 详细信息

目的探讨腰椎后路棘突间Coflex植入术治疗退行性腰椎管狭窄症(DLSS)的临床疗效。方法 2012年2月至2013年9月期间收治的74例DLSS患者,按愿意分为对照组33例和治疗组41例,其中对照组接受全椎板减压植骨融合内固定术,治疗组接受Coflex植入术。比较两组手术时间、出血量、并发症;日本整形外科学会(JOA)下腰痛评分、疼痛视觉模拟标尺(VAS)评分、美国脊柱损伤协会(ASIA)神经功能分级;X线片测定植入节段椎间隙前后缘的高度、椎弓根间距及Cobb角。结果治疗组与对照组相比,手术时间缩短[(1.02±0.32)h vs(2.13±0.58)h]、术中出血量减少[(145.5±36.0)mL vs(279.3±56.8)mL]、并发症减少(0 vs 9.1%)(P0.05);两组患者手术前后植入节段椎间隙前缘高度、椎弓根间距及Cobb角均无明显变化,椎间隙后缘高度均增大[治疗组术前与术后比较[(7.31±1.36)mm vs(8.98±1.56)mm],对照组术前与术后比较[(7.19±1.08)mm vs(8.61±1.41)mm,P均<0.05],但组间比较差异无统计学意义。结论腰椎后路棘突间Coflex植入术是一种治疗退行性腰椎管狭窄症安全、有效的手术方法。

关键词： Coflex植入全椎板减压植骨融合内固定退行性腰椎管狭窄症

Simulation of Rock Complex Resistivity Using an Inversion Method

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2022年第3期18卷 679-688页

作者： Yu Tang Jingcun Yu Benyu su zhixiong Li School of Resources and Geosciences China University of Mining and TechnologyXuzhou221116China Faculty of Mechanical Engineering Opole University of TechnologyOpole45-758Poland Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Natural ResourcesXi’an710021China

The complex resistivity of coal and related rocks contains abundant physical property information,which can be indirectly used to study the lithology and microstructure of these *** aspects are closely related to the fluids inside the considered coal rocks,such as gas,water and coalbed *** the present analysis,considering different lithological structures,and using the Cole-Cole model,a forward simulation method is used to study different physical parameters such as the zero-frequency resistivity,the polarizability,the relaxation time,and the frequency correlation ***,using a least square technique,a complex resistivity“inversion”algorithm is *** comparison of the initial model parameters and those obtained after inversion is used to verify the stability and accuracy of such *** method is finally applied to primary-structure coal considered as the experimental sample for complex resistivity measurements.

关键词： Complex resistivity zero frequency resistivity polarizability frequency correlation coefficient relaxation time inversion fitting least square method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一类单机排序问题的新伪多项式时间精确算法

工业工程与管理 2024年第5期29卷 74-84页

作者：魏汉英原梦迪苏志雄江西师范大学管理科学与工程研究中心江西南昌330022 南昌工程学院工商管理学院江西南昌330099

本文以最小化所有工件的最大延误时间为目标,研究了带有工件释放时间和交付时间的单机排序问题。该问题是机器排序的经典基础性问题,是NP-hard问题。首先,从该问题的结构特征入手,通过揭示工件单机排序结构(各工件的排序位置)与工件最... 详细信息

本文以最小化所有工件的最大延误时间为目标,研究了带有工件释放时间和交付时间的单机排序问题。该问题是机器排序的经典基础性问题,是NP-hard问题。首先,从该问题的结构特征入手,通过揭示工件单机排序结构(各工件的排序位置)与工件最大延误时间(相比交付时间)之间的关联规律,从工件加工顺序链的视角考虑,建立了新的基于工件分配位置变量的0-1混合线性规划模型。该模型的结构特征具备更好的优化潜力。其次,结合Dantzig-Wolfe分解等整数优化理论和方法,对模型进行优化处理,进而开发出该单机排序问题的伪多项式时间精确算法。最后,通过仿真模拟测试验证算法的有效性。结果表明:该算法在计算该单机排序问题算例(特别是大型算例)的精确解方面具备显著的效率优势,例如,该算法能够在3000秒内计算出包含1200个工件规模的算例的最优解。

关键词：单机排序最大延误混合0-1线性规划伪多项式时间精确算法 Dantzig-Wolfe分解

Auto Machine Learning Assisted Preparation of Carboxylic Acid by TEMPO-Catalyzed Primary Alcohol Oxidation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第2期41卷 143-150页

作者： Jia Qiu Yougen Xu Shimin su Yadong Gao Peiyuan Yu zhixiong Ruan Kuangbiao Liao Guangdong Laboratory Animals Monitoring Institute Guangdong Provincial Key Laboratory of Laboratory AnimalsGuangzhouGuangdong 510663China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China Bioland Laboratory GuangzhouGuangdong 510005China Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518055China Guangzhou Laboratory GuangzhouGuangdong 510320China

Though alcohol oxidations were considered as well-established reactions,selecting productive conditions or predicting reaction yields for unseen alcohols remained as major ***,an auto machine learning(ML)model for TEMPO-catalyzed oxida-tion of primary alcohols to the corresponding carboxylic acids is disclosed.A dataset of 3444 data,consisting of 282 primary alco-hols and 45 conditions,were generated using high-throughput experimentation(HTE).With the HTE data and 105 descriptors,a multi-label prediction was performed with AutoGluon(an open-source auto machine learning framework)and KNIME(an open-source data analytics platform).For the independent test of 240 reactions(a full matrix of 20 unseen alcohols and 12 condi-tions),AutoGluon with multi-label prediction for yield prediction(AGMP)gave excellent *** external test of 1308 re-actions(consisting of 84 alcohols and 45 conditions),AGMP still afforded good results with R2 as 0.767 and MAE as 4.9%.The model also revealed that the newly generated descriptor(Y/N,classification of the reaction reactivity)was the most relevant descriptor for yield prediction,offering a new perspective to integrate HTE and ML in organic synthesis.

关键词： TEMPO Oxidation Primary alcohols Carboxylic acids AutoGluon

Effects of dietary Bacillus amyloliquefaciens supplementation on growth performance,intestinal morphology, inflammatory response, and microbiota of intra-uterine growth retarded weanling piglets

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2018年第2期9卷 480-495页

作者： Yue Li Hao Zhang Weipeng su zhixiong Ying Yueping Chen Lili Zhang Zhaoxin Lu Tian Wang College of Animal Science and Technology Nanjing Agricultural University College of Food Science and Technology Nanjing Agricultural University

Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation(IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance,intestinal morphology, inflammatory response, and microbiota of IUGR ***: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight(NBW) and two IUGR piglets in each litter(i.e., 18 NBW and 36 IUGR piglets in total). At weaning, the NBW piglet and one of the IUGR piglets were assigned to groups fed a control diet(i.e., the NBW-CON and IUGR-CON groups). The other IUGR piglet was assigned to a group fed the control diet supplemented with 2.0 g BA per kg of diet(i.e., IUGR-BA group). The piglets were thus distributed across three groups for a four-week ***: IUGR reduced the growth performance of the IUGR-CON piglets compared with the NBW-CON piglets. It was also associated with decreased vil us sizes, increased apoptosis rates, reduced goblet cel numbers, and an imbalance between pro-and anti-inflammatory cytokines in the smal intestine. supplementation with BA improved the average daily weight gain and the feed efficiency of the IUGR-BA group compared with the IUGR-CON group(P supplementation with BA increased interleukin 10 content, but it decreased tumor necrosis factor alpha level in the smal intestines of the IUGR-BA piglets(P < 0.05). Furthermore, compared with the IUGR-CON piglets, the IUGR-BA piglets had less Escherichia coli in their jejunal digesta, but more Lactobacil us and Bifidobacter

关键词： Apoptosis Bacillus amyloliquefaciens Immune status Intra-uterine growth retardation Microbiota Piglet Small intestine

Experiment Research on the Mechanical Performance of Alkali-activated Slag Cementitious Material

在线全文

学校读者我要写书评

暂无评论

Experiment Research on the Mechanical Performance of Alkali-...

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

第三届材料科学应用与能源材料国际研讨会

作者： Qing su zhixiong Tao Wuchang University of Technology CITIC General institute of Architectural Design and Research Co. Ltd.

The influence of three different kinds of alkali(sodium hydroxide, sodium sulfate and water glass) excitation agents on the mechanical properties of slag cement materials has been studied by compressive test. The results show that the effect of excitation of sodium silicate is better than that of sodium hydroxide and sodium sulfate, with the increase of alkali equivalent excitation agent, compressive strength of mortar specimens remarkably, compared with alkali equivalent of 3.1% of the sodium sulfate, the 28 d compressive strength of mortar specimens with alkali equivalent of 4.65% and 6.2%, has been increased by 140% and 31.5% respectively.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO zhixiong YANG GUANGHUA CHEN WENMEI su Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

An Efficient and Versatile Tool for Automatic Fragment-Based Design

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Efficient and Versatile Tool for Automatic Fragment-Based...

基于CFD的沟槽-织构复合型滑动轴承性能分析

第十届全国化学生物学学术会议

作者： Yan Li zhixiong Zhao Zhihai Liu Minyi su Renxiao Wang State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

In structure-based drug design, automated de novo design methods are helpful tools for lead discovery as well as lead optimization. In a previous study（J. Chem. ***., 2011, 51, 1474–1491）, we reported a new de novo design method, namely Automatic Tailoring and Transplanting（AutoT＆T）. It overcomes some intrinsic problems in conventional fragment-based build-up methods. In this study, we describe an upgraded version, i.e. AutoT＆T2. Structural operations conducted by AutoT＆T2 have been largely optimized by introducing several new algorithms. As result, its overall efficiency in multi-round optimization jobs has been speeded up by a few thousand folds. With this improvement, it is now practical to conduct structural crossover among multiple lead molecules by using AutoT＆T2. Three different test cases are described in this study, which demonstrate the new features and versatile applications of AutoT＆T2. The AutoT＆T2 software suite is available to the ***, a web portal for running AutoT＆T2 on-line is provided at http://***/software/att2 for testing.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

润滑与密封 2017年第7期42卷 19-25页

作者：苏华余志雄西北工业大学机电学院陕西西安710072

为进一步提高滑动轴承的承载力以满足大功率滑动轴承的设计要求,在织构型滑动轴承上增加浅沟槽,提出沟槽-织构复合型滑动轴承结构;建立沟槽-织构复合型滑动轴承性能数值分析模型,通过CFD数值仿真研究沟槽结构参数对织构型滑动轴承承载... 详细信息

为进一步提高滑动轴承的承载力以满足大功率滑动轴承的设计要求,在织构型滑动轴承上增加浅沟槽,提出沟槽-织构复合型滑动轴承结构;建立沟槽-织构复合型滑动轴承性能数值分析模型,通过CFD数值仿真研究沟槽结构参数对织构型滑动轴承承载能力和摩擦特性的影响。结果表明:采用沟槽-织构复合形式可进一步提升轴承的承载力及综合性能;在织构参数一定的情况下,沟槽尺寸和分布形式对轴承性能有很大影响,当沟槽布置在织构上游区、沟槽轴向边长大于周向边长时有利于提高轴承的综合性能;在一定的使用条件下,合理设计沟槽深度、沟槽长宽比及周向布置区域大小,不仅能够有效提高轴承的承载力,而且能够减小轴承的摩擦力和端泄量,进一步改善滑动轴承的性能。

关键词：径向滑动轴承沟槽-织构复合型承载力摩擦力