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Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

Chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： XIU Ye WANG Sihao ZHANG Ping LI Chengwei wu zhixin WEN Jincai XU Yingjie LV Guiji ZHAO Xiaomei DONG Xu CHEN Yichong LI Junjie WANG Yan ZOU Liang XIAO Xiaohe BAI Zhaofang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and *** this,the clinical approval of drugs targeting the cGAS-STING pathway has been *** Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our *** found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1(THP-1)*** inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 10(CXCL10),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling *** vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

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Amplifying protection against acute lung injury:Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair

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Chinese Herbal Medicines 2024年第3期16卷 422-434页

作者： Junjie Li Ming Dong Qing Yao Xu Dong Yuanyuan Chen Jincai Wen Yingjie Xu zhixin wu Xiaomei Zhao Ye Xiu Xiaoyan Zhan Zhaofang Bai Xiaohe Xiao Chengde Medical University Chengde 067000China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Key Laboratory of Kidney Diseases The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Stomatology Heilongjiang Key Lab of Oral Biomedicine Materials and Clinical Application&Experimental Center for Stomatology EngineeringJiamusi UniversityJiamusi 154007China Southern Medical University Guangzhou 510515China

Objective:Acute lung injury(ALI)is characterized by inflammation and currently lacks an efficacious pharmacological *** medicine combination of Lonicerae Japonicae Flos(LJF)and Forsythiae Fructus(FF)demonstrates combined properties in its anti-infective,anti-inflammatory,and therapeutic effects,particularly in alleviating respiratory *** previous studies,Chinese medicine has shown promising efficacy in lipopolysaccharides(LPS)-induced ***,there have been no reports of LJF and FF pairing for lung *** aim of this study is to compare the efficacy of herb pair Lonicerae Japonicae Flos-Forsythiae Fructus(LF)with LJF or FF alone in the treatment of ALI,and to explore whether LJF and FF have a combined effect in the treatment of lung injury,along with the underlying mechanism ***:A total of 36 mice were divided into six groups(control,model,LJF,FF,LF,dexamethasone)based on the treatments they received after undergoing sham-operation/LPS tracheal instillation.H&E staining and pulmonary edema indexes were used to evaluate lung injury *** exudate cells(AECs)were counted based on cell count in bronchoalveolar lavage fluid(BALF),and neutrophil percentage in BALF was measured using flow ***(MPO)activity in BALF was measured using enzyme-linked immunosorbent assay(ELISA),while the production of IL-1β,TNF-α,and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction(qPCR)and *** effect of LJF,FF,and LF on the expression of Caspase-1 and IL-1βproteins in bone marrow derived macrophages(BMDMs)supernatant was assessed using Western blot method under various inflammasome activation *** addition,the concentration of IL-1βand changes in lactatedehydrogenase(LDH)release levels in BMDMs supernatant after LJF,FF,and LF administration,respectively,were measured using ***,the effects of LJF,FF and LF on STING and IRF3 phosphor

关键词： acute lung injury BMDMS inflammasomes Lonicerae Japonicae Flos-Forsythia Fructus drug pair STING

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仿生侵蚀介质对滚刀/大理岩滚动摩擦磨损行为的影响

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表面技术 2024年第9期53卷 117-126页

作者：杨康辉吴志鑫苏叶茂刘少锐郑靖周仲荣西南交通大学机械工程学院成都610031 中铁工程服务有限公司成都610083

目的对比去离子水和仿生侵蚀介质2种工况下,滚刀/大理岩摩擦副在不同法向载荷作用下的滚动摩擦磨损行为,阐明仿生侵蚀介质对大理岩破碎去除和滚刀磨损的影响规律和作用机制,为化学手段辅助提升全断面隧道掘进机(TBM)破岩效率提供参考。... 详细信息

目的对比去离子水和仿生侵蚀介质2种工况下,滚刀/大理岩摩擦副在不同法向载荷作用下的滚动摩擦磨损行为,阐明仿生侵蚀介质对大理岩破碎去除和滚刀磨损的影响规律和作用机制,为化学手段辅助提升全断面隧道掘进机(TBM)破岩效率提供参考。方法表征自制仿生侵蚀介质对大理岩和H13钢滚刀的腐蚀性,基于自制滚压破岩模拟试验机研究滚刀/大理岩摩擦副的滚动摩擦磨损行为。结果仿生侵蚀介质对滚刀无明显腐蚀性,但会诱导大理岩表面产生次生裂隙和溶蚀孔,弱化岩石表面的力学性能。在法向载荷为45、75、105N时,相较于去离子水工况,在仿生侵蚀介质工况下大理岩的磨损体积分别提高了25.3%、9.3%、17.5%,滚刀破岩比能分别下降了28.3%、11.4%、20.0%。在法向载荷为45 N时,岩石表面的破坏形式主要为矿物颗粒破碎剥落。在法向载荷为75N时,岩石的去除量明显增大,表面形成了密实核。在法向载荷为105N时,岩石表面发生显著开裂和去除现象。结论仿生侵蚀介质能促进大理岩的破碎和去除,降低滚刀磨损和破岩比能。仿生侵蚀介质的作用受到岩石破坏形式的影响,在法向载荷较低时,岩石表面破坏形式以矿物颗粒剥落和密实核形成为主,仿生侵蚀介质仅作用于岩石表层,其效果有限;在法向载荷较高时,岩石表面会产生裂纹和开裂,有利于仿生侵蚀介质向岩石内部的渗透,刀具的破岩效率显著提高。

关键词： TBM滚刀大理岩仿生侵蚀介质滚动法向载荷摩擦磨损

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Performance evaluation of creep feed grinding ofγ-TiAl intermetallics with electroplated diamond wheels

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Chinese Journal of Aeronautics 2021年第6期34卷 100-109页

作者： Xinxin XI Wenfeng DING zhixin wu Lama ANGGEI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenyang Liming Aero-Engine Co. Ltd.Aero-Engine Corporation of ChinaShenyang 110043China

This paper evaluates the performance of creep feed grindingγ-TiAl intermetallic(Ti-45 Al-2 Mn-2 Nb)using electroplated diamond ***,a comparative analysis with the grinding results by using electroplated CBN wheels was conducted,mainly involving abrasive wheel wear behavior and maximum material removal rate below surface burn *** was found that the diamond wheel would produce much better grinding results including lower wheel wear rate and higher maximum material removal *** the surface integrity obtained at different level of material removal rate was characterized with the utilization of the diamond *** poor ductility of thisγ-TiAl intermetallic material was found to have a marginal effect on the surface integrity,as no severe surface defects such as material pullout were generated during the stable wheel wear *** the involved operating parameters,a deformation layer was produced with~10μm or more in thickness depending on the material removal rate ***,a work-hardened layer extending to more than 100μm was produced with a maximum microhardness of above 520 HV0.05(bulk value 360 HV0.05).The residual stress remained compressive,with a value of above-100 MPa and even up to-500 MPa for an elevated material removal *** chip was the main chip type,indicating good wheel sharpness in the grinding process.

关键词： Creep feed grinding Electroplated abrasive wheels Surface integrity Wheel wear γ-TiAl intermetallic

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Effect of driving cycles on energy efficiency of electric vehicles

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Science China(Technological Sciences) 2009年第11期52卷 3168-3172页

作者： JI FenZhu XU LiCong wu zhixin School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Tianjin Qingyuan Electric Vehicle Co. LtdTianjin 300162China

Based on several typical domestic and foreign driving cycles, the energy usage efficiency of the EVs-XL 2000 type electric vehicle (EV) is analyzed. The energy usage efficiency of EVs and the evaluation index of electromotor efficiency are studied. The concepts of "interval usage percentage of energy efficiency" and "exertion degree of energy efficiency" of electromotor are presented. The effects of driving cycles on the distribution of the running status of electromotor and the efficiency are investi-gated. The efficiency of electromotor and the trend of average driving force at different driving cycles are discussed. The exertion degree of energy efficiency and the total power train efficiency of the EVs-XL 2000 type electric vehicle at typical driving cycles are analyzed and calculated. The result indicates that the driving cycle engenders a big influence on the exertion degree of electromotor energy efficiency at different driving cycles. Dissimilar driving cycles result in different efficiency distributions of electromotor, the control system as well as the average driving force and driving range are variable.

关键词： electric vehicles electromotor driving cycle energy efficiency evaluation index

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老年急性脑出血患者并发低钾血症的相关危险因素及风险预测模型构建

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中华老年心脑血管病杂志 2024年第9期26卷 1039-1043页

作者：刘绍辉吴曦盛文乾君吴智鑫魏思源雷俊娜广州中医药大学第八临床医学院、佛山市中医院神经重症医学科 528000 广州中医药大学第八临床医学院、佛山市中医院神经外科 528000 广州中医药大学第八临床医学院、佛山市中医院全科医学科 528000

目的探讨老年急性脑出血患者并发低钾血症的相关危险因素,并且基于logistic回归构建风险预测模型。方法选取2022年6月至2024年5月佛山市中医院诊治的老年急性脑出血患者190例,根据有无并发低钾血症分为低钾血症组(血钾20 mg/d比例高... 详细信息

目的探讨老年急性脑出血患者并发低钾血症的相关危险因素,并且基于logistic回归构建风险预测模型。方法选取2022年6月至2024年5月佛山市中医院诊治的老年急性脑出血患者190例,根据有无并发低钾血症分为低钾血症组(血钾20 mg/d比例高于正常组(P20 mg/d为老年急性脑出血患者并发低钾血症的危险因素(P20 mg/d为老年急性脑出血患者并发低钾血症的危险因素(OR=6.393,95%CI:2.138~19.112,P=0.001;OR=3.123,95%CI:2.161~4.513,P=0.000;OR=3.327,95%CI:1.137~9.736,P=0.028;OR=3.111,95%CI:1.083~8.933,P=0.035)。ROC曲线分析显示,女性、入院时NIHSS评分、肾小球滤过率≤60 ml/min、呋塞米剂量>20 mg/d及综合指数预测急性脑出血患者并发低钾血症的曲线下面积分别为0.621、0.897、0.601、0.613、0.857,敏感性分别为52.90%、76.50%、49.00%、54.90%、72.50%,特异性分别为71.20%、88.50%、71.20%、67.60%、87.80%。结论女性、入院时NIHSS评分、肾小球滤过率≤60 ml/min、呋塞米剂量>20 mg/d可能会对急性脑出血患者并发低钾血症产生影响,并依据这些危险因素构建综合指数模型对预测急性脑出血患者并发低钾血症具有较高的效能。

关键词：脑出血低钾血症危险因素综合指数模型

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瓶装饮用水中微塑料的含量研究

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环境工程技术学报 2024年第3期14卷 758-763页

作者：郑涵云武志鑫李全威杨颖王慢想安立会王菲菲环境基准与风险评估国家重点实验室中国环境科学研究院

聚焦瓶装水中微塑料污染的来源特征(水源及包装材料)和小粒径微塑料检测方法的瓶颈问题,选择市面上常见的不同品牌及不同类型的瓶装水作为研究对象,采用热脱附-气相色谱质谱法(ATD-GCMS)对水中5种微塑料(PP、PE、PS、PVC、PET)的含量进... 详细信息

聚焦瓶装水中微塑料污染的来源特征(水源及包装材料)和小粒径微塑料检测方法的瓶颈问题,选择市面上常见的不同品牌及不同类型的瓶装水作为研究对象,采用热脱附-气相色谱质谱法(ATD-GCMS)对水中5种微塑料(PP、PE、PS、PVC、PET)的含量进行检测。结果显示:瓶装水中微塑料主要成分为PVC[(2.95±2.03)μg/L]、PET [(1.84±2.14)μg/L]及PE [(1.86±1.84)μg/L];国内外不同品牌瓶装矿泉水中PVC和PET含量存在显著性差异(P<0.05),PE含量差异不显著;不同品牌纯净水之间PVC和PET含量差异不具有统计学意义,但PE含量存在显著差异(P<0.05)。瓶装水中微塑料的赋存情况受到水源水中微塑料污染情况的影响和包装材料微塑料的释放影响,通过比较分析瓶装饮用水中微塑料赋存特征可为未来制定降低饮用水微塑料摄入风险和健康风险防控相关管理措施提供数据支撑。

关键词：微塑料瓶装水饮用水瓶身材料瓶盖材料塑料包装

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Is Tetranychus urticae suitable prey for development and reproduction of nafve Coleomegilla maculata？

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Insect Science 2014年第1期21卷 83-92页

作者： Eric W. Riddick zhixin wu M~ Guadalupe Rojas National Biological Control Laboratory Agricultural Research Service USDA 59 Lee Road Stoneville MS 38776 USA

The lady beetle Coleomegilla maculata De Geer is an omnivorous predator that could help suppress aphid and spider mite populations on plants in greenhouses, plantscapes or interiorscapes. We are assessing the nutritional requirements and feeding behavior of C. maculata on target prey （spider mites） and factitious （unnatural） food. Our ultimate goal is to develop an efficacious diet to mass produce C. maculata. In this study, we tested the hypothesis that Tetranychus urticae Koch （two-spotted spider mite） is not suitable prey for development and reproduction of naive C. maculata （i.e., with no prior exposure to T. urticae）. Our objectives were to （i） provide baseline data on the effects of consuming T. urticae on C. maculata life history, （ii） to compare the effects of consuming all stages of T. urticae versus eggs ofMusca domestica L. （common housefly）, and （iii） to determine if the consumption of plant products was beneficial. We used C. maculata from a colony reared only on Ephestia kuehniella Zeller （Mediterranean flour moth） eggs. In experiments, C. maculata larvae were reared from the first instar to adult stage with prey/food in replicated arenas; adult females were paired with a single male with prey/food. The results showed that naive C. maculata readily attacked and consumed T. urticae. Nevertheless, T. urticae was less suitable than M. domestica eggs for C. maculata development and reproduction. Applying a synthetic pollen-Chlorella alga powder （SPCA） in arenas containing T. urticae appeared to boost C. maculata female development and reproduction.

关键词： behavior biocontrol CoccineUidae nutrition rearing

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基于LabVIEW的滚压破岩模拟试验机研制

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机械 2024年第4期51卷 50-58页

作者：杨康辉吴志鑫刘少锐郑靖西南交通大学机械工程学院摩擦学研究所四川成都610031

为考察不同环境工况下TBM滚刀的破岩特性,研制了一台小型滚压破岩模拟试验机。该试验机采用模块化设计,主要由基体及动力执行模块、数据采集模块、介质流率与温度控制模块三部分组成。其中,基体及动力执行模块主要包含试验机基体、加载... 详细信息

为考察不同环境工况下TBM滚刀的破岩特性,研制了一台小型滚压破岩模拟试验机。该试验机采用模块化设计,主要由基体及动力执行模块、数据采集模块、介质流率与温度控制模块三部分组成。其中,基体及动力执行模块主要包含试验机基体、加载主轴、滚刀夹具和岩石夹具,用来支撑试验装置和提供动力;基于LabVIEW的数据采集模块(力信号监测与分析系统)可在试验过程中实时显示和存储滚刀试样的法向力、滚动力、侧向力和摩擦系数数据;介质流率与温度控制模块由精密恒流蠕动泵、温度控制器和加热负载组成,用于试验过程中介质溶液的引入和温度保持。试验机的滚刀安装半径、介质环境、法向载荷、运动速率和时长等工况参数均可调。滚刀/大理岩在25℃去离子水介质工况下两种法向载荷作用的滚动摩擦磨损试验结果表明,该试验机可开展TBM滚刀在不同温度介质环境下的滚压破岩模拟试验。

关键词： TBM滚刀滚压破岩模拟试验机 LabVIEW

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Comparative Study on Different Methods for Prediction of Thermal Insulation Performance of Thermal Barrier Coating Used on Turbine Blades

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Journal of Thermal Science 2024年第1期33卷 172-189页

作者： ZHANG zhixin ZENG wu ZHANG Xiaodong ZENG Yuntao Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Innovation Academy for Light-duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

As turbine inlet temperature gets higher and higher,thermal barrier coating(TBC) is more and more widely used in turbine *** turbine blades with TBC,it is of great significance to evaluate the temperature distribution of its substrate metal quickly and accurately,especially during the design *** different degrees of simplification such as whether to consider the change of the geometric size of the fluid domain by TBC and whether to consider the planar heat conduction in TBC,three different methods used in conjugate heat transfer(CHT) simulation to model the TBC of the turbine blades have been developed and widely used by ***,little research has been conducted to investigate the influence of the three methods on the temperature distribution of turbine *** fill this gap,three geometric models were *** are a solid conduction model with a substrate metal layer and a TBC layer,a transonic turbine vane with internal cooling and TBC,and a plate cylindrical film hole cooling model with *** methods were used in these geometric models and their differences were carefully analyzed and *** result shows that for the conduction model used in this paper,with the same TBC surface temperature distribution,the difference between the three methods is very small and can be *** a transonic turbine vane with internal cooling,regarding the local maximum temperature of the substrate-TBC interface,the largest difference between the method in which TBC is considered as a thermal resistance or a virtual layer of cells and the method in which three-dimensional heat conduction equation of TBC is solved occurs at the trailing *** difference near the leading edge is below *** employed to the film cooling model,the difference of the laterally averaged temperature of the substrate-TBC interface can be 8 K which is mainly due to the change of the length to diameter ratio of the film cooling hole by *** the substrate

关键词： turbine blade thermal barrier coating conjugate heat transfer film cooling hole

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