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Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy

Nano-Micro Letters 2022年第9期14卷 95-131页

作者： Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102People’s Republic of China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361102

As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.

关键词： Calcium-based nanomaterials Cancer therapy Calcium signaling Tumor calcification Theranostics

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Halogenated thiophene substitutions on quinoxaline unit to achieve morphology optimization in efficient organic solar cells

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Nano Research 2023年第9期16卷 11630-11637页

作者： Dingding Qiu Jianqi Zhang Kun lu zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish Center for Education and Research Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Halogenated thiophenes are generally used units for constructing organic semiconductor materials for photovoltaic applications.Here,we introduced thiophene,2-bromothiophene,and 2-chlorothiophene units to the central core of quinoxaline-based acceptors and obtained three acceptors,Qx-H,Qx-Br,and Qx-Cl,respectively.Compared with Qx-H,Qx-Br and Qx-Cl showed enhanced absorption,down-shifted energy levels,improved crystallinity,and reduced energy disorder.The improved crystallinity significantly optimized the blend morphology,leading to efficient charge generation and transport and,therefore,less bimolecular recombination.Eventually,PM6:Qx-Br-based devices exhibited an outstanding power conversion efficiency of 17.42%with a high open-circuit voltage(VOC)of 0.915 V.Furthermore,Y6 was introduced into the PM6:Qx-Br binary system to improve the light utilization,and the resulting ternary devices delivered a high PCE of 18.36%.This study demonstrated the great potential of halogenated thiophene substitution in quinoxaline-based acceptors for building high-performance organic solar cell acceptor materials.

关键词： halogenated thiophene units non-fullerene acceptors organic solar cells quinoxaline acceptors morphology optimization

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Oligomeric donor with appropriate crystallinity for organic solar cells

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Chinese Chemical Letters 2024年第2期35卷 289-294页

作者： Kaiming Yang Min Lv Yanhong Chang Kun lu zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource Treatment of Typical Industrial Pollutants Beijing 100083China

Improving the performance of all-small-molecule organic solar cells(ASM-OSCs)largely depends on the design and application of novel donors with appropriate crystallinity.Extending molecular conjugation is an effective method for regulating molecular stacking and crystallinity.In this work,we successfully designed and synthesized two novel acceptor-donor-donor-donor-acceptor(A-D-D-D-A)type oligomeric donors with three dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b']dithiophene(DTBDT)as the central unit,named as 3DTBDT-Cl and 3DTBDT,depending on with and without chlorine substitution on the thiophene side chains.We found that the introduction of chlorine atoms makes the blend films display stronger crystallinity but with large-scale phase separation morphology and more defects,which eventually leads to a power conversion efficiency(PCE)of only 10.83%,whereas the blend films based 3DTBDT with appropriate crystallinity achieved 13.74%PCE.Compared with 3DTBDT-Cl/L8-BO,the 3DTBDT/L8-BO films exhibited a nanoscale bi-continuous interpenetrating network morphology with a smaller domain size and more suitable crystallinity,which guarantees the corresponding devices obtained more efficient exciton dissociation,efficient charge transport,reduced bimolecular recombination,and performed more balanced carrier mobility.These results demonstrated that regulating the crystallinity of oligomeric donors to obtain the desired phase separation morphology in the blend films could facilitate further improving the performance of ASM-OSCs.

关键词： Linked donor unit Oligomeric donors Crystallinity regulation Organic solar cells

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Evaluation of groundwater sustainability based on groundwater age simulation in the Zhangye Basin of Heihe River watershed, northwestern China

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Journal of Arid Land 2014年第3期6卷 264-272页

作者： Heng WEI HongLang XIAO ZhenLiang YIN Zhixiang Lu Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences University of Chinese Academy of Sciences

Water resources, as the primary limiting factor, constrain the economic and social development in arid inland areas. The Zhangye Basin is a representative area of inland river basins, which is located in the middle parts of the Heihe River watershed, northwestern China. Facing with the huge water shortage, people exploited ground- water at a large scale in recent years. The reducing recharge from surface water and over-exploitation of ground- water led to the decline of groundwater levels and threatened the sustainability of water resources. This study con- structed a conceptual and numerical groundwater flow model and calibrated the model based on the observed wells A solute transport model was built using MT3DMS to calculate the groundwater age distribution in the Zhangye Basin. The simulated result shows that the youngest groundwater is distributed near the most upstream areas in the model domain, which is less than 1,000 a, older groundwater is distributed in deeper parts of the aquifer and near the discharge outlets, ranging from 6,000 a to over 20,000 a. Spatial variation of groundwater ages in the middle area indicates the recharge diversity between unconfined and confined aquifer. Groundwater age can serve as an indicator to evaluate groundwater＇s renewal capacity and sustainability. The formation of groundwater resources in the lower stream area would spend 10,000 a or even more than 20,000 a, so exploitation of groundwater in these areas should be restrained.

关键词： groundwater flow groundwater age numerical modeling water resource sustainability

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The heterogeneity of hydrometeorological changes during the period of 1961-2016 in the source region of the Yellow River, China

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Research in Cold and Arid Regions 2020年第2期12卷 104-118页

作者： Zhixiang Lu Qi Feng SongBing Zou JiaLi Xie ZhenLiang Yin Fang Li Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China

Runoff in the source region of a river makes up most of water resources in the whole basin in arid and semi-arid areas. It is very important for water resources management to timely master the latest dynamic changes of the runoff and quantitatively reveal its main driving factors. This paper aims to discover the variation heterogeneity of runoff and the impacts of climatic factors on this runoff in the source region of the Yellow River(SRYR) in China from 1961 to 2016. We divided SRYR into four sub-regions, and analyzed changes of their contributions to total runoff in SRYR. We also revealed the impacts of precipitation, temperature and potential evapotranspiration on runoff in each sub-region by constructing the regression relationships between them at multiple temporal scales. The changes of runoff in the four sub-regions and their contributions to the total runoff were not exactly consistent. The climatic variables’ changes also have heterogeneity, and runoff was mainly affected by precipitation compared to influences of temperature or potential evapotranspiration. Their impacts on runoff have spatiotemporal heterogeneity and can be reflected by very significant-linear regression equations.It provided a simple method to predict headwater runoff for better water management in the whole basin.

关键词： source region of the Yellow River hydrometeorology spatiotemporal variation runoff contribution heterogeneity

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Conjugation expansion strategy enables highly stable all-polymer solar cells

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中国化学快报:英文版 2023年第8期34卷 439-443页

作者： Dingding Qiu Yanan Shi Yi Li Jianqi Zhang Kun lu zhixiang Wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Molecular Dynamic Chemistry CenterTianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceTianjin UniversityTianjin 300354China Sino-Danish Center for Education and Research Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China

The stability issue is one of the key factors hindering the commercial application of organic solar cells.All-polymer organic solar cell is one of the effective ways to solve the stability problem.In this work,we designed and synthesized two polymer donor materials PBDT and PDTBDT with different conjugation ranges,and demonstrated for the first time that extending the conjugation range of donor materials in all polymer solar cells can significantly improve device efficiency and stability.The experimental results of materials and devices show that PDTBDT with a larger conjugation range has stronger crystallinity and a more planar structure,which endows the active layer in its corresponding device with higher exciton dissociation probability,lower carrier recombination probability,more balanced charge transport properties and more favorable film morphology.As a result,the PDTBDT:PYF-T-o devices display an outstanding PCE of 13.38%,which is much higher than PBDT with smaller conjugation range based devices.Moreover,the PDTBDT:PYF-T-o device retains 0.86 of the initial PCE after over 500 h in the air atmosphere,exhibiting significantly improved stability.The improved stability is attributed to the enhanced moisture and air tolerance of active layer film thanks to the strong crystallinity of the donor material.These results demonstrate that the conjugation expansion strategy is one of the effective ways to obtain efficient and stable all-polymer organic solar cells.

关键词： Polymer donor Conjugation expansion All-polymer organic solar cells Stability Crystallinity

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Remote-sensing data reveals the response of soil erosion intensity to land use change in Loess Plateau, China

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Research in Cold and Arid Regions 2016年第4期8卷 325-333页

作者： JiaLi Xie ChangZhen Yan Zhixiang Lu Sen Li Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Key Laboratory of Ecohydrology of Inland River Basin Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences

Developing an effective approach to rapidly assess the effects of restoration projects on soil erosion intensity and theirextensive spatial and temporal dynamics is important for regional ecosystem management and the development of soilconservation strategies in the future. This study applied a model that was developed at the pixel scale using water soilerosion indicators （land use, vegetation coverage and slope） to assess the soil erosion intensity in the Loess Plateau,China. Landsat TM/ETM＋ images in 2000, 2005 and 2010 were used to produce land use maps based on the object-oriented classification method. The MODIS product MOD13Q1 was adopted to derive the vegetation coveragemaps. The slope gradient maps were calculated based on data from the digital elevation model. The area of watersoil-eroded land was classified into six grades by integrating slope gradients, land use and vegetation coverage. Resultsshow that the Grain-To-Green Project in the Loess Plateau worked based on the land use changes from 2000 to 2010and enhanced vegetation restoration and ecological conservation. These projects effectively prevented soil erosion.During this period, lands with moderate, severe, more severe and extremely severe soil erosion intensities significantlydecreased and changed into less severe levels, respectively. Lands with slight and light soil erosion intensities increased.However, the total soil-eroded area in the Loess Plateau was reduced. The contributions of the seven provincesto the total soil-eroded area in the Loess Plateau and the composition of the soil erosion intensity level in eachprovince are different. Lands with severe, more severe and extremely severe soil erosion intensities are mainly distributedin Qinghai, Ningxia, Gansu and Inner Mongolia. These areas, although relatively small, must be prioritised andpreferentially treated.

关键词： remote sensing soil erosion intensity land use Loess Plateau

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Semitransparent Flexible Organic Solar Cells

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Chemical Research in Chinese Universities 2020年第3期36卷 343-350页

作者： WANG Yuhcng CHANG Yilin ZHANG Jianqi lu Guanghao WEI zhixiang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190P.R.China Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

The semitransparent flexible organic solar cell takes advantages of flexibility,transparency,color adjust ment property,which is more conducive to integrate on buidings and mobile terminals.Ascribing to the developments of narrow band gap donors and the new non-fullerene acceptors,the power conversion efficiency of semitransparent flexible organic solar cells has been achieved 10% to 12% with average visible transmittance of 17% to 21%.This review summarizes the molecular design of the most representative layer materials,and discusses the characterization of semitransparent parameters paradigms,then we discuss how to optimize the device in combination with optical simulation,and finally list the recent development of semitransparent flexible electrodes of ITO-free organic solar cells,and give our perspectives on the next step direction.

关键词： Semitransparent Flexible Organic solar cell Electrode Optical simulation

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Liquid embolic agents for interventional embolization

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ChemPhysMater 2022年第1期1卷 39-50页

作者： Yonghe Jiang Yang Zhang Zhixiang Lu Xiaoyong Wang Shuang Bai Yulun Chen Jingsong Mao Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361102China Department of Radiology Xiang’an Hospital of Xiamen UniversityXiamen 361102China

Minimally invasive interventional embolization has tremendous advantages over conventional surgery in the treatment of vascular diseases and malignant tumors.Particularly,liquid embolic agents have garnered much attention owing to their properties of deep vascular penetration and full occlusion of vasculature independent of thrombus formation,which relies on the patient’s coagulation system.Despite their drawbacks,traditional liquid embolic agents,such as lipiodol,N-butyl-2-cyanoacrylate,and Onyx,have benefited numerous patients.The original liquid embolic agents have been modified and optimized,and novel liquid embolic agents have also been developed using different strategies and mechanisms.This minireview provides a brief overview of liquid embolic agents,including approved and potential ones.Challenges,prospects,and rational design guidelines are also discussed.This review may spark interest in liquid embolic agents and open new avenues for the smart design of improved embolic agents in the development of personalized and precision medicine.

关键词： Liquid embolic agents Intervention Embolization Vascular diseases Tumor

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Elicitor hydrophobin Hyd1 interacts with Ubiquilin1-like to induce maize systemic resistance

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Journal of Integrative Plant Biology 2020年第4期62卷 509-526页

作者： Chuanjin Yu Kai Dou Shaoqing Wang Qiong Wu Mi Ni Tailong Zhang Zhixiang Lu Jun Tang Jie Chen Key Laboratory of Urban Agriculture(South)Ministry of Agriculture School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240China School of Life Science Fuyang Normal UniversityFuyang 236037China

Trichoderma harzianum is a plant-beneficial fungus that secretes small cysteine-rich proteins that induce plant defense responses;however, the molecular mechanism involved in this induction is largely unknown.Here, we report that the class Ⅱ hydrophobin Th Hyd1 acts as an elicitor of induced systemic resistance(ISR) in plants. Immunogold labeling and immunofluorescence revealed Th Hyd1 localized on maize(Zea mays) root cell plasma membranes. To identify host plant protein interactors of Hyd1, we screened a maize B73 root c DNA library. Th Hyd1 interacted directly with ubiquilin1-like(UBL). Furthermore, the N-terminal fragment of UBL was primarily responsible for binding with Hyd1 and the eight-cysteine amino acid of Hyd1 participated in the protein-protein interactions. Hyd1 from T. harzianum(Thhyd1) and ubl from maize were co-expressed in Arabidopsis thaliana, they synergistically promoted plant resistance against Botrytis cinerea. RNA-sequencing analysis of global gene expression in maize leaves 24 h after spraying with Curvularia lunata spore suspension showed that Thhyd1-induced systemic resistance was primarily associated with brassinosteroid signaling, likely mediated through BAK1. Jasmonate/ethylene(JA/ET)signaling was also involved to some extent in this response. Our results suggest that the Hyd1-UBL axis might play a key role in inducing systemic resistance as a result of Trichoderma-plant interactions.

关键词： Zea mays resistance maize

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