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Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic,Clinical and Immunological Characteristics in Cancers

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Biomedical and Environmental Sciences 2024年第7期37卷 698-715页

作者： Jiaojiao Wang Yong liao Pinglian Yang Weile Ye Yong Liu Chunxia Xiao Weixiong liao Chunbo Chen Zhiping Liu Zunnan Huang Center of Scientific Research Department of CardiologyMaoming People’s HospitalMaoming 525000GuangdongChina Department of Pharmacy Maoming People’s HospitalMaoming 525000GuangdongChina State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632GuangdongChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632GuangdongChina Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory of Computer-Aided Drug Design of Dongguan CityKey Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguan 523808GuangdongChina Department of Critical Care Medicine Maoming People’s HospitalMaoming 525000GuangdongChina

Objective To examine the precise function of influenza A virus target genes(IATGs)in *** Using multi-omics data from the TCGA and TCPA datasets,33 tumor types were evaluated for *** expression in cancer cells was analyzed using transcriptome *** number variation(CNV)was assessed using GISTICS ***’s analysis was used to correlate mRNA expression with methylation *** was used for the enrichment ***’s correlation analysis was used to examine the association between IATG mRNA expression and *** ImmuCellAI algorithm was used to calculate the infiltration scores of 24 immune cell *** In 13 solid tumors,IATG mRNA levels were atypically *** for UCS,UVM,KICH,PCPG,THCA,CHOL,LAMI,and MESO,most cancers contained somatic IATG *** main types of CNVs in IATGs are heterozygous amplifications and *** most tumors,IATG mRNA expression is adversely associated with ***-PCR demonstrated that EGFR,ANXA5,CACNA1C,CD209,UVRAG were upregulated and CLEC4M was downregulated in KIRC cell lines,consistent with the TCGA and GTEx *** Genomic changes and clinical characteristics of IATGs were identified,which may offer fresh perspectives linking the influenza A virus to cancer.

关键词： Genomic changes Immune microenvironment Prognosis Drug resistance Experimental validation

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Effect of CO_(2)flooding in an oil reservoir with strong bottom-water drive in the Tahe Oilfield,Tarim Basin,Northwest China

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Energy Geoscience 2024年第1期5卷 230-233页

作者： Li Zhang Haiying liao Maolei Cui R&D Center of Sustainable Development of Continental Sandstone Mature Oilfield Beijing100083China Petroleum Exploration and Production Research Institute SinopecBeijing100083China

The dissolution and diffusion of CO_(2)in oil and water and its displacement mechanism were investigated by laboratory experiment and numerical simulation for Block 9 in the Tahe oilfield,a sandstone oil reservoir with strong bottom-water drive in Tarim Basin,Northwest *** parameters were analyzed as solubility ratio of CO_(2)in oil,gas and water,interfacial tension,in-situ oil viscosity distribution,remaining oil saturation distribution,and oil *** results show that CO_(2)flooding could control water coning and increase oil *** the early stage of the injection process,CO_(2)expanded vertically due to gravity differentiation,and extended laterally under the action of strong bottom water in the intermediate and late *** CO_(2)got enriched and extended at the oil-water interface,forming a high interfacial tension zone,which inhibited the coning of bottom water to some extent.A miscible region with low interfacial tension formed at the gas injection front,which reduced the in-situ oil viscosity by about 50%.The numerical simulation results show that enhanced oil recovery(EOR)is estimated at 5.72%and the oil exchange ratio of CO_(2)is 0.17 t/t.

关键词： Strong bottom-water drive reservoir CO_(2)flooding Enhanced oil recovery Coning of bottom water Tahe oilfield Tarim Basin Northwest China

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Introduction to the Special Issue on Machine Learning-Guided Intelligent Modeling with Its Industrial Applications

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 7-11页

作者： Xiong Luo Yongqiang Cheng Zhifang liao School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Faculty of Technology University of SunderlandSunderlandSR60DDUK School of Computer Science and Engineering Central South UniversityChangsha410083China

With the advancement of Artificial Intelligence(AI)technology,traditional industrial systems are undergoing an intelligent transformation,bringing together advanced computing,communication and control technologies,Machine Learning(ML)-based intelligentmodelling has become a newparadigm for solving problems in the industrial domain[1–3].With numerous applications and diverse data types in the industrial domain,algorithmic and data-driven ML techniques can intelligently learn potential correlations between complex data and make efficient decisions while reducing human ***,in real-world application scenarios,existing algorithms may have a variety of limitations,such as small data volumes,small detection targets,low efficiency,and algorithmic gaps in specific application domains[4].Therefore,many new algorithms and strategies have been proposed to address the challenges in industrial applications[5–8].

关键词： Intelligence bringing intelligent

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System Reliability Analysis of Reservoir Landslides: Insights from Long-Term Reservoir Operation

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Journal of Earth Science 2024年第5期35卷 1583-1593页

作者： Kang liao Yiping Wu Fasheng Miao Faculty of Geosciences and Engineering Southwest Jiaotong University Faculty of Engineering China University of Geosciences

The reservoir operation awakens numerous landslides with multiple sliding surfaces known as reservoir landslides, and the systematic stability analysis for such landslides is becoming increasingly urgent. Taking the Majiagou landslide as an example, this paper analyses the comprehensive performance of the landslide from a probabilistic point of view. Under a reservoir operation cycle, a series of numerical analyses are carried out to simulate the migration of the seepage field, then the dynamic stability of the landslide is quantified accordingly. Subsequently, the wetting-drying cycles test is used to model the weakening of strength parameters in hydro-fluctuation belt under the long-term reservoir operation. Considering the weakening effect of long-term reservoir operation on the hydrofluctuation belt, the system reliability is evaluated using the Ditlevsen ' s bounds. The results suggest that the reservoir operation can affect the stability of the landslide by changing the seepage field. The system failure probability gradually rises as the number of wetting-drying cycles increases. Compared with conventional probabilistic analysis that calculates the failure probability of each sliding surface mechanically, analyzing the landslide in terms of system reliability can effectively narrow the failure probability range, which provides an insightful idea for evaluating the systematic stability of analogous reservoir landslides.

关键词： reservoir operation reservoir landslides hydro-fluctuation belt system reliability ditlevsen's bounds engineering geology

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Chemical defense mediates population density-driven on anuran brain size evolution

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Science China(Life Sciences) 2024年第5期67卷 1076-1078页

作者： Ying Jiang Lianju Yuan Wenbo liao Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchong 637009China Key Laboratory of Artificial Propagation and Utilization in Anurans of Nanchong City China West Normal UniversityNanchong 637009China

Dear Editor,The evolutionary arms race between predator and prey is a strong selective force for producing a wide array of defense strategies in animals,including strong limbs,body armor,poisonousness,mimicry,or cryps... 详细信息

关键词： evolution size media

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Exploring differentiated improvement strategies of cultivated land quality in China

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 282-291页

作者： Wenguang CHEN Xiangbin KONG Yubo liao College of Land Science and Technology China Agricultural UniversityBeijing 100193China

Quality is the core feature of cultivated land. In the face of deteriorating cultivated land quality and growing food demand, improving cultivated land quality is a top priority for guaranteeing the sustainable use of resources and national food security. Cultivated land quality in the new era can be considered in four dimensions: suitability, contiguity, resistance and ecological stress. Cultivated land suitability in China shows a decreasing trend from east to west, cultivated land contiguity is high in the north-east and low in the south-west. In terms of cultivated land resistance, the number of strongly and weakly resistant cropping fields is small and spatially clustered. Cultivated land with ecological stress is mainly located in the northern region. Based on the current situation of cultivated land quality and the strategic needs of national high-quality development, China's future goals for improving cultivated land quality include four aspects: promoting the sustainable use of resources,improving the economic benefits of farming, coping with extreme meteorological disasters and meeting the transition of the food *** the backdrop of a volatile international environment and high domestic demand for food, China should guarantee a safe supply of staples, a stable supply of animal feed and a moderate supply of high-nutrient food. In the future, China should create three major food production spaces: highstandard, low-to medium-yield, and marginal cultivated land. China urgently needs to construct three paths to implement the goal of improving cultivated land quality, namely the development of high-standard cultivated land with the core of spatial optimization, resilience enhancement and scale coupling,the transformation of low-to medium-yield cultivated land with the core of obstacle elimination, tenure adjustment, ecological sustainable, and the conservation development of marginal cultivated land with a focus on sustainable use.

关键词： China cultivated land quality differentiated improvement food security

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Helicobacter pylori mediated niche environment aberrations promote the progression of gastric cancer

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Genes & Diseases 2024年第5期11卷 113-116页

作者： Teng Yan Hang Sun Yuhui liao Jiajian Zhou Nanfang Hospital The First School of Clinical MedicineSouthern Medical UniversityGuangzhouGuangdong 510515China Dermatology Hospital Southern Medical UniversityGuangzhouGuangdong 510091China

Intestinal metaplasia(IM)is a key stage in the tumorigenic Correa cascade from gastritis to final intestinal-type gastric cancer(GC).1 Helicobacter pylori(***)infection is the most common trigger of IM,and it promotes GC progression through induction of gastric epithelial transition.2 Currently,the mechanism by which *** infection promotes tumorigenesis in IM patients is poorly *** et *** a single-cell transcriptomic atlas on premalignant lesions and identified biomarkers of gastric early-malignant cells,providing an opportunity to explore the molecular mechanism of GC progression at the molecular level.

关键词： gastric pylori Helicobacter

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A new species of Bolbochromus Boucomont,1909(Coleoptera:Geotrupidae:Bolboceratinae)from Guangdong,China

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Zoological Systematics 2024年第3期49卷 276-279页

作者： Weiqi liao College of Agricultural Sciences Guangdong Ocean UniversityGuangdong 524088China

The genus Bolbochromus Boucomont,1909 includes 3 subgenera(Bolbochromops Krikken&Li,2013;Metabolbochromus Krikken&Li,2013 and Bolbochromus Boucomont,1909)and 27 species(Krikken&Li,2013;Li et al.,2019;Selking,2019).Its geographic distribution is known ranging eastward from India and Sri Lanka in the Himalayas to Southeast Asia,Southern China,the Greater Sunda Islands,the Philippines,and its neighboring islands(Li et al.,2013).The genus is distinguished from other beetles of Bolboceratinae by:imagoes body usually bicolored with brownish yellow or reddish-brown markings;body length 5.8–13.0mm(Li et al.,2019);ocular canthi completely bisecting the eyes;arcuate anterior clypeal margin;pronotum lack tubercles(Krikken&Li,2013);distal antennomere lacking grooves,and inner surface of first antennomere with a polished,glabrous disc(Selking,2019).The members of Bolbochromus can be occasionally attracted to light(Krikken&Li,2013),the feature can be used to set up flight interception traps to obtain specimens.

关键词： Coleoptera yellow neighboring

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Joint Communication-Caching-Computing Resource Allocation for Bidirectional Data Computation in IRS-Assisted Hybrid UAV-Terrestrial Network

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Chinese Journal of Electronics 2024年第4期33卷 1093-1103页

作者： Yangzhe liao Lin LIU Yuanyan SONG Ning XU School of Information Engineering Wuhan University of Technology

Joint communication-caching-computing resource allocation in wireless inland waterway communications enables resource-constrained unmanned surface vehicles(USVs) to provision computation-intensive and latencysensitive tasks forward beyond fifth-generation(B5G) and sixth-generation(6G) era. The power of such resource allocation cannot be fully studied unless bidirectional data computation is properly managed. A novel intelligent reflecting surface(IRS)-assisted hybrid UAV-terrestrial network architecture is proposed with bidirectional tasks. The sum of uplink and downlink bandwidth minimization problem is formulated by jointly considering link quality, task execution mode selection, UAVs trajectory, and task execution latency constraints. A heuristic algorithm is proposed to solve the formulated challenging problem. We divide the original challenging problem into two subproblems, i.e., the joint optimization problem of USVs offloading decision, caching decision and task execution mode selection, and the joint optimization problem of UAVs trajectory and IRS phase shift-vector design. The Karush–Kuhn–Tucker conditions are utilized to solve the first subproblem and the enhanced differential evolution algorithm is proposed to solve the latter one. The results show that the proposed solution can significantly decrease bandwidth consumption in comparison with the selected advanced algorithms. The results also prove that the sum of bandwidth can be remarkably decreased by implementing a higher number of IRS elements.

关键词： Wireless communication Heuristic algorithms Bandwidth Network architecture Downlink Trajectory Resource management

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Cyclic-acyclic monomers metathesis polymerization to access photodegradable polydicyclopentadiene and polyethylene-like materials

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Science China Chemistry 2024年第4期67卷 1311-1315页

作者： Wu Li Daohong liao Yougui Li Guifu Si Changle Chen School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

The development of degradable and recyclable polymers is an attractive strategy to tackle the post-consumption pollution issue of commercial ***-acyclic monomers metathesis polymerization(CAMMP)has been recently reported to produce degradable thermoset,thermoplastic and elastomeric polymers,and their degradability is enabled with addition of various *** this contribution,we demonstrate that the utilization of diene comonomers containing photodegradable moiety can give access to thermoset and thermoplastic materials bearing photo-degradation *** copolymerization of a series easily accessible diene comonomers bearing photodegradable ortho-nitrobenzyl moieties with dicyclopentadiene(DCPD)or cyclooctene(COE)leads to the formation of photodegradable p DCPD thermosets and p COE thermoplastic polymers with mechanical properties comparable to their non-degradable *** importantly,their photo-degradation properties can be efficiently tuned with the addition of ultraviolet absorber during in-situ polymerization.

关键词： metathesis polymerization photodegradable polydicyclopentadiene polyethylene-like materials

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