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Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 125-135页

作者： zhixiang cui Shuman cui Lu Qin Yalin An Xin Zhang Jian Guan Tin Wui Wong Shirui Mao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Particle Design Research Group Faculty of PharmacyUniversiti Teknologi MARA SelangorPuncak Alam 42300Malaysia Non-Destructive Biomedical and Pharmaceutical Research Centre Smart Manufacturing Research InstituteUniversiti Teknologi MARA SelangorPuncak Alam 42300Malaysia

Virus-capsid mimicking mucus-permeable nanoparticles are promising oral insulin carriers which surmount intestinal mucus barrier.However,the impact of different viruscapsid mimicking structure remains unexplored.In this study,utilizing biotin grafted chitosan as the main skeleton,virus-mimicking nanoparticles endowed with biologicshell(streptavidin coverage)and polymeric-shell(hyaluronic acid/alginate coating)were designed with insulin as a model drug by self-assembly processes.It was demonstrated that biologic-shell mimicking nanoparticles exhibited a higher intestinal trans-mucus(>80%,10 min)and transmucosal penetration efficiency(1.6–2.2-fold improvement)than polymeric-shell counterparts.Uptake mechanism studies revealed caveolae-mediated endocytosis was responsible for the absorption of biologic-shell mimicking nanoparticles whereas polymeric-shell mimicking nanoparticles were characterized by clathrin-mediated pathway with anticipated lysosomal insulin digestion.Further,in vivo hypoglycemic study indicated that the improved effect of regulating blood sugar levels was virus-capsid structure dependent out of which biologic-shell mimicking nanoparticles presented the best performance(5.1%).Although the findings of this study are encouraging,much more work is required to meet the standards of clinical translation.Taken together,we highlight the external structural dependence of virus-capsid mimicking nanoparticles on the mucopenetrating and uptake mechanism of enterocytes that in turn affecting their in vivo absorption,which should be pondered when engineering virus-mimicking nanoparticles for oral insulin delivery.

关键词： Oral insulin Streptavidin Virus-mimicking Nanoparticles Muco-penetrating Mucus

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Bi_(2)S_(3) spheres coated with MOF-derived Co_(9)S_(8) and N-doped carbon composite layer for half/full sodium-ion batteries with superior performance

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Journal of Energy Chemistry 2021年第8期30卷 473-481,I0010页

作者： Youzhang Huang Xueshuang Zhu Daoping Cai zhixiang cui Qianting Wang Hongbing Zhan Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350118China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China

Bismuth sulfide(Bi_(2)S_(3))has attracted particular interest as a potential anode material for sodium-ion batteries(SIBs).However,the low electrical conductivity and dramatic volumetric change greatly restrict its practical applications.In view of the apparent structural and compositional advantages of metal-organic frameworks(MOFs)derived carbon-based composite,herein,as a proof of concept,Bi_(2)S_(3) spheres coated with the MOF-derived Co_(9)S_(8) and N-doped carbon composite layer(Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres)have been rational designed and synthesized.As expected,the core-shell Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres exhibit remarkable electrochemical performance in terms of high reversible capacity(597 m Ah g^(-1) after 100 cycles at 0.1 A g^(-1)),good rate capability(341 m Ah g^(-1) at 8 A g^(-1))and long-term cycling stability(458 m Ah g^(-1) after 1000 cycles at 1 A g^(-1))when investigated as anode materials for SIBs.Electrochemical analyses further reveal the favorable reaction kinetics in the Bi_(2)S_(3)@Co_(9)S_(8)/NC composite spheres.In addition,the possible sodium storage mechanism has been studied by ex-situ X-ray diffraction technique.More importantly,a sodium-ion full cell based on Na_(3) V_(2)(PO_(4))_(3)/r GO as cathode and Bi_(2)S_(3)@Co_(9)S_(8)/NC as anode is also fabricated,suggesting their potential for practical applications.It is anticipated that the present work could be extended to construct other advanced electrode materials using MOFs-derived carbon-based composites as surface coating materials for various energy storagerelated applications.

关键词： Bi_(2)S_(3) Metal-organic frameworks Surface coating Anode materials Sodium-ion batteries

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Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 175-187页

作者： Xin Shen zhixiang cui Yidan Wei Yingnan Huo Duo Yu Xin Zhang Shirui Mao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great challenges due to the blood brain barrier(BBB)and limited drug distribution in the AD nidus sites.Thus,in this study,using vinpocetine(VIN)as a model drug,the objective is to explore the feasibility of tackling the above bottleneck via intranasal drug delivery in combination with a brain guider,borneol(BOR),using nanoemulsion(NE)as the carrier.First of all,the NE were prepared and characterized.In vivo behavior of the NE after intranasal administration was investigated.Influence of BOR dose,BOR administration route on drug brain targeting behavior was evaluated,and the influence of BOR addition on drug brain subregion distribution was probed.It was demonstrated that all the NE had comparable size and similar retention behavior after intranasal delivery.Compared to intravenous injection,improved brain targeting effect was observed by intranasal route,and drug targeting index(DTI)of the VIN–NE group was 154.1%,with the nose-to-brain direct transport percentage(DTP)35.1%.Especially,remarkably enhanced brain distribution was achieved after BOR addition in the NE,with the extent depending on BOR dose.VIN brain concentration was the highest in the VIN-1-BOR-NE group at BOR dose of 1 mg/kg,with the DTI reaching 596.1%and the DTP increased to 83.1%.BOR could exert better nose to brain delivery when administrated together with the drug via intranasal route.Notably,BOR can remarkably enhance drug distribution in both hippocampus and cortex,the nidus areas of AD.In conclusion,in combination with intranasal delivery and the intrinsic brain guiding effect of BOR,drug distribution not only in the brain but also in the cortex and hippocampus can be enhanced significantly,providing the perquisite for improved therapeutic efficacy of AD.

关键词： Vinpocetine Borneol Nanoemulsions Intranasal administration Brain targeting Brain subregion distribution

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玄武岩纤维/玄武岩颗粒增强高密度聚乙烯复合材料性能

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工程塑料应用 2024年第5期52卷 65-71页

作者：闫锦锦司军辉崔志香福建理工大学材料科学与工程学院福州350118

玄武岩纤维(BF)和玄武岩颗粒(BP)增强高密度聚乙烯(PE-HD)力学性能优良,特别是硬度较高,用于防白蚁高压电缆护套的制造。首先利用硅烷偶联剂KH550对BF和BP进行表面改性,然后利用转矩流变仪熔融共混BP、BF和PE-HD,最后通过微型注塑机制... 详细信息

玄武岩纤维(BF)和玄武岩颗粒(BP)增强高密度聚乙烯(PE-HD)力学性能优良,特别是硬度较高,用于防白蚁高压电缆护套的制造。首先利用硅烷偶联剂KH550对BF和BP进行表面改性,然后利用转矩流变仪熔融共混BP、BF和PE-HD,最后通过微型注塑机制备不同填料含量的PE-HD/BF/BP复合材料。通过扫描电子显微镜、差示扫描量热仪、同步热分析仪、万能试验机、动态力学性能分析仪、邵氏硬度计、流变仪等研究复合材料的形态、力学性能、结晶性能、热稳定性能及流变性能等。结果表明,与PE-HD相比,BF和BP填料的引入显著增强了PE-HD/BF/BP复合材料的力学性能和热稳定性能,当BF含量为20份,BP含量为10份时(BF20BP10),复合材料的力学性能最优,拉伸强度和拉伸弹性模量分别为47.51 MPa和3331.39 MPa,分别增加了41.7%和211%,硬度达到70.2HD,明显超出防白蚁电缆对硬度的要求,即大于65HD,因此具有更优异的防白蚁啃食性能。与其它配方相比,BF20BP10复合材料具有较高的结晶度、储能模量,较小的损耗因子。因此,PE-HD/BF/BP复合材料的最优配方为BF含量20份,BP含量10份,制备获得的样品具有优异的硬度、良好的热稳定性和流变性能,有望在电缆护套材料领域得到广泛的应用。

关键词：高密度聚乙烯玄武岩纤维玄武岩颗粒复合材料力学性能

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SLAM技术在矿井智能化的研究现状与应用进展

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安徽工业大学学报（自然科学版） 2024年第3期41卷 294-304页

作者：徐中华张鑫付信凯崔智翔江松中钢集团山东富全矿业有限公司山东济宁272516 西安建筑科技大学资源工程学院陕西西安710055 西安市智慧工业感知、计算与决策重点实验室陕西西安710055 金属矿山安全与健康国家重点实验室安徽马鞍山243000

智能采矿是矿井生产发展过程中的重要阶段,直接影响矿产企业的安全生产、矿产产量、经济效益和社会效益,随着矿井智能化水平的提高和相应政策的颁布,特别是我国智慧矿山和智能感知设备的快速发展和普及,矿井智能化地图构建和定位导航技... 详细信息

智能采矿是矿井生产发展过程中的重要阶段,直接影响矿产企业的安全生产、矿产产量、经济效益和社会效益,随着矿井智能化水平的提高和相应政策的颁布,特别是我国智慧矿山和智能感知设备的快速发展和普及,矿井智能化地图构建和定位导航技术已成为重要的研究课题。回顾传统矿井地图绘制和定位技术的发展历程,结合矿井环境特点分析传统技术面临的挑战。介绍同步定位与建图(SLAM)技术在矿井智能化应用方面的优势,综述SLAM技术在非结构化复杂矿井工作环境下数字地图构建及无网络井下人、机/车定位导航的研究现状与应用进展。最后,对未来SLAM技术在矿井智能化领域中的发展趋势进行展望,即融合深度学习、三维重建与可视化、5G与云计算等。

关键词：同步定位与建图(SLAM) 矿井智能化智慧矿山采矿工程

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Job shop scheduling problem based on DNA computing

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Journal of Systems Engineering and Electronics 2006年第3期17卷 654-659页

作者： Yin zhixiang cui Jianzhong Yang Yan Ma Ying Dept. of Mathematics and Physics Anhui Univ. of Science and Technology Huainan 232001 P.R. China

To solve job shop scheduling problem, a new approach-DNA computing is used in solving job shop scheduling problem. The approach using DNA computing to solve job shop scheduling is divided into three stands. Finally, optimum solutions are obtained by sequencing A small job shop scheduling problem is solved in DNA computing, and the ＂operations＂ of the computation were performed with standard protocols, as ligation, synthesis, electrophoresis etc. This work represents further evidence for the ability of DNA computing to solve NP-complete search problems.

关键词： DNA computing job shop scheduling problem weighted tournament.

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Painting into Gardens:The Influence of Chinese Traditional Painting on Garden Making

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Journal of Landscape Research 2022年第5期14卷 93-96页

作者： GUO Dasong MI Dengxing cui zhixiang School of Design Nanjing University of the ArtsNanjingJiangsu 210013China Tianshui Ting Yuan Engineering Design Co. Ltd.TianshuiGansu 741020China School of Architecture and Urban Planning Shenzhen UniversityShenzhenGuangdong 518060China

Since the Wei,Jin,Northern and Southern Dynasties(220-589),the purpose of the construction of the garden had gradually transformed from the land of crops production to the site of aestheti c pleasure.The painting theory and practice based on nature have had an important influence on garden bui lding activities.The article analyses their relationship in four aspects:the artistic design of nature themed spa ce,the application of plants in composing landscape,the symbiosis of the Shan and the Shui,and the intera ction between mountains and rivers in the overall space.

关键词： Traditional painting Classical garden making Nature interpenetration

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Fabrication and Characterization of 3D Graded PDMS Scaffolds Using Vacuum-Assisted Resin Transfer Moulding

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Journal of Wuhan University of Technology(Materials Science) 2018年第5期33卷 1263-1270页

作者：司军辉 LIN Jiahe ZHENG Zifeng cui zhixiang WANG Qianting School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350118China

Graded porous scaffold can be applied to study the interactions between cells and scaffold with different pore sizes. Polydimethylsiloxane（PDMS） scaffold with an axial pore size grade was successfully manufactured via vacuum-assisted resin transfer moulding（VARTM） and particle leaching technologies. The properties of graded PDMS scaffolds, including porosity, water absorption, interconnectivity, compression modulus, as well as compression strength were investigated. The results showed that the smaller the size of the NaCl particles is, the higher the porosity and water absorption of graded PDMS scaffolds would be. The graded PDMS scaffold fabricated had a compressive modulus and a compressive strength of 19.69±1.42 kPa and 4.76±0.22 kPa, respectively. Moreover, the graded chitosan（CS）-coated PDMS scaffolds were prepared by using dip-coating technique under low vacuum and their hydrophilicity was examined. It is found that the water contact angle（WCA） will decrease with an increase in the CS solution concentration and the coating time, which indicates that CS-coated PDMS scaffolds exhibit noticeable hydrophilicity compared with graded PDMS scaffold.

关键词： polydimethylsiloxane（PDMS） graded porous scaffold biomedical applications

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Morphological, Mechanical and Thermal Properties of Poly(lactic acid)(PLA)/Cellulose Nanofibrils(CNF) Composites Nanofiber for Tissue Engineering

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Journal of Wuhan University of Technology(Materials Science) 2019年第1期34卷 207-215页

作者：杨章强 LI Xiaojie 司军辉 cui zhixiang PENG Kaiping School of Materials Science and Engineering Fuzhou University School of Materials Science and Engineering Fujian University of Technology Fujian Provincial Key Laboratory of Advanced Materials Processing and Application

Composite nanofiber membranes based on biodegradable poly(lactic acid)(PLA) and cellulose nanofibrils(CNF) were produced via electrospinning. The influence of CNF content on the morphology, thermal properties, and mechanical properties of PLA/CNF composite nanofiber membranes were characterized by field scanning electron microscopy(FE-SEM), differential scanning calorimetry(DSC), thermogravimetric analysis(TGA), and dynamic mechanical analysis(DMA), respectively. The results show that the PLA/CNF composite nanofibers with smooth, free-bead surface can be successfully fabricated with various CNF contents. The introduction of CNF is an effective approach to improve the crystalline ability, thermal stability and mechanical properties for PLA/CNF composite fibers. The Young's moduli and tensile strength of the PLA/CNF composite nanofiber reach 106.6 MPa and 2.7 MPa when the CNF content is 3%, respectively, which are one times higher and 1.5 times than those of pure PLA nanofiber. Additionally, the water contact angle of PLA/CNF composite nanofiber membranes decreases with the increase of the CNF loading, resulting in the enhancement of their hydrophilicity.

关键词： poly(lactic acid)(PLA) cellulose nanofibrils(CNF) electrospinning mechanical and thermal properties

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Influence of Diameter on Electrochemical Thermodynamics of Metal Nanowires Electrodes in Theory and Experiment

Influence of Diameter on Electrochemical Thermodynamics of M...

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中国化学会第十九届全国化学热力学和热分析学术会议

作者： Qingjuan Lei Zhengguo Zhang Qiangzhi Wang Yongqiang Xue zhixiang cui Department of Applied Chemistry Taiyuan University of Technology College of Science North University of China College of Materials Science and Engineering North University of China

Metal nanowire electrode electrochemical properties present difference compared with corresponding bulk electrodes,the diameter is the main influencing factor,but the influences of diameter on electrochemical thermodynamics of the electrodes are unclear.Theoretically,the diameter dependence of electrochemical thermodynamic equations of nanowire electrodes have been derived.Experimentally,Cu nanowires with different diameter were prepared,the influence regulation of Cu nanowires diameter on the thermodynamic properties of the the electrodes were obtained.The experimental regularities accord with the theoretical equations,the results indicate that diameter of metal nanowires has a significant influence on electrochemical properties of metal nanowire electrodes.With the diameter of metal nanowires decreasing,the standard electrode potential and the equilibrium constant of electrode reaction decrease,while the temperature coefficient,the molar reaction Gibbs energy,the molar reaction enthalpy,the molar reaction entropy and the reversible molar reaction heat increase.Moreover,all these physical quantities are linearly related with the reciprocal of nanowire diameter.Our research can provide a significant guidance for the research and application of metal nanoparticles electrodes.

关键词： Nanowire diameter Cu nanowire Nano-metal electrode Electrochemical thermodynamics properties

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