检索结果-南通市图书馆

Versatile biomimetic nanomedicine for treating cancer and inflammation disease

在线全文

学校读者我要写书评

暂无评论

Medical Review 2023年第2期3卷 123-151页

作者： zhiwen zhao Dangge Wang Yaping Li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesNo.555Rd ZuchongzhiPudong DistrictShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000Shandong ProvinceChina Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000Shandong ProvinceChina

Nanosized drug delivery systems(NDDSs)have emerged as a powerful tool to optimize drug delivery in complex diseases,including cancer and ***,the therapeutic effect of NDDSs is still far from satisfactory due to their poor circulation time,low delivery efficiency,and innate ***,biomimetic approaches offer new opportunities to develop nanomedicine,which is derived from a variety of native biomolecules including cells,exosomes,bacteria,and so *** inheriting the superior biocompatibility and versatile functions of natural materials,biomimetic nanomedicine can mimic biological processes,prolong blood circulation,and lower immunogenicity,serving as a desired platform for precise drug delivery for treating cancer and inflammatory *** this review,we outline recent advances in biomimetic NDDSs,which consist of two concepts:biomimetic exterior camouflage and bioidentical molecule *** summarize engineering strategies that further functionalized current biomimetic NDDSs.A series of functional biomimetic NDDSs created by our group are *** conclude with an outlook on remaining challenges and possible directions for biomimetic *** hope that better technologies can be inspired and invented to advance drug delivery systems for cancer and inflammation therapy.

关键词： biomimetic cancer immunotherapy nanomedicine nanoparticles

Research on Building Exterior Wall Decoration and Its Energy Saving Optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Technology Management 2015年第2期 47-49页

作者： zhiwen zhao Hangzhou Polytechnic Hangzhou Zhejiang311402China

This paper mainly uses the method of numerical simulation, and study thermal insulation and energy saving characteristics on the exterior walls of the building and analyze the optimal layout scheme of building exterior wall and thermal insulation system. Finally, the paper study optimal thickness of insulation materials. The paper elaborate scheme of the existing building energy-saving for exterior wall and the scope of application, the system structure and the construction technology. The results showed that： extruded benzene board that can be used for exterior insulation, frame structure filled with wall preferred ceramsite hollow block. The paper can provides reference selection of insulation for building external wall energy-saving transformation scheme.

关键词： Thermal optimization Building energy-saving Thermal insulation Exterior wall decoration

Reliable Quantum Teleportation Based on Quantum Dense Coding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光学应用（中英文版） 2013年第3期2卷 43-49页

作者： Haiming Long zhiwen zhao Xiaodong Xiong Qinting Han Yong Wang College of Information Science and Technology Beijing Normal University 19 Xinjiekou Outside Street Beijing 100875China Key Lab of Inertial Technology for National Defense Beihang University 37 Xueyuan Road Beijing 100191 China

Identification of potential core genes in colorectal cancer using bioinformatics analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of potential core genes in colorectal cancer ...

RNA demethylase ALKBH5 prevents colon adenocarcinoma progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Mengyue Tian Xinghui Zhuang Chunyan Dai zhiwen zhao Fujian Medical University 福建医科大学附属协和医院

Background: Colorectal cancer(CRC) is a common human malignancy worldwide. The tumorigenesis mechanism in CRC is *** and methods: To explore potential therapeutic targets for CRC, we analyzed 3 microarray datasets(GSE20347, GSE38129, and GSE67269) derived from the gene expression omnibus(GEO)database. Then, the GEO2 R tool was used to screen out differently expressed genes(DEGs) between CRC and normal tissue. Gene ontology function and kyoto encyclopedia of genes and genomes pathway enrichment analysis were performed using the database for annotation, visualization and integrated discovery to identify the pathways and functional annotation of DEGs. Protein–protein interaction of these DEGs was analyzed based on the search tool for the retrieval of interacting genes database and visualized by Cytoscape software. In addition, we used encyclopedia of RNA interactomes(ENCORI), gene expression profiling interactive analysis(GEPIA), and the human protein atlas to confirm the expression of hub genes in CRC. Finally, GEPIA was used to evaluate the prognostic value of hub genes expression in CRC patients and we estimated the associations between hub genes expression and immune cell populations(B Cell, CD8+T Cell, CD4+T Cell, Macrophage,Neutrophil, and Dendritic Cell) in CRC using tumor immune estimation resource(TIMER).Results: In this study, 707 DEGs(including 385 upregulated genes and 322 downregulated genes) and 6 hub genes(cyclin B1 [CCNB1], cyclin dependent kinase 1 [CDK1], aurora kinase A [AURKA],ubiquitin conjugating enzyme E2 C [UBE2 C], cyclin A2 [CCNA2], and cell division cycle 20[CDC20]) were identified. All of the 6 hub genes were highly expressed in CRC tissues. Among of them, only CCNB1 and CDC20 were associated with stage of CRC and all of them were not associated with survival time of ***: DEGs and hub genes were confirmed in our study, providing a thorough, scientific and comprehensive research goals for the pathogenesis of CRC.

关键词： colorectal cancer hub genes expression profiling data bioinformatics analysis differently expressed genes

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

RNA demethylase ALKBH5 prevents colon adenocarcinoma progres...

Analysis and Control of Bulgaria Onion Cold Soup

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Mengyue Tian Xinghui Zhuang zhiwen zhao Chunyan Dai Fujian Medical University 福建医科大学附属协和医院

Background: N6-methyladenosine(m6 A) is the most abundant reversible methylation modification of eukaryotic mR NA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6 A demethylase ALKBH5 in colon adenocarcinoma(COAD).Methods: The expression of ALKBH5 and its clinicopathological impact were evaluated in COAD *** effects of ALKBH5 on the biological characteristics of COAD cells were investigated on the basis of gain-of-function and loss-of-function analyses. Subcutaneous and orthotopic models further uncovered the role of ALKBH5 in tumour growth. mR NA and m6 A sequencing and assays of m6 A methylated RNA immunoprecipitation-qPCR(MeRIP-qPCR) were performed to identify the targeted effect of ALKBH5 on PER1. P53-binding sites in the ALKBH5 promoter were investigated by ChIP and luciferase assays to reveal the interplay between ALKBH5 and PER1-activated ATM-CHK2-P53/CDC25 C ***: ALKBH5 loss characterized the occurrence and poor clinicopathological manifestations in patients with COAD. Overexpression of ALKBH5 reduced tumoural proliferative, migrative, invasive activities in vitro and ameliorated tumour growth in vivo, whereas ALKBH5 knockdown facilitated COAD progression. Mechanistically, ALKBH5 posttranscriptionally activated PER1 by m6 A demethylation in an m6 A-YTHDF2-dependent manner. PER1 upregulation led to the reactivation of ATM-CHK2-P53/CDC25 C signaling, which inhibited cell growth. P53-induced activation of ALKBH5 transcription acted as a feedback loop regulating the m6 A modifications in ***: ALKBH5 serves as a COAD suppressor by regulating the posttranscriptional activation of PER1 through m6 A abolishment, which may highlight a demethylation-based approach for COAD diagnosis and therapy.

关键词： colon adenocarcinoma m6A ALKBH5 PER1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

当代农业（中英文版） 2014年第1期3卷 9-16页

作者： Xi Liu Yunsheng Jiang Jiangnang Guo Tao Ren zhiwen zhao Jingling Zhu School of Tourism and Culinary Science Yangzhou University Yangzhou 225127 China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

寒冷地区专用改性沥青防水卷材的制备及性能

新型建筑材料 2019年第8期46卷 150-153,162页

作者：赵志文乌兰察布市公路路政执法监察支队内蒙古乌兰察布012000

针对内蒙古寒冷地区的气候特点,选择具有热电特性及离子释放性的电气石负离子粉与SBS作为沥青改性剂,通过剪切共混法成功制备出新型电气石负离子粉/SBS复合改性沥青及其沥青防水卷材,并进行相关物理性能试验。结果表明,电气石负离子粉... 详细信息

针对内蒙古寒冷地区的气候特点,选择具有热电特性及离子释放性的电气石负离子粉与SBS作为沥青改性剂,通过剪切共混法成功制备出新型电气石负离子粉/SBS复合改性沥青及其沥青防水卷材,并进行相关物理性能试验。结果表明,电气石负离子粉能够显著改善复合改性沥青的高低温性能及弹性恢复率,且制备的电气石负离子粉/SBS复合改性沥青防水卷材具有优良的拉伸性能、低温柔性、耐热性、不透水性及抗剥离性能。

关键词：寒冷地区电气石负离子粉改性沥青防水卷材

在线全文

学校读者我要写书评

暂无评论

被分析物在微流体器件中的分散特性

机械工程学报 2006年第3期42卷 93-98页

作者：赵志文陈兴 LAM Y C 北京师范大学电子学系北京100875 新加坡-MIT联盟新加坡南洋理工大学机械与航空航天学院新加坡639798

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的Y型微流体器件中两种同物性流体的流... 详细信息

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的Y型微流体器件中两种同物性流体的流动特性,采用平均分析法,对微型矩形窄缝中的压力流的传质现象进行了初步研究,提出二维分析模型,并导出了其分析解。

关键词：扩散/对流传质微流体器件压力定常流泰勒分散

在线全文

学校读者我要写书评

暂无评论

缺失数据下随机系数自回归模型的参数估计

统计与决策 2022年第1期38卷 16-20页

作者：赵志文高敏吉林师范大学数学学院吉林四平136000

随机系数自回归模型能够较好地描述模型系数随时间变化的特性,因此得到了广泛应用。文章讨论具有缺失数据的随机系数自回归模型的参数估计问题,在缺失数据情形下给出了四种模型参数估计方法:无数据填充条件最小二乘法、均值填充法、条... 详细信息

随机系数自回归模型能够较好地描述模型系数随时间变化的特性,因此得到了广泛应用。文章讨论具有缺失数据的随机系数自回归模型的参数估计问题,在缺失数据情形下给出了四种模型参数估计方法:无数据填充条件最小二乘法、均值填充法、条件均值填充法以及桥填充法。最后,通过随机模拟说明了上述估计方法的精确性,并给出了应用实例。

关键词：随机系数自回归模型缺失数据条件均值最小二乘法

同方期刊数据库博看期刊