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Numerical Hydrodynamics Study Around Turbine Array of Tidal Stream Farm in Zhoushan, China

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Journal of Ocean University of China 2017年第4期16卷 703-708页

作者： yu zhiwen ZHANG Jisheng ZHAI Yanyan ZHANG Tiantian ZHENG Jinhai State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 P. R. China College of Harbor Coastal and Offshore Engineering Hohai University Nanjing 210098 P. R. China Powerchina Water Environment Governance Shenzhen 518100 P. R. China China Three Gorges Corporation Beijing 100038 P. R. China

In recent decades,great efforts have been made to efficiently explore tidal stream energy due to its unique advantages of easy prediction and great *** recently launched a national tidal stream farm demonstration project in the waterway between Putuoshan and Hulu Islands in the Zhoushan *** deployment of the turbine array,it is necessary to understand the hydrodynamic changes associated with the construction of a turbine *** this study,we developed a depth-averaged hydrodynamics model that solves the shallow water governing equations to simulate the tidal hydrodynamics around the Zhoushan *** simulation results agree with field data in terms of the water elevation and stream *** considered two types of turbine arrays in this study and investigated their impacts on the local *** general,the stream velocity in the northern and southern areas is reduced due to the power take-off of the turbine array,whereas stream velocity in the western and eastern areas is slightly increased due to the blockage impact of the turbine array.

关键词： tidal stream farm turbine array tidal hydrodynamics numerical simulation demonstration project

当前形势下金融领域如何做好网络安全风险管理

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金融科技时代 2024年第9期32卷 6-9,15页

作者：陈卫兵范志文俞檑芳中国银行广东省分行

近年来,随着信息科技的快速发展,金融行业数字化转型不断提速。金融机构作为高价值目标,经常受到网络犯罪分子的集中攻击,其网络安全威胁日益复杂。金融行业属于强监管行业,对高风险零容忍。因此,文章主要研究如何使用新技术强化技术风... 详细信息

近年来,随着信息科技的快速发展,金融行业数字化转型不断提速。金融机构作为高价值目标,经常受到网络犯罪分子的集中攻击,其网络安全威胁日益复杂。金融行业属于强监管行业,对高风险零容忍。因此,文章主要研究如何使用新技术强化技术风险管理和风险控制。文章主要参考了公安部第三研究所金融行业网络安全研究报告以及大数据技术、区块链技术、金融业网络安全风险管理的相关文献,并结合中国银行广东省分行风险管理的实践和未来金融网络安全发展趋势进行深入分析并提出建议。

关键词：网络安全人工智能区块链风险控制

美洲鲥Ⅳ、Ⅴ期卵巢营养成分、卵黄蛋白原、组织蛋白酶D及其mRNA表达的比较分析

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上海海洋大学学报 2024年第3期33卷 623-634页

作者：袁新程施永海徐嘉波于爱清邓平平张之文蒋飞上海市水产研究所上海市水产技术推广站上海200433

为探明美洲鲥(Alosa sapidissima)雌鱼发育后期卵巢内营养物质的变化规律,提高卵子受精率,采用生化分析、酶联免疫吸附及荧光定量PCR等方法,对性腺发育期Ⅳ期和Ⅴ期的卵巢内氨基酸、脂肪酸、卵黄蛋白原(VTG)和组织蛋白酶D(CTSD)含量及其... 详细信息

为探明美洲鲥(Alosa sapidissima)雌鱼发育后期卵巢内营养物质的变化规律,提高卵子受精率,采用生化分析、酶联免疫吸附及荧光定量PCR等方法,对性腺发育期Ⅳ期和Ⅴ期的卵巢内氨基酸、脂肪酸、卵黄蛋白原(VTG)和组织蛋白酶D(CTSD)含量及其mRNA表达量进行对比分析。结果显示,Ⅳ期卵巢中水分含量(75.73%)显著低于Ⅴ期(90.64%),而粗蛋白含量(16.07%)、粗脂肪含量(2.86%)和粗灰分含量(1.28%)均显著高于Ⅴ期(5.83%、1.25%、0.81%)。在Ⅳ、Ⅴ期卵巢内各检测出18种氨基酸,其中谷氨酸含量最高(8.64%和8.13%);8种必需氨基酸中,Ⅳ期苏氨酸、苯丙氨酸、赖氨酸和色氨酸含量均显著高于Ⅴ期,且二者第一限制氨基酸均为色氨酸;Ⅳ期氨基酸总量(TAA)、半必需氨基酸(HEAA)和非必需氨基酸总量(NEAA)均显著高于Ⅴ期。两期卵巢内共检测出19种脂肪酸,Ⅳ期C17∶0、C20∶1n9、C20∶4n6和C20∶5n3含量显著高于Ⅴ期;其中ΣMUFA、ΣPUFA、ΣUFA、Σn3PUFA和EPA+DHA含量均大于Ⅴ期,ΣUFA(70.54%)达到显著性差异。Ⅳ期卵巢中VTG含量高于Ⅴ期,但不显著;而Ⅳ期卵巢中CTSD含量明显比Ⅴ期低。Ⅴ期卵巢VTG基因表达量是Ⅳ期的13.88倍;而Ⅴ期肝脏内VTG基因表达明显低于Ⅳ期,是Ⅳ期的25%。从Ⅳ期至Ⅴ期,卵巢中CTSD mRNA表达出现下调,肝脏中CTSD mRNA表达出现上调,但均不明显。因此,当前养殖条件下,美洲鲥雌鱼亲本后期发育过程中,卵巢内营养物质积累不均衡,建议适当调整饲料配方,提高限制性氨基酸色氨酸、蛋氨酸、苯丙氨酸及含量较低的赖氨酸、苏氨酸比例和调高多不饱和脂肪酸C20∶3n6、C20∶4n6(AA)、C22∶6n3(DHA)和C20∶5n3(EPA)比例,降低C18∶2n6c的比例,保证卵巢后期发育所需营养的均衡。

关键词：美洲鲥卵巢营养成分卵黄蛋白原组织蛋白酶D mRNA表达

Antibody drug conjugate:the“biological missile”for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1066-1090页

作者： zhiwen Fu Shijun Li Sifei Han Chen Shi yu Zhang Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan 430022People’s Republic of China Drug Delivery Disposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University(Parkville Campus)381 Royal ParadeParkvilleVIC 3052Australia Faculty of Pharmacy China Pharmaceutical University639 Longmian AvenueJiangning DistrictNanjing 211198People’s Republic of China

Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical *** combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer *** the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far ***,over 100 ADC candidates have been investigated in clinical stages at *** kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer ***,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ***,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs.

关键词： Antibody drugs conjugate

Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone

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Chinese Chemical Letters 2021年第1期32卷 1-4页

作者： zhiwen Chu Ruiqi Tong yufan yang Xuanyi Song Tian bao Hu yu Fan Chen Zhao Lu Gao Zhenlei Song Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

A convergent approach to 1,5-hydroxy ketones,the general precursors for constructing the C ring of bryostatins,has been developed via a Zn/Cu-promoted conjugate addition of a-hydroxy iodides with *** reaction leads to direct formation of the C21-C22 bond and tolerates diverse functionalities at the C17-,C18-and *** approach also enables a more concise synthesis of the known C ring intermediate(10 longest linear steps and 14 total steps),in contrast to its previous synthesis(17 longest linear steps and 22 total steps) in our total synthesis of bryostatin 8.

关键词： Bryostatins Zn/Cu-promoted conjugate addition α-Hydroxy iodide Enones 1,5-Hydroxy ketones

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高海拔特高压变压器均压环结构设计

电力工程技术 2024年第5期43卷 216-223页

作者：廖文龙丁理杰朱天宇黄治文张榆魏文赋国网四川省电力公司电力科学研究院四川成都610041 西南交通大学电气工程学院四川成都611756

特高压变压器在投运前需要进行严格的交接试验以保证其能安全可靠运行,而变压器上均压环的均压能力会影响交接试验的准确性。高海拔环境下均压环结构出现问题时其均压能力会发生变化,因此研究设计面对不同状况都能有良好均压能力的均压... 详细信息

特高压变压器在投运前需要进行严格的交接试验以保证其能安全可靠运行,而变压器上均压环的均压能力会影响交接试验的准确性。高海拔环境下均压环结构出现问题时其均压能力会发生变化,因此研究设计面对不同状况都能有良好均压能力的均压环尤为重要。文中首先采用COMSOL软件搭建了500 kV变压器耐压试验回路三维模型;其次研究均压环的管径、环径和环间距变化对均压环均压能力的影响;最后研究均压环在毛糙状态下的均压能力变化。研究发现在均压环管径和环径增大或环间距减小时,均压环均压能力会增强,其中管径改变带来的影响最大;均压环为毛糙表面时其均压能力会显著下降,其中粘附圆锥颗粒时均压能力下降最显著,凹陷时下降最少,说明均压环表面越平整,均压能力越好。该研究能为高海拔特高压变压器均压环设计相关工作提供一定帮助。

关键词：高海拔变压器均压环电场分布电晕放电毛糙问题

CrowdDesigner:information-rich and personalized product description generation

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Frontiers of Computer Science 2022年第6期16卷 183-185页

作者： Qiuyun ZHANG Bin GUO Sicong LIU Jiaqi LIU zhiwen yu School of Computer Science Northwestern Polytechnical UniversityXi'an 710072China

1 Introduction Withthe rapid development of the E-commerce,more consumers turn to shop *** online shoppers search for products using keywords,the related products appear with their brief *** conduct a real-world survey and find that most shoppers are dissatisfied with the existing"onefit-all product descriptions"and they have to spend more time to scan detail ***,handcrafting the attractive product descriptions is always costly.

关键词： attractive Designer spend

Relative manifold based semi-supervised dimensionality reduction

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Frontiers of Computer Science 2020年第1期14卷 236-236页

作者： Xianfa CAI Guihua WEN Jia WEI zhiwen yu School of Medical Information Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Shenzhen Key Laboratory of High Performance Data Mining Shenzhen 518055China

Figure 8 of this article shows YaleB and CMU PIE with incorrect legend titles:YaleB(Tr=1900,Te=514,NOC=100)should be YaleB(Tr=1900,Te=514,d=100)(Fig.8(a));TIE(Tr=1200,Te=2880,d=100)should be PIE(Tr=1200,Te=2880,d=100)... 详细信息

关键词： Figure dimensionality correct

The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response

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Cellular & Molecular Immunology 2021年第8期18卷 1981-1994页

作者： zhiwen Gu Xueying Chen Wenyong yang yu Qi Hui yu Xiaomeng Wang Yanqiu Gong Qianqian Chen Bo Zhong Lunzhi Dai Shiqian Qi Zhiqiang Zhang Huiyuan Zhang Hongbo Hu Department of Rheumatology and Immunology National Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu610041China Department of Virology College of Life SciencesDepartment of ImmunologyMedical Research InstituteWuhan UniversityWuhan430072China Department of General Practice and Lab of PTM State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu610041China Department of Urology State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengdu610041China Immunobiology and Transplant Science Center Houston Methodist HospitalHoustonTXUSA77030

Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications,including ubiquitination,SUMOylation,and phosphorylation;however,the underlying molecular mechanism is not fully *** this study,TRIM60 negatively regulated the formation and activation of the TAK1 *** of TRIM60 in macrophages led to enhanced MAPK and NF-κB activation,accompanied by elevated levels of proinflammatory cytokines but not ***-mass spectrometry assays identified TAB2 as the target of TRIM60 for SUMOylation rather than ubiquitination,resulting in impaired formation of the TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-κB *** SUMOylation sites of TAB2 mediated by TRIM60 were identified as K329 and K562;substitution of these lysines with arginines abolished the SUMOylation of *** vivo experiments showed that TRIM60-deficient mice showed an elevated immune response to LPS-induced septic shock and *** *** data reveal that SUMOylation of TAB2 mediated by TRIM60 is a novel mechanism for regulating the innate immune response,potentially paving the way for a new strategy to control antibacterial immune responses.

关键词： SUMOylation innate immune response TRAM60 TAB2