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Chromosomal microarray analysis vs.karyotyping for fetal ventriculomegaly:a meta-analysis

Chinese Medical Journal 2022年第3期135卷 268-275页

作者： Yan Sun Weiyuan Zhang Zhiwen Wang Likui Guo Shaowen Shi Department of Perinatal Medicine Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100010China Department of Obstetrics First Hospital of QinhuangdaoHebei 066000China

Background:Chromosomal abnormalities are important causes of ventriculomegaly(VM).In mild and isolated cases of fetal VM,obstetricians rarely give clear indications for pregnancy termination.We aimed to calculate the incidence of chromosomal abnormalities and incremental yield of chromosomal microarray analysis(CMA)in VM,providing more information on genetic counseling and prognostic evaluation for fetuses with VM.Methods:The Chinese language databases Wanfang Data,China National Knowledge Infrastructure,and China Biomedical Literature Database(from January 1,1991 to April 29,2020)and English language databases PubMed,Embase,and Cochrane Library(from January 1,1945 to April 29,2020)were systematically searched for articles on fetal VM.Diagnostic criteria were based on ultrasonographic or magnetic resonance imaging(MRI)assessment of lateral ventricular atrium width:≥10 to<15 mm for mild VM,and≥15 mm for severe VM.Isolated VM was defined by the absence of structural abnormalities other than VM detected by ultrasonography or MRI.R software was used for the meta-analysis to determine the incidence of chromosomal abnormalities and incremental yield of CMA in VM,and the combined rate and 95%confidence interval(CI)were calculated.Results:Twenty-three articles involving 1635 patients were included.The incidence of chromosomal abnormalities in VM was 9%(95%CI:5%-12%)and incremental yield of CMA in VM was 11%(95%CI:7%-16%).The incidences of chromosomal abnormalities in mild,severe,isolated,and non-isolated VM were 9%(95%CI:4%-16%),5%(95%CI:1%-11%),3%(95%CI:1%-6%),and 13%(95%CI:4%-25%),respectively.Conclusions:Applying CMA in VM improved the detection rate of abnormalities.When VM is confirmed by ultrasound or MRI,obstetricians should recommend fetal karyotype analysis to exclude chromosomal abnormalities.Moreover,CMA should be recommended preferentially in pregnant women with fetal VM who are undergoing invasive prenatal diagnosis.CMA cannot completely replace chromosome karyotype analysis.

关键词： Ventriculomegaly Chromosome Karyotype Chromosomal microarray analysis Meta-analysis

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The Least Eigenvalue of Unicyclic Graphs with Application to Spectral Spread

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Algebra Colloquium 2022年第2期29卷 265-272页

作者： Jiming Guo Gege Zhang Zhiwen Wang Panpan Tong School of Mathematics East China University of Science and Technology Shanghai 200237China

Let U^(g)_(n)be the set of connected unicyclic graphs of order n and girth g.Let C(T_(1),T_(2),…,T_(g))∈U^(g)_(n)be obtained from a cycle v_(1)v_(2)…v_(g)v_(1)(in an anticlockwise direction)by identifying v_(i)with the root of a rooted tree T_(i)of order n_(i)for each i=1,2,…,g,where n_(i)≥1 and∑^(g)_(i=1)n_(i)=n.In this note,the graph with the minimal least eigenvalue(and the graph with maximal spread)in C(T_(1),T_(2),…,T_(g))is determined.

关键词： adjacency matrix least eigenvalue eigenvector unicyclic graph

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An international comprehensive benchmarking analysis of synthetic biology in China from 2015 to 2020

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Chinese Journal of Chemical Engineering 2022年第8期35卷 211-226页

作者： Meiru Jiang Cong Chen Tao Chen Chao Zhao Zhiwen Wang Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) SynBio Research PlatformCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Center for Biosafety Research and Strategy Tianjin UniversityTianjin 300072China

As a new interdisciplinary field,synthetic biology has led to valuable innovations in the fields of medicine,chemistry,agriculture,energy and environment.In this paper,we systematically review the development status of global synthetic biology in the past six years,and make an in-depth benchmarking analysis of the field in China.With the aid of Scopus and SciVal,we analyze the scholarly output of synthetic biology in the world and individual countries,including publication distribution,popular journals and eminent institutions.Furthermore,the research focus and concepts,citation impact and collaborations are also examined using numerical index methods such as the field-weighted citation impact(FWCI)and relative activity index(RAI),showing the differences between data more intuitively.This study aims to offer a comprehensive understanding of the research status of synthetic biology in China and the world,offering a benchmarked overview of the results as a reference to guide the development of this field in the future.

关键词： Synthetic biology Scopus SciVal Output Citation impact Collaboration

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Two‑Dimensional Metal Halides for X‑Ray Detection Applications

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Nano-Micro Letters 2023年第8期15卷 405-422页

作者： Yumin Li Yutian Lei Haoxu wang zhiwen Jin School of Physical Science and Technology and Lanzhou Center for Theoretical Physics and Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000People’s Republic of China

Metal halide perovskites have recently emerged as promising candidates for the next generation of X-ray detectors due to their excellent optoelectronic properties.Especially,two-dimensional(2D)perovskites afford many distinct properties,including remarkable structural diversity,high generation energy,and balanced large exciton binding energy.With the advantages of 2D materials and perovskites,it successfully reduces the decomposition and phase transition of perovskite and effectively suppresses ion migration.Meanwhile,the existence of a high hydrophobic spacer can block water molecules,thus making 2D perovskite obtain excellent stability.All of these advantages have attracted much attention in the field of X-ray detection.This review introduces the classification of 2D halide perovskites,summarizes the synthesis technology and performance characteristics of 2D perovskite X-ray direct detector,and briefly discusses the application of 2D perovskite in scintillators.Finally,this review also emphasizes the key challenges faced by 2D perovskite X-ray detectors in practical application and presents our views on its future development.

关键词： Two-dimensional perovskite High stability Ion migration Charge transport X-ray Detector

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A comparative analysis of China and other countries in metabolic engineering: Output, impact and collaboration

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Chinese Journal of Chemical Engineering 2021年第2期34卷 37-45页

作者： Cong Chen Tao Chen Zhiwen Wang Xueming Zhao Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) SynBio Research PlatformCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

In recent years,metabolic engineering has made great progress in both academic research and industrial applications.However,we have not found any articles that specifically analyze the current state of metabolic engineering in China in comparison with other countries.Here,we review the current development and future trends of global metabolic engineering,conduct an in-depth benchmarking analysis of the development situation of China’s metabolic engineering,and identify current problems as well as future trends.We searched publications in the Scopus database from 2015 to September 2020 in the field of metabolic engineering,and analyzed the output in general,including publication trends,research distribution,popular journals,hot topics and vital institutions,but also analyzed the share of citations,field-weighted citation impact,and production in collaboration with strategic countries in science and technology.This study aims to serve as a reference for later studies,offering a comprehensive view of China’s contribution to metabolic engineering,and as a tool for the elaboration of national public policy in science and technology.

关键词： Metabolic engineering Output Citation impact Collaboration China Science metric

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Surface functionalized Pt/SnNb_(2)O_(6)nanosheets for visible-light-driven the precise hydrogenation of furfural to furfuryl alcohol

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Journal of Energy Chemistry 2022年第3期31卷 566-575,I0015页

作者： Yingzhang Shi Huan wang Zhiwen Wang Cheng Liu Mingchuang Shen Taikang Wu Ling Wu State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116FujianChina State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of ScienceFuzhou 350002FujianChina

Photocatalytic upgrading of renewable biomass is a promising way to relieve energy crisis and environmental pollution.However,low photocatalytic efficiency and uncontrollable selectivity still limit its development.Herein,ultrathin SnNb_(2)O_(6)nanosheets with high dispersed Pt nanoparticles(Pt/SN)were successfully developed as an efficient photocatalyst for the precise hydrogenation of furfural(FUR)to furfuryl alcohol(FOL)under visible light irradiation and exhibited the high conversion of FUR(99.9%)with the high selectivity for FOL(99.9%).It was revealed that SN with only 4.1 nm thickness possess good separation ability of photo-generated carriers and abundant surface Lewis acid sites(Nb^(5+))which would selectively chemisorb and activate FUR molecules via the Nb···O=C coordination.Meanwhile,Pt nanoparticles would gather photo-generated electrons for greatly promoting the generation of active H species to support the hydrogenation of FUR to FOL.The synergistic effects between SnNb_(2)O_(6)nanosheets and Pt nanoparticles remarkably facilitate the photocatalytic performance for hydrogenation.This work not only confirms the great potential of ultrathin nanosheet photocatalyst with functional metal sites for precise upgrading of biomass but also provides an in-depth view to understand the surface/interface interaction between reactant molecules and surface sites of a photocatalyst.

关键词： Biomass conversion Hydrogenation of furfural Two-dimensional materials Sn2NbO6 nanosheet Pt nanoparticle Photocatalysis

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Efficient acetoin production from pyruvate by engineered Halomonas bluephagenesis whole-cell biocatalysis

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Frontiers of Chemical Science and Engineering 2023年第4期17卷 425-436页

作者： Meiyu Zheng Zhenzhen Cui Jing Zhang Jing Fu Zhiwen Wang Tao Chen Department of Biochemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Department of Biology and Biological Engineering Chalmers University of TechnologyGothenburg 41296Sweden

Acetoin is an important platform chemical,which has a wide range of applications in many industries.Halomonas bluephagenesis,a chassis for next generation of industrial biotechnology,has advantages of fast growth and high tolerance to organic acid salts and alkaline environment.Here,α-acetolactate synthase andα-acetolactate decarboxylase from Bacillus subtilis 168 were co-expressed in H.bluephagenesis to produce acetoin from pyruvate.After reaction condition optimization and further increase ofα-acetolactate decarboxylase expression,acetoin production and yield were significantly enhanced to 223.4 mmol·L^(-1) and 0.491 mol·mol^(-1) from 125.4 mmol·L^(-1) and 0.333 mol·mol^(-1),respectively.Finally,the highest titer of 974.3 mmol·L^(-1)(85.84 g·L^(-1))of acetoin was accumulated from 2143.4 mmol·L^(-1)(188.6 g·L^(-1))of pyruvic acid within 8 h in fed-batch bioconversion under optimal reaction conditions.Moreover,the reusability of the cell catalysis was also tested,and the result illustrated that the whole-cell catalysis obtained 433.3,440.2,379.0,442.8 and 339.4 mmol·L^(-1)(38.2,38.8,33.4,39.0 and 29.9 g·L^(-1))acetoin in five repeated cycles under the same conditions.This work therefore provided an efficient H.bluephagenesis whole-cell catalysis with a broad development prospect in biosynthesis of acetoin.

关键词： acetoin pyruvate α-acetolactate synthetase α-acetolactate decarboxylase Halomonas bluephagenesis whole-cell biocatalysis

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Versatile biomimetic nanomedicine for treating cancer and inflammation disease

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Medical Review 2023年第2期3卷 123-151页

作者： zhiwen Zhao Dangge wang Yaping Li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesNo.555Rd ZuchongzhiPudong DistrictShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000Shandong ProvinceChina Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000Shandong ProvinceChina

Nanosized drug delivery systems(NDDSs)have emerged as a powerful tool to optimize drug delivery in complex diseases,including cancer and inflammation.However,the therapeutic effect of NDDSs is still far from satisfactory due to their poor circulation time,low delivery efficiency,and innate toxicity.Fortunately,biomimetic approaches offer new opportunities to develop nanomedicine,which is derived from a variety of native biomolecules including cells,exosomes,bacteria,and so on.Since inheriting the superior biocompatibility and versatile functions of natural materials,biomimetic nanomedicine can mimic biological processes,prolong blood circulation,and lower immunogenicity,serving as a desired platform for precise drug delivery for treating cancer and inflammatory disease.In this review,we outline recent advances in biomimetic NDDSs,which consist of two concepts:biomimetic exterior camouflage and bioidentical molecule construction.We summarize engineering strategies that further functionalized current biomimetic NDDSs.A series of functional biomimetic NDDSs created by our group are introduced.We conclude with an outlook on remaining challenges and possible directions for biomimetic NDDSs.We hope that better technologies can be inspired and invented to advance drug delivery systems for cancer and inflammation therapy.

关键词： biomimetic cancer immunotherapy nanomedicine nanoparticles

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Real-world gaseous emission characteristics of natural gas heavy-duty sanitation trucks

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Journal of Environmental Sciences 2022年第5期34卷 319-329页

作者： Jiguang wang Huaqiao Gui zhiwen Yang Tongzhu Yu Xiaowen Zhang Jianguo Liu Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China China Automotive Technology and Research Center Co. LtdTianjin 300300China Innovation excellence center for urban atmospheric environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

As compared to conventional diesel heavy-duty vehicles,natural gas vehicles have been proved to be more eco-friendly due to their lower production of greenhouse gas and pollu-tant emissions,which are causing enormous adverse effects on global warming and air pol-lution.However,natural gas vehicles were rarely studied before,especially through on-road measurements.In this study,a portable emission measurement system(PEMS)was em-ployed to investigate the real-world emissions of nitrogen oxides(NO_(x))(nitrogen monoxide(NO),nitrogen dioxide(NO_(2))),total hydrocarbons(THC),carbon monoxide(CO),and carbon dioxide(CO_(2))from two liquified natural gas(LNG)China V heavy-duty cleaning sanitation trucks with different weight.Associated with the more aggressive driving behaviors,the ve-hicle with lower weight exhibited higher CO_(2)(3%)but lower NO_(x)(48.3%)(NO_(2)(78.2%)and NO(29.4%)),CO(44.8%),and THC(3.7%)emission factors.Aggressive driving behaviors were also favorable to the production of THC,especially those in the medium-speed range but sig-nificantly negative to the production of CO and NO_(2),especially those in the low-speed range with high engine load.In particular,the emission rate ratio of NO_(2)/NO decreased with the increase of speed/scaled tractive power in different speed ranges.

关键词： Natural gas sanitation vehicle PEMS Gaseous pollutant emission

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Dimensionality regulation in tin halide perovskite solar cells: Toward high performance and stability

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Journal of Energy Chemistry 2023年第2期77卷 144-156,I0005页

作者： Huanhuan Yao Shurong wang zhiwen Jin Liming Ding Feng Hao School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Materials and Energy&School of Physical Science and Technology&Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000GansuChina Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Tin halide perovskites(THPs)have received extensive attention due to their low toxicity and excellent optoelectronic properties,and are considered to be the most promising alternatives to develop efficient lead-free perovskite solar cells.However,due to the unique and inherent characteristics of Sn^(2+)being easily oxidized to Sn^(4+)and fast crystallization,tin perovskite solar cells(TPSCs)show relatively poor performance and stability,compared to the lead counterparts.Recently,the introduction of bulky organic spacers into three-dimensional(3D)THPs for dimensional regulation can not only prevent the intrusion of water and oxygen,but also inhibit the self-doping effect and ion migration.In this review,we will detail how dimensional regulation enables TPSCs with high performance and superior stability.First,we summarize the intrinsic properties of THPs and analyze the root causes of their poor performance and instability.Next,we discuss the specific structure and types of the dimensional regulation strategy.Then,the mechanism of dimensional regulation is discussed in detail,mainly from inhibiting the Sn^(2+)oxidation,optimizing crystallization,passivating defects,and improving energy level alignment.Finally,future challenges and prospects for dimensional regulation are elaborated to help researchers develop more efficient and stable TPSCs.

关键词： Organic spacers Dimensional regulation Long-term stability Performance Photovoltaics

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