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关于CRH2A/2C/380A平台动车组120万km三级检修调试项目的研究及优化

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铁道车辆 2024年第4期62卷 154-162页

作者：李波李渊代歧张志文中国铁路武汉局集团有限公司湖北武汉430071

为了降低动车组120万km三级检修修时资源占用率,在确保动车组检修质量的前提下,通过对比三级修各工序检修要求、梳理重复确认项点、分析故障情况、评估安全性、跟踪验证、制定保障措施等方式,优化了31项三级检修调试项目,其中包括规程优... 详细信息

为了降低动车组120万km三级检修修时资源占用率,在确保动车组检修质量的前提下,通过对比三级修各工序检修要求、梳理重复确认项点、分析故障情况、评估安全性、跟踪验证、制定保障措施等方式,优化了31项三级检修调试项目,其中包括规程优化4项、工艺优化8项、工序迁移3项、合并16项重复试验项目,并逐项制定了运用安全保障措施。该项目完全落地可节省120万km三级检修修时约16.5 h,按每组动车组上线一天营业额30万元计算,每年可增加营业额1.8亿元。此外,同步减少轴温报警工装、特高耐压试验机、司机台指令器的配备,从而降低动车组全寿命周期的维护成本。

关键词：动车组三级修调试项目优化效益

双模式热管堆电热原理样机设计及验证实验研究

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原子能科学技术 2023年第1期57卷 66-73页

作者：李潘潇张智鹏代智文王成龙田文喜秋穗正苏光辉西安交通大学核科学与技术学院陕西西安710049

固态热管反应堆是未来新型装备最佳能源动力解决方案之一,然而其关键技术尚未成熟,可行性及可靠性有待近一步研究。本文提出了动静结合双模式热管堆概念设计,搭建了“模拟堆芯-高温热管-斯特林-温差发电”一体化集成实验装置,利用紫铜... 详细信息

固态热管反应堆是未来新型装备最佳能源动力解决方案之一,然而其关键技术尚未成熟,可行性及可靠性有待近一步研究。本文提出了动静结合双模式热管堆概念设计,搭建了“模拟堆芯-高温热管-斯特林-温差发电”一体化集成实验装置,利用紫铜基体及加热棒模拟反应堆堆芯,利用弯折高温钾热管实现堆芯冷却及能量传输过程,利用斯特林热电转换装置及碲化铋温差发电元件实现动态/静态热电转换过程,验证了双模式热管堆技术的可行性。实验结果表明,所研制的弯折高温钾热管符合设计需求,输入功率为878 W时,热管轴向壁面温差低于60 K,不凝气体段长度小于5 cm。对于碲化铋温差发电器件,输入功率为4.2 kW、热端温度为310℃、冷端温度为20℃时,30片热电器件共发电102.6 W,热电转换效率为2.44%。对于斯特林发电机,输入功率为3.3 kW时,发电功率为429 W,热电转换效率为13.1%。本文结果可为双模式热管堆概念设计及研制提供实验数据支撑。

关键词：双模式热管堆原理样机验证实验

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空间核反应堆电源热工水力特性研究综述

原子能科学技术 2019年第7期53卷 1296-1309页

作者：代智文刘天才王成龙张大林田文喜秋穗正苏光辉西安交通大学能源与动力工程学院陕西西安710049 中国原子能科学研究院反应堆工程技术研究部北京102413

随着空间探索领域的快速发展,研究高功率、安全、可靠的空间核反应堆电源将变得愈发重要。本文针对国内外空间核反应堆电源的热工水力关键问题,即空间堆系统稳态和事故瞬态研究、堆芯单冷却剂通道及全堆芯的三维流动换热、静态与动态热... 详细信息

随着空间探索领域的快速发展,研究高功率、安全、可靠的空间核反应堆电源将变得愈发重要。本文针对国内外空间核反应堆电源的热工水力关键问题,即空间堆系统稳态和事故瞬态研究、堆芯单冷却剂通道及全堆芯的三维流动换热、静态与动态热电转换装置分析、热工水力特性试验研究等进行研究,分析了空间核反应堆电源热工水力研究的趋势。本文结果可为空间核反应堆电源设计分析及热工水力安全特性研究提供帮助和指导。

关键词：空间核反应堆电源热工水力研究综述

辐照条件下高温锂热管不凝性气体产生特性研究

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原子能科学技术 2021年第6期55卷 1024-1030页

作者：张明昊王成龙孙浩代智文张大林田文喜秋穗正苏光辉西安交通大学核科学与技术学院陕西西安710049

在新型热管冷却反应堆中,高温金属热管会受到持续的中子辐照。锂在热中子区的中子反应微观截面很大,会产生一定量的氦气,氦气作为不凝性气体将影响高温热管的正常运行。本文分析了堆内中子辐照条件对高温锂金属热管中不凝性气体产生特... 详细信息

在新型热管冷却反应堆中,高温金属热管会受到持续的中子辐照。锂在热中子区的中子反应微观截面很大,会产生一定量的氦气,氦气作为不凝性气体将影响高温热管的正常运行。本文分析了堆内中子辐照条件对高温锂金属热管中不凝性气体产生特性的影响。首先对稳态标准算例进行了产氦量分析,并转换得到了不凝性气体体积份额。此外,得到了不凝性气体产量随热管充液量、金属锂富集度、中子通量密度、热管工作温度等因素的变化关系。不凝性气体产量随热管充液量、锂富集度的增大而增加。控制转鼓位于不同角度时,中子通量密度改变有限,对产氦量影响不大,由于高温锂热管工作温度很高,高温下中子反应微观截面差距很小,因此热管工作温度对产氦量影响也有限。本研究可为热管冷却反应堆内高温锂热管中锂富集度设计提供借鉴。

关键词：热管冷却反应堆高温锂热管中子辐照条件不凝性气体

Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks

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Virologica Sinica 2016年第1期31卷 57-68页

作者： Yining He zhiwen Xie Jinglong dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei College of Animal Science and Technology Guangxi University

Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both ***, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney.

关键词： infectious bronchitis virus Toll-like receptor signal pathway melanoma differentiation-associated protein 5 signal pathway cytokines

Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome based on purinergic 2X7 receptor/NOD-like receptor pyrin domaincontaining 3 signal pathway

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Journal of Traditional Chinese Medicine 2022年第6期42卷 965-971页

作者： XU Chang LI Na WU Xiaoling dai Xingye YANG zhiwen SUN Qianhui SHI Tianyu CHAI Yemao PANG Dandan CHENG Kai Major in Acupuncture and Tuina school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Experimental science of acupuncture and moxibustion teaching and research section school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Complex laboratory school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Meridians and acupoints teaching and research section school of Acupuncture and TuinaBeijing University of Chinese MedicineBeijing 100029China Academy of Chinese Medical Sciences Beijing 100700China

OBJECTIVES: To study the expression of inflammatory signal in local prostate tissue of chronic pelvic pain syndrome(CPPS) rats by electroacupuncture(EA) of Guanyuan(CV4), Zhongji(CV3), Huiyang(BL35) and Sanyinjiao(SP6), and to explore the possible mechanism of anti-inflammatory and analgesic effects of EA. METHODS : A total of 36 Sprague-Dawley male rats were randomly divided into three groups: control, model and EA(n=12 rats/group). The CPPS model was made by injection of CFA into ventral lobes of the prostate(0.1 m L). Electric acupuncture apparatus was applied to stimulate Guanyuan(CV4), Zhongji(CV3), bilateral Huiyang(BL35) and Sanyinjiao(SP6) acupoints in EA group. The general condition of rats was observed and the prostate index(PI) was calculated. The thermal pain threshold was collected after each therapeutic course. Histopathological changes of the prostate tissue were examined by hematoxylin-eosin staining method. The expression levels of tumor necrosis factor α(TNF-α), interleukin-1β(IL-1β) and prostaglandin E2(PGE2) in prostatic homogenates were measured by enzyme linked immunosorbent assay(ELISA). Moreover, the expression levels of purinergic 2X7 receptor(P2X7R), NOD-like receptor pyrin domain-containing 3(NLRP3), caspase-1 and interleukin-18(IL-18) m RNA were quantified by quantitative real-time polymerase chain reaction. RESULTS: Compared with control group, the PI of rats increased, and the thermal pain threshold decreased significantly in model group. The morphological structure of prostate tissues of rats in model group was severely damaged with a large number of inflammatory cells infiltration. Additionally, the levels of TNF-α, IL-1β and PGE2 were higher, and the expressions of P2X7R, NLRP3, caspase-1 and IL-18 m RNA were higher than those in control group. After EA treatment, the PI was significantly decreased, the thermal pain threshold was significantly increased, and the tissue damage was significantly improved. The expressions of inflammator

关键词： electroacupuncture inflammatory cytokines receptors purinergic P2X7 NLR family pyrin domain-containing 3 protein signal transduction chronic pelvic pain syndrome

局部枸橼酸抗凝在脓毒症合并高乳酸血症患者连续性肾脏替代治疗中的应用

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华西医学 2024年第7期39卷 1075-1081页

作者：郑燚王瑶代礼王芳陈志文张凌王艳艳四川大学华西医院肾脏内科/四川大学华西护理学院成都610041 四川大学华西医院肾脏内科/肾脏病研究所成都610041 四川大学华西护理学院/四川大学华西医院护理创新研究室/护理学四川省重点实验室成都610041

目的探索局部枸橼酸抗凝(regional citrate anticoagulation,RCA)在脓毒症合并高乳酸血症患者连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)中的应用情况,为此类患者的RCA临床应用提供依据。方法回顾性纳入2021年5月-... 详细信息

目的探索局部枸橼酸抗凝(regional citrate anticoagulation,RCA)在脓毒症合并高乳酸血症患者连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)中的应用情况,为此类患者的RCA临床应用提供依据。方法回顾性纳入2021年5月-2023年5月在四川大学华西医院行RCA-CRRT的脓毒症患者。根据CRRT开始前初始乳酸水平将患者分为乳酸正常组(≤2.0 mmol/L)和高乳酸血症组(>2.0 mmol/L),并对中度高乳酸血症(2 mmol/L0.05)。乳酸正常组与高乳酸血症组的枸橼酸蓄积发生率分别为13.0%和25.9%(P0.05)。Kaplan-Meier生存分析显示,乳酸正常组与高乳酸血症组首个体外循环寿命差异无统计学意义(P>0.05)。213例高乳酸血症患者中,中度高乳酸血症186例,重度高乳酸血症27例。PSM前,中度与重度高乳酸血症组的男性比例、糖尿病比例、白蛋白水平、国际标准化比值、白细胞介素-6差异均有统计学意义(P0.05)。中度高乳酸血症组与重度高乳酸血症组的枸橼酸蓄积发生率分别为18.2%和50.0%(P0.05)。Kaplan-Meier生存分析显示,中度高乳酸血症组与重度高乳酸血症组首个体外循环寿命差异无统计学意义(P>0.05)。结论RCA用于脓毒症伴高乳酸血症患者的CRRT抗凝时,枸橼酸蓄积发生率较高(尤其是重度高乳酸血症患者),应严密监测。

关键词：脓毒症高乳酸血症连续性肾脏替代治疗局部枸橼酸抗凝

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On the robustness of EEG tensor completion methods

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Science China(Technological Sciences) 2021年第9期64卷 1828-1842页

作者： DUAN Feng JIA Hao ZHANG zhiwen FENG Fan TAN Ying dai YangYang CICHOCKI Andrzej YANG ZhengLu CAIAFA Cesar F. SUN Zhe SOLE-CASALS Jordi College of Artificial Intelligence Nankai UniversityTianjin 300350China Skolkowo Institute of Science and Technology Moscow 121205Russia College of Computer Science Hangzhou Dianzi UniversityHangzhou 310018China Department of Informatics Nicolaus Copernicus UniversityTorun 87-100Poland Systems Research Institute Polish Academy of SciencesWarsaw 01-447Poland College of Computer Science Nankai UniversityTianjin 300350China Instituto Argentino de Radioastronom´ıa IAR-CCT La Plata CONICET/CIC-PBA/UNLPVilla Elisa 1894Argentina Computational Engineering Applications Unit Head Office for Information Systems and CybersecurityRIKENWako-Shi 351-0106Japan Department of Psychiatry University of CambridgeCambridge CB28AHUK Data and Signal Processing Research Group University of Vic-Central University of CataloniaCatalonia 08500Spain

During the acquisition of electroencephalographic(EEG) signals, data may be missing or corrupted by noise and artifacts. To reconstruct the incomplete data, EEG signals are firstly converted into a three-order tensor(multi-dimensional data) of shape time × channel × trial. Then, the missing data can be efficiently recovered by applying a tensor completion method(TCM).However, there is not a unique way to organize channels and trials in a tensor, and different numbers of channels are available depending on the EEG setting used, which may affect the quality of the tensor completion results. The main goal of this paper is to evaluate the robustness of EEG completion methods with several designed parameters such as the ordering of channels and trials, the number of channels, and the amount of missing data. In this work, the results of completing missing data by several TCMs were compared. To emulate different scenarios of missing data, three different patterns of missing data were ***, the amount of missing data on completion effects was analyzed, including the time lengths of missing data and the number of channels or trials affected by missing data. Secondly, the numerical stability of the completion methods was analyzed by shuffling the indices along channels or trials in the EEG data tensor. Finally, the way that the number of electrodes of EEG tensors influences completion effects was assessed by changing the number of channels. Among all the applied TCMs, the simultaneous tensor decomposition and completion(STDC) method achieves the best performance in providing stable results when the amount of missing data or the electrode number of EEG tensors is changed. In other words, STDC proves to be an excellent choice of TCM, since permutations of trials or channels have almost no influence on the complete results. The STDC method can efficiently complete the missing EEG signals. The designed simulations can be regarded as a procedure to validate whether or

关键词： electroencephalogram corrupted data missing data tensor completion tensor decomposition

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精准判断高阻故障的选线录波装置的研究

机电工程技术 2024年第8期53卷 296-302页

作者：李智玲戴景琪刘轶钟赛宋志文史迪康李彬内蒙古电力(集团)有限责任公司包头供电分公司内蒙古包头014030 广州市宁志电力科技有限公司广州511400

配网各种中性点接地模式保护的共性难题是存在高阻接地故障盲区,是电网安全领域亟待解决的问题。由于配电网线路分布广,负荷不均衡等原因,造成不同地区配电网络中出现单个或多个站点发生单相接地故障现象,容易导致各区域内同一供电设备... 详细信息

配网各种中性点接地模式保护的共性难题是存在高阻接地故障盲区,是电网安全领域亟待解决的问题。由于配电网线路分布广,负荷不均衡等原因,造成不同地区配电网络中出现单个或多个站点发生单相接地故障现象,容易导致各区域内同一供电设备相继跳闸,为了解决上述普遍存在的共性问题,通过深入研究和分析各种中性点接地方式下的单相接地故障特征,开发并研制了具有多处理器硬件内核的选线录波装置,创新了一种符合接地故障规律的算法和判据。基于此算法和判据所研发的装置经过10 kV真型配网试验平台多种接地试验,最终结果证实其能够精准感知各类接地故障、高耐受接地过渡电阻,消除高阻保护盲区,成倍扩大保护范围,提升整个电网系统的安全性和可靠性。

关键词：高阻接地接地过渡电阻采样精度算法判据试验验证

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