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Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic

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National Science Review 2022年第11期9卷 87-96页

作者： Dan Cui Simiao Chen Luzhao Feng Mengmeng Jia Yeming Wang Weijun Xiao Yanxia Sun Qiangru Huang Libing Ma zhiwei leng Hao Wang Bin Cao Weizhong Yang Juntao Yang Chen Wang Department of Pulmonary and Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin Medical University Department of Pulmonary and Critical Care Medicine National Center for Respiratory Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory Diseases China-Japan Friendship Hospital Heidelberg Institute of Global Health Faculty of Medicine and University Hospital Heidelberg University School of Population Medicine and Public Health Chinese Academy of Medical Sciences &Peking Union Medical College Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Guilin Medical University Institute of Respiratory Medicine Chinese Academy of Medical Science State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019(COVID-19)in Jianghan District(Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had depressive symptoms at the 17-month follow-up. The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19hospitals was 31.6% and 41.1%, respectively, and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8% and 60.9%, respectively. Female sex(odds ratio[OR] = 1.48, 95% confidence interval [CI]: 1.16–1.88), severe disease(OR = 1.46, 95% CI: 1.01–2.10)and a higher number of initial symptoms(OR = 1.31, 95% CI: 1.23–1.40) were associated with the development of sequelae symptoms at 17 months. This study involving community-dwelling COVID-19adults may help determine the long-term effects of COVID-19 during the first pandemic wave.Nonetheless, larger follow-up studies are needed to characterize the post-COVID-19 condition.

关键词： SARS-CoV-2 post-COVID-19 syndrome follow-up studies

Role of social organization engagement in high-risk groups intervention against HIV/AIDS:a case study from 176 cities of China

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Infectious Diseases of Poverty 2022年第6期11卷 70-83页

作者： zhiwei leng Sha Sha Shuyu Dai Xuehui Meng Jinfeng Li Junyi Jin Wenlin Zheng Weihua Yang Chuanju Mao Zhenzhong Wang Liujin Zhang Peng Wang Tao Yang Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Chinese Preventive Medicine Association BeijingChina Zhejiang Chinese Medical University HangzhouChina Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Chinese Academy of Medical Sciences&Peking Union Medical College BeijingChina

Background: A high-risk prevention strategy is an effective way to fight against human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). The China AIDS Fund for Non-Governmental Organizations (CAFNGO) was established in 2015 to help social organizations intervene to protect high-risk populations in 176 cities. This study aimed to evaluate the role of social organizations in high-risk population interventions against HIV/AIDS.Methods: This study was based on the CAFNGO program from 2016 to 2020. The collected data included the number and types of social organizations participating in high-risk group interventions and the amount of funds obtained by these organizations each year. We explored the factors influencing the number of newly diagnosed AIDS cases using a spatial econometric model. Furthermore, we evaluated the effectiveness of intervention activities by comparing the percentages of the individuals who initially tested positive, and the individuals who took the confirmatory test, as well as those who retested positive and underwent the treatment.Results: Overall, from 2016 to 2020, the number of social organizations involved in interventions to protect HIV/AIDS high-risk populations increased from 441 to 532, and the invested fund increased from $3.98 to $10.58 million. The number of newly diagnosed cases decreased from 9128 to 8546 during the same period. Although the number of cities with overall spatial correlations decreased, the spatial agglomeration effect persisted in the large cities. Citywise, the number of social organizations (direct effect 19.13), the permanent resident population (direct effect 0.12), GDP per capita (direct effect 17.58;indirect effect -15.38), and passenger turnover volume (direct effect 5.50;indirect effect -8.64) were the major factors influencing new positive cases confirmed through the testing interventions performed by the social organizations. The initial positive test rates among high-risk populations were below 5.5%, the retesting rates among

关键词： Social organization High-risk groups HIV/AIDS Spatial effect

Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study

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Infectious Diseases of Poverty 2023年第2期12卷 125-125页

作者： Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai Mingyu Si Jiaqi Fu Xu Chen Mengmeng Jia zhiwei leng Dan Cui Winnie W.S.Mak Liming Dong Xiaoyou Su School of Population Medicine and Public Health Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Pulmonary and Critical Care Medicine National Center for Respiratory Medicine Center of Respiratory Medicine National Clinical Research Center for Respiratory Diseases China-Japan Friendship Hospital Beijing China Department of Pulmonary and Critical Care Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin Medical University Harbin China Diversity and Well-Being Laboratory Department of Psychology The Chinese University of Hong Kong Hong Kong China

Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience.

关键词： COVID-19 Survivor Mental health Resilience Mediating affect Stigma

A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China

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Engineering 2021年第7期7卷 948-957页

作者： Ting Zhang Qing Wang zhiwei leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Division of Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102206China Department of Respiratory and Critical Care Medicine The Affiliated Hospital of Guilin Medical UniversityGuilin 541001China

The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation.

关键词： COVID-19 Transmission dynamics model Clinical resource demands Vaccination

Controlled flight of a self-powered micro blimp driven by insect-sized flapping-wing thrusters

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Chinese Journal of Aeronautics 2024年第6期37卷 127-136页

作者： Xian YU zhiwei LIU Jiaming leng Mingjing QI Xiaojun YAN School of Energy and Power Engineering Beihang UniversityBeijing 100191China Collaborative Innovation Center of Advanced Aero-Engine Beijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics Beihang UniversityBeijng 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beihang UniversityBeijing 100191China

Micro aerial platforms face significant challenges in achieving long controlled endurance as most of the energy is consumed to overcome the weight of the body.In this study,we present a controllable micro blimp that addresses this issue through the use of a helium-filled balloon.The micro blimp has a long axis of 23 cm and is propelled by four insect-sized flapping-wing thrusters,each weighing 80 mg and with a wingspan of 3.5 cm.These distributed thrusters enable controlled motions and provide the micro blimp with an advantage in flight endurance compared to multirotors or flapping-wing micro aerial vehicles at the same size scale.To enhance the performance of the controlled flight,we propose a wireless control module that enables manipulation from a distance of up to 100 m.Additionally,a smartphone application is developed to send instructions to the circuit board,allowing the blimp to turn left and right,ascend and descend,and achieve a combination of these movements separately.Our findings demonstrate that this micro blimp is one of the smallest controlled self-powered micro blimps to date.

关键词： Microairvehicle Aircraft control Self-powered micro blimp Flapping-wing thruster Wireless flight

我国医药制造业研发投入状况及其影响的实证研究

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中国医药科学 2024年第10期14卷 119-123页

作者：刘玉霞温路张刘晋安澜冷志伟中国医学科学院北京协和医院科研处北京100730 山东大学公共卫生学院卫生管理与政策研究中心山东济南250012 北京协和医院临床医学研究所转化医学国家重大科技基础设施卫生政策与卫生经济研究平台北京100730

目的分析我国医药制造业研发投入现况,探索其对科技创新产出的影响,进而为卫生健康科技创新投入提出相关建议。方法收集2009年1月至2020年12月我国内地31个省、自治区、直辖市(不含港、澳、台)医药制造业研究与试验发展(R&D)支出、R&... 详细信息

目的分析我国医药制造业研发投入现况,探索其对科技创新产出的影响,进而为卫生健康科技创新投入提出相关建议。方法收集2009年1月至2020年12月我国内地31个省、自治区、直辖市(不含港、澳、台)医药制造业研究与试验发展(R&D)支出、R&D活动企业数、R&D人员数、R&D人员全时当量、年人均卫生费用、每千人卫生人员数、人均受教育年限和有效发明专利数等数据,运用描述性统计分析医药制造业研发投入的变化趋势、区域差距,建立面板数据计量经济学模型,分析医药制造业研发投入对有效发明专利数的影响作用。结果 2009—2020年,我国医药制造业R&D经费投入总量从154.5亿元上升到906.5亿元,总体增长486.7%,年均增长17.5%。面板计量经济学模型结果显示,创新企业个数、医药制造业研发投入和年人均卫生费用对有效发明专利数的影响有统计学意义,具体为:每增加1个R&D活动企业,有效发明专利增加3.884个;R&D投入每增加1万元,有效发明专利增加0.004个;年人均卫生费用每增加1元,有效发明专利增加0.081个。结论 2009—2020年,我国医药制造业研发投入对科技创新作用的推动作用具有积极意义,建议未来进一步加强对医药创新企业的支持,继续增加医药制造业研发投入,并促进健康服务业发展,以加快我国卫生健康科技创新。

关键词：医药制造业科技创新研究与试验发展投入专利产出

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深部岩体爆破冲击波能量分布特征

兵工学报 2024年第6期45卷 1735-1746页

作者：杨建华彭超叶志伟冷振东魏彬南昌大学工程建设学院江西南昌330031 中国葛洲坝集团易普力股份有限公司重庆401121 河南省新乡市交通运输局河南新乡453000

地应力对岩体爆炸应力与爆炸能量的分布有重要影响。针对深部岩体爆破冲击波能量分布,基于叠加原理,计算地应力和爆炸荷载双重作用下岩体爆炸应力分布,结合岩体破坏准则,得到了冲击波作用下深部岩体的破坏特征,分析不同工况下传递入深... 详细信息

地应力对岩体爆炸应力与爆炸能量的分布有重要影响。针对深部岩体爆破冲击波能量分布,基于叠加原理,计算地应力和爆炸荷载双重作用下岩体爆炸应力分布,结合岩体破坏准则,得到了冲击波作用下深部岩体的破坏特征,分析不同工况下传递入深部岩体引起爆破扩腔、径向裂隙扩张及岩石弹性变形的冲击波能量占比,采用数值模拟方法探究了地应力对岩体爆破冲击波能量分布的影响。研究结果表明:岩体性质、炸药性能及地应力水平均会对深部岩体冲击波能量分布产生显著影响;高地应力环境下,硝铵炸药传递入硬岩(花岗岩)的冲击波总能量占比及有效能量的占比较于软岩(页岩)更小,与低性能炸药相比,采用高性能炸药爆破时传递入花岗岩的冲击波总能量占比及有效能量的占比更大;随地应力增大,用于爆腔膨胀的冲击波能量占比基本不变,用于裂隙扩张的冲击波能量占比近似呈线性减小,用于引起弹性变形的冲击波能量占比近似呈指数增长;高地应力环境下,传递入岩体的冲击波总能量占比虽然较大,但有效能量的占比较小;研究成果可为改善深部岩体爆破冲击波能量分布及提升岩体爆破效果提供参考。

关键词：深部岩体爆破冲击波能量高地应力能量分布

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可门电厂某高陡岩质边坡稳定性研究

山西建筑 2022年第22期48卷 85-88,103页

作者：刘勇贺广零许资冷志威湖南三一智慧新能源设计有限公司湖南长沙410000

岩质边坡的稳定性研究一直是岩土工程领域的研究难点,也是许多工程实践中需解决的问题。对位于可门电厂某高陡的岩质边坡进行了稳定性分析、从该边坡的工程地质条件、岩体结构特征、稳定性分析与评价等方面进行了论述,提出了赤平极射投... 详细信息

岩质边坡的稳定性研究一直是岩土工程领域的研究难点,也是许多工程实践中需解决的问题。对位于可门电厂某高陡的岩质边坡进行了稳定性分析、从该边坡的工程地质条件、岩体结构特征、稳定性分析与评价等方面进行了论述,提出了赤平极射投影法定性分析、极限平衡法、强度折减法定量分析相结合的方法,对岩质边坡可能的变形破坏形式都进行了研究,达到了比较准确判定岩质边坡破坏形式的效果,解决了如何针对性进行岩质边坡防护的问题。

关键词：岩质边坡稳定性分析赤平极射投影法极限平衡法

群医学:弥合预防医学与临床医学裂痕的新兴学科

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中华医学杂志 2020年第26期100卷 2001-2005页

作者：杨维中冷志伟单广良王辰中国医学科学院北京协和医学院群医学及公共卫生学院北京100730 中国医学科学院基础医学研究所北京协和医学院基础学院北京100005 中国医学科学院北京协和医学院北京100730

在医学实践中,预防医学与临床医学的裂痕由来已久,其根源性因素在于两类学科一直并行发展,弱化了对医学生大健康意识的培养,固化了医学生的思维。近些年,国际上提出群医学概念,为弥补这一裂痕提出了思路。本文通过回顾群医学的定义、发... 详细信息

在医学实践中,预防医学与临床医学的裂痕由来已久,其根源性因素在于两类学科一直并行发展,弱化了对医学生大健康意识的培养,固化了医学生的思维。近些年,国际上提出群医学概念,为弥补这一裂痕提出了思路。本文通过回顾群医学的定义、发展、学科建设、人才培养及实践情况,认为当前我国实施健康中国战略,必须通过群医学学科建设推动"以治病为中心"向"以人民健康为中心"的转变,具体措施包括建立完整的涵盖学历教育、毕业后教育、继续教育的群医学教育培训体系,在临床及公共卫生实践中灌输群医学理念,建立群医学示范基地,并开展宣传倡导推动群医学学科在全国发展。

关键词：预防医学临床医学群医学弥合裂痕