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Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs

Chinese Journal of Cancer Research 2016年第4期28卷 383-396页

作者： Donika Ivanova zhivko zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi Medical Faculty Trakia University Institute of Biophysics & Biomedical Engineering Bulgarian Academy of Sciences Department of Molecular Imaging and Theranostics National Institute of Radiological SciencesNational Institute for Quantum and Radiological Science and Technology Medical Faculty Sofia University

Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS^independent pathways. We try to answer the question：＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.

关键词： Cancer reactive oxygen species chemotherapy ROS-independent apoptosis ROS-dependent apoptosis

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Haematology of Pelophylax ridibundus(Amphibia: Ranidae) of Striataand MaculataMorphs in Populations Living in Conditions of Anthropogenic Pollution in Southern Bulgaria

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Open Journal of Animal Sciences 2014年第4期4卷 206-216页

作者： zhivko Marinov zhelev Muhammad Arif Georgi Sashev Popgeorgiev Mamoona Rauf Nikolai Hristov Mehterov Bulgarian Society for the Protection of Birds (BSPB) Plovdiv Bulgaria Department of Human Anatomy and Physiology Faculty of Biology University of Plovdiv “PaisiiHilendarski” Plovdiv Bulgaria Department of Medical Biology Medical University Plovdiv Bulgaria Institute of Biochemistry and Biology University of Potsdam Potsdam Germany

Basic haematological parameters were studied in adult, sexually mature individuals of colour morphs (striata and maculata) in the populations of Pelophylax ridibundus living in biotopes with various degrees of anthropogenic pollution (control, domestic sewage pollution and heavy metal pollution) in Southern Bulgaria. We found that in the polluted biotopes in individuals of both morphs of P. ridibundus the blood parameters: erythrocyte (RBC) and leukocyte (WBS) count, haemoglobin concentration (Hb), haematocrit (PCV) were statistically reliably higher, the number of lymphocytes (Ly) decreased, and the parameters: mean cell haemoglobin (MCH), mean cell haemoglobin concentration (MCHC), mean cell volume (MCV) and differential blood formula changed considerably in comparison with the control group. In terms of anthropogenic pollution, the average values of RBC and Hb were higher in P. ridibundus of striata morph.

关键词： Striata and Maculata Morphs Pelophylax ridibundus Anthropogenic Pollution Bio-Indication Haematological Parameters Southern Bulgaria

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