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Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Genes & Diseases 2024年第2期11卷 1009-1021页

作者： Gaojia zhang Ling Li Yan Kong Dandan Xu Yu Bao zhiting zhang Zhixiang Liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng Zhijun zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Shenzhen Key Laboratory of Drug Addiction Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of Sciences (CAS)ShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute (BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Shenzhen-Hong Kong Institute of Brain Sciences-Shenzhen Fundamental Research Institutions ShenzhenGuangdong 518000China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD ***,the role of VDBP as a potential biomarker of MDD diagnosis was further *** extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among *** in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus *** levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed *** main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis.

关键词： Biomarker Cerebrospinal fluid Major depressive disorder Microglia derived extracellular vesicles Vitamin-D binding protein

Fully implantable wireless brain-computer interface for humans: Advancing toward the future

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The Innovation 2024年第3期5卷 3-4页

作者： zhiting zhang Ji Dai Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China

On January 29,2024,Elon Musk made a public announcement via social media about the successful implantation of a Neuralink device in *** after,a collaborative team from Xuanwu Hospital and Tsinghua University in China revealed the advancements in their clinical experiment testing the Neural Electronic Opportunity(NEO)—a wireless brain-computer interface(BCI).1 These simultaneous developments sparked widespread interest and renewed enthusiasm for BCIs worldwide.

关键词： wireless computer interface

SPECT/CT的简易Z-score影像系统在评估颈动脉内膜切除术对颈动脉狭窄的治疗效果中的价值

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国际放射医学核医学杂志 2024年第6期48卷 343-350页

作者：张志婷王萱孙丹阳李玮天津医科大学总医院核医学科天津300052 天津市胸科医院核医学科天津300222

目的探讨SPECT/CT的简易Z-score影像系统(eZIS)在评估颈动脉内膜切除术(CEA)对颈动脉狭窄的治疗效果中的价值,并分析其与磁共振血管成像(MRA)的一致性。方法回顾性分析2018年6月至2021年1月在天津医科大学总医院常规行99Tcm-双半胱乙酯... 详细信息

目的探讨SPECT/CT的简易Z-score影像系统(eZIS)在评估颈动脉内膜切除术(CEA)对颈动脉狭窄的治疗效果中的价值,并分析其与磁共振血管成像(MRA)的一致性。方法回顾性分析2018年6月至2021年1月在天津医科大学总医院常规行99Tcm-双半胱乙酯脑血流灌注SPECT/CT显像及MRA检查的18例颈动脉狭窄(单侧或双侧)患者的临床资料,根据是否行CEA,将患者分为手术治疗组和非手术治疗组,其中,手术治疗组7例,包括男性5例、女性2例,年龄(58.4±7.6)岁,这7例患者均于术前及术后6个月内行SPECT/CT显像和MRA检查;非手术治疗组11例,包括男性8例、女性3例,年龄(62.6±11.1)岁,这11例患者均接受常规药物治疗,并于治疗前及治疗后行SPECT/CT显像和MRA检查,且所有检查均于6个月内完成。测量患者病变部位局部脑血流量并通过eZIS计算出治疗前后Z-score的变化。对2组患者治疗前后Z-score及颈动脉狭窄程度的比较采用配对样本t检验。对MRA与SPECT/CT的eZIS结果的一致性行Kappa检验。结果手术治疗组患者术后Z-score(0.54±2.71)较术前(-1.34±2.68)明显升高,且差异有统计学意义(t=3.899,P=0.008),而非手术治疗组患者治疗后Z-score(-0.33±2.58)较治疗前(1.84±2.62)明显下降,且差异有统计学意义(t=4.618,P=0.001)。手术治疗组患者术后颈动脉狭窄程度较术前明显减轻,且差异有统计学意义(t=3.063,P=0.022);非手术治疗组患者治疗后颈动脉狭窄程度较治疗前明显加重,且差异有统计学意义(t=4.820,P=0.001)。MRA和SPECT/CT的eZIS对颈动脉狭窄治疗前后病情评估的一致性较好(Kappa值=0.766,P<0.001)。结论SPECT/CT的eZIS能够无创、可视化评估CEA对颈动脉狭窄的治疗效果,其方法简便且结果与MRA具有较好的一致性。

关键词：颈动脉狭窄颈动脉内膜切除术脑血流灌注显像磁共振血管造影术体层摄影术发射型计算机单光子体层摄影术 X线计算机简易Z-score影像系统

Mapping the emergence of visual consciousness in the human brain via brain-wide intracranial electrophysiology

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The Innovation 2022年第3期3卷 88-96页

作者： Liang Shan Hui Huang zhiting zhang Yuyin Wang Fei Gu Mingwei Lu Wen Zhou Yi Jiang Ji Dai Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and ManipulationThe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China

Consciousness lies at the heart of our existence and *** probe how perceptual consciousness emerges in the brain,we recorded brainwide intracranial electroencephalography signals from human patients while their perceptual consciousness was effectively manipulated using the continuous flash suppression *** observed substantial differences in brain activities when visual information gradually enters consciousness.

关键词： visual flash Mapping

The photo-decomposition and self-restructuring dynamic equilibrium mechanism of Cu_(2)(OH)_(2)CO_(3)for stable photocatalytic CO_(2)reduction

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Journal of Energy Chemistry 2024年第5期92卷 104-112页

作者： Yaqing Zhi Haoning Mao Guangxing Yang Qiao zhang zhiting Liu Yonghai Cao Siyuan Yang Feng Peng School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina College of Materials and Energy South China Agricultural UniversityGuangzhou 510642GuangdongChina School of Chemistry and Chemical Engineering South China University and TechnologyGangzhou 510640GuangdongChina

Developing suitable photocatalysts and understanding their intrinsic catalytic mechanism remain key challenges in the pursuit of highly active,good selective,and long-term stable photocatalytic CO_(2)reduction(PCO_(2)R)***,monoclinic Cu_(2)(OH)_(2)CO_(3)is firstly proven to be a new class of photocatalyst,which has excellent catalytic stability and selectivity for PCO_(2)R in the absence of any sacrificial agent and *** on a Cu_(2)(OH)_(2)^(13)CO_(3)photocatalyst and 13CO_(2)two-sided^(13)C isotopic tracer strategy,and combined with in situ diffused reflectance infrared Fourier transform spectroscopy(DRIFTS)analysis and density functional theory(DFT)calculations,two main CO_(2)transformation routes,and the photo-decomposition and self-restructuring dynamic equilibrium mechanism of Cu_(2)(OH)_(2)CO_(3)are definitely *** PCO_(2)R activity of Cu_(2)(OH)_(2)CO_(3)is comparable to some of state-of-the-art novel ***,the PCO_(2)R properties can be further greatly enhanced by simply combining Cu_(2)(OH)_(2)CO_(3)with typical TiO_(2)to construct composites *** highest CO_(2)and CH_(4)production rates by 7.5 wt%Cu_(2)(OH)_(2)CO_(3)-TiO_(2)reach 16.4μmol g^(-1)h^(-1)and 116.0μmol g^(-1)h^(-1),respectively,which are even higher than that of some of PCO_(2)R systems containing sacrificial agents or precious metals modified *** work provides a better understanding for the PCO_(2)R mechanism at the atomic levels,and also indicates that basic carbonate photocatalysts have broad application potential in the future.

关键词： CO_(2)photocatalytic reduction Photocatalysis Basic copper carbonate Self-reconstruction Photocatalyst

Systematic engineering of BiVO_(4)photoanode for efficient photoelectrochemical water oxidation

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Carbon Energy 2024年第4期6卷 12-21页

作者： zhiting Liang Meng Li Kai‐Hang Ye Tongxin Tang Zhan Lin Yuying Zheng Yongchao Huang Hongbing Ji Shanqing zhang Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouChina Chemical Engineering Guangdong Laboratory Jieyang Branch of ChemistryJieyangChina Key Laboratory for Water Quality and Conservation of the Pearl River Delta Institute of Environmental Research at Greater Bay AreaMinistry of EducationGuangzhou UniversityGuangzhouChina State Key Laboratory Breeding Base of Green‐Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhouChina School of Environment and Science Centre for Catalysis and Clean EnergyGriffith UniversityGold Coast CampusSouthportQueenslandAustralia

BiVO_(4)is one of the most promising photoanode materials for photoelectrochemical(PEC)solar energy conversion,but it still suffers from poor photocurrent density due to insufficient light‐harvesting efficiency(LHE),weak photogenerated charge separation efficiency(Φ_(Sep)),and low water oxidation efficiency(Φ_(OX)).Herein,we tackle these challenges of the BiVO_(4)photoanodes using systematic engineering,including catalysis engineering,bandgap engineering,and morphology *** particular,we deposit a NiCoO_(x)layer onto the BiVO_(4)photoanode as the oxygen evolution catalyst to enhance theΦ_(OX)of Fe‐g‐C_(3)N_(4)/BiVO_(4)for PEC water oxidation,and incorporate Fe‐doped graphite‐phase C_(3)N_(4)(Fe‐g‐C_(3)N_(4))into the BiVO_(4)photoanode to optimize the bandgap and surface areas to subsequently expand the light absorption range of the photoanode from 530 to 690 nm,increase the LHE andΦ_(Sep),and further improve the oxygen evolution reaction activity of the NiCoO_(x)catalytic ***,the maximum photocurrent density of the as‐prepared NiCoO_(x)/Fe‐g‐C_(3)N_(4)/BiVO_(4)is remarkably boosted from 4.6 to 7.4 mA cm^(−2).This work suggests that the proposed systematic engineering strategy is exceptionally promising for improving LHE,Φ_(Sep),andΦ_(OX)of BiVO_(4)‐based photoanodes,which will substantially benefit the design,preparation,and large‐scale application of next‐generation high‐performance photoanodes.

关键词： bismuth vanadate carbon nitride charge separation heterojunction water oxidation

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法国符号学的过去与今日

外国语文 2022年第4期38卷 1-12页

作者：张智庭南开大学外国语学院天津300071

法国符号学在当代世界范围内的符号学研究中一直占据重要的位置。文章旨在从各种文化的相互影响之中厘清法国符号学产生、发展的脉络和今后的发展前景,明确说明其前后两个发展时期的研究内容,并对两个时期符号学名称的汉语译名发表自己... 详细信息

法国符号学在当代世界范围内的符号学研究中一直占据重要的位置。文章旨在从各种文化的相互影响之中厘清法国符号学产生、发展的脉络和今后的发展前景,明确说明其前后两个发展时期的研究内容,并对两个时期符号学名称的汉语译名发表自己的看法。

关键词：系统论符号学叙述论符号学传播符号学结构意指

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绿氢在石化和化工行业的减碳经济性分析

化工进展 2024年第6期43卷 3021-3028页

作者：张真张凡云祉婷山东氢谷新能源技术研究院山东济南251401 中国电动汽车百人会低碳融合发展研究院北京100085 西安交通大学能源与动力工程学院陕西西安710049

通过使用可再生能源电力电解水所制取的氢气(即绿氢)来替代使用煤炭、天然气等化石燃料所制取的氢气(即灰氢)作为石化和化工原料,可以促进石化和化工行业低碳转型。虽然当前绿氢成本较高,但在电价不断下降、化石能源价格持续上涨以及碳... 详细信息

通过使用可再生能源电力电解水所制取的氢气(即绿氢)来替代使用煤炭、天然气等化石燃料所制取的氢气(即灰氢)作为石化和化工原料,可以促进石化和化工行业低碳转型。虽然当前绿氢成本较高,但在电价不断下降、化石能源价格持续上涨以及碳税、碳交易的综合影响下,绿氢的经济性将具有与灰氢相竞争的优势。本文以石化和化工行业中氢气消费量和碳排放量最高的三个子行业为研究对象,即合成氨、合成甲醇、原油加工,首先介绍了氢气参与到石化和化工过程中的工艺特征和发展趋势,包括传统工艺和新兴工艺,如电化学合成氨、二氧化碳加氢制甲醇、生物油加氢脱氧;接着,对石化和化工行业碳排放进行总结,重点分析了氨、甲醇、精制柴油的碳排放强度;最后,对绿氢替代当前化石燃料制氢、工业副产氢的减碳经济性进行分析,结果表明在碳交易价格为100CNY/t时,绿氢具有替代煤制氢的经济可行性成本为14CNY/kg。

关键词：氢二氧化碳合成合成气预测

R32管内流动沸腾传热系数关联式和摩擦压降关联式

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上海交通大学学报 2023年第1期57卷 45-54页

作者：谷波杜仲星曾炜杰田镇张智铤上海交通大学机械与动力工程学院上海200240 上海海事大学商船学院上海201306

建立了适用于大范围几何参数和流动参数的R32制冷剂管内流动沸腾传热和摩擦压降计算关联式.从公开文献中收集了R32传热和摩擦压降的数据源构建两个组合数据库.其中,传热数据库由来自8个文献的1 489个数据点组成,涵盖的水力直径为1~6.3 ... 详细信息

建立了适用于大范围几何参数和流动参数的R32制冷剂管内流动沸腾传热和摩擦压降计算关联式.从公开文献中收集了R32传热和摩擦压降的数据源构建两个组合数据库.其中,传热数据库由来自8个文献的1 489个数据点组成,涵盖的水力直径为1~6.3 mm,压降数据库由来自8个文献的496个数据点组成,涵盖水力直径范围为0.643~6 mm.以上述数据库为基础,利用无量纲参数分析预测法并考虑参数主导作用,建立了新的传热系数关联式和摩擦压降关联式.此外,利用现有的关联式对新关联式进行评估.结果表明,现有的几个关联式均具有较大的平均绝对误差(MAE)和最大绝对误差(MAX).而新的传热系数计算关联式具有良好的预测精度,其MAE为14.59%,有90.85%的数据点在±30%误差带以内;新的压降关联式预测精度高,其MAE为17.86%.总之,上述两个新关联式都具有较广的应用范围和良好的预测精度,非常适用于分析工质为R32的换热器的传热和压降性能.

关键词： R32 流动沸腾传热系数压降新关联式